LOCUS       NM_009334               5901 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus transcription factor AP-2 beta (Tfap2b), transcript
            variant 1, mRNA.
ACCESSION   NM_009334
VERSION     NM_009334.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5901)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5901)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5901)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   4  (bases 1 to 5901)
  AUTHORS   Shao,F., Phan,A.V., Yu,W., Guo,Y., Thompson,J., Coppinger,C.,
            Venugopalan,S.R., Amendt,B.A., Van Otterloo,E. and Cao,H.
  TITLE     Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling
            lineage specification of mandibular epithelium during tooth
            initiation
  JOURNAL   PLoS Genet 20 (7), e1011364 (2024)
   PUBMED   39052671
  REMARK    GeneRIF: Transcriptional programs of Pitx2 and Tfap2a/Tfap2b
            controlling lineage specification of mandibular epithelium during
            tooth initiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5901)
  AUTHORS   Nakai,A., Kashiwagi,M., Fujiyama,T., Iwasaki,K., Hirano,A.,
            Funato,H., Yanagisawa,M., Sakurai,T. and Hayashi,Y.
  TITLE     Crucial role of TFAP2B in the nervous system for regulating NREM
            sleep
  JOURNAL   Mol Brain 17 (1), 13 (2024)
   PUBMED   38413970
  REMARK    GeneRIF: Crucial role of TFAP2B in the nervous system for
            regulating NREM sleep.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5901)
  AUTHORS   Moser,M., Ruschoff,J. and Buettner,R.
  TITLE     Comparative analysis of AP-2 alpha and AP-2 beta gene expression
            during murine embryogenesis
  JOURNAL   Dev Dyn 208 (1), 115-124 (1997)
   PUBMED   8989526
REFERENCE   7  (bases 1 to 5901)
  AUTHORS   Williamson,J.A., Bosher,J.M., Skinner,A., Sheer,D., Williams,T. and
            Hurst,H.C.
  TITLE     Chromosomal mapping of the human and mouse homologues of two new
            members of the AP-2 family of transcription factors
  JOURNAL   Genomics 35 (1), 262-264 (1996)
   PUBMED   8661133
REFERENCE   8  (bases 1 to 5901)
  AUTHORS   Moser,M., Imhof,A., Pscherer,A., Bauer,R., Amselgruber,W.,
            Sinowatz,F., Hofstadter,F., Schule,R. and Buettner,R.
  TITLE     Cloning and characterization of a second AP-2 transcription factor:
            AP-2 beta
  JOURNAL   Development 121 (9), 2779-2788 (1995)
   PUBMED   7555706
REFERENCE   9  (bases 1 to 5901)
  AUTHORS   Peters,L.L., John,K.M., Lu,F.M., Eicher,E.M., Higgins,A.,
            Yialamas,M., Turtzo,L.C., Otsuka,A.J. and Lux,S.E.
  TITLE     Ank3 (epithelial ankyrin), a widely distributed new member of the
            ankyrin gene family and the major ankyrin in kidney, is expressed
            in alternatively spliced forms, including forms that lack the
            repeat domain
  JOURNAL   J Cell Biol 130 (2), 313-330 (1995)
   PUBMED   7615634
REFERENCE   10 (bases 1 to 5901)
  AUTHORS   Mermod,N., Williams,T.J. and Tjian,R.
  TITLE     Enhancer binding factors AP-4 and AP-1 act in concert to activate
            SV40 late transcription in vitro
  JOURNAL   Nature 332 (6164), 557-561 (1988)
   PUBMED   2833704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132356.3.
            
            On Nov 8, 2022 this sequence version replaced NM_009334.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017373.1, SRR9219381.300330.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC132356.3         135567-135668       c
            103-561             AC132356.3         130406-130864       c
            562-622             AC132356.3         125562-125622       c
            623-842             AC132356.3         118160-118379       c
            843-961             AC132356.3         116255-116373       c
            962-1103            AC132356.3         113661-113802       c
            1104-5901           AC132356.3         105968-110765       c
FEATURES             Location/Qualifiers
     source          1..5901
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.19 cM"
     gene            1..5901
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="transcription factor AP-2 beta"
                     /db_xref="GeneID:21419"
                     /db_xref="MGI:MGI:104672"
     exon            1..102
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1401
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activating enhancer-binding protein 2 beta"
                     /codon_start=1
                     /product="transcription factor AP-2-beta isoform 1"
                     /protein_id="NP_033360.2"
                     /db_xref="CCDS:CCDS14839.1"
                     /db_xref="GeneID:21419"
                     /db_xref="MGI:MGI:104672"
                     /translation="MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLG
                     SVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQ
                     QHPWGQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDA
                     GMGDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGF
                     LGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAK
                     SKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAK
                     AVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQ
                     SCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTNRHTSGEGPGSKT
                     GDKEEKHRK"
     exon            103..561
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            562..622
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            623..842
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            843..961
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1103
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..5901
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1412..1417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="hexamer: ATTAAA"
     polyA_site      1444
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="major polyA site"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="hexamer: AATAAA"
     polyA_site      1739
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
     regulatory      4330..4335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="hexamer: AATAAA"
     polyA_site      4352
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
     regulatory      5607..5612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="hexamer: AATAAA"
     polyA_site      5627
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
     regulatory      5878..5883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="hexamer: AATAAA"
     polyA_site      5901
                     /gene="Tfap2b"
                     /gene_synonym="AP-2(beta); AP2-beta; E130018K07Rik;
                     Tcfap2b"
                     /note="major polyA site"
ORIGIN      
        1 agacatctgc tcctcacatg aatgcactca cctcctagag accaggctgc gatcatgctc
       61 tggaaactcg tggagaatgt caagtacgaa gacatctatg aggaccggca cgatggcgtc
      121 ccaagccata gctcgagact ctctcaactg ggctctgtgt cccaaggacc ctactcaagc
      181 gccccgccgc tgtcccacac gccatcatcg gacttccagc caccctactt tccgcccccc
      241 taccagccgc taccctacca ccagagtcaa gacccgtact cccacgtcaa cgatccctac
      301 tccctgaacc ctctgcatca gccccagcag cacccgtggg ggcaacggca acgccaagaa
      361 gtgggctcag aagccggctc tctcctgccc cagccccggg cagccttgcc ccagctctcc
      421 ggccttgatc cccgaaggga ctaccactct gtccgccggc cggacgtgct gctgcattcc
      481 gcacatcacg gcctggacgc cggcatgggc gacagcctct cgttgcacgg ccttgggcat
      541 cccggcatgg aagacgtgca gtcagttgaa gatgccaata acagcggcat gaacctattg
      601 gaccagtcag tcattaaaaa agttcctgtc cctcccaaat ctgtgacttc tctaatgatg
      661 aataaagatg gcttcttggg aggaatgtca gtcaacaccg gcgaggtatt ttgctcagtc
      721 ccgggccgtt tatctctact cagttcaact tcaaagtaca aagtcactgt gggcgaagtt
      781 cagagaaggc tctcgccccc tgaatgcctc aatgcatctc tcctgggcgg cgtcctcaga
      841 agagccaaat cgaaaaatgg ggggagatcc ttgagagaaa ggctagaaaa aatcggtttg
      901 aatttacccg cgggcaggcg caaagcagca aatgtcacgt tactcacctc actggtagaa
      961 ggggaagctg ttcacttagc tcgggatttc gggtatattt gtgaaacaga gtttcctgct
     1021 aaagccgtgt ccgagtattt gaacagacag cacacggacc ccagtgacct gcactccaga
     1081 aagaatatgc tgctggccac caagcaactt tgtaaagaat ttacggatct gctggctcag
     1141 gaccggacac cgatcggaaa cagcaggccc agccccatcc tggagccggg catccaaagc
     1201 tgtctcacgc acttcagtct catcacgcac ggcttcggtg ccccggccat ttgcgctgcg
     1261 ctcacggccc tgcagaacta tctcaccgag gcgctcaaag gcatggacaa gatgttcttg
     1321 aacaacacca ctaacaggca cacgtctggg gaaggcccag gtagtaaaac tggcgacaag
     1381 gaggagaaac acaggaaatg aaaaaaaaaa aattaaagag aaggaaaatg ttttaaatac
     1441 aaaaggaaaa cagaaaaaaa ataaatttag ctttaacata ttggattggc tttggaggaa
     1501 ttatattagg tagaatacac atacaatcaa aatttaaaaa gaaagctaaa taacgttaaa
     1561 aaaaaataaa ctgaggcata caacggagca acaaaccggc tctcggtgtc tatttcaaga
     1621 tacacgtgga gacaaccgtc cggattttcc acttcggttc tttcgaattt agtaatacag
     1681 ataaaaaagg aaaactatga atcccccttt tggaaaataa aacgtgagac taaacatgag
     1741 aacacgctaa cttattggaa gaaaattgga gaaacgttgg tgtcaatgct tttgagagct
     1801 ggttgactga gacgcacgaa cttttaaatc tttaatttaa tttttttttt ttttaaggaa
     1861 actctcgcac ttcgcgccct ccatttctcc tcattctcct caccgctgct tccctttctc
     1921 ccttcctcac agcgatcccg gaaatctgct gggtgatcac gagtgtgatt agctctctgg
     1981 tgttagcccc tttggtgtcc agaccgcgcc ttgcgttcct aactcccctg agcccaactc
     2041 ccctacctcc cctccacccc caccctcacc ctcaccccgc cccggtgtgt ttaattaggg
     2101 aggccaaggg tgggggtggg ggacaggcgg aggctctagc ttttgatcca ggcttgagag
     2161 cccaggctcc cgcggcagag aggaaaccga taagttgatt catcttggtt ccttttagaa
     2221 aatgttacta gtctcccaga cgtgacagca cctgttcaca gagaatatta catttgttat
     2281 acttgtgtca tctagcggta tagtttaaaa agaaaggaaa agaaaggaaa aaacaaaaac
     2341 caaaacatga aaactttgat tagtatgtaa ttccttcgga ggggtatgta ccactgactc
     2401 tcttctgttt ccccaagctt tacccgcatg gtttatgagc ttcttcaagg aagatttggg
     2461 cttcctacac aatctataag gtactgagaa acaacagcaa caacctgatc ctttttaaag
     2521 ttaaagcctg cctgtcagat tcggcaggtt ttacttcttt aaagaagctc aaagagaatc
     2581 atttaggaag tggccagtgt tggggggagc ggctttggat ttcttgctaa cacacctcaa
     2641 cgcaggaatt ccagcagggg cgggacactg cagaatgcat tttaagggag tcgagtaagg
     2701 tatcttggct ttgggaccta tattgtaatg gtattgtctt tactggaaaa atggattcca
     2761 tttccttggg ctctttgggg actggatgtt ttaatggggg aaagaagtag ttttgctgag
     2821 tgattgggga agacagtcta taaactacca tgactctgct ttatgaatga aacagttttc
     2881 cttctcagac acacaggtat tttggcataa aatggtacac acacacacac acacacacac
     2941 acacacacac acacacacac cagaaacaca aggcaaaggg aacgagattg tatttcaact
     3001 ttgaattcct gtcttgattt attgggaata ttcctaatgg atgaagttcc atgaatttaa
     3061 tgtatctctc ttctcttagt ccaacttttt actgtacccc atcttaatat taccacgaag
     3121 taaaaccggc acctttagca agttcaagga gtagagtatt tgattggtgc acacatttag
     3181 tttgggtaca cttatttttt ttcacctacc tagacgggaa ctttataaaa tccattagga
     3241 tatatgttca gatgttttct gtgatttaca cagtcccttc ccccagtagt ctggactctc
     3301 agtattccta tctttttcaa tccactttga agcaagggaa ggggttgaag ttttagggac
     3361 cctctgaggg aatcgctcaa aggatgaagg ttgtaaacaa aaattgaggt caggcaacat
     3421 ctctgctcct atctctagct gcttctgagc cccataggtt tccaggacac agccctagac
     3481 gaggctgaaa ggagtagaaa gggcaggaaa aaatacatgt gtgaactata gattctcatc
     3541 tttcctcagt ttagaagccc accccatttg tccaagaacc tggacgcttg cattagttga
     3601 attctgattg cacgaagcca gcagaaaaca cattgaaaaa catcgtctcc tttccttgca
     3661 gggcaacgcg ccccacgcgt gtgacatcga gagacgcgat ggatgcgcct tgctcttact
     3721 gtgcaggtcc tgggaacatg tgggccactg aagcccagtg gtgttgagga catagaatca
     3781 gcagctgctg agggcgcgag ccgtacaggc ccttcttgct ctcggcctca ccctaagggc
     3841 taaggcagcc gcgaagggcc ggttcccgag taggtaaagg ggcggcgccc cactggctgc
     3901 tgcgggggag ggatgccaga gctctgtaaa gccattttgc cgcaagcggt cactaggggc
     3961 tctactctca gagaccttgt agcttggaaa agtccatgga atttgaaact tccatgtgtt
     4021 ctttattgcc aggaagtgtg gacatttttt ttaattgcct gaagtgtgga catgaaataa
     4081 gaactgtcat tcttgggtag gtaggctccc ttagatgccc tgatgttcct gtgagcatca
     4141 gcgaaggggc agctagatag acctggcttg aggcttccct cccccatctc cggggttgtc
     4201 ttctgtttct gttctttttc tctctcttca cgtcggacct ttcgccccca tgctttcctt
     4261 agccaagccg gctacattta tctgataatt gagttattaa aagatttggt ttccttggat
     4321 ttataaatca ataaacagta ggattaacgc aagagtttgc cttttaagtc aaggaaaaac
     4381 gtttaaggcc aggccctttg agttttgttt tcaaaccaaa caggtgagtt acagtcctat
     4441 actctcccct gcactctgta gatggcttat cttatctagg cccgctccca ccacccccaa
     4501 gccctaccaa atgccggggg tccaaaacca aatagctaaa gactgaagcg taggccggtg
     4561 actgctggag ttcccccaag gtccttggag ccccttcttt ttgaatcaag catcctccta
     4621 cttttattct gagtctcatg gagtttgttc ctaggtgagg attccctctc cagagacctt
     4681 taattttcat cccaactacg aagtaacttt cttttcttct tttcaccaac ttatcttgcc
     4741 cccccccact tcctcacttc cccacttacc tgcccaaaac ctactccttc ttccatagct
     4801 ttctccaccc ccatataaag agctcaacgg gcttttgaag atccgacctt tgttggcctt
     4861 ggccaggaac tttctcttaa gcaattattt cataaccttt gaaaactggt cgaatgggaa
     4921 accccaacct tccaactttt ctacacactt cgttcatggt tacaagaccc ctccctattt
     4981 agagtattga tagaaaattc atcgccatac ctgatatcct gtacttgtaa tacattctgt
     5041 gggaaggaac tgatgacctc aaaccatcag actctgcctc aagtgctcag agaaacaaga
     5101 gcttccctcc tttgctgata tacattaaat tattggtaaa agaaaaaaaa accagaagta
     5161 ttggattgtt ttcttaaaac aaaacaaaac aaaaacccaa aaaacacaaa aaaacaacaa
     5221 aaacaacggg gtgaacacca tttcttcttt aatgccaaaa ccgtttctcc ttttgagttg
     5281 gcctttaatt cagtaccatt tgttttgacc acccagtcaa gaggtaacaa ctgcctcttc
     5341 tcgagggcac tctggagggt atctgtgtta agtttgtata tatttattta tgcttaattt
     5401 aatgggaatg tgtaaatatg atgagcaagt agtttgggat tatttatctg tgactctata
     5461 cctctgtgaa tgggtggttt aaaagaaaaa aagaaccgct tgaccctagc tagaatccta
     5521 tttgaattct tctgttcttt atagacaagc tgttatggta ttgggtagaa attggtttat
     5581 tgtccagtgt taatctgatt tacataaata aaaaagattg ttgtgttttt gttgtgttct
     5641 cctcttcagt tccttaaaca taaagattgt tccattctac agacagaaac aaagatatag
     5701 caaaaaagat ttcttccttt tgcacccccg ccacagacgt acatacagtg tttttgttac
     5761 aacagaaata taataaattt tgcatatcag aaaaatgaac acttttattt ccagtaggag
     5821 gtgcttttta aaaaactctt aaaacttcaa atggatacta gtcccaatca tatttgtaat
     5881 aaaagttcat gttaactgca a
//
