LOCUS       NM_009335               2853 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus transcription factor AP-2, gamma (Tfap2c), transcript
            variant 1, mRNA.
ACCESSION   NM_009335
VERSION     NM_009335.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Chen,R., Fan,R., Chen,F., Govindasamy,N., Brinkmann,H.,
            Stehling,M., Adams,R.H., Jeong,H.W. and Bedzhov,I.
  TITLE     Analyzing embryo dormancy at single-cell resolution reveals dynamic
            transcriptional responses and activation of integrin-Yap/Taz
            prosurvival signaling
  JOURNAL   Cell Stem Cell 31 (9), 1262-1279 (2024)
   PUBMED   39047740
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Bi,S., Huang,L., Chen,Y., Hu,Z., Li,S., Wang,Y., Huang,B.,
            Zhang,L., Huang,Y., Dai,B., Du,L., Tu,Z., Wang,Y., Xu,D., Xu,X.,
            Sun,W., Kzhyshkowska,J., Wang,H., Chen,D., Wang,F. and Zhang,S.
  TITLE     KAT8-mediated H4K16ac is essential for sustaining trophoblast
            self-renewal and proliferation via regulating CDX2
  JOURNAL   Nat Commun 15 (1), 5602 (2024)
   PUBMED   38961108
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2853)
  AUTHORS   Zhu,M., Meglicki,M., Lamba,A., Wang,P., Royer,C., Turner,K.,
            Jauhar,M.A., Jones,C., Child,T., Coward,K., Na,J. and
            Zernicka-Goetz,M.
  TITLE     Tead4 and Tfap2c generate bipotency and a bistable switch in
            totipotent embryos to promote robust lineage diversification
  JOURNAL   Nat Struct Mol Biol 31 (6), 964-976 (2024)
   PUBMED   38789684
  REMARK    GeneRIF: Tead4 and Tfap2c generate bipotency and a bistable switch
            in totipotent embryos to promote robust lineage diversification.
REFERENCE   5  (bases 1 to 2853)
  AUTHORS   Gao,R., Yang,G., Wang,M., Xiao,J., Yi,S., Huang,Y., Guo,Z.,
            Kang,Y., Fu,Q., Wang,M., Xu,B., Shen,S., Zhu,Q., Liu,M., Wang,L.,
            Cui,X., Yi,S., Kou,X., Zhao,Y., Gu,L., Wang,H., Gao,S., Jiang,C.
            and Chen,J.
  TITLE     Defining a TFAP2C-centered transcription factor network during
            murine peri-implantation
  JOURNAL   Dev Cell 59 (9), 1146-1158 (2024)
   PUBMED   38574734
  REMARK    GeneRIF: Defining a TFAP2C-centered transcription factor network
            during murine peri-implantation.
REFERENCE   6  (bases 1 to 2853)
  AUTHORS   Williamson,J.A., Bosher,J.M., Skinner,A., Sheer,D., Williams,T. and
            Hurst,H.C.
  TITLE     Chromosomal mapping of the human and mouse homologues of two new
            members of the AP-2 family of transcription factors
  JOURNAL   Genomics 35 (1), 262-264 (1996)
   PUBMED   8661133
REFERENCE   7  (bases 1 to 2853)
  AUTHORS   Oulad-Abdelghani,M., Bouillet,P., Chazaud,C., Dolle,P. and
            Chambon,P.
  TITLE     AP-2.2: a novel AP-2-related transcription factor induced by
            retinoic acid during differentiation of P19 embryonal carcinoma
            cells
  JOURNAL   Exp Cell Res 225 (2), 338-347 (1996)
   PUBMED   8660922
REFERENCE   8  (bases 1 to 2853)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
REFERENCE   9  (bases 1 to 2853)
  AUTHORS   Lim,L.C., Fang,L., Swendeman,S.L. and Sheffery,M.
  TITLE     Characterization of the molecularly cloned murine alpha-globin
            transcription factor CP2
  JOURNAL   J Biol Chem 268 (24), 18008-18017 (1993)
   PUBMED   8349681
REFERENCE   10 (bases 1 to 2853)
  AUTHORS   Keitges,E., Rivest,M., Siniscalco,M. and Gartler,S.M.
  TITLE     X-linkage of steroid sulphatase in the mouse is evidence for a
            functional Y-linked allele
  JOURNAL   Nature 315 (6016), 226-227 (1985)
   PUBMED   3858674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY016798.1, AK145603.1, X94694.1 and BQ033542.1.
            
            On Apr 29, 2009 this sequence version replaced NM_009335.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X94694.1, AK145166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               BY016798.1         2-351
            351-445             AK145603.1         246-340
            446-2825            X94694.1           425-2804
            2826-2853           BQ033542.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 94.87 cM"
     gene            1..2853
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /note="transcription factor AP-2, gamma"
                     /db_xref="GeneID:21420"
                     /db_xref="MGI:MGI:106032"
     exon            1..290
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1592
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AP2-gamma; activating enhancer-binding protein 2 gamma;
                     stimulated by retinoic acid gene 2"
                     /codon_start=1
                     /product="transcription factor AP-2 gamma isoform 1"
                     /protein_id="NP_033361.2"
                     /db_xref="CCDS:CCDS17135.1"
                     /db_xref="GeneID:21420"
                     /db_xref="MGI:MGI:106032"
                     /translation="MLWKITDNVKYEEDCEDRHDSSSNGNPRIPHLSSPGQHLYSPAP
                     PLSHTGVAEYQPPPYFPPPYQQLAYSQSADHYSHLGEAYAAAMNPLHQPAATGSQQQA
                     WPGRQSQEGSSLASHHSRSASLIPHISGLEGGSVSARREVYRRSDLLLPHAHALEAGL
                     AENLGLHEMAHPIEEVQNVDDAHLLLHDQTVIRKGPISMTKNPLGLPCQKDLVGVVMN
                     PSEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRS
                     LREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKAVADYLT
                     RPHLGGRNEMATRKSMLLAAQQVCKEFTDLLHQDRTPNGNNRPAQVLEPNIQNCLSHF
                     SLITHGFGSQAICAAVSAVQNYIKEALIAIDKSYMNPGDQSPADSSKTMEKMEKHRK"
     exon            291..773
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            774..825
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1042
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1161
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1306
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..2838
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2807..2812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /note="hexamer: AATAAA"
     polyA_site      2838
                     /gene="Tfap2c"
                     /gene_synonym="Ap-2.2; AP2gamma; Stra2; Tcfap2c"
                     /note="major polyA site"
ORIGIN      
        1 gggacacact gtgagggtga ggcttctccg gtccacggct gcggcctcta cacacccacg
       61 gcgaccacat ctctgtgcac agccaccgat gcgcgtccag tgactgggac agcaaggccg
      121 gcgcgcgcgg cgggggcggc ggcagacgcc tggccaccgt gaccccgatt gtggatttac
      181 cgctcggggg gtggggggag cctggattta actggcgact attttggggg acgccggacg
      241 ccatgttgtg gaaaataaca gataatgtca agtatgaaga ggattgcgag gatcgccacg
      301 actcgagcag taatggcaac cctcgcatcc ctcacctctc ctctccggga caacatctct
      361 acagtcccgc gccgcctctc tcgcacaccg gggttgcaga gtaccagccg cctccttact
      421 tcccgccgcc ttaccagcag ctggcatact cgcagtccgc cgaccattac tcgcatctgg
      481 gagaggctta cgctgccgcc atgaaccccc tgcaccagcc tgcggccacc ggcagccagc
      541 aacaggcctg gccgggtcga cagagtcagg agggctctag cctggcctcg caccacagcc
      601 gctctgcaag tctaataccc catatttcag ggctggaggg gggctcggtg agcgcccggc
      661 gggaagtcta ccgccggtcc gacctgctgc tgcctcacgc gcacgccctg gaagccggcc
      721 tggctgagaa cctggggctg cacgagatgg ctcaccccat agaggaggtg cagaatgtgg
      781 acgacgcgca cttgctccta cacgatcaga ctgtcattcg caaaggaccc atttcgatga
      841 ccaagaaccc tttggggctc ccttgccaga aggacctggt gggagtggtc atgaacccca
      901 gtgaggtctt ctgctcggtc cctggaagac tgtccctgct cagctccacg tcgaagtaca
      961 aagtaactgt ggctgaggta cagaggcgac tgtcaccacc ggaatgccta aacgcctcgc
     1021 tcctgggagg tgtgctcaga agagcaaagt ccaaaaatgg aggccggtcc ttgagggaga
     1081 agttggacaa aattggattg aaccttccgg ccgggagacg gaaagctgcc cacgtcactc
     1141 tcctcacgtc tctcgtggaa ggtgaagccg tccacctagc acgggacttc gcctatgtct
     1201 gcgaagctga gttccctagt aaagcggtgg ctgactattt aacgagacca catcttgggg
     1261 gacggaatga gatggccacg cggaagagta tgttgttggc tgcacagcag gtgtgcaagg
     1321 agttcactga ccttctccat caagatcgga cacccaacgg gaacaacagg cccgcccagg
     1381 tcttggagcc gaacatacaa aactgtttgt ctcatttcag cctgataact catggctttg
     1441 gcagccaggc catctgtgcg gcggtctccg cagtgcagaa ttatatcaag gaggctctaa
     1501 tcgccatcga taagtcctac atgaacccgg gggaccagag tccggctgat tccagcaaga
     1561 cgatggagaa aatggaaaag cacaggaagt aaaatggctg caaggaggcc agagagcaga
     1621 aggagaggac ccaggcccct ccactggggc agcccgggaa gtgtccagag cagcagcagc
     1681 agcagggaag cagttacaac ccgcccgccc acaccgcact ctggacctgc cctcttggag
     1741 tctttgtgac ttttccattt aaccctggac atgctatcct gaagccactt ggtttggttc
     1801 ttttattcat taaacatgtg tgttttttgt ttttttttta aatccgttcc ctctcttgaa
     1861 aggtgctacg agttttagaa ccctttgtaa gaactccctg ggcagacaag aaactccacg
     1921 cttagctgct aacacagcag gtgcatggga gtcgtcagat aaagggatcg atcaatcata
     1981 acttatttct ttttcagtgt taagataata gctggctttt atgtccacta aaatatttat
     2041 ctaaaaaaaa atagtattta tctagttttc cccaccacct tgtcaatcac accttctggt
     2101 aggaggcaga agtcagagat gctcttagca ggcagctact taccagtggt atgtgacagg
     2161 cttccagcta ctcattcaaa aaaggggtcc cctgttttta aggaacttga aagcaaagcc
     2221 tgctgtttct ttcctgtttc cttcctcttt taaaaaaata ttgaaagttt aaaattcttt
     2281 agataatagg atttttaaat gatctgttcc tttaaggtag agaagtttta tttgcatatt
     2341 tatttcagat cttgattttt ttttttccac aaaacttgaa gagggtaggc acacagcggc
     2401 gcctgccatc cctaagtccc cgaggaggct ccgtgctgag aaactgttga gtgtacagat
     2461 tttatttatg cataatttaa tgggatctgt aaatacttct tatgactttt tgagaaatgg
     2521 gattcgattt taaaattacc ttttaatggt ggtgggtcat gtagcccctc tagcttttat
     2581 gcgagtgcac acagggtatt gaaactgaag atgaagctgg gcttttctct cttggctggt
     2641 caagtattat ttgattggag ctgtttagga agcaataggc atctcatttc tgcgggctga
     2701 accggaagag aatggagttt agtttgtgtg ggtgacgtgt ggattgggac tggacctcta
     2761 agcctgtccg tgctccttaa ataattgttg tgtgtgatac ctgtataata aaaaatattc
     2821 tcgatagaat ctctgaaaaa aaaaaaaaaa aaa
//
