LOCUS       NM_011547               3208 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus transcription factor AP-2, alpha (Tfap2a), transcript
            variant 1a, mRNA.
ACCESSION   NM_011547
VERSION     NM_011547.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3208)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3208)
  AUTHORS   Feng,W. and Williams,T.
  TITLE     Cloning and characterization of the mouse AP-2 epsilon gene: a
            novel family member expressed in the developing olfactory bulb
  JOURNAL   Mol Cell Neurosci 24 (2), 460-475 (2003)
   PUBMED   14572467
  REMARK    GeneRIF: A conserved N-terminus is observed for alpha, beta, gamma,
            and epsilon members of this gene family.
REFERENCE   3  (bases 1 to 3208)
  AUTHORS   Holt,E.H. and Lane,M.D.
  TITLE     Downregulation of repressive CUP/AP-2 isoforms during adipocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 288 (4), 752-756 (2001)
   PUBMED   11688971
  REMARK    GeneRIF: downregulation of repressive isoforms during adipocyte
            differentiation
REFERENCE   4  (bases 1 to 3208)
  AUTHORS   Ohtaka-Maruyama,C., Hanaoka,F. and Chepelinsky,A.B.
  TITLE     A novel alternative spliced variant of the transcription factor
            AP2alpha is expressed in the murine ocular lens
  JOURNAL   Dev Biol 202 (1), 125-135 (1998)
   PUBMED   9758708
REFERENCE   5  (bases 1 to 3208)
  AUTHORS   Zhang,J., Hagopian-Donaldson,S., Serbedzija,G., Elsemore,J.,
            Plehn-Dujowich,D., McMahon,A.P., Flavell,R.A. and Williams,T.
  TITLE     Neural tube, skeletal and body wall defects in mice lacking
            transcription factor AP-2
  JOURNAL   Nature 381 (6579), 238-241 (1996)
   PUBMED   8622766
REFERENCE   6  (bases 1 to 3208)
  AUTHORS   Schorle,H., Meier,P., Buchert,M., Jaenisch,R. and Mitchell,P.J.
  TITLE     Transcription factor AP-2 essential for cranial closure and
            craniofacial development
  JOURNAL   Nature 381 (6579), 235-238 (1996)
   PUBMED   8622765
REFERENCE   7  (bases 1 to 3208)
  AUTHORS   Meier,P., Koedood,M., Philipp,J., Fontana,A. and Mitchell,P.J.
  TITLE     Alternative mRNAs encode multiple isoforms of transcription factor
            AP-2 during murine embryogenesis
  JOURNAL   Dev Biol 169 (1), 1-14 (1995)
   PUBMED   7750631
REFERENCE   8  (bases 1 to 3208)
  AUTHORS   Moser,M., Pscherer,A., Bauer,R., Imhof,A., Seegers,S., Kerscher,M.
            and Buettner,R.
  TITLE     The complete murine cDNA sequence of the transcription factor AP-2
  JOURNAL   Nucleic Acids Res 21 (20), 4844 (1993)
   PUBMED   8233835
REFERENCE   9  (bases 1 to 3208)
  AUTHORS   Nieto,M.A., Gilardi-Hebenstreit,P., Charnay,P. and Wilkinson,D.G.
  TITLE     A receptor protein tyrosine kinase implicated in the segmental
            patterning of the hindbrain and mesoderm
  JOURNAL   Development 116 (4), 1137-1150 (1992)
   PUBMED   1295734
REFERENCE   10 (bases 1 to 3208)
  AUTHORS   Williams,T., Admon,A., Luscher,B. and Tjian,R.
  TITLE     Cloning and expression of AP-2, a cell-type-specific transcription
            factor that activates inducible enhancer elements
  JOURNAL   Genes Dev 2 (12A), 1557-1569 (1988)
   PUBMED   3063603
  REMARK    GeneRIF: N-terminal peptide sequencing indicates use of a
            downstream start codon in the human ortholog of AP-2.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007471.1, AK140956.1 and
            AC123834.4.
            
            On Aug 7, 2019 this sequence version replaced NM_011547.4.
            
            Summary: This gene is a member of the activator protein 2 (AP-2)
            transcription factor family. The protein encoded by this gene can
            act as both an activator and repressor of gene transcription, and
            plays an important role in early embryogenesis, specifically in
            cranial development. This protein forms both homodimers and
            heterodimers, and binds to a GC-rich consensus sequence found in
            some promoters and enhancers. Disruption of this gene causes
            perinatal death, with neural tube, craniofacial, and limb
            mesenchyme defects. Alternative splicing results in multiple
            transcript variants that encode multiple protein isoforms.
            [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1a) represents the shortest
            transcript and encodes the longer isoform (1, PMID: 7750631). Both
            variants 1a and 1b encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to start at an
            upstream in-frame start codon that is supported by conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007471.1, X74216.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BC007471.1         4-129
            127-193             AK140956.1         166-232
            194-1778            BC007471.1         197-1781
            1779-3208           AC123834.4         19755-21184
FEATURES             Location/Qualifiers
     source          1..3208
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 20.01 cM"
     gene            1..3208
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /note="transcription factor AP-2, alpha"
                     /db_xref="GeneID:21418"
                     /db_xref="MGI:MGI:104671"
     exon            1..126
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1395
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /note="isoform 1 is encoded by transcript variant 1a;
                     activator protein 2; activating enhancer-binding protein 2
                     alpha"
                     /codon_start=1
                     /product="transcription factor AP-2-alpha isoform 1"
                     /protein_id="NP_035677.3"
                     /db_xref="CCDS:CCDS26467.1"
                     /db_xref="GeneID:21418"
                     /db_xref="MGI:MGI:104671"
                     /translation="MKMLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSA
                     PPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQR
                     QSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLGSGLGDLPIHSLPHAIED
                     VPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPG
                     RLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGL
                     NLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQV
                     ARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPA
                     VCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK"
     exon            127..561
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            562..613
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            614..845
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            846..964
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1106
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..3208
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /note="hexamer: AATAAA"
     polyA_site      1924
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /note="major polyA site"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /note="hexamer: AATAAA"
     polyA_site      2838
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /note="major polyA site"
     regulatory      3182..3187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
                     /note="hexamer: AATAAA"
     polyA_site      3208
                     /gene="Tfap2a"
                     /gene_synonym="AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf;
                     Tcfap2a"
ORIGIN      
        1 gcactttgcg ctaacccaga gagtagctcc gctggggtgc gaggcgcaga ggggcaaatc
       61 cgatcacgcc gatccatgaa aatgctttgg aaactgacgg ataatatcaa gtacgaagac
      121 tgcgaggacc gtcacgacgg caccagcaac gggacggcac ggttgcccca gctgggcact
      181 gtaggtcaat ctccctacac cagcgccccg ccgctgtccc acacccctaa tgccgacttc
      241 cagcctccct acttcccccc gccctaccag cctatctacc cccagtcgca agatccttac
      301 tcccacgtca acgaccccta cagcctgaat cctctgcacg cccagccgca gccgcagcac
      361 ccgggctggc ccggtcagag gcagagccag gaatctgggc tcttacacac acaccggggc
      421 ttaccccacc aactgtcggg cctggaccct cgcagggact atcggcggca cgaggacctc
      481 ttgcacggcc cgcacgggct cggctctggg ctcggggacc tcccgatcca ctccttacct
      541 cacgccatcg aggacgtccc gcacgtagaa gacccgggta ttaacatccc agatcaaact
      601 gtaattaaga aaggccccgt gtccctgtcc aagtccaaca gcaatgctgt ctccgccatc
      661 cctattaaca aggacaacct cttcggtggc gtggtaaacc ccaacgaagt cttctgttca
      721 gttccgggtc gcctgtcgct cctcagctcc acctcgaagt acaaggtcac ggtggcggaa
      781 gtacagcggc gcctctcacc gcccgagtgt cttaacgcgt cgctcctggg cggagtactg
      841 cggagagcga agtctaagaa tggagggaga tctttaagag aaaaactgga caagatagga
      901 ttgaatctgc cagcagggag acgtaaagct gccaacgtta ccctcctcac gtcactagtg
      961 gaaggagaag ccgtccacct agccagggac tttgggtacg tgtgcgaaac tgaatttcct
     1021 gccaaagcag tagcagaatt tctcaaccga caacattccg atcccaatga gcaagtggca
     1081 agaaaaaaca tgctcctggc cacaaaacag atctgcaaag agttcactga cctgctggct
     1141 caggaccgat ctcccctggg gaactcgcgg cccaatccta tcctggagcc tggcatccag
     1201 agttgcttga cccacttcaa cctcatctcc catggcttcg gcagcccggc ggtgtgtgca
     1261 gcggttacgg ccctgcagaa ctatctcacc gaggccctca aggccatgga caaaatgtac
     1321 ctcagcaaca accccaacag ccacacggac aacagcgcca aaagcagtga caaagaagag
     1381 aaacacagaa agtgaggctc tcctcccgcc ccgcccccgc ccgcctcacc ggcccgcgtc
     1441 cccccactcg cccctccccc acccggcagg tgacagctcc gggaccagcc actcctactg
     1501 ctgctgctac tctgcgttgc cgcgccgccc ttcgtccccg gagtcctccg gattgctctc
     1561 tcgactgcca gtggggcagc cgctgcctac tcagcgcctt gcctcaactt ccccatcagt
     1621 accaacaccc cctttaccct cgtgtggagc ctaagagaac agaacaggtc gtgaagccag
     1681 caaagaaaag ttctgtcgcg tttgtgaacc tttttttttt ttaatcaaat cgacaacaaa
     1741 cattaaaact tttttttttt aaaaaggacg ttaaaaaatt taaaaagtat atgagcttca
     1801 tgggactaac tcatcgcctt cccttgcgta cttcagattg tagccatact tttaaaaaaa
     1861 aaggcaaaga ggataatgac attttttatc agtattgtga ataaacttga acacaaatac
     1921 agaagttcta tgtcctgtct tcagttgtag aagttgtctt ctgcaaggta caaccaccca
     1981 cttgaacttc ctctgatgac acaatccaca attctataag ggaatcagtg ttcacgtctc
     2041 tgtatatatt tatttatgtg taatttaatg ggatttgtaa atatggtgag tctgttttaa
     2101 accttttttt atttatctgg tgatctcgtt tacctcctgt ttagtgggct ttggatcctc
     2161 cctgttagtt cttcatgtgg ttttacttag aaatccaagg tttgggtaag actccccctc
     2221 cccacccctt ttctccaatt catggattta gccccgtggt agcatgttaa acgattataa
     2281 tgaaacagct gaacaaaaac atttttaagg taaaataaaa atttatatat aattagtatt
     2341 acatttagct tttcattgaa ctgacaggaa aaaaatcagt gatattggga gattggaaaa
     2401 aaatttctta aactggagtg atttgataat ccttctatgg tatcatgggg agaaaaataa
     2461 agtttatttg agttcactgt cctcccttaa aagcatcctt cgagcaataa atgaatattg
     2521 tctttaaacc aagggttagg gatttctctt ctcttctctt ctcttctctt ctcttctctt
     2581 ctcttctctt ctcttctctt ctctctctct ctctctctct ctctctgcct ttctctctct
     2641 ctttctctgt ctctctctct ctgcctctct ttgttcatct ttaaacattt gggaccacct
     2701 gggcttcctt gtcttcgctg gccacattgg aagcagtcct agctgcactg tgttgagttg
     2761 ctctggcagg agcctctatg cctgtcaatg tatcatagtc ctttgttgcc cagataaata
     2821 aatatttgat acgctttatg tcgatttttt tttttattca gtggctgtct ttacccaggc
     2881 gtatttttgt tcttggcagt attttttatt cagtatggtt acagtaattg agtttaactc
     2941 tcccttggca attgctcttt gcaataagca gctgaaccca ttgcttccct caagtataat
     3001 aaaaacttac tttcaacttg gagttcagag cagggtatca tttagatatt ccactgagtc
     3061 tgtattcaga caaacgaccc aataaagccc gatgtattct tttggataaa agattgtttg
     3121 tactgctaaa ggaatgacat gctattgctt cctgaccggg ggcattaact ttattattaa
     3181 aaataaagtt ttattttatt tatgttga
//
