LOCUS       NM_031374               8408 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus testis expressed gene 15 meiosis and synapsis
            associated (Tex15), mRNA.
ACCESSION   NM_031374
VERSION     NM_031374.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8408)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   2  (bases 1 to 8408)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8408)
  AUTHORS   Schopp,T., Zoch,A., Berrens,R.V., Auchynnikava,T., Kabayama,Y.,
            Vasiliauskaite,L., Rappsilber,J., Allshire,R.C. and O'Carroll,D.
  TITLE     TEX15 is an essential executor of MIWI2-directed transposon DNA
            methylation and silencing
  JOURNAL   Nat Commun 11 (1), 3739 (2020)
   PUBMED   32719317
  REMARK    GeneRIF: TEX15 is an essential executor of MIWI2-directed
            transposon DNA methylation and silencing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8408)
  AUTHORS   Yang,F., Lan,Y., Pandey,R.R., Homolka,D., Berger,S.L., Pillai,R.S.,
            Bartolomei,M.S. and Wang,P.J.
  TITLE     TEX15 associates with MILI and silences transposable elements in
            male germ cells
  JOURNAL   Genes Dev 34 (11-12), 745-750 (2020)
   PUBMED   32381626
  REMARK    GeneRIF: TEX15 associates with MILI and silences transposable
            elements in male germ cells.
            GeneRIF: Loss of TEX15 leads to DNA hypomethylation and
            de-silencing of transposable elements, at a level comparable to
            loss of MILI or DNMT3C but not MIWI2.  TEX15 is associated with
            MILI in testis.  piRNA biogenesis is intact in TEX15-deficient male
            germ cells.
REFERENCE   5  (bases 1 to 8408)
  AUTHORS   Ni,L., Xie,H. and Tan,L.
  TITLE     Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3
            conditional knockout mouse models
  JOURNAL   Mol Reprod Dev 83 (12), 1060-1069 (2016)
   PUBMED   27739607
REFERENCE   6  (bases 1 to 8408)
  AUTHORS   Singh,P. and Schimenti,J.C.
  TITLE     The genetics of human infertility by functional interrogation of
            SNPs in mice
  JOURNAL   Proc Natl Acad Sci U S A 112 (33), 10431-10436 (2015)
   PUBMED   26240362
REFERENCE   7  (bases 1 to 8408)
  AUTHORS   Le Masson,F., Razak,Z., Kaigo,M., Audouard,C., Charry,C., Cooke,H.,
            Westwood,J.T. and Christians,E.S.
  TITLE     Identification of heat shock factor 1 molecular and cellular
            targets during embryonic and adult female meiosis
  JOURNAL   Mol Cell Biol 31 (16), 3410-3423 (2011)
   PUBMED   21690297
REFERENCE   8  (bases 1 to 8408)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   9  (bases 1 to 8408)
  AUTHORS   Yang,F., Eckardt,S., Leu,N.A., McLaughlin,K.J. and Wang,P.J.
  TITLE     Mouse TEX15 is essential for DNA double-strand break repair and
            chromosomal synapsis during male meiosis
  JOURNAL   J Cell Biol 180 (4), 673-679 (2008)
   PUBMED   18283110
  REMARK    GeneRIF: Based on these data, we propose that TEX15 regulates the
            loading of DNA repair proteins onto sites of DSBs and, thus, its
            absence causes a failure in meiotic recombination.
            GeneRIF: Tex15 is essential for male meiosis and for chromosomal
            synapsis. DNA double-strand breaks (DSBs) are formed but not
            repaired in Tex15-deficient males.
REFERENCE   10 (bases 1 to 8408)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139025.9, AF285589.1 and BC063106.1.
            
            On Dec 5, 2006 this sequence version replaced NM_031374.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF285589.1, AK008726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7035              AC139025.9         45594-52628         c
            7036-7058           AF285589.1         7036-7058
            7059-8405           BC063106.1         1280-2626
            8406-8408           AF285589.1         8406-8408
FEATURES             Location/Qualifiers
     source          1..8408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 20.59 cM"
     gene            1..8408
                     /gene="Tex15"
                     /gene_synonym="2210014E14Rik"
                     /note="testis expressed gene 15 meiosis and synapsis
                     associated"
                     /db_xref="GeneID:104271"
                     /db_xref="MGI:MGI:1934816"
     CDS             1..8358
                     /gene="Tex15"
                     /gene_synonym="2210014E14Rik"
                     /note="testis-expressed sequence 15 protein"
                     /codon_start=1
                     /product="testis-expressed protein 15"
                     /protein_id="NP_113551.2"
                     /db_xref="CCDS:CCDS22232.1"
                     /db_xref="GeneID:104271"
                     /db_xref="MGI:MGI:1934816"
                     /translation="MTYFFIYVSTERACSLNNCTIAKRIGKGKDATVIFEHFRKPVDP
                     FVQENCPCKALNSEMGPFSSDTSSSYGNVQNGNNSVLEAYNRQTENSSNLRDASQVYT
                     HNSGFSFIPTGNTASGNGDLFSVTYLRSILSSISAAFPSHNNTGSSTVITSKLIKDPR
                     LMKREQSMRNKSDTAGLSDVLPLDKSLGCGDSQIKLTCMPTSSISSSEVPADNTITSC
                     LNASCFKFSSESSHYQAHNSSSKGHDCIASSSIAVTEQFKEQHSSSFPSSLSNAFSDV
                     RKQKHSEEQVQRAQMRSNVPVLTALSSESRNSDESENTCSNDSQGHFSQESPSSDINS
                     IYKVGHQMSTVFPAQKKGNLCEYIQDTGMMRASISTEDSTKDGVNHTWCKETVLSNET
                     VSSPIDNSNTLYQEHKEGGNLNSLSGNCEKIGVTHKLQVPKFPISSTGDKNELYRAAL
                     ELECSLTPTIECLSQKYPQHSLEHEDNTNFAMTQGLIELKTVQNNQNFGNILSDAFQE
                     AKDVPLASEKLIDRVISSAAIDISLDSSVCNIIGEYTCVRRENENGEASPYNCHKEEA
                     SRVKDGVQDHSLSYDAELSCDLNLKINLQEQRDDKNPNEAKEHNTDNINGSEKQDCLA
                     NDHFTNIVEMREIKSNTEVEILNSEECFTFNSFRGKNGKPAETASSESEAVEQRHAPN
                     DQRGLEHLVSSFPEIEGSSVCVASNATKQIVGTTVLTVSTSLGDHQKDELKEICSSES
                     SDLGLVKHSISECEIDTDKDKLQDFHQLVNENSALKTGLGSEIEVDLEHDNASVFQQN
                     MHSQGNDLCEEFELYESLKSRIDWEGLFGSSYEEIESSSFARREGTDQHSSTECNCVS
                     FCSQDKRELHNPIFLPDLQVTITNLLSLRISPTDESLELKDNFYKQVTESTEPETNKE
                     GNASGFGMCSQPSGENSSFSCANKFGNSVQESGDVSKSESSHSSNSSHNTHVDQGSGK
                     PNNDSLSTEPSNVTVMNDKSKCPTKSKPVFNDTRNKKDMQSRSSKRTLHASSSRGQNI
                     ANKDLREHETHEKKRRPTSHGSSDRFSSLSQGRIKTFSQSEKHIRNVLNILNNEASLC
                     KSKHLSRKLNKAVLHLKKAHRRVHTSLQLISKVGQKRKGPLPKAYAVIHNNFWESCDH
                     QGDSLMSERRYSKHFLSKRKYDKQGDKRFLRFDIEESLTPVSKHRLYRTNRERIAECL
                     SNEVMSGHVSSSLTTFHVREFCDEEQFPEPQLPLAYTSQSISQLEYTNSIVGNESSSE
                     LEHFSETSGNMLDPKETLTEKEYQTHTQLCNSDSAKLKNHTTHSIRDIAKECNSEDKT
                     VLCESNPVYLSFIKENTSHSPDKSYDSNCKANTDIHISVLGSKKKHILSVDIYEQDNC
                     VSDGVKSGEAIFPIEKCTVPMETTSSIPTENIASKSYTIPPVSSILVTAGEEESSVGE
                     NGLFDVNENEMNITMHSKLDLTSVTEESKICKKNMKNLSCNDSSMLLKENITGPSKRY
                     MAKYIEEEKIRKIEQAVYKKIITEGSPISFKYKSQNKILKEKSFHVNKKIITNNLTDS
                     HLSIKNSTVDTIALKDIPNQLKERKEAGQIKVNNNSHSDCLSKPAIVETNHRPVLHGN
                     PKVATLQKELKEHRSPNYTSHVTELSQILQRADEAASLQILEEETKLCQNILPLFVQA
                     FERQQECSIDQILISRKLLVEQNLWNNCRLKLKPCAVDTWVELQMAMETIQFIENKKR
                     FLEGKPTFRSLLWYDESLYSELLRRPRGYQLQSNFYPGFQGRLKYNAFCELQNYHNQL
                     VEFLTETKKENNSYYALLKYKRQINECEAIMKHYSDCFDFCLSVPFACGVNFGDSLGD
                     LETLRKSTLKLISVPGGSPKVHSYPGKKDHLWIIIEIVSSKVSFIKSNEEISIKICLY
                     GLEHIYFDAAKSLVWKEKSCSLPKKHSEKNREMEEINERAFSKLKKIYDVLSKGLNNE
                     PTSIGLQEDAIIASKQSTLGSISNCRLNKAWLSYPDISCVGEILDQAKSADLEELQGL
                     TLRCTDHLEILKKYFQMLQEDNIDNIFIMEENVLDMLSNHNLGAVILKPEAIEIYIEI
                     VMISETIHYLKNLIAKKLHNQRFRGMLWFDWSLLPELIGCQEEVVSLSVGDTQTHCLW
                     KLVETAISVLKKELAVIYEYGEASNCSYALHLFYRELKELTGVKRLLNNSKYSVSTYI
                     DLVPHTASVNFGNTVAELEHNYKQFFLLLKNVMSVPQKDFGKMVHIIKVMKTIEHMKL
                     LSAKDTKLSTHLLFLQMLRNKRNALQQNRQEKMETPVTEPGEDSSQPGVSEQTPPGTE
                     CTVKNISDSSKKRPVTADTCEVSQGKGNTDTVPSWKKQKVTMKDVGNIQTVSKHPSTT
                     GSPPNDENKIGSNSSDSLKSISASPEVVKRQSSVLGSVSPAESVQDTCTPKSESKVEP
                     TDSLPDSLASLTEQQENSNVIEKRNGNSSVAETNDKKDCPLVTCDQKDIDASYSPDHT
                     PAQESHKTPVDHTQISPSNLTAGNDDPLVPDASLLSVSASQSEKDVYLSGTDFHHENN
                     KILNLSTEDCTGTSSPEPVCIKDKISVLQVDKTQPIKSESPKKSMTDAPNPNTAPFGS
                     YGNSALNVNGTVQHTHSEQNSKVLTQKVGTSRNIPPQSACSPVHNSSAHSFGTSYPYY
                     SWCFYQYSSSNGTAVTHTYQGMTAYEIQQPPPPVLTTVASTVQSTHFNRSYSEHFSYF
                     PGQPQANSFNPGNGYFPSHTPVSYNYQQPVYSQFASHQPVPQATYPYPPNPGAPPQVP
                     WTYAPWQQNPFLRRP"
     exon            1..7035
                     /gene="Tex15"
                     /gene_synonym="2210014E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7036..7085
                     /gene="Tex15"
                     /gene_synonym="2210014E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7086..8320
                     /gene="Tex15"
                     /gene_synonym="2210014E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            8321..8408
                     /gene="Tex15"
                     /gene_synonym="2210014E14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8380..8385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tex15"
                     /gene_synonym="2210014E14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8408
                     /gene="Tex15"
                     /gene_synonym="2210014E14Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgacatact tttttattta tgtttccaca gaaagagcat gttctctgaa taactgtaca
       61 attgctaaaa gaattggaaa aggaaaagat gctacagtca tctttgaaca cttcaggaaa
      121 cctgtggatc catttgttca ggaaaattgt ccatgtaaag cactaaattc agagatgggt
      181 cctttcagct cagatacttc tagttcttat ggaaatgtac aaaatggaaa caattctgtg
      241 cttgaagcat acaacagaca gacagaaaat tcatcaaatc ttagagatgc ttctcaagta
      301 tacacacaca attcaggttt ttctttcata cccactggta acacagcaag tggtaatggt
      361 gacctgttca gtgtgacata tcttagaagt attttaagta gtatttctgc tgcttttccc
      421 tctcacaaca atactggctc aagtacagtt attacttcaa aactcattaa ggacccaaga
      481 cttatgaaga gagaacagag catgagaaac aaaagtgata ctgcaggttt gagtgatgtt
      541 ttgccattgg ataagagttt gggttgtggt gattcacaaa taaagctgac atgtatgcca
      601 actagttcca tctcttcatc ggaagttcct gctgataata ccattactag ttgtttgaat
      661 gcctcttgct tcaaattctc ttctgaaagt tcacactatc aggctcataa tagcagctca
      721 aagggccatg actgtatagc atccagtagc attgctgtta cagaacaatt taaagagcaa
      781 cacagttctt ccttccccag ttctttatca aatgcatttt cagatgtcag gaaacaaaaa
      841 cacagtgaag aacaggtcca gagagctcaa atgagaagca atgtcccagt tttaacagct
      901 ctgagcagtg agtcacggaa ctccgatgaa tcagaaaata cttgtagcaa cgactctcag
      961 ggtcatttct ctcaagagtc accatcttct gatataaaca gtatatataa ggttggtcac
     1021 cagatgtcta cagtcttccc agcccagaag aaaggaaatc tatgtgaata catccaagat
     1081 acgggaatga tgagagcctc catcagcaca gaagacagca ctaaagatgg agtaaaccat
     1141 acttggtgca aagaaactgt tcttagtaat gaaactgtta gtagcccaat tgataattcc
     1201 aatacattgt accaggaaca caaagaagga ggaaatctta attctttaag tggtaattgt
     1261 gaaaaaatcg gagttactca taagttacaa gtgcccaagt ttcccatatc ttccacaggg
     1321 gataaaaatg aactatatcg tgcagcattg gaattagagt gttctcttac tccaactata
     1381 gagtgtcttt cacaaaagta cccgcaacac tctttggagc atgaagataa tacaaatttt
     1441 gccatgactc aagggctaat agaattaaaa acagtacaaa ataatcagaa ctttggtaac
     1501 attttgtctg atgccttcca ggaagcaaaa gatgttcccc tggccagtga aaagctcatt
     1561 gatagagtta tttcatcagc tgccattgac atctctcttg acagttcagt ttgcaacata
     1621 attggagaat atacatgtgt ccggagggaa aatgaaaatg gggaagcatc accatataac
     1681 tgtcacaaag aagaagcttc tcgtgttaaa gatggtgtgc aggatcacag cctatcttat
     1741 gatgcagaat tgagctgtga tctgaacttg aaaattaatt tgcaagaaca aagagatgat
     1801 aaaaatccaa atgaggctaa agaacacaat acagataaca taaatggaag tgagaaacaa
     1861 gattgtcttg caaatgacca tttcaccaat atagttgaaa tgagggaaat taagagtaac
     1921 accgaagtag aaattctgaa ttctgaagaa tgtttcacat ttaactcatt tcggggaaaa
     1981 aacggtaaac cagcagaaac agcatcatca gagagtgaag ctgtagaaca aaggcatgca
     2041 ccaaatgatc aaagaggcct agagcacttg gtgtcctcat ttccagaaat tgaaggctct
     2101 tcagtgtgtg tagcctcaaa tgctacaaaa caaatagttg gcactactgt ccttacagta
     2161 agcacaagtc ttggggatca tcaaaaagat gagttaaaag aaatttgttc ctctgagagt
     2221 tcagatttgg gtttagtaaa acacagcatt tctgaatgtg aaattgatac tgataaagat
     2281 aaattacaag actttcatca gttggtaaat gagaattcag ctcttaaaac tggattggga
     2341 agtgaaattg aggtagatct tgaacatgat aatgcttctg tatttcaaca aaatatgcat
     2401 agccagggaa atgacctttg tgaagaattt gagttatatg agtctctaaa gtctcggatt
     2461 gattgggaag gcctatttgg aagcagttat gaggaaatag aatcctcaag ttttgcaaga
     2521 agggagggta ctgatcagca tagttctaca gaatgtaact gtgtttcttt ctgttcacaa
     2581 gacaaaagag agctccacaa cccaattttt cttccagatc tacaagttac aattacaaac
     2641 ttacttagtc tacgaatcag tcccactgat gaatctttag agttgaaaga taatttttac
     2701 aaacaggtaa ctgaatctac agaaccagaa acaaataagg aagggaatgc ttctggattt
     2761 ggcatgtgct cccaaccttc tggagaaaat tcaagttttt catgtgcaaa taagtttggt
     2821 aattcagtgc aagaatcagg agatgtgagc aagtctgaga gttcccattc ttccaactca
     2881 agtcataata cacatgtgga tcaaggatct ggaaaaccaa acaatgactc tttgtctact
     2941 gaaccatcta atgtcacagt aatgaatgat aagagcaaat gccccacaaa atcaaaacct
     3001 gtctttaatg atactagaaa taaaaaggac atgcaatcaa gaagtagcaa aagaaccctg
     3061 catgcatctt cttccagggg tcagaacata gccaataaag acttaaggga gcatgaaact
     3121 cacgagaaga agagaaggcc aacaagccat ggctcatctg accgtttctc ttccttatcc
     3181 caaggacgaa ttaaaacatt ttcgcagtca gagaagcaca ttaggaatgt actgaatatt
     3241 ctaaataatg aagcatcttt atgtaaaagc aaacatctgt ccaggaaatt gaacaaagct
     3301 gttcttcact taaaaaaagc ccatagaaga gttcatacat ctttgcagct tatatctaaa
     3361 gtgggacaaa agaggaaggg cccattacca aaagcatatg cagtaataca taataatttc
     3421 tgggaaagtt gtgatcatca aggtgatagt ttgatgtctg aaagaagata ttctaagcat
     3481 tttttgtcca aaagaaaata tgacaaacag ggagataaaa gatttttaag atttgacatt
     3541 gaggagtcat tgaccccggt atcaaagcac agattatata gaacaaacag agagaggatt
     3601 gcagagtgcc tttctaatga agtcatgtct gggcatgttt ccagtagtct taccactttc
     3661 catgtgagag aattttgtga tgaagaacag tttccagaac cacagttacc tctagcttat
     3721 acatctcaga gtataagtca gttagaatac actaatagca ttgtgggaaa tgaaagctct
     3781 tctgaacttg aacatttttc tgaaacaagt gggaatatgc ttgacccaaa agaaacacta
     3841 actgaaaaag aatatcagac acatacacag ttatgtaata gtgactctgc aaaacttaaa
     3901 aaccatacaa cacatagtat tagggatata gcaaaagaat gtaattctga ggataaaaca
     3961 gttctctgtg aaagcaatcc agtgtattta agtttcataa aagaaaacac aagtcatagt
     4021 ccagataaaa gttatgattc aaattgtaaa gccaacactg acatacatat ttcagtttta
     4081 ggctccaaaa aaaagcacat tttaagtgtt gatatttatg aacaagataa ttgtgtatct
     4141 gatggtgtta aaagtggaga agcaattttt cctatagaaa agtgtacagt tcctatggag
     4201 accacatcaa gcattcctac ggaaaatata gcaagcaaaa gttacactat tcctccggtc
     4261 tcatcaattc tagtgacagc tggagaggaa gaatcttctg taggggaaaa tggactcttc
     4321 gatgtaaatg agaatgagat gaatattact atgcattcta aattagatct aacatcagta
     4381 actgaagaaa gtaaaatttg taagaaaaat atgaagaacc tatcttgcaa tgatagttct
     4441 atgctattaa aggagaatat aacgggtcct tcaaaaagat atatggcaaa atacattgag
     4501 gaagaaaaaa ttaggaaaat tgagcaagca gtttacaaaa aaattattac tgaaggatca
     4561 cctattagtt ttaagtacaa aagtcaaaat aagatcctaa aggaaaaatc atttcatgtt
     4621 aacaagaaaa taattacaaa caacttgact gattctcacc taagcattaa aaattctact
     4681 gtagacacaa ttgctttgaa agacattcct aatcagctta aagaaagaaa ggaagcaggg
     4741 caaattaaag ttaataacaa ctctcactct gactgtctct ccaagccagc cattgtagaa
     4801 actaatcata ggcctgtttt acatgggaac cctaaagttg ctactcttca gaaggaatta
     4861 aaagaacatc gctcacctaa ttacacatct catgtaacag aactgtctca aattttacag
     4921 agagcagatg aagcagcatc tcttcagatt ttagaagaag agactaagct ttgtcaaaat
     4981 attctccctt tatttgttca agcttttgaa agacagcaag aatgttcaat tgaccaaatc
     5041 ctgatttcaa gaaagctatt ggtagaacaa aacttgtgga ataattgtag acttaaattg
     5101 aaaccatgtg ctgttgatac ttgggtagaa cttcagatgg caatggaaac tattcaattt
     5161 attgaaaaca aaaaaagatt cttagaaggt aaaccaacat tccgaagctt gctttggtat
     5221 gatgagagct tgtacagtga actgcttcgc aggccacgtg gatatcaact gcagtccaat
     5281 ttctaccctg gttttcaagg acgactaaaa tacaatgcat tctgtgagtt acagaattat
     5341 cataatcagt tagttgaatt cttaacagaa acaaaaaaag aaaataattc atattacgca
     5401 ttattaaaat acaaacggca aattaatgaa tgtgaagcca taatgaagca ctattctgat
     5461 tgctttgact tttgtctttc tgttccattt gcctgtggag ttaactttgg agatagttta
     5521 ggagacctgg aaaccttaag aaaaagcact ctgaagctga tcagtgtacc tgggggctct
     5581 cctaaagtcc attcctaccc aggaaagaaa gatcatttgt ggatcattat agaaatagtc
     5641 tcctcaaagg ttagttttat caagagcaat gaagaaataa gtatcaaaat ctgtctttat
     5701 ggtctggagc atatatattt tgatgctgca aaaagtcttg tatggaaaga aaaaagctgc
     5761 tctttaccca aaaaacattc agaaaagaat agagaaatgg aggaaataaa tgagagagct
     5821 ttttctaagt tgaagaagat ctatgatgtc ttatctaaag gtttaaacaa tgaacccact
     5881 agtattggac ttcaagaaga tgctattatt gcttccaaac aatccactct aggtagcata
     5941 tcaaactgta ggctgaacaa agcttggctt tcatatccag atatttcttg tgttggtgag
     6001 atactggatc aagctaaatc tgcagaccta gaggagttac agggcctcac tctcagatgt
     6061 acagatcact tagaaatttt aaaaaaatac tttcagatgc tgcaagaaga taacatagat
     6121 aatattttta tcatggaaga aaatgttttg gatatgctaa gcaaccacaa cctgggagca
     6181 gtcattttaa agcctgaagc tattgagatt tatattgaaa ttgtcatgat ctcagaaaca
     6241 attcactacc ttaaaaattt aatagcaaag aaactgcaca accagagatt tcgaggtatg
     6301 ctctggttcg attggtctct tcttcctgag ctaattggct gccaagaaga agtggtttcc
     6361 ctttctgttg gtgacaccca aacacattgc ctttggaaac tggtagagac tgcaatttct
     6421 gtccttaaga aagagctggc tgttatctat gaatatggtg aagcttctaa ctgttcctat
     6481 gctctacatt tattctacag agaacttaag gaacttacag gcgttaaaag gcttctgaat
     6541 aactctaagt attcagtttc cacgtatatt gacttggtgc cacatactgc atctgtaaat
     6601 tttggaaaca ctgtggcaga attagaacat aactacaagc agttttttct attactcaaa
     6661 aatgtaatgt ctgtccctca gaaagatttt ggaaaaatgg ttcatattat aaaagttatg
     6721 aagacaattg aacatatgaa gctgctaagt gctaaagata ctaaattgtc cactcatctt
     6781 ctctttctcc aaatgctgcg caacaaaagg aatgctttgc aacaaaacag acaagaaaag
     6841 atggagacac ccgttacaga acctggggag gacagcagtc aacctggggt ttctgagcag
     6901 acacctccag gtacagagtg cacagtaaaa aacatttcag actcctctaa aaagcgacct
     6961 gtgactgcag acacatgtga agtctctcag ggaaaaggaa atacagacac tgttcccagt
     7021 tggaaaaaac aaaaggttac catgaaagat gttggaaata tacagacagt atccaaacat
     7081 ccaagcacta caggatctcc tcccaatgat gaaaacaaaa taggatcaaa ttcctctgac
     7141 agtctgaaaa gcatctctgc atctccagaa gtggtcaaaa gacagagctc agtacttggt
     7201 tcagtgtcac ctgctgaaag tgtacaagac acttgcacac caaagtcaga aagcaaagta
     7261 gagccaacag acagcttacc tgattcttta gcatctctca ctgaacagca ggaaaactca
     7321 aatgtcatag agaaaagaaa tgggaattct agtgtggctg aaacaaatga taagaaagac
     7381 tgtcctttag taacttgtga ccaaaaggat atagatgcct cttactcacc tgaccacaca
     7441 cctgcacagg aatcccataa aacccctgtg gatcacacac agatctctcc ttcaaaccta
     7501 acagcaggaa atgatgaccc tcttgtgcct gatgcatctc tgctctcagt gtctgcttcc
     7561 cagtcagaga aggacgttta tttgagtggc acagactttc accatgaaaa taataaaata
     7621 ctaaatttgt ctactgaaga ttgtacaggc accagctctc cagaacctgt gtgtatcaag
     7681 gacaaaattt ctgtcctgca agtagataaa acacagccta taaaaagtga atcgccaaaa
     7741 aaaagtatga ctgatgctcc aaatcccaat actgcaccat ttggctcata tgggaactca
     7801 gcccttaatg tgaatggaac agtacagcac actcactctg aacagaattc aaaagtcctg
     7861 actcagaaag ttggcacatc caggaatata cctccacagt ctgcatgttc tccagtacat
     7921 aactcttctg cacattcatt tggaacttca tatccatact actcttggtg tttctatcag
     7981 tacagcagca gcaatggcac tgctgttact cacacatacc aagggatgac agcatatgag
     8041 atacaacagc ctcctcctcc agtgttgact acagttgcaa gtactgttca gagcacacat
     8101 ttcaatcgtt catactctga acattttagt tactttcctg gacagccaca agcaaattcc
     8161 tttaacccag gaaacgggta ttttccatct cacacgcctg tttcttacaa ttaccaacaa
     8221 ccagtttatt cacagtttgc ttctcatcaa ccagtcccac aggctacata tccttatccg
     8281 cctaacccag gtgcgcctcc tcaagttcct tggacttatg ctccatggca acagaatccg
     8341 tttctacgaa ggccttaaaa ataaatctct tcatactgaa ataaatgcaa cttaagtttt
     8401 ctcaagta
//
