LOCUS       NM_028602               1740 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus testis expressed gene 19.1 (Tex19.1), mRNA.
ACCESSION   NM_028602
VERSION     NM_028602.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Reichmann,J., Dobie,K., Lister,L.M., Crichton,J.H., Best,D.,
            MacLennan,M., Read,D., Raymond,E.S., Hung,C.C., Boyle,S.,
            Shirahige,K., Cooke,H.J., Herbert,M. and Adams,I.R.
  TITLE     Tex19.1 inhibits the N-end rule pathway and maintains acetylated
            SMC3 cohesin and sister chromatid cohesion in oocytes
  JOURNAL   J Cell Biol 219 (5) (2020)
   PUBMED   32232464
  REMARK    GeneRIF: Tex19.1 inhibits the N-end rule pathway and maintains
            acetylated SMC3 cohesin and sister chromatid cohesion in oocytes.
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   Wanner,N., Vornweg,J., Combes,A., Wilson,S., Plappert,J.,
            Rafflenbeul,G., Puelles,V.G., Rahman,R.U., Liwinski,T., Lindner,S.,
            Grahammer,F., Kretz,O., Wlodek,M.E., Romano,T., Moritz,K.M.,
            Boerries,M., Busch,H., Bonn,S., Little,M.H., Bechtel-Walz,W. and
            Huber,T.B.
  TITLE     DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal
            and Differentiation
  JOURNAL   J Am Soc Nephrol 30 (1), 63-78 (2019)
   PUBMED   30518531
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   MacLennan,M., Garcia-Canadas,M., Reichmann,J., Khazina,E.,
            Wagner,G., Playfoot,C.J., Salvador-Palomeque,C., Mann,A.R.,
            Peressini,P., Sanchez,L., Dobie,K., Read,D., Hung,C.C.,
            Eskeland,R., Meehan,R.R., Weichenrieder,O., Garcia-Perez,J.L. and
            Adams,I.R.
  TITLE     Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in
            mouse embryonic stem cells
  JOURNAL   Elife 6, e26152 (2017)
   PUBMED   28806172
  REMARK    GeneRIF: Here the authors show that TEX19.1, which is induced by
            developmentally programmed DNA hypomethylation, can directly
            interact with the LINE-1 (L1) retrotransposon-encoded protein
            L1-ORF1p, stimulate its polyubiquitylation and degradation, and
            restrict L1 mobilization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   Crichton,J.H., Playfoot,C.J., MacLennan,M., Read,D., Cooke,H.J. and
            Adams,I.R.
  TITLE     Tex19.1 promotes Spo11-dependent meiotic recombination in mouse
            spermatocytes
  JOURNAL   PLoS Genet 13 (7), e1006904 (2017)
   PUBMED   28708824
  REMARK    GeneRIF: These data suggest that Tex19.1 and Ubr2 are required for
            mouse spermatocytes to accumulate sufficient Spo11-dependent
            recombination to ensure that the homology search is consistently
            successful, and reveal a hitherto unknown genetic pathway promoting
            meiotic recombination in mammals.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Yang,F., Cheng,Y., An,J.Y., Kwon,Y.T., Eckardt,S., Leu,N.A.,
            McLaughlin,K.J. and Wang,P.J.
  TITLE     The ubiquitin ligase Ubr2, a recognition E3 component of the N-end
            rule pathway, stabilizes Tex19.1 during spermatogenesis
  JOURNAL   PLoS One 5 (11), e14017 (2010)
   PUBMED   21103378
  REMARK    GeneRIF: Results suggest that the binding of Ubr2 to Tex19.1
            metabolically stabilizes Tex19.1 during spermatogenesis, revealing
            a new function for Ubr2 outside the conventional N-end rule
            pathway.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Zeng,M., Lu,Y., Liao,X., Li,D., Sun,H., Liang,S., Zhang,S., Ma,Y.
            and Yang,Z.
  TITLE     DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1
            expression
  JOURNAL   Mol Biol Rep 36 (8), 2399-2403 (2009)
   PUBMED   19247806
  REMARK    GeneRIF: Mouse DAZL protein can bind to 3'UTR of mTex19.1 mRNAs and
            may repress mTex19.1 expression at the translational
            level.Confirmed by both electrophoretic mobility shift assay and
            translation assay in Zebrafish embryo detecting the luciferase
            activity.
REFERENCE   8  (bases 1 to 1740)
  AUTHORS   Ollinger,R., Childs,A.J., Burgess,H.M., Speed,R.M.,
            Lundegaard,P.R., Reynolds,N., Gray,N.K., Cooke,H.J. and Adams,I.R.
  TITLE     Deletion of the pluripotency-associated Tex19.1 gene causes
            activation of endogenous retroviruses and defective spermatogenesis
            in mice
  JOURNAL   PLoS Genet 4 (9), e1000199 (2008)
   PUBMED   18802469
  REMARK    GeneRIF: Tex19.1 repressed transposable genetic elements and
            maintained genomic stability through successive generations.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1740)
  AUTHORS   Kuntz,S., Kieffer,E., Bianchetti,L., Lamoureux,N., Fuhrmann,G. and
            Viville,S.
  TITLE     Tex19, a mammalian-specific protein with a restricted expression in
            pluripotent stem cells and germ line
  JOURNAL   Stem Cells 26 (3), 734-744 (2008)
   PUBMED   18096721
  REMARK    GeneRIF: Tex19 is a mammalian-specific protein duplicated in mouse
            and rat, renamed Tex19.1 and Tex19.2, whereas only one form is
            found in human.
REFERENCE   10 (bases 1 to 1740)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662887.13.
            
            On Jan 23, 2019 this sequence version replaced NM_028602.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF285590.1, BC053492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AL662887.13        179284-179363
            81-154              AL662887.13        179669-179742
            155-1740            AL662887.13        179870-181455
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 85.0 cM"
     gene            1..1740
                     /gene="Tex19.1"
                     /gene_synonym="2410081M02Rik; mTex19.1; Tex19; Tex19a"
                     /note="testis expressed gene 19.1"
                     /db_xref="GeneID:73679"
                     /db_xref="MGI:MGI:1920929"
     exon            1..80
                     /gene="Tex19.1"
                     /gene_synonym="2410081M02Rik; mTex19.1; Tex19; Tex19a"
                     /inference="alignment:Splign:2.1.0"
     exon            81..154
                     /gene="Tex19.1"
                     /gene_synonym="2410081M02Rik; mTex19.1; Tex19; Tex19a"
                     /inference="alignment:Splign:2.1.0"
     exon            155..1740
                     /gene="Tex19.1"
                     /gene_synonym="2410081M02Rik; mTex19.1; Tex19; Tex19a"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1299
                     /gene="Tex19.1"
                     /gene_synonym="2410081M02Rik; mTex19.1; Tex19; Tex19a"
                     /note="testis-expressed protein 19A; testis-expressed
                     sequence 19A; testis expressed gene 19"
                     /codon_start=1
                     /product="testis-expressed protein 19.1"
                     /protein_id="NP_082878.2"
                     /db_xref="CCDS:CCDS25768.1"
                     /db_xref="GeneID:73679"
                     /db_xref="MGI:MGI:1920929"
                     /translation="MCPPVSVRHGARGMSCLYEAWLYHLVHGEQTKICFACFKAAFLL
                     NKLYLEMGDWQEEEEEEEEEDADLLEYLSESESESEQEPGPEQDAWRGLGSLYVPQSV
                     SEGSGVLLPTPVWTQGILFSIFVPTELFPQEAVPLDLGPEDAEWTQALPWRLDGLFPC
                     SHQLIPPLTWWDIFDVMPSPGQPVLLELRCHWPLDQTVAQSWLQDQKFVLLLDSVQSR
                     CHLLSMRVRWVVRTQVQHWQVLLDPGEMWVAHFRKEVGQHGLYHQSLNPWRLSILTAS
                     ELGMELLPATCYLWNKGFWVGSFLPWHINMPETWSWEPGERLFITDATICGTDYHLAQ
                     SFLDSHPTPHPLLTLTP"
ORIGIN      
        1 cctccctggt gttcagtgct tagcgaggag agcctggctc tggagtccat tagctggcac
       61 ctgggcgctc agtcagggag ctccccatat attggagcaa gtgtgaagct gaagaagttt
      121 ctggaagctc aagcctgtct acttcttcag agagcctctg tggttctgtt gacctgacct
      181 cctcagtcca tcgagcaagt ctgaatctgt gtgtccgctt agctgcagac agacttcttg
      241 accatgtgtc ccccagtcag cgttcgccat ggggccaggg gcatgtcctg cctctatgag
      301 gcatggctgt accatcttgt ccatggggaa cagacgaaga tctgctttgc ttgcttcaag
      361 gcagctttcc tattgaataa actctacctg gagatgggag actggcaaga ggaggaagag
      421 gaagaggaag aggaagatgc tgatctcctg gaatacttgt cagagtcaga gtcagagtct
      481 gagcaggagc cagggcctga gcaggatgca tggcggggat tggggtccct ttatgtgcca
      541 cagagtgtct ctgaagggtc tggggtcctg ctgccaaccc ctgtgtggac acagggcata
      601 ctattctcca tttttgtgcc cactgagctc tttcctcagg aagctgtacc cctggatctg
      661 ggtcctgagg atgctgagtg gacccaggcc cttccctgga gacttgatgg gctttttccc
      721 tgctcgcacc agctcatccc tcctctgact tggtgggata tttttgatgt gatgccatct
      781 cctgggcaac ctgtgttgtt ggagttgaga tgccactggc ccttggacca gacagtagca
      841 caatcctggt tgcaagacca gaagtttgtc ctcctgttgg atagcgtcca atctaggtgc
      901 cacctgctgt caatgcgtgt ccgctgggtc gtaaggactc aggtccagca ctggcaggtg
      961 ttgctggacc ctggtgagat gtgggtggcc cattttcgga aagaagttgg gcagcacggc
     1021 ctgtaccatc agagcctgaa tccctggagg ctgagcatcc tgacagcttc agaattaggg
     1081 atggagttat tgcctgccac ctgctacctg tggaataaag gcttctgggt aggttccttc
     1141 ttgccctggc acattaacat gccagagacc tggagctggg agccaggaga gaggctgttt
     1201 atcacagatg ctactatttg tggtactgac taccaccttg ctcagtcttt ccttgattcc
     1261 caccccaccc cccaccccct cctgaccctt actccctgat gcacattcct gagacactaa
     1321 agctcagaca ttccccaggg ccctggggac tgtgaagagc aagaggttgc ctgttctgag
     1381 cagctcaggg gaacagttgg tccaggactt gagggggcat cttgaacatc ctgtgagctt
     1441 atgaacctca gagggaagtc tggcatgttc gtgtcagtgt tcagtgtttg gtaggtgagg
     1501 cctagctgta tgtttagctg tatggagtgt tgtgtggtgg gtgttatggg ggctccggtc
     1561 acagatctac gtatgtatgg actctgaggc actagttgac cttactgtca taggggtcat
     1621 atgcttactg tcttagggtc aagatacctg attttagggt tcactgtttt tgttgtttta
     1681 ctttgttcgt tactcgtgct ccttttgagg gcttttgttg aataaagttg gtgttttaaa
//
