LOCUS       NM_031384               3250 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus testis expressed gene 11 (Tex11), transcript variant
            1, mRNA.
ACCESSION   NM_031384
VERSION     NM_031384.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Ghieh,F., Passet,B., Poumerol,E., Castille,J., Calvel,P.,
            Vilotte,J.L., Sellem,E., Jouneau,L., Mambu-Mambueni,H.,
            Garchon,H.J., Pailhoux,E., Vialard,F. and Mandon-Pepin,B.
  TITLE     A partial deletion within the meiosis-specific sporulation domain
            SPO22 of Tex11 is not associated with infertility in mice
  JOURNAL   PLoS One 19 (9), e0309974 (2024)
   PUBMED   39231187
  REMARK    GeneRIF: A partial deletion within the meiosis-specific sporulation
            domain SPO22 of Tex11 is not associated with infertility in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Li,Y., Wu,Y., Khan,I., Zhou,J., Lu,Y., Ye,J., Liu,J., Xie,X.,
            Hu,C., Jiang,H., Fan,S., Zhang,H., Zhang,Y., Jiang,X., Xu,B., Ma,H.
            and Shi,Q.
  TITLE     M1AP interacts with the mammalian ZZS complex and promotes male
            meiotic recombination
  JOURNAL   EMBO Rep 24 (2), e55778 (2023)
   PUBMED   36440627
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Kazi,S., Castaneda,J.M., Savolainen,A., Xu,Y., Liu,N., Qiao,H.,
            Ramirez-Solis,R., Nozawa,K., Yu,Z., Matzuk,M.M. and
            Prunskaite-Hyyrylainen,R.
  TITLE     MRNIP interacts with sex body chromatin to support meiotic
            progression, spermatogenesis, and male fertility in mice
  JOURNAL   FASEB J 36 (9), e22479 (2022)
   PUBMED   35920200
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Shin,Y.H., Choi,Y., Erdin,S.U., Yatsenko,S.A., Kloc,M., Yang,F.,
            Wang,P.J., Meistrich,M.L. and Rajkovic,A.
  TITLE     Hormad1 mutation disrupts synaptonemal complex formation,
            recombination, and chromosome segregation in mammalian meiosis
  JOURNAL   PLoS Genet 6 (11), e1001190 (2010)
   PUBMED   21079677
  REMARK    Erratum:[PLoS Genet. 2011;7(2). doi:
            10.1371/annotation/8aa656b6-55f7-4795-a441-cf243ea62175]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3250)
  AUTHORS   Velasco,G., Hube,F., Rollin,J., Neuillet,D., Philippe,C.,
            Bouzinba-Segard,H., Galvani,A., Viegas-Pequignot,E. and
            Francastel,C.
  TITLE     Dnmt3b recruitment through E2F6 transcriptional repressor mediates
            germ-line gene silencing in murine somatic tissues
  JOURNAL   Proc Natl Acad Sci U S A 107 (20), 9281-9286 (2010)
   PUBMED   20439742
REFERENCE   8  (bases 1 to 3250)
  AUTHORS   Adelman,C.A. and Petrini,J.H.
  TITLE     ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand
            break repair and the regulation of crossing over
  JOURNAL   PLoS Genet 4 (3), e1000042 (2008)
   PUBMED   18369460
  REMARK    GeneRIF: Zip4h (Tex11), a male germ cell specific X-linked gene was
            isolated. Zip4h(-/Y) mutant mice were fertile. Analysis of
            spermatocytes revealed a delay in meiotic double strand break
            repair and decreased crossover formation.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3250)
  AUTHORS   Yang,F., Gell,K., van der Heijden,G.W., Eckardt,S., Leu,N.A.,
            Page,D.C., Benavente,R., Her,C., Hoog,C., McLaughlin,K.J. and
            Wang,P.J.
  TITLE     Meiotic failure in male mice lacking an X-linked factor
  JOURNAL   Genes Dev 22 (5), 682-691 (2008)
   PUBMED   18316482
  REMARK    GeneRIF: TEX11 promotes initiation and/or maintenance of synapsis
            and formation of crossovers, and may provide a physical link
            between these two meiotic processes.
            GeneRIF: Tex11 forms discrete foci on meiotic chromosomes. Tex11 is
            essential for meiosis and fertility in males. Tex11 promotes both
            chromosomal synapsis and crossover formation in mice and may link
            these two meiotic processes by interacting with Sycp2 in vivo.
REFERENCE   10 (bases 1 to 3250)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
  REMARK    GeneRIF: Tex11 was first identified from mouse spermatogonia and
            was specifically expressed in mouse testis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029799.1 and BC116709.1.
            
            On Nov 21, 2009 this sequence version replaced NM_031384.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029799.1, AF285572.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN00849382 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK029799.1         1-4
            5-3169              BC116709.1         1-3165
            3170-3250           AK029799.1         3171-3251
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..3250
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /note="testis expressed gene 11"
                     /db_xref="GeneID:83558"
                     /db_xref="MGI:MGI:1933237"
     exon            1..127
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            128..189
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2993
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis-expressed sequence 11 protein; protein ZIP4
                     homolog; testis-expressed protein 11"
                     /codon_start=1
                     /product="testis-expressed protein 11 isoform 1"
                     /protein_id="NP_113561.2"
                     /db_xref="CCDS:CCDS30308.1"
                     /db_xref="GeneID:83558"
                     /db_xref="MGI:MGI:1933237"
                     /translation="MDRITDFYFLDFRESVKTLIITGNSWRLQEMIDRFFTNISNFNR
                     ESLTEIQNIQIEEIAVNLWNWAVTKRVELSVRKNQAAKLCYIACKLVYMHGISVSSEE
                     AIQRQILMNIKTGKEWLYTGNAQIADEFFQAAMTDLERLYVRLMQSCYTEANVCVYKM
                     IVEKGIFHVLSYQAESAVAQGDFKKASMCVLRCKDMLMRLPNMTKYLHVLCYNLGIEA
                     SKRNKYKESSFWLGQSYEIGKMDRRSVEPQMLAKTLRLLATIYLNCGGEAYYTKAFIA
                     ILIANKEHLHPAGLFLKMRILMKGNSCNEELLEAAKEILYLAMPLEFYLSIIQFLIDN
                     KRESVGFRFLRIISDNFKSPEDRKRILLFYIDTLLQKDQDMIAEEKIKDVLKGYQTRS
                     RLSRDLVNWLHNILWGKASRSVKVQKYADALHWYSYSLKLYEYDKADLDLIKLKRNMV
                     SCYLSLKQLDKAKEAIAEVEQKDPTHVFTRYYIFKIAIMEGDAFRALQVVSALKKSLM
                     DGESEDRGLIEAGVSTLTILSLSIDFALENGQQFVAERALEYLCQLSKDPKEVLGGLK
                     CLMRIILPQAFHMPESEYKKKEMGRLWNYLNTALLKFSEYFNEAPSTLDYMVNDANWF
                     RKIAWNLAVQSEKDLEAMKNFFMVSYKLSLFCPLDQGLLIAQKTCLLVAAAVDLDRGR
                     KAPTICEQNMLLRTALEQIKKCKKVWNLLKKTGDFSGDDCGVLLLLYEFEVKTKTNDP
                     SLSRFVDSVWKMPDLECRTLETMALLAMDKPAYYPTIAHKAMKKLLLMYRKQEPVDVL
                     KYSVCMHNLIKLLVADEVWNISLYPLKEVQSHFKNTLSIIRQNEGYPEEEIVWLMIKS
                     WNIGILMSSKNKYISAERWAAMALDFLGHLSTLKTSYEAKVNLLYANLMEILDKKTDL
                     RSTEMTEQLRALIVPPEDQGSVSSTNVAAQNHL"
     exon            190..311
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            312..396
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            397..476
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            477..557
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            558..677
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            678..758
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            759..844
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            845..899
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            900..995
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1077
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1156
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1308
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1394
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1532
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1635
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1760
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1846
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1903
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1944
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2031
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2102
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2219
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2292
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2442
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2551
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2672
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2837
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..3250
                     /gene="Tex11"
                     /gene_synonym="4930565P14Rik; ZIP4H"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagacgga gacggagtcg gagacgcgag acgccagcaa gcgtttcggg tgtgggagag
       61 cagacgcctc cctgtttaac aactttctcc tggatttgca gcttcctcaa cgtccctgca
      121 ccttcaggct ggagccagac atttaaaaaa tggaccgcat tactgacttt tacttcttgg
      181 acttcagaga atctgttaaa accctgatca taactggtaa ttcatggaga ctacaagaaa
      241 tgattgacag attcttcaca aacatatcaa atttcaacag agagtctctg actgaaatac
      301 agaatattca gattgaagaa attgcagtga acctgtggaa ctgggcagtt actaagagag
      361 tagaactgtc tgtgaggaaa aaccaggcag ctaaactgtg ttatattgct tgcaagctgg
      421 tatatatgca tggaatctca gtctcttcag aagaagctat tcaaagacag attttgatga
      481 atataaaaac aggaaaagag tggttgtata ctggaaatgc tcagattgct gatgaatttt
      541 ttcaagctgc catgactgat ctggagagat tatatgtcag attaatgcag agctgctaca
      601 ccgaggccaa cgtgtgtgtg tataagatga ttgttgagaa aggcatcttc catgtgcttt
      661 cttaccaagc tgagtcagct gttgctcaag gggatttcaa gaaagcatct atgtgcgtct
      721 tacgttgcaa agatatgctg atgagactcc ctaacatgac aaaatatctt catgtactct
      781 gttacaacct tggcatagaa gcaagcaagc ggaataaata caaagagagt tcattctggc
      841 ttggccaaag ctatgaaatt gggaagatgg ataggcgttc tgttgagcca caaatgctgg
      901 ctaaaacgct gcggttacta gccactattt atttgaattg tggtggcgaa gcatattata
      961 ccaaggcctt cattgctata ctcattgcaa acaaggaaca tttacatcca gctgggcttt
     1021 tcttaaagat gaggatcctc atgaaaggca actcatgtaa tgaagaactc cttgaagctg
     1081 ctaaggaaat actatatctt gctatgcctt tggaattcta tctgagcatt attcaattcc
     1141 tgatagataa taaaagagag tctgttgggt ttcgctttct gagaatcatc tctgacaatt
     1201 ttaagtcgcc agaagatagg aagagaattc tgttgttcta cattgacacg cttttacaaa
     1261 aggatcaaga catgattgct gaagagaaga ttaaagacgt ccttaaaggt taccaaacaa
     1321 gaagtcgact gtcaagagat ttggtaaatt ggttacacaa cattctgtgg ggaaaggctt
     1381 ccagaagtgt taaggtccaa aaatatgctg atgccctaca ctggtacagt tattctctga
     1441 agttgtatga gtatgataaa gcagatctgg atttgatcaa gctgaagagg aacatggttt
     1501 cctgttactt atctttgaaa caacttgata aggctaaaga ggccatagca gaagttgagc
     1561 aaaaggatcc tacacatgtt ttcactcggt attatatatt caagatcgca atcatggagg
     1621 gtgatgcttt cagagcttta caggtggtca gtgctttaaa gaaatcatta atggatggag
     1681 aatcagaaga tcgtggacta attgaagctg gagtttcaac tctcacaatc ctaagtttat
     1741 ctatagattt tgctctagag aatggacagc aatttgtggc agaaagagct ttggaatatt
     1801 tatgtcaact ttcaaaagac ccaaaagaag tacttggagg tttaaagtgt ctcatgcgga
     1861 ttattcttcc acaagctttt catatgccag aatctgaata taaaaagaaa gaaatgggta
     1921 gactttggaa ctacttgaat acagcactcc tgaaattttc tgaatatttt aatgaagctc
     1981 cctcaacttt ggattatatg gttaatgatg ccaattggtt caggaaaata gcttggaact
     2041 tagctgtgca atctgagaag gatctagagg caatgaaaaa ctttttcatg gtttcttata
     2101 agctgtccct tttttgtcct ttggatcaag gactactgat tgcacagaaa acgtgtttac
     2161 ttgtagcagc tgcagttgat ctggatagag gaagaaaagc tccaacaatt tgtgagcaga
     2221 acatgttact aagaacagca cttgagcaga taaagaaatg caaaaaagtt tggaatctcc
     2281 tgaaaaaaac aggggacttc tcaggtgatg actgtggggt attgcttctg ctctatgaat
     2341 ttgaagttaa aaccaaaacg aatgatccat cactgagcag atttgtggat tcagtttgga
     2401 agatgcctga tttagaatgc agaacacttg aaacaatggc attactagct atggataaac
     2461 ctgcatacta tcctactatt gcacataagg ccatgaaaaa acttttattg atgtacagaa
     2521 aacaggagcc agttgatgtt ttaaaataca gcgtatgcat gcacaacttg attaaacttc
     2581 tggtggcaga tgaagtatgg aatatatcgc tgtatcccct aaaagaagtt cagagccatt
     2641 ttaaaaatac tctgagcatc attcgccaaa acgaaggata cccagaagag gagattgtat
     2701 ggctaatgat caagtcttgg aatattggaa tactgatgtc tagcaagaac aagtatatat
     2761 ctgcagaaag gtgggctgca atggcattgg atttccttgg ccaccttagc accctcaaaa
     2821 caagctatga agcaaaggtg aatcttctgt atgccaacct catggaaata ttagataaaa
     2881 agacggattt aagatctaca gagatgactg aacaattaag agcacttatt gttcctccgg
     2941 aggatcaagg ttcagtttcc agcaccaacg tggcagctca aaaccatctg taattccagt
     3001 tccagggaat ctgatactcc cctctggtca ctgtgggtac atgtgataaa agtaaagagt
     3061 gattttactt ttcagtggag agtcataatg attgaaggag gttgtagaaa gcagactagc
     3121 tcacagcaac ttgaaggtgt atattcatga gccgctgact atttcagtgt gtgtcatatg
     3181 ttccctggaa cttttgtttt cttaagcctt gttgactgaa attttctcaa ataaaagcat
     3241 tttgactttc
//
