LOCUS       NM_009360               3918 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus transcription factor A, mitochondrial (Tfam), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_009360
VERSION     NM_009360.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3918)
  AUTHORS   Nielsen,B.E. and Ford,C.P.
  TITLE     Reduced striatal M4-cholinergic signaling following dopamine loss
            contributes to parkinsonian and l-DOPA-induced dyskinetic behaviors
  JOURNAL   Sci Adv 10 (47), eadp6301 (2024)
   PUBMED   39565858
REFERENCE   2  (bases 1 to 3918)
  AUTHORS   Mennuni,M., Wilkie,S.E., Michon,P., Alsina,D., Filograna,R.,
            Lindberg,M., Sanin,D.E., Rosenberger,F., Schaaf,A., Larsson,E.,
            Pearce,E.L. and Larsson,N.G.
  TITLE     High mitochondrial DNA levels accelerate lung adenocarcinoma
            progression
  JOURNAL   Sci Adv 10 (44), eadp3481 (2024)
   PUBMED   39485842
REFERENCE   3  (bases 1 to 3918)
  AUTHORS   Li,Y., Tian,L., Li,S., Chen,X., Lei,F., Bao,J., Wu,Q., Wen,Y. and
            Jie,Y.
  TITLE     Disrupted mitochondrial transcription factor A expression promotes
            mitochondrial dysfunction and enhances ocular surface inflammation
            by activating the absent in melanoma 2 inflammasome
  JOURNAL   Free Radic Biol Med 222, 106-121 (2024)
   PUBMED   38797339
  REMARK    GeneRIF: Disrupted mitochondrial transcription factor A expression
            promotes mitochondrial dysfunction and enhances ocular surface
            inflammation by activating the absent in melanoma 2 inflammasome.
REFERENCE   4  (bases 1 to 3918)
  AUTHORS   Kim,H.J., Lee,S.H., Jeong,C., Han,Y.H. and Lee,M.O.
  TITLE     RORalpha-GABP-TFAM axis alleviates myosteatosis with fatty atrophy
            through reinforcement of mitochondrial capacity
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (2), 615-630 (2024)
   PUBMED   38272857
  REMARK    GeneRIF: RORalpha-GABP-TFAM axis alleviates myosteatosis with fatty
            atrophy through reinforcement of mitochondrial capacity.
REFERENCE   5  (bases 1 to 3918)
  AUTHORS   Ay,M., Charli,A., Langley,M., Jang,A., Padhi,P., Jin,H.,
            Anantharam,V., Kalyanaraman,B., Kanthasamy,A. and Kanthasamy,A.G.
  TITLE     Mito-metformin protects against mitochondrial dysfunction and
            dopaminergic neuronal degeneration by activating upstream PKD1
            signaling in cell culture and MitoPark animal models of Parkinson's
            disease
  JOURNAL   Front Neurosci 18, 1356703 (2024)
   PUBMED   38449738
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3918)
  AUTHORS   Larsson,N.G., Barsh,G.S. and Clayton,D.A.
  TITLE     Structure and chromosomal localization of the mouse mitochondrial
            transcription factor A gene (Tfam)
  JOURNAL   Mamm Genome 8 (2), 139-140 (1997)
   PUBMED   9060414
REFERENCE   7  (bases 1 to 3918)
  AUTHORS   Larsson,N.G., Garman,J.D., Oldfors,A., Barsh,G.S. and Clayton,D.A.
  TITLE     A single mouse gene encodes the mitochondrial transcription factor
            A and a testis-specific nuclear HMG-box protein
  JOURNAL   Nat Genet 13 (3), 296-302 (1996)
   PUBMED   8673128
REFERENCE   8  (bases 1 to 3918)
  AUTHORS   Boissonneault,G. and Lau,Y.F.
  TITLE     A testis-specific gene encoding a nuclear high-mobility-group box
            protein located in elongating spermatids
  JOURNAL   Mol Cell Biol 13 (7), 4323-4330 (1993)
   PUBMED   8321234
REFERENCE   9  (bases 1 to 3918)
  AUTHORS   Parisi,M.A. and Clayton,D.A.
  TITLE     Similarity of human mitochondrial transcription factor 1 to high
            mobility group proteins
  JOURNAL   Science 252 (5008), 965-969 (1991)
   PUBMED   2035027
REFERENCE   10 (bases 1 to 3918)
  AUTHORS   Fisher,R.P., Parisi,M.A. and Clayton,D.A.
  TITLE     Flexible recognition of rapidly evolving promoter sequences by
            mitochondrial transcription factor 1
  JOURNAL   Genes Dev 3 (12B), 2202-2217 (1989)
   PUBMED   2628167
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC153509.3 and
            AC079680.34.
            
            On Apr 27, 2007 this sequence version replaced NM_009360.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050446.1, AK167348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC153509.3         96111-96315
            206-321             AC153509.3         97124-97239
            322-392             AC153509.3         98542-98612
            393-542             AC153509.3         99141-99290
            543-638             AC079680.34        174035-174130       c
            639-695             AC079680.34        169765-169821       c
            696-3918            AC079680.34        166155-169377       c
FEATURES             Location/Qualifiers
     source          1..3918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 36.83 cM"
     gene            1..3918
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /note="transcription factor A, mitochondrial"
                     /db_xref="GeneID:21780"
                     /db_xref="MGI:MGI:107810"
     exon            1..205
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..836
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /note="testis-specific HMG-box protein m-tsHMG; TS-HMG;
                     testis-specific high mobility group protein"
                     /codon_start=1
                     /product="transcription factor A, mitochondrial precursor"
                     /protein_id="NP_033386.1"
                     /db_xref="CCDS:CCDS23916.1"
                     /db_xref="GeneID:21780"
                     /db_xref="MGI:MGI:107810"
                     /translation="MALFRGMWSVLKALGRTGVEMCAGCGGRIPSSISLVCIPKCFSS
                     MGSYPKKPMSSYLRFSTEQLPKFKAKHPDAKLSELVRKIAALWRELPEAEKKVYEADF
                     KAEWKAYKEAVSKYKEQLTPSQLMGMEKEARQRRLKKKALVKRRELILLGKPKRPRSA
                     YNIYVSESFQEAKDDSAQGKLKLVNEAWKNLSPEEKQAYIQLAKDDRIRYDNEMKSWE
                     EQMAEVGRSDLIRRSVKRSGDISEH"
     exon            206..321
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /inference="alignment:Splign:2.1.0"
     exon            322..392
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /inference="alignment:Splign:2.1.0"
     exon            393..542
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /inference="alignment:Splign:2.1.0"
     exon            543..638
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /inference="alignment:Splign:2.1.0"
     exon            639..695
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /inference="alignment:Splign:2.1.0"
     exon            696..3918
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /note="hexamer: AATAAA"
     polyA_site      1459
                     /gene="Tfam"
                     /gene_synonym="Hmgts; mtTFA; tsHMG"
                     /note="major polyA site"
ORIGIN      
        1 aacaagcccc cggagttccc acgctggtag tgtggcagtc cataggcacc gtattgcgtg
       61 agacgaaccg gacggcgccg ggccatcatt cgtcggcccg agcgatggcg ctgttccggg
      121 gaatgtggag cgtgctaaaa gcactggggc gcacgggggt cgagatgtgc gcgggctgcg
      181 ggggtcgcat cccctcgtct atcagtcttg tctgtattcc gaagtgtttt tccagcatgg
      241 gtagctatcc aaagaaacct atgagttcat accttcgatt ttccacagaa cagctaccca
      301 aatttaaagc taaacaccca gatgcaaaac tttcagaatt ggttaggaaa attgcagccc
      361 tgtggaggga gctaccagaa gcagaaaaaa aggtttatga agctgatttt aaagctgagt
      421 ggaaagcata caaagaagct gtgagcaagt ataaagagca gctaactcca agtcagctga
      481 tgggtatgga gaaggaggcc cggcagagac ggttaaaaaa gaaagcactg gtaaagagaa
      541 gagaattaat tttgcttgga aaaccaaaaa gacctcgttc agcatataac atttatgtat
      601 ctgaaagctt ccaggaggca aaggatgatt cggctcaggg aaaattgaag cttgtaaatg
      661 aggcttggaa aaatctgtct cctgaggaaa agcaggcata tattcagctt gctaaagatg
      721 ataggattcg ttacgacaat gaaatgaagt cttgggaaga gcagatggct gaagttggac
      781 gaagtgatct catccgtcga agtgtgaaac gatccggaga catctctgag cattaagatg
      841 gaagacggag ttgtcattgg gattaggccc aagaaaccag ttaggtctca aagccttaaa
      901 gtgtcaaact agaacggata aaggtggtta acctttgaca ttcagatcat ttttctgtag
      961 ccatggactt tctgttaata ctttgagcct tgacagaaga tgatgctgag ttctgccttt
     1021 tgcttaagaa ctggaacgga gactgtccat gcatctgcat gcagtggtga atcattctgc
     1081 atttgatggg ctagatagac tgtgaagtga ctttcacact ggtgacagtt gtgtggtggt
     1141 tttgtgatgt ttttacactg atgaccgtta catatgggtg tggcccttgg gtcccaggcc
     1201 ggacctgctc tcccagctgt ggcagagctg tggataactg cattttcaaa gaagctgcca
     1261 ggctttccta gatgaaatga ttcctagaca taaatcatgt gtaagttgat gtttgtatat
     1321 aataagcgat tgctgatgtc ctgatagcat tttatagtag taacagagag atttacacat
     1381 ctttctcaaa ttaagaaatt atgtaccaag tctatgcata ggtttttctt gcatagaata
     1441 aaaactctaa ttttccaaac atgtttctga aattatgtat tttaagatga accatttggt
     1501 taacagattt tttttttttc aattttaggt agggacttta gaaattactt ttcatttgag
     1561 agtattcata gagcttgtgt ggtataaatt tttaaatgag aaaatgtgaa aaacaagtct
     1621 gcaaagtcag aaatctgaaa gcttatccat gacagctaaa ggcctatgca ggagaaagcc
     1681 aactgtggtg agccagccag gtccagctca ctaactgctc ttcagggcct actcatcaag
     1741 aaatggattt atgttctaaa taggttttta aaaaggaaag tatcagtgtg aaaattaata
     1801 tgatctttag tgtttgtgaa tagaatttct tggaacacag ccacatgctt tcttgggttt
     1861 gttgtgtgtg ggtgctctgt gctccagaga ctacactggg aaaccacagc atacagggat
     1921 ggcccttcgc agacagtttg ccaccatggt gtctcacggc cactggccat gcaaggcttt
     1981 tcctcagatg tccttgatgt ttctgtgata ttgtcaccct atcttggggt catcactggg
     2041 tccctataag cctaactgtt ctctgtgtta gcaaggaaaa tattctttaa cctggaatcc
     2101 tggtgtagca cagtacagaa gaccactgtg tggagcgaga ccctcctaat ctttactgtt
     2161 gcacaggaaa aagtgtcttc cccactttga gctggcaaat cccataagcc cttagagaac
     2221 tcatggcttc aaccaccaca ccactgagca gatctctgag acacaggaca acagagttca
     2281 tactcatgta tgttttgtat tgaggaggct tagagattgt acattttggg aaagtaagtt
     2341 tgcagtcact gaacttgaca aggtaggaac agaagaacgc atggaggaga gatgtaagag
     2401 ttatatatgt aaaacagggt atttgagctg ggtagaaaac ttgcctagaa tgtacaaggc
     2461 cttggatcca aatcccagaa ctgcaactct ccccagaaga gataatcaga attttagaga
     2521 tgaatttaag aaaatataat ttttcccgtg gattggaatt ctgggttgtt ggatggcatg
     2581 ggtttaagcc atagtttgaa ggtggtggaa ggaggccagt gtgaaccagt gcagtctgtc
     2641 tttccaaagt gcaaatccag gagagacgtg agctctacac gcccctggtt tctggaaagg
     2701 aactaactcc aagctgtcct tagaatggag aaaatggtga ctcagagaat tgaccatgtg
     2761 cttcagagca actcaggagc agcaggcact acagcgatac agggatgccc ggacctctaa
     2821 gatgtaacta cttagctcct agctttccag gcaccctgca gagtgttcaa ggactcggag
     2881 ctcagtctgg gaagggaatg ggaaaggtag aggcctgggc ggaagccttc tcatggtact
     2941 tggttcagtt tggttttcct tgtttgtaaa acaagcttac tgataacatt gtaatctgct
     3001 ttccatgtcc tgttttctaa cgacagagtc tcttttaagc aaaagcagtt gccagaggat
     3061 cggggaggtg ttgggaggag ctgaaggcat gcggtgaagc tgcacaagct gacaagggct
     3121 cagtgctgtt tctacttatt gtcatgtaac tgcaattggg ctgccctgtt ttccagtatc
     3181 cttaaaaaca acaaacccta gttggtctaa gtgtgaacct ctgaatttaa agctggtgtt
     3241 agcatacgga tgtacagtag ctagaaagcc ttcctgggtt cacccgcacg cactggacca
     3301 ccagggggcg ctgaaaccac agctttaatg cagacggagc catagtgccc atcagttctg
     3361 tttggccata ttataagaat tttcttcctc tgatagcaac cctcctttct cccaggtttt
     3421 gtttatttgt ttttgtttgt ttgtttgttt gtttgtttgt ttttcgagac agggtttctc
     3481 tgcgttgccc tgcctgtcct gtaactcact ttgtagacca gctggctgta gactcggaga
     3541 cctacctcag attaagtgct gagattaaga gcttgcctca ccaccaccat caggcttcct
     3601 ccctcctctt ccgaatttgc caccagcctg tcactgacaa gtttgcaaat gctaaaacag
     3661 tgcctgtatg ttttgaagtg taaagaacat atttcttttt ttgtaattga gcttaagaga
     3721 taaaatgaat gtattactca tttgtaaaac ttcctaagca aaaggtaaaa ttatgcacaa
     3781 ctggtaacca tcaattgttt atcattcaca aatcaaatat tttcgttatt taaccactga
     3841 tagtaattca ttataaaacc attcttttgc acagttagga atgctgacca agaaactgca
     3901 ttatttaaat taaatgct
//
