LOCUS       NM_001347313           11613 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus tet methylcytosine dioxygenase 3 (Tet3), transcript
            variant 1, mRNA.
ACCESSION   NM_001347313 XM_006505773
VERSION     NM_001347313.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11613)
  AUTHORS   Gioulbasani,M., Aijo,T., Liu,S., Montgomery,S.A., Montgomery,N.D.,
            Corcoran,D. and Tsagaratou,A.
  TITLE     Concomitant loss of TET2 and TET3 results in T cell expansion and
            genomic instability in mice
  JOURNAL   Commun Biol 7 (1), 1606 (2024)
   PUBMED   39627458
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11613)
  AUTHORS   Mulet,I., Grueso-Cortina,C., Cortes-Cano,M., Gerovska,D., Wu,G.,
            Iakab,S.A., Jimenez-Blasco,D., Curtabbi,A., Hernansanz-Agustin,P.,
            Ketchum,H., Manjarres-Raza,I., Wunderlich,F.T., Bolanos,J.P.,
            Dawlaty,M.M., Hopf,C., Enriquez,J.A., Arauzo-Bravo,M.J. and
            Tapia,N.
  TITLE     TET3 regulates terminal cell differentiation at the metabolic level
  JOURNAL   Nat Commun 15 (1), 9749 (2024)
   PUBMED   39557858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11613)
  AUTHORS   Gioulbasani,M., Aijo,T., Valenzuela,J.E., Bettes,J.B. and
            Tsagaratou,A.
  TITLE     TET proteins regulate Drosha expression and impact microRNAs in
            iNKT cells
  JOURNAL   Front Immunol 15, 1440044 (2024)
   PUBMED   39364402
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11613)
  AUTHORS   MacArthur,I.C., Ma,L., Huang,C.Y., Bhavsar,H., Suzuki,M. and
            Dawlaty,M.M.
  TITLE     Developmental DNA demethylation is a determinant of neural stem
            cell identity and gliogenic competence
  JOURNAL   Sci Adv 10 (35), eado5424 (2024)
   PUBMED   39196941
REFERENCE   5  (bases 1 to 11613)
  AUTHORS   Yang,Y., Rivera,L., Fang,S., Cavalier,M., Suris,A., Zhou,Y. and
            Huang,Y.
  TITLE     Maternal high-fat diet alters Tet-mediated epigenetic regulation
            during heart development
  JOURNAL   iScience 27 (9), 110631 (2024)
   PUBMED   39262804
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11613)
  AUTHORS   Iqbal,K., Jin,S.G., Pfeifer,G.P. and Szabo,P.E.
  TITLE     Reprogramming of the paternal genome upon fertilization involves
            genome-wide oxidation of 5-methylcytosine
  JOURNAL   Proc Natl Acad Sci U S A 108 (9), 3642-3647 (2011)
   PUBMED   21321204
REFERENCE   7  (bases 1 to 11613)
  AUTHORS   Wossidlo,M., Nakamura,T., Lepikhov,K., Marques,C.J.,
            Zakhartchenko,V., Boiani,M., Arand,J., Nakano,T., Reik,W. and
            Walter,J.
  TITLE     5-Hydroxymethylcytosine in the mammalian zygote is linked with
            epigenetic reprogramming
  JOURNAL   Nat Commun 2, 241 (2011)
   PUBMED   21407207
REFERENCE   8  (bases 1 to 11613)
  AUTHORS   Ito,S., D'Alessio,A.C., Taranova,O.V., Hong,K., Sowers,L.C. and
            Zhang,Y.
  TITLE     Role of Tet proteins in 5mC to 5hmC conversion, ES-cell
            self-renewal and inner cell mass specification
  JOURNAL   Nature 466 (7310), 1129-1133 (2010)
   PUBMED   20639862
  REMARK    GeneRIF: all three mouse Tet proteins (Tet1, Tet2 and Tet3) can
            also catalyse conversion of 5-methylcytosine of DNA to
            5-hydroxymethylcytosine
REFERENCE   9  (bases 1 to 11613)
  AUTHORS   Tahiliani,M., Koh,K.P., Shen,Y., Pastor,W.A., Bandukwala,H.,
            Brudno,Y., Agarwal,S., Iyer,L.M., Liu,D.R., Aravind,L. and Rao,A.
  TITLE     Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in
            mammalian DNA by MLL partner TET1
  JOURNAL   Science 324 (5929), 930-935 (2009)
   PUBMED   19372391
REFERENCE   10 (bases 1 to 11613)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090648.5 and AC159713.6.
            
            On Nov 19, 2016 this sequence version replaced XM_006505773.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JX946278.1, SRR13422597.536821.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC090648.5         135433-135536       c
            105-835             AC090648.5         133894-134624       c
            836-892             AC090648.5         120361-120417       c
            893-3050            AC090648.5         81811-83968         c
            3051-3141           AC090648.5         65129-65219         c
            3142-3235           AC159713.6         195405-195498       c
            3236-3444           AC159713.6         192299-192507       c
            3445-3595           AC159713.6         191283-191433       c
            3596-3685           AC159713.6         189316-189405       c
            3686-3823           AC159713.6         188727-188864       c
            3824-4160           AC159713.6         185916-186252       c
            4161-11613          AC159713.6         177906-185358       c
FEATURES             Location/Qualifiers
     source          1..11613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..11613
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /note="tet methylcytosine dioxygenase 3"
                     /db_xref="GeneID:194388"
                     /db_xref="MGI:MGI:2446229"
     exon            1..104
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            105..835
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..5944
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /EC_number="1.14.11.80"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable methylcytosine dioxygenase TET3; tet oncogene
                     family member 3"
                     /codon_start=1
                     /product="methylcytosine dioxygenase TET3 isoform 1"
                     /protein_id="NP_001334242.1"
                     /db_xref="CCDS:CCDS85071.1"
                     /db_xref="GeneID:194388"
                     /db_xref="MGI:MGI:2446229"
                     /translation="MSQFQVPLAVQPDLSGLYDFPQGQVMVGGFQGPGLPMAGSETQL
                     RGGGDGRKKRKRCGTCDPCRRLENCGSCTSCTNRRTHQICKLRKCEVLKKKAGLLKEV
                     EINAREGTGPWAQGATVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSTSGAPVNGAR
                     EPAGPGLLGAAGPWRVDQKPDWEAASGPTHAARLEDAHDLVAFSAVAEAVSSYGALST
                     RLYETFNREMSREAGSNGRGPRPESCSEGSEDLDTLQTALALARHGMKPPNCTCDGPE
                     CPDFLEWLEGKIKSMAMEGGQGRPRLPGALPPSEAGLPAPSTRPPLLSSEVPQVPPLE
                     GLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTSQASCPLPEALSPSAP
                     FRSPQSYLRAPSWPVVPPEEHPSFAPDSPAFPPATPRPEFSEAWGTDTPPATPRNSWP
                     VPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPVPSPISQR
                     EAPLLSSEPDTHQKAQTALQQHLHHKRNLFLEQAQDASFPTSTEPQAPGWWAPPGSPA
                     PRPPDKPPKEKKKKPPTPAGGPVGAEKTTPGIKTSVRKPIQIKKSRSRDMQPLFLPVR
                     QIVLEGLKPQASEGQAPLPAQLSVPPPASQGAASQSCATPLTPEPSLALFAPSPSGDS
                     LLPPTQEMRSPSPMVALQSGSTGGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPI
                     QEPENQSTCLPAPESPFATRSPKKIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENP
                     LTPTLSGFLESPLKYLDTPTKSLLDTPAKKAQSEFPTCDCVEQIVEKDEGPYYTHLGS
                     GPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLC
                     LVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDR
                     TCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQ
                     DLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQ
                     HNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKVSSGA
                     IQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKLQKEKLSTPEKIKQEALELAG
                     VTTDPGLSLKGGLSQQSLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGSCRPSDPYSM
                     SSVYSYHSRYAQPGLASVNGFHSKYTLPSFGYYGFPSSNPVFPSQFLGPSAWGHGGSG
                     GSFEKKPDLHALHNSLNPAYGGAEFAELPGQAVATDNHHPIPHHQQPAYPGPKEYLLP
                     KVPQLHPASRDPSPFAQSSSCYNRSIKQEPIDPLTQAESIPRDSAKMSRTPLPEASQN
                     GGPSHLWGQYSGGPSMSPKRTNSVGGNWGVFPPGESPTIVPDKLNSFGASCLTPSHFP
                     ESQWGLFTGEGQQSAPHAGARLRGKPWSPCKFGNGTSALTGPSLTEKPWGMGTGDFNP
                     ALKGGPGFQDKLWNPVKVEEGRIPTPGANPLDKAWQAFGMPLSSNEKLFGALKSEEKL
                     WDPFSLEEGTAEEPPSKGVVKEEKSGPTVEEDEEELWSDSEHNFLDENIGGVAVAPAH
                     CSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAE
                     RARQRQEEAARLGLGQQEAKLYGKKRKWGGAMVAEPQHKEKKGAIPTRQALAMPTDSA
                     VTVSSYAYTKVTGPYSRWI"
     exon            836..892
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            893..3050
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3141
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3235
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3444
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3595
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3685
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3823
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..4160
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..11613
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11582..11587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      11613
                     /gene="Tet3"
                     /gene_synonym="B430006D22Rik; D230004J03Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcgcac accttgggcc gtggcggtgg cggtggcggc ggtggcagcg gcaggctggg
       61 aaactttgcc cctttgtgcg ctccgccccg gaggcggcgg gcaggcagcg tagccttctc
      121 catcatcctg acccagggag ggagaagtgt caggaggaaa ctcctcaccc caatctgccc
      181 caccacacac ccattggctc acctcatgcc tgagccccgg gtgggtgagg gtgaagaacc
      241 cacccagcca agatgaaatc ttccttgggg gctgccgccg ccactgtctt gccccagatc
      301 ctggggccct gcaggtggga gactggtcct ggaaggaacc ctgtgagccg gctgcagagg
      361 aggtgaagag ggttaagaag aggcacccac cccatcccat cccagaggcg gagctccttg
      421 ccttcaccct tgtagacttg tttaggagag aaggacctgt ttgcaggcag caggagactg
      481 gacagtagtt taacctggca cctatgcccc cttccctggc aacggcggca tcatgagcca
      541 gtttcaggtg cccttggcgg tccagccgga cctgtcagga ctttatgatt tcccgcaggg
      601 ccaggtgatg gtagggggct tccaggggcc tgggcttcct atggctggga gtgagaccca
      661 actgcgaggg ggtggagatg ggcggaagaa aaggaaacgg tgtgggacct gcgatccctg
      721 ccgacggctg gaaaactgtg ggtcttgtac cagctgcacc aatcgtcgca cacaccagat
      781 ctgcaaactc cgcaagtgtg aggtgctgaa gaaaaaagcg gggcttctta aggaggtgga
      841 aataaatgct cgtgaaggaa cggggccctg ggcacaaggg gcgactgtca agacaggctc
      901 agagctcagc ccagttgatg gacctgttcc aggtcagatg gactcagggc cagtgtacca
      961 tggagattca aggcagctaa gcacctcagg ggcgccggtc aatggtgcta gagagcccgc
     1021 cggacccggt cttctgggag ctgcgggtcc ttggcgggta gaccagaagc ccgactggga
     1081 ggctgcctca ggccccactc acgctgctcg tctggaagat gcccacgacc tggtggcctt
     1141 ttcggccgtg gccgaagctg tgtcatctta cggggccctt agtacccggc tctatgaaac
     1201 cttcaaccgt gagatgagtc gtgaggctgg gagcaacggc aggggccccc ggcctgagag
     1261 ctgctctgag ggcagtgaag acctggacac gctgcagaca gccctggccc ttgcaaggca
     1321 tggcatgaaa ccacccaact gcacctgcga tggcccagag tgccccgact tcctcgagtg
     1381 gctggagggc aagatcaagt ctatggccat ggagggaggg caggggcggc ctaggctccc
     1441 aggcgctctg cctcccagtg aggctggcct cccagcccct agcaccagac cgccactcct
     1501 tagctctgag gtcccccagg tacctcccct ggagggcctg cctctgtccc agagcgcgct
     1561 gagcattgcc aaggaaaaaa acatcagcct gcagacagcc atcgccatcg aggccctcac
     1621 acagctctcc tccgccctcc ctcagccttc tcattccacc tcccaggctt cttgtccact
     1681 ccctgaggcc ttgtcccctt ctgccccttt caggtctccc cagtcctacc tccgggcccc
     1741 ctcatggcct gtggttcccc cagaggaaca tccatccttt gctcctgaca gcccagcctt
     1801 ccctccagca accccaagac ctgagttttc tgaagcgtgg ggcactgaca cccccccagc
     1861 gacaccccgg aactcctggc ctgtacctcg cccaagccct gaccctatgg cagaactgga
     1921 gcagctattg ggcagcgcca gtgattacat ccagtcagta ttcaagcggc ctgaggccct
     1981 gcccaccaag cccaaggtca aggttgaggc cccctcttct tcccctgctc cggtaccatc
     2041 tcctatttct cagagggagg ctcccctgct gtcttcagag cctgacaccc accagaaggc
     2101 ccagacagcc cttcagcaac atcttcatca caagcgcaac ctattcttgg aacaggccca
     2161 agatgcctcc ttccctactt ccacagagcc tcaggctcct ggttggtggg cccctcccgg
     2221 ctcacctgcc ccaaggcctc ctgacaaacc acccaaggaa aagaaaaaga agccccccac
     2281 ccctgctgga ggtcccgtgg gagcagagaa aaccacccct gggatcaaga ccagtgtccg
     2341 aaagcccatt cagatcaaga aatccaggtc cagggacatg cagcccctct tcctgcctgt
     2401 taggcagatt gttctggaag ggctaaaacc ccaagcctca gaaggacagg caccgttacc
     2461 cgcccagctc tctgtcccac ctcctgcctc ccagggtgct gcatcccaga gctgtgccac
     2521 ccctctaacc ccagaacctt ctcttgcgct atttgcacct agtccctccg gggacagcct
     2581 gctgccccct actcaggaaa tgagatcccc cagccccatg gtagccctgc agtcaggctc
     2641 cactggtggc ccccttcccc ctgccgatga caagctggag gagctcatcc ggcaatttga
     2701 ggctgaattt ggggatagct ttgggcttcc cggcccacct tcggtgccca ttcaagaacc
     2761 tgaaaaccaa tcaacatgtc tcccagctcc ggagagccct tttgccaccc gctcccccaa
     2821 gaagatcaag atcgagtcct caggggccgt gactgtgctc tcaactacct gcttccattc
     2881 agaagagggg ggacaggagg ccacgcccac caaggctgag aacccactca caccaaccct
     2941 cagtggcttc ttggagtcac ctctaaagta cctagacaca cctactaaga gtctgctgga
     3001 cacaccggcc aagaaggctc agtccgagtt ccctacctgc gattgtgtcg aacaaatagt
     3061 ggagaaagat gaaggcccat attacactca cctgggatct ggccccacag tagcttctat
     3121 ccgggaactc atggaggatc ggtatggaga aaaggggaaa gctatccgga ttgagaaggt
     3181 catctacacg ggcaaggagg ggaagagttc tcgaggctgt cccatcgcca agtgggtgat
     3241 ccgaagacac acactggagg agaagctgct gtgcctggtg cggcatcggg caggccacca
     3301 ttgtcagaac gccgtgattg ttatcttgat cctggcctgg gagggcatcc ctcgaagcct
     3361 tggggacacc ctctaccagg agcttactga taccctccgg aagtatggca accctaccag
     3421 ccggagatgt ggcctcaatg atgaccggac ctgtgcttgc caaggcaaag accctaacac
     3481 ctgcggtgcc tccttctcct tcggctgttc ctggagcatg tacttcaacg gctgcaaata
     3541 tgctcggagc aagacgccac gaaagttccg cctcacggga gacaatccga aggaggagga
     3601 ggtgctccgg aatagctttc aggatctggc cactgaagtt gctcccctct acaagcggct
     3661 cgcaccccag gcctatcaga accaggtgac caatgaggat gtggcgatcg actgccgcct
     3721 ggggctgaag gaagggagac ccttctcagg ggtcacagcc tgcatggact tctgtgccca
     3781 cgcccacaag gaccaacata acctctacaa tgggtgcact gtggtctgca ccctgaccaa
     3841 ggaagacaat cgctgcgtgg gccagatccc tgaggacgag caactgcacg tgctgcccct
     3901 ctacaagatg gccagcacgg atgagtttgg cagcgaggaa aaccagaacg ccaaggtcag
     3961 tagtggggcc atccaggtgc tcacagcatt ccccagagag gtccggcggc tgcctgagcc
     4021 tgccaagtcc tgccgccaac ggcagctgga agccaggaag gcggcggccg agaagaagaa
     4081 gctgcagaag gagaaactga gcacgccaga gaagatcaag caggaggccc tggagttggc
     4141 tggagtcacc actgacccag gcctgtctct gaagggtgga ttgtcccagc aaagcctgaa
     4201 gccctccctc aaggtggagc ctcagaacca ctttagctcc tttaagtaca gtggcaatgc
     4261 ggtggtggaa agctactcgg tgctgggcag ctgccggccc tccgacccct acagcatgag
     4321 cagtgtgtat tcctaccatt cgcgctatgc acagcctggc ctggcctctg tcaacggctt
     4381 ccactccaag tacacacttc cctcctttgg ctactatggc tttccatcaa gcaaccctgt
     4441 cttcccctcc cagttcctgg gtcccagtgc ctgggggcat gggggcagtg gaggcagttt
     4501 tgagaagaag ccagacctcc atgctctaca caacagcctg aacccagcct acggtggtgc
     4561 tgagtttgcc gagctgccag gtcaggctgt tgccacagac aaccaccacc ccatccctca
     4621 ccaccagcag cctgcttacc caggccccaa ggaatatctg ctacccaagg tcccccagct
     4681 ccacccagca tccagggacc cctctccctt tgctcagagt tccagttgct acaacagatc
     4741 catcaagcaa gagccaatag accctctgac ccaggctgag tccattccca gagactctgc
     4801 taagatgagt agaacaccct tgccggaagc atctcagaat gggggaccca gtcatctgtg
     4861 gggacagtac tcaggaggcc caagcatgtc cccgaagagg actaacagtg taggtggcaa
     4921 ctggggcgtg ttccctccgg gggagagccc taccattgtt cccgacaagc tcaattcttt
     4981 tggggccagc tgtctcactc cttcacactt cccagaaagc cagtggggac tgttcactgg
     5041 tgaaggccag cagtcggccc cccatgctgg agcacggctt cgaggcaagc catggagccc
     5101 ctgcaagttt gggaacggca cctctgcctt gactggtccc agcctaactg agaagccatg
     5161 ggggatggga accggggatt tcaaccccgc cctgaaaggt ggacctgggt tccaagacaa
     5221 gttgtggaat cctgtgaagg tggaggaggg caggattccc acaccggggg ccaacccgct
     5281 agacaaagcc tggcaagcct ttggcatgcc cttgagctcc aacgagaagc tatttggggc
     5341 cctgaagtca gaggagaaac tgtgggatcc cttcagcctg gaggagggga cagctgagga
     5401 gccccccagc aagggggtgg tgaaggaaga gaagagtgga cccacagtgg aagaggacga
     5461 ggaggaactg tggtcggaca gtgaacacaa cttcctggat gagaacatag gcggggtggc
     5521 cgtggccccc gcccattgct ccatcctcat cgagtgtgcc cggcgagagc tgcatgccac
     5581 cactccactc aaaaaaccca accgctgcca ccccacccgc atctcgctgg tcttctacca
     5641 acacaagaac ctcaaccagc ccaaccacgg gctggcgctc tgggaggcca agatgaagca
     5701 gctggcggaa cgggcgcggc agcggcaaga ggaggccgca cgcctgggcc tgggccagca
     5761 ggaggccaag ctctacggga agaagcgaaa atgggggggt gctatggtgg ctgagcccca
     5821 gcacaaagaa aagaaggggg ctatccctac ccggcaggcg ctggccatgc ccacagactc
     5881 cgcggtcacc gtgtcctctt acgcctacac aaaggtcact ggcccctaca gccgctggat
     5941 ctaggtgcca ggagccagcg tacctcagcg tcgggcccgg cccgagctgc tctgtggtgc
     6001 ttttgccctc atgcccgggg gcgggttggg ggtgcagaag tctctctata tctacatata
     6061 tggatatgct tatcatatat atgtatttat ggtccaaacc tcagaactga cccgccctcc
     6121 ctcctcttct tccccagcac tttgaagaaa ctacggctgt cgggtgattt tttttttttt
     6181 ttgatcttaa tatttatatc tccacgtttt atttttcccc ttgttttgag ggggctttta
     6241 ttttcctttt gtttttaaaa ctttatcctt gtatatcaca ataatggaaa gaaagtttat
     6301 agtgtccttt cacaaaggag cgtagtttta aaattccatt taaaatatgt atttattggg
     6361 tttttttaaa gcaacaatag taatgggtta caggtgggca ggaaaggccg gcagtgcttc
     6421 ctgcctggca agcccagcct cctgggggct gcaggctctc tcagccatct gccccacaaa
     6481 ccaaggttag catgtagccc tggtctatcc ctccttccca caggctgggg agccttttgg
     6541 gaccaccccg ttctcctctg tggaatgggg gaagctgcag acatctgggg gcctggcctg
     6601 gaaatgctgg tgttagatat ccccagaaac caggttggaa gtagacagct tcaagcttgc
     6661 tagtctccac actgaatcct ctctgtccgt tatttaccaa gtcatatgat gtcctggttc
     6721 gctaggcagc acctcaagct ggagcaggag tcgagaggct ccgaggagct cttctcgtcc
     6781 cgttgataaa gccggtgagt actgggccga aaggaagctt agtggcagtt ttcttaaaaa
     6841 tcgccccaaa gtttgtcgat actgaaaaag ggctactgta tctatagaat caagaagttg
     6901 aacccaagct gtgaagagcc agtgtgctgt acggtgctct gcgggtgctc tgcggtgctg
     6961 tgtggtgctg gagcctggtg ctgtagtagt gcgctgggac ttttctgact ctcggggcag
     7021 gtggcatcct gccggagctc agccagccaa tgtgatggca ggtcacgcat cgtccttatt
     7081 cctggatctt cacacgggac aatggtgcag cccttgcagg gcatggccta cacttcattt
     7141 aaagtgcaag ggtcaggcgt tttcaacagg ttgctatgct tttcctcctt caagggggcc
     7201 agttctccat tggatctttt ctctcctccc tctcccttct ccacctcccc tgaaacacgc
     7261 ccatcctaaa atcctggtgc attcattcag ctctttgaaa atgagaacgt tggtgcttta
     7321 atttctgtga cattgagagg ttgggcctga caggtggcag cggcagtggc agtggcagtg
     7381 gcagtggcgt gtctgcagca ggtcagtcct caagagtgtt tttcagaagc cgttagccgt
     7441 gtagtcaggc tgcccgtgcg tgcgaacgtg tgtggtgagt gggggggctt catcaggaca
     7501 cacacagtgg cagccgagcc ctgagacagc agttagcacg tggctctagc caggtttggt
     7561 cttaataaac tgagcgtagc aatcccatga caatgctgaa ggcaggtccg agtccccaag
     7621 cttcgcggtg ccttgtgcca gagccgagag ccgagcggcc gggtgttgac tagagccctt
     7681 cggaagcgct ggcagagagt ggctaaaaag gtgtcctgag catttttgtg gtctggtttt
     7741 aactgtaaat agtgaaagat ttttttaagc acttttgcct agatttaaac agcaacttga
     7801 aaagaataaa aagtacattt taacctgtaa ttgtgggaga gactgtaaat agtagctgaa
     7861 tatttaatgt gctttgtcaa tccaccttta ccatagtctg taaagttgca attattttac
     7921 aggacaaaaa aaatgaaatt attattgctt ttgaaataaa tacccaagag cttatcagga
     7981 cttagaatta ttcagaattc agatttatag gaaggcctct gaccctctgt ttgacaagct
     8041 aaagagtcag aggctttaag gcgcatgcta attgctaatt ttctagtttt gagggagagt
     8101 tgggtccttt aaatgctatt ttgctatcta tcgcatcagt gcttttacac aggtctcatc
     8161 tgactccgtg cttaggtaga tgcgggggtg ccttgaaaaa cttcatttta aataatctta
     8221 aatatgatat tttacaaagc atttggagaa tgtgaccgtg tatatggccc atggaagccc
     8281 caggttggct gatggcttgc gaggtcctga gcgtggccca ggtgatactg ttgctggcag
     8341 tgtgtggatc tctcggacgt gaattcagta tgctccaaac ctcctcaccc tttggtagca
     8401 aagccattat tagatgaatg gagaaaccag tacaagctaa aaagcatgtg atgtccatcc
     8461 cccaagcctg cacagccttt gttcatgagc tctagaccag gaagcaggct gccgtgaggt
     8521 gaggcaggca agaggctttc cacgttggcc cttcaggtcc gagcgagcga gcgagcgagc
     8581 gctgtttcgg ggctctgcgc cgcggctgtg cttgagcccg tgctgacttt cacacactac
     8641 atgtataacc tacctcaaat ctgtcactga attgagcatg ctttagacat gtatttaaga
     8701 cgtaactatg cacagttcta tatcccccat cccttgctgc tgaaggcttc ttaaagagaa
     8761 aaatcaaaat ttttattttt actggcacta tcatttttta agtcctgaag atgattgaca
     8821 agacattttt atcatgagaa gaaaaaaata aataaataaa gccattgcaa ctcaagaacc
     8881 tgacggcacg agcaagtttt aagagtagtg ttatagccgg gaagatgatg gcttcggagt
     8941 ctgctcccag ggtgcccgtc tgtccgtccg tccgtccgtc cgtccatccg tctccacagt
     9001 ccacaggcag tgcaagcgtt tggtgccccg cccccagctt tgtttccttc cgccttgttt
     9061 ttgttgtccc tgcctgctgt gtgcaagagg acttttgaag ttctgacctg agagattttc
     9121 ttttagaata taagtcattt gcagcaggag ctcacaaaat aactggagaa accacctgtc
     9181 agtagcaaca ctgagggtct cacggggatt gggggagggg tcagtttgaa gtctggtttt
     9241 tagtggggac cgagcagccc agcccagccc tccagggtgc tgctttgcct ctttgctgtg
     9301 gtggccctgg cccatgggaa gggactctgc cttctctggc cctcccacct gctgctttaa
     9361 agaaacagta gtttgcagag ctaggggttg ttagtgctga gcgacagaag tcgaagggct
     9421 ttgttgctcc atagctgatg gcggtggatg tgtgagtggt ctgacagtag ctgaaaatcc
     9481 agtgtcacag agcgaggaga cttgactgcc tcagatgtca aagcaaggcc aagctggtgg
     9541 gaaactgata tatccctgat gtgcctcaac cgatctcttt tgttactgaa gtgtgttttc
     9601 tggacttgga agcattttta tgaattgaaa tagtctaata aatggtgcta tggtgtttca
     9661 atgtgactgt ccctgatctt gtctccctga ggtgctatca acgtttgaaa ccacaaccaa
     9721 ccaaaaaaac gaggtgggcc ccgtctctcg gcttttcttc cctcttttgg tgctgtcttt
     9781 gtggacctct gtttaccgcg ttgtgtctgc tctgagcagg gttctgggtc tggtgtcttg
     9841 ttgttcccct tggtggccaa agctaggctc agagaaggca gcttgctctg cgcaaggaca
     9901 gcagaggccc gcctgtgggt ttgtctatct ccttagccag gttagagagg gagtggtggc
     9961 tttgagaagg ggaggcagga cccctgcctc tccttgtgtg tcaggtattc tcttgtgtcc
    10021 cagggtgcta accccagagg ggacaggctg tggtccagag gcagcgcctt tacctggccc
    10081 cggcagggac gggatgcgca agactttggg ttcttgctgc tcattggtag ctagctcctg
    10141 gtgctcagac taaaggcagg tgcttttttt gtccctcaat gccaccaagg ccgcttttag
    10201 ttggtgctaa acttctccct gtgtccacat aagctgacgc aaaatttaag atctcgacag
    10261 gaagcttcat ttttacatca tccactgtca caattttttt ttaaatacct caaaacagga
    10321 cattgtgaca acttagattc catgagggta tgatactcac aggctgtccg tgggatgact
    10381 tccttggcct tgacacatct agggtcattc tctgtgcatt aagcagtaaa atgccagagt
    10441 gcttaaggga aggagcgtgg ttggattttt tccattctct taagttttgc ttttgaataa
    10501 aaatgtgaat ctcctctgtc catctcatcg agctttctgt catggttgct gtcatttgaa
    10561 aatctacgca gcacttggtt tatctgctgt cctaccaggc caacttcacc acataccctg
    10621 gaccaaataa cacattggag gtgcatacgc caacccatct gcgcatagat gattctggga
    10681 gtgccgcctt cctgaggggg cggagccata ggcttctcac ctgaggggag acctcagcac
    10741 agaagccggg ttctgggctc tgtgcctgtg gatctgttca gcctgctcct cgttcgcttc
    10801 tattctgata tcagggatgc tttctgtagg gtgtctgtca gtcatgctct tctcgctccg
    10861 actgctcgtc attcaggggg aaccctcact cttcatatgg ggacagataa taattggctc
    10921 atctggacat cccaaatttt cttgattcca atatagattt tttttccttt ttcttttggg
    10981 ggtagaggga gagagacggg agtgatgtca tttatttttc ttgtgtttaa agaagcaagg
    11041 actggctgtc tcacagcata ctaatgcttt agacttgatc tagaaccctt gtagcttttg
    11101 gatgtgtttt atttcttatc tctttgaatt cctgtttggt tgcctggctt ccaatggagg
    11161 tgaacttaac aaccatactt gaatattccg tcttgacttt gtaaactgtg gctacttgaa
    11221 atgaagttta tctggggttg atggatgaat ggtaggtttt tgcaatgtct caaggcaata
    11281 ggatgtgtat tattaaactg tagatatctt agtacagtaa atttatgctg ataattttat
    11341 tttgtataat ttttaccttt ttgttaatat tttccttcca gtttattggt ttgtctcctg
    11401 agctaccacc gccttccttc ccctttcctt ctcccccagt gtttcagtaa atttaattta
    11461 gggtgcctag aaattgcaag tatgtatcct tttttgattt gtattttatt ataatttaca
    11521 caaacaactg ggtttgtgaa ctgtattact cctggcatct ttaaaatatt gtgggtgttt
    11581 taataaattt tatatttatt ttttgcactc aaa
//
