LOCUS       NM_153154               4002 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus transcription factor AP-2, delta (Tfap2d), transcript
            variant 1, mRNA.
ACCESSION   NM_153154
VERSION     NM_153154.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4002)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4002)
  AUTHORS   Tran,H.N., Nguyen,Q.H., Jeong,J.E., Loi,D.L., Nam,Y.H., Kang,T.H.,
            Yoon,J., Baek,K. and Jeong,Y.
  TITLE     The embryonic patterning gene Dbx1 governs the survival of the
            auditory midbrain via Tcf7l2-Ap2delta transcriptional cascade
  JOURNAL   Cell Death Differ 30 (6), 1563-1574 (2023)
   PUBMED   37081114
  REMARK    GeneRIF: The embryonic patterning gene Dbx1 governs the survival of
            the auditory midbrain via Tcf7l2-Ap2delta transcriptional cascade.
REFERENCE   3  (bases 1 to 4002)
  AUTHORS   Luo,X., Xia,Y., Li,X.D. and Wang,J.Y.
  TITLE     The effect of AP-2delta on transcription of the Prestin gene in
            HEI-OC1 cells upon oxidative stress
  JOURNAL   Cell Mol Biol Lett 24, 45 (2019)
   PUBMED   31297132
  REMARK    GeneRIF: Oxidative stress inhibits the expression of Prestin
            protein, and the transcription mechanism is triggered to compensate
            for the loss of Prestin protein in HEI-OC1 cells. AP-2delta is one
            of the important TFs that suppresses transcription of the Prestin
            gene, and AP-2delta suppression further boosted Prestin mRNA
            activation under oxidative stress.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4002)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4002)
  AUTHORS   Jain,S., Glubrecht,D.D., Germain,D.R., Moser,M. and Godbout,R.
  TITLE     AP-2epsilon Expression in Developing Retina: Contributing to the
            Molecular Diversity of Amacrine Cells
  JOURNAL   Sci Rep 8 (1), 3386 (2018)
   PUBMED   29467543
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4002)
  AUTHORS   Winger,Q., Huang,J., Auman,H.J., Lewandoski,M. and Williams,T.
  TITLE     Analysis of transcription factor AP-2 expression and function
            during mouse preimplantation development
  JOURNAL   Biol Reprod 75 (3), 324-333 (2006)
   PUBMED   16672719
REFERENCE   7  (bases 1 to 4002)
  AUTHORS   Feng,W. and Williams,T.
  TITLE     Cloning and characterization of the mouse AP-2 epsilon gene: a
            novel family member expressed in the developing olfactory bulb
  JOURNAL   Mol Cell Neurosci 24 (2), 460-475 (2003)
   PUBMED   14572467
REFERENCE   8  (bases 1 to 4002)
  AUTHORS   Zhao,F., Lufkin,T. and Gelb,B.D.
  TITLE     Expression of Tfap2d, the gene encoding the transcription factor
            Ap-2 delta, during mouse embryogenesis
  JOURNAL   Gene Expr Patterns 3 (2), 213-217 (2003)
   PUBMED   12711551
REFERENCE   9  (bases 1 to 4002)
  AUTHORS   Werling,U. and Schorle,H.
  TITLE     Transcription factor gene AP-2 gamma essential for early murine
            development
  JOURNAL   Mol Cell Biol 22 (9), 3149-3156 (2002)
   PUBMED   11940672
REFERENCE   10 (bases 1 to 4002)
  AUTHORS   Zhao,F., Satoda,M., Licht,J.D., Hayashizaki,Y. and Gelb,B.D.
  TITLE     Cloning and characterization of a novel mouse AP-2 transcription
            factor, AP-2delta, with unique DNA binding and transactivation
            properties
  JOURNAL   J Biol Chem 276 (44), 40755-40760 (2001)
   PUBMED   11522791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF421891.2, CO424726.1, AC098736.4 and BB676311.1.
            
            On Nov 22, 2016 this sequence version replaced NM_153154.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF421891.2, AK132112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1753              AF421891.2         2-1754
            1754-2360           CO424726.1         23-629
            2361-3612           AC098736.4         10372-11623         c
            3613-3780           BB676311.1         24-191
            3781-3781           AC098736.4         10203-10203         c
            3782-3975           BB676311.1         193-386
            3976-4002           BB676311.1         388-414
FEATURES             Location/Qualifiers
     source          1..4002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.08 cM"
     gene            1..4002
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /note="transcription factor AP-2, delta"
                     /db_xref="GeneID:226896"
                     /db_xref="MGI:MGI:2153466"
     exon            1..273
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1593
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AP2-delta; activating enhancer-binding protein 2-delta"
                     /codon_start=1
                     /product="transcription factor AP-2-delta isoform 1"
                     /protein_id="NP_694794.1"
                     /db_xref="CCDS:CCDS14838.1"
                     /db_xref="GeneID:226896"
                     /db_xref="MGI:MGI:2153466"
                     /translation="MSTTFPGLVHDAEIRHDGSNSYRLMQLGCLESVANSTVAYSSSS
                     PLTYSTTGTEFASPYFSTNHQYTPLHHQSFHYEFQHSHPAVTPDAYSLNSLHHSQQYY
                     QQIHHGEPTDFINLHNARALKSSCLDEQRRELGCLDAYRRHDLSLMSHGSQYGMHPDQ
                     RLLPGPSLGLAAAGADDLQGSVEAQCGIVLNGQGGVIRRGGTCVVNPTDLFCSVPGRL
                     SLLSSTSKYKVTIAEVKRRLSPPECLNASLLGGILRRAKSKNGGRCLREKLDRLGLNL
                     PAGRRKAANVTLLTSLVEGEALHLARDFGYTCETEFPAKAVGEHLARQHMEQKEQTAR
                     KKMILATKQICKEFQDLLSQDRSPLGSSRPTPILDLDIQRHLTHFSLITHGFGTPAIC
                     AALSTFQTVLSEMLNYLEKHTTHKNGGAADSGQGHANSEKAPLRKASEAAVKEGKTEK
                     TD"
     exon            274..771
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /inference="alignment:Splign:2.1.0"
     exon            772..832
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /inference="alignment:Splign:2.1.0"
     exon            833..998
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1117
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1259
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1373
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..4002
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2900..2905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /note="hexamer: AATAAA"
     polyA_site      2924
                     /gene="Tfap2d"
                     /gene_synonym="Tcfap2d"
                     /note="major polyA site"
ORIGIN      
        1 agggagctgc ttttgtgcag agggaaaatt ttgttcctac aggtttttta agtgggtacg
       61 aggcaaggag ctatctgatc cgggcaaaac cattacagtt tagatctcta tctacggaac
      121 attttttttc ttcctttaaa aaaaattgga aaatacaaga agttttggat ttttttttcc
      181 tgattctttt tttggagggg gaaattgcat cgtaagcttt tggagaaacc catcatgtca
      241 actacctttc ccggactagt ccacgatgcg gagatacgtc acgacggatc aaacagctac
      301 cgtttgatgc agcttggctg tctggagtcc gtagccaatt ccacggttgc ctattcctcc
      361 tcctctcctt taacttactc taccaccggc accgagtttg cgtcccccta cttctccact
      421 aaccaccagt acaccccgct ccaccaccag tccttccatt acgagttcca gcacagccac
      481 ccggcggtca ctcccgacgc ctactctctg aactcgctcc accactcaca acagtactac
      541 cagcagattc accacgggga gcccaccgac tttattaacc tgcacaatgc gcgggctctc
      601 aagtcctcct gcctggacga gcagaggcgg gagctgggtt gcctcgatgc ctaccgccgc
      661 cacgacctgt ccctcatgag ccatggctct cagtatggaa tgcacccaga tcaaagactc
      721 ctgccagggc ccagcctggg gctggccgcc gcgggagccg acgacttgca gggttccgtg
      781 gaagcccagt gtgggattgt tctcaacggc caaggggggg tgatcagaag aggtggcacc
      841 tgtgtagtca accccacaga cttgttttgc tcagttcccg gtcgtttgtc tcttctcagt
      901 tctacttcca aatacaaggt gactatcgct gaggtaaaga ggcgcctctc accacccgag
      961 tgcctcaatg cttcacttct gggaggcatt ctgaggagag caaaatccaa gaatggtggt
     1021 cgttgcctga gagaaaaact ggataggctt ggcctaaact tgccagctgg aagacggaaa
     1081 gcagccaacg ttaccttgct cacttcttta gttgaaggtg aggctttgca cttggctcgg
     1141 gattttggct acacgtgtga aaccgagttt ccagccaagg cagtgggaga gcatctcgcc
     1201 agacaacata tggaacagaa agaacagact gcaagaaaaa agatgatcct agccaccaag
     1261 caaatttgta aagaatttca agacctcctg agccaggata gatcaccact gggatcctcc
     1321 agacccactc ccattctaga ccttgacatc cagaggcact taacacattt cagtttgatc
     1381 actcatggtt ttgggacacc agcaatatgt gcagctctaa gcactttcca aacagtcctc
     1441 agtgagatgc ttaactactt ggaaaaacac actactcaca aaaacggtgg tgcggcagac
     1501 tctggccaag gacatgccaa ctcggagaaa gccccgctgc ggaaagcttc agaggctgct
     1561 gtgaaagagg gcaaaacaga aaagacagac tagctgcatc aaacagaatc tatttccaga
     1621 gagtcttgct gctcatattt ttttttctaa tatatacatc attgagggtg actaatcttc
     1681 agcggaccaa atctttaccc tccctgagcc ctccataaaa tgaaatcaaa agtggaaatg
     1741 aaaacaaaaa aaagtaaaca aaaaaatgac agatccaaaa caatgagaaa gaggaaaacg
     1801 gcagtgtaac tatgtgatgg aattgtcact tttttttttg ttgttgttat gataaaactt
     1861 ctgtgcacgt acttgattgc tctgaattat atacaccaca gttttcaagc acttctggac
     1921 ttcggagagg cagcacatgc tttttcacat ataattgatg cactttctta tccagctata
     1981 tagttagggg tcagtcagag agcatgacca aactggagtc tgtcaccaat gactgctgct
     2041 ccagtcttcc ctgacttaac tccccatcac tgaagagtgc ctctttctat taaataggcc
     2101 aatctgaaat taaccactaa tacatgtttg aggaactgaa aaggacagtc acaaactttt
     2161 tgagctgaca gcagttctaa atatttgatc accccagatt actgaattat ccgtgccttg
     2221 gtggtgttta aaaattccag aaactgtctc ccttcctttc ctcttagctc ccctttccca
     2281 tttctaagaa cataatcaaa agacttatac aacactgtag ggataagaga tgaactcttc
     2341 catgccaact gcacagttca aagaaacact gaatttggtc aatggggtat acagatgcag
     2401 aggaggggag ctttgccatt attgggctct ctgtcaaatg caatgacatt attttgccta
     2461 aaaattatga gaataggagg agggtatttc tgatcagtcc tgcctttaag acatgggacc
     2521 cccttcaaag tgctggtggc aatgattgtg tggttgaagt gagagccatg tttttgcgct
     2581 tctatgctat ttctacctgt tccacatgtt ctaaactttt agaggcacaa aagcaccctg
     2641 gctgtgttca ataaagaaag caaacagaat aattagagaa gacttttgct tttcagatgt
     2701 tttctctttt ttcccatagc ttgttatagc ttttttacct ttcatttaag acactacaaa
     2761 caagaagttc ctgactgcaa aagccaggga taattgaaag aatgtttggt ccacataaac
     2821 ctgtatatgt caagaaagtt ggttgccact acattgttct agcttttcta ctgttaacaa
     2881 ttaaacttca atataggcaa ataaaaacat agatcattat gtaataaagt aattattttc
     2941 atgtgtggat attcaacact tagtttagca tgaaaatatt accctctcat taacatactt
     3001 caattatttt aaagagctct gccatattat aactttttca agaatattag cattatagct
     3061 aatgagagga agtatctgga attttcatgt atgaatcaaa gaagctattt ttacctgaca
     3121 ttaattctta aaaccattat cttgagtctt gtacagaaat gaaccataac cactgaaaac
     3181 ctaaagtttt tagattaaat ttattcaaca ggagacatgt ttgaagaatt ccataacaat
     3241 aggatattat agtaatacag tagaagagct tgaaataaaa ataaaagaat tatgatttca
     3301 tgtgtttagt tccatttttc aattttatca ttattgatgg ctttaatttc ttaagtaaaa
     3361 taaagcaaaa ccaacattct tccacaattc caaatttcat cagaaaatga gtgatactat
     3421 gttacaagtc tcccacattg taaaatatgc acacaaaaca aaaataatat ttgagtttag
     3481 taagtggtag gaaagttaca tctagataat gtggactact atatctgcaa tgaaatttcc
     3541 acattaattg ttctttatcg catttattat taacaataca tttgtattta atgtggcatt
     3601 ttaagatgca tactgctagg tacttgatgc tataaccatg gcaaatgttc acaaatattc
     3661 aaatggaact ctagatctgg cttatgttac aagtcaactt cttcaccctt agttgtaact
     3721 ggcttggatt caaaacacct cagaggtggt gttatttatt agccttgaaa caaaatgtaa
     3781 ctataactac agtgcatatt atttaccagg attgtgggtg ttttaagagc cttcatgaac
     3841 agcgcccacc atttcactct accagtcatt agaacataat caagttgaag gactggtcca
     3901 gtttaaaatc atcatttatt atcatattct aatatacatt gttaatacca ccttttgcct
     3961 tgtatataat aggtactcaa cactttttaa ataaatgagt aa
//
