LOCUS       NM_025687                647 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus testis expressed 12 (Tex12), mRNA.
ACCESSION   NM_025687
VERSION     NM_025687.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 647)
  AUTHORS   Li,M., Huang,T., Li,M.J., Zhang,C.X., Yu,X.C., Yin,Y.Y., Liu,C.,
            Wang,X., Feng,H.W., Zhang,T., Liu,M.F., Han,C.S., Lu,G., Li,W.,
            Ma,J.L., Chen,Z.J., Liu,H.B. and Liu,K.
  TITLE     The histone modification reader ZCWPW1 is required for meiosis
            prophase I in male but not in female mice
  JOURNAL   Sci Adv 5 (8), eaax1101 (2019)
   PUBMED   31453335
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 647)
  AUTHORS   Liu,H., Huang,T., Li,M., Li,M., Zhang,C., Jiang,J., Yu,X., Yin,Y.,
            Zhang,F., Lu,G., Luo,M.C., Zhang,L.R., Li,J., Liu,K. and Chen,Z.J.
  TITLE     SCRE serves as a unique synaptonemal complex fastener and is
            essential for progression of meiosis prophase I in mice
  JOURNAL   Nucleic Acids Res 47 (11), 5670-5683 (2019)
   PUBMED   30949703
REFERENCE   3  (bases 1 to 647)
  AUTHORS   Hernandez-Hernandez,A., Masich,S., Fukuda,T., Kouznetsova,A.,
            Sandin,S., Daneholt,B. and Hoog,C.
  TITLE     The central element of the synaptonemal complex in mice is
            organized as a bilayered junction structure
  JOURNAL   J Cell Sci 129 (11), 2239-2249 (2016)
   PUBMED   27103161
REFERENCE   4  (bases 1 to 647)
  AUTHORS   Fukuda,T., Fukuda,N., Agostinho,A., Hernandez-Hernandez,A.,
            Kouznetsova,A. and Hoog,C.
  TITLE     STAG3-mediated stabilization of REC8 cohesin complexes promotes
            chromosome synapsis during meiosis
  JOURNAL   EMBO J 33 (11), 1243-1255 (2014)
   PUBMED   24797475
REFERENCE   5  (bases 1 to 647)
  AUTHORS   Fraune,J., Brochier-Armanet,C., Alsheimer,M. and Benavente,R.
  TITLE     Phylogenies of central element proteins reveal the dynamic
            evolutionary history of the mammalian synaptonemal complex: ancient
            and recent components
  JOURNAL   Genetics 195 (3), 781-793 (2013)
   PUBMED   24026100
REFERENCE   6  (bases 1 to 647)
  AUTHORS   Schramm,S., Fraune,J., Naumann,R., Hernandez-Hernandez,A., Hoog,C.,
            Cooke,H.J., Alsheimer,M. and Benavente,R.
  TITLE     A novel mouse synaptonemal complex protein is essential for loading
            of central element proteins, recombination, and fertility
  JOURNAL   PLoS Genet 7 (5), e1002088 (2011)
   PUBMED   21637789
REFERENCE   7  (bases 1 to 647)
  AUTHORS   Borgel,J., Guibert,S., Li,Y., Chiba,H., Schubeler,D., Sasaki,H.,
            Forne,T. and Weber,M.
  TITLE     Targets and dynamics of promoter DNA methylation during early mouse
            development
  JOURNAL   Nat Genet 42 (12), 1093-1100 (2010)
   PUBMED   21057502
REFERENCE   8  (bases 1 to 647)
  AUTHORS   Hamer,G., Wang,H., Bolcun-Filas,E., Cooke,H.J., Benavente,R. and
            Hoog,C.
  TITLE     Progression of meiotic recombination requires structural maturation
            of the central element of the synaptonemal complex
  JOURNAL   J Cell Sci 121 (Pt 15), 2445-2451 (2008)
   PUBMED   18611960
  REMARK    GeneRIF: TEX12 is a component of the central element structure of
            the synaptonemal complex required for propagation of synapsis along
            the paired homologous chromosomes and maturation of early
            recombination events into crossovers
REFERENCE   9  (bases 1 to 647)
  AUTHORS   Hamer,G., Gell,K., Kouznetsova,A., Novak,I., Benavente,R. and
            Hoog,C.
  TITLE     Characterization of a novel meiosis-specific protein within the
            central element of the synaptonemal complex
  JOURNAL   J Cell Sci 119 (Pt 19), 4025-4032 (2006)
   PUBMED   16968740
  REMARK    GeneRIF: TEX12 specifically co-precipitated with SYCE2.
REFERENCE   10 (bases 1 to 647)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC048458.1.
            
            On Jun 10, 2007 this sequence version replaced NM_025687.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048458.1, AK014896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.75 cM"
     gene            1..647
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /note="testis expressed 12"
                     /db_xref="GeneID:66654"
                     /db_xref="MGI:MGI:1913904"
     exon            1..43
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            44..109
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..418
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /note="testis-expressed sequence 12 protein; testis
                     exprtessed gene 12; testis expressed gene 12"
                     /codon_start=1
                     /product="testis-expressed protein 12"
                     /protein_id="NP_079963.1"
                     /db_xref="CCDS:CCDS40621.1"
                     /db_xref="GeneID:66654"
                     /db_xref="MGI:MGI:1913904"
                     /translation="MMANHLVKPDSRNCKRARELEPQVSDSPQVSSLGKSESSLSEAS
                     GLFYKEEALEKDLSDMSKEINLMLSTYAKILSERAAVDASYIDEIDGLFKEANIIENF
                     LVQKREFLKQRFTVITNTLHK"
     exon            110..221
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            222..273
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            274..617
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      484..489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      513
                     /gene="Tex12"
                     /gene_synonym="5730518K06Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcaggtcgt ggccgaatct ccgcttgcga gtggggccag aggagaatga tggcaaacca
       61 ccttgtaaaa cccgactcta gaaactgcaa gagggcaaga gaattggagc ctcaggtgtc
      121 tgatagtcca caggtatctt ctcttggaaa atcagagtca tctctctctg aggcttctgg
      181 actcttttat aaagaggaag ctctggagaa ggatttgagc gatatgagca aggaaattaa
      241 tctgatgttg tctacatatg caaagatttt aagtgaaaga gcagcagtag atgcatctta
      301 catcgatgag atagatggac tcttcaaaga agccaatatt attgaaaact ttctagtaca
      361 aaaaagagag ttcctgaagc agaggtttac agtaattacc aacaccctac acaagtaatg
      421 tgcctatgcc agctaaaagt ttttcctgtt actgctgtgt tcttcttgct agagaaaaca
      481 tatattaaac tgtaactttt tctaaattta aaagaagttt taagatagat attaatatga
      541 agtgtgtaat atttcttttg agggtcaaat atttggcaca ttatataaaa atataaatta
      601 aaaattatat gcatgttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
