LOCUS       NM_001040400            9199 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus tet methylcytosine dioxygenase 2 (Tet2), transcript
            variant 1, mRNA.
ACCESSION   NM_001040400 XR_001578 XR_001642 XR_004554
VERSION     NM_001040400.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9199)
  AUTHORS   Gioulbasani,M., Aijo,T., Liu,S., Montgomery,S.A., Montgomery,N.D.,
            Corcoran,D. and Tsagaratou,A.
  TITLE     Concomitant loss of TET2 and TET3 results in T cell expansion and
            genomic instability in mice
  JOURNAL   Commun Biol 7 (1), 1606 (2024)
   PUBMED   39627458
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9199)
  AUTHORS   Mulet,I., Grueso-Cortina,C., Cortes-Cano,M., Gerovska,D., Wu,G.,
            Iakab,S.A., Jimenez-Blasco,D., Curtabbi,A., Hernansanz-Agustin,P.,
            Ketchum,H., Manjarres-Raza,I., Wunderlich,F.T., Bolanos,J.P.,
            Dawlaty,M.M., Hopf,C., Enriquez,J.A., Arauzo-Bravo,M.J. and
            Tapia,N.
  TITLE     TET3 regulates terminal cell differentiation at the metabolic level
  JOURNAL   Nat Commun 15 (1), 9749 (2024)
   PUBMED   39557858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9199)
  AUTHORS   Liang,X., Liu,H., Hu,H., Ha,E., Zhou,J., Abedini,A.,
            Sanchez-Navarro,A., Klotzer,K.A. and Susztak,K.
  TITLE     TET2 germline variants promote kidney disease by impairing DNA
            repair and activating cytosolic nucleotide sensors
  JOURNAL   Nat Commun 15 (1), 9621 (2024)
   PUBMED   39511169
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9199)
  AUTHORS   Zou,Z., Dou,X., Li,Y., Zhang,Z., Wang,J., Gao,B., Xiao,Y., Wang,Y.,
            Zhao,L., Sun,C., Liu,Q., Yu,X., Wang,H., Hong,J., Dai,Q.,
            Yang,F.C., Xu,M. and He,C.
  TITLE     RNA m5C oxidation by TET2 regulates chromatin state and
            leukaemogenesis
  JOURNAL   Nature 634 (8035), 986-994 (2024)
   PUBMED   39358506
  REMARK    GeneRIF: RNA m[5]C oxidation by TET2 regulates chromatin state and
            leukaemogenesis.
REFERENCE   5  (bases 1 to 9199)
  AUTHORS   Gioulbasani,M., Aijo,T., Valenzuela,J.E., Bettes,J.B. and
            Tsagaratou,A.
  TITLE     TET proteins regulate Drosha expression and impact microRNAs in
            iNKT cells
  JOURNAL   Front Immunol 15, 1440044 (2024)
   PUBMED   39364402
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9199)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 9199)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 9199)
  AUTHORS   Lorsbach,R.B., Moore,J., Mathew,S., Raimondi,S.C., Mukatira,S.T.
            and Downing,J.R.
  TITLE     TET1, a member of a novel protein family, is fused to MLL in acute
            myeloid leukemia containing the t(10;11)(q22;q23)
  JOURNAL   Leukemia 17 (3), 637-641 (2003)
   PUBMED   12646957
REFERENCE   9  (bases 1 to 9199)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 9199)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF463367.1, DQ079067.1, AK153311.1, AK129389.1 and BE137977.1.
            
            On Sep 7, 2007 this sequence version replaced NM_001040400.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               BF463367.1         1-452
            453-3808            DQ079067.1         431-3786
            3809-5764           AK153311.1         799-2754
            5765-8927           AK129389.1         2952-6114
            8928-9175           AK129389.1         6118-6365
            9176-9199           BE137977.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..9199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 61.84 cM"
     gene            1..9199
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /note="tet methylcytosine dioxygenase 2"
                     /db_xref="GeneID:214133"
                     /db_xref="MGI:MGI:2443298"
     exon            1..191
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            192..336
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            337..3542
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..6121
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /EC_number="1.14.11.80"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable methylcytosine dioxygenase TET2; tet oncogene 2;
                     tet oncogene family member 2"
                     /codon_start=1
                     /product="methylcytosine dioxygenase TET2 isoform 1"
                     /protein_id="NP_001035490.2"
                     /db_xref="CCDS:CCDS51071.1"
                     /db_xref="GeneID:214133"
                     /db_xref="MGI:MGI:2443298"
                     /translation="MEQDRTTHAEGTRLSPFLIAPPSPISHTEPLAVKLQNGSPLAER
                     PHPEVNGDTKWQSSQSCYGISHMKGSQSSHESPHEDRGYSRCLQNGGIKRTVSEPSLS
                     GLHPNKILKLDQKAKGESNIFEESQERNHGKSSRQPNVSGLSDNGEPVTSTTQESSGA
                     DAFPTRNYNGVEIQVLNEQEGEKGRSVTLLKNKIVLMPNGATVSAHSEENTRGELLEK
                     TQCYPDCVSIAVQSTASHVNTPSSQAAIELSHEIPQPSLTSAQINFSQTSSLQLPPEP
                     AAMVTKACDADNASKPAIVPGTCPFQKAEHQQKSALDIGPSRAENKTIQGSMELFAEE
                     YYPSSDRNLQASHGSSEQYSKQKETNGAYFRQSSKFPKDSISPTTVTPPSQSLLAPRL
                     VLQPPLEGKGALNDVALEEHHDYPNRSNRTLLREGKIDHQPKTSSSQSLNPSVHTPNP
                     PLMLPEQHQNDCGSPSPEKSRKMSEYLMYYLPNHGHSGGLQEHSQYLMGHREQEIPKD
                     ANGKQTQGSVQAAPGWIELKAPNLHEALHQTKRKDISLHSVLHSQTGPVNQMSSKQST
                     GNVNMPGGFQRLPYLQKTAQPEQKAQMYQVQVNQGPSPGMGDQHLQFQKALYQECIPR
                     TDPSSEAHPQAPSVPQYHFQQRVNPSSDKHLSQQATETQRLSGFLQHTPQTQASQTPA
                     SQNSNFPQICQQQQQQQLQRKNKEQMPQTFSHLQGSNDKQREGSCFGQIKVEESFCVG
                     NQYSKSSNFQTHNNTQGGLEQVQNINKNFPYSKILTPNSSNLQILPSNDTHPACEREQ
                     ALHPVGSKTSNLQNMQYFPNNVTPNQDVHRCFQEQAQKPQQASSLQGLKDRSQGESPA
                     PPAEAAQQRYLVHNEAKALPVPEQGGSQTQTPPQKDTQKHAALRWLLLQKQEQQQTQQ
                     SQPGHNQMLRPIKTEPVSKPSSYRYPLSPPQENMSSRIKQEISSPSRDNGQPKSIIET
                     MEQHLKQFQLKSLCDYKALTLKSQKHVKVPTDIQAAESENHARAAEPQATKSTDCSVL
                     DDVSESDTPGEQSQNGKCEGCNPDKDEAPYYTHLGAGPDVAAIRTLMEERYGEKGKAI
                     RIEKVIYTGKEGKSSQGCPIAKWVYRRSSEEEKLLCLVRVRPNHTCETAVMVIAIMLW
                     DGIPKLLASELYSELTDILGKCGICTNRRCSQNETRNCCCQGENPETCGASFSFGCSW
                     SMYYNGCKFARSKKPRKFRLHGAEPKEEERLGSHLQNLATVIAPIYKKLAPDAYNNQV
                     EFEHQAPDCCLGLKEGRPFSGVTACLDFSAHSHRDQQNMPNGSTVVVTLNREDNREVG
                     AKPEDEQFHVLPMYIIAPEDEFGSTEGQEKKIRMGSIEVLQSFRRRRVIRIGELPKSC
                     KKKAEPKKAKTKKAARKRSSLENCSSRTEKGKSSSHTKLMENASHMKQMTAQPQLSGP
                     VIRQPPTLQRHLQQGQRPQQPQPPQPQPQTTPQPQPQPQHIMPGNSQSVGSHCSGSTS
                     VYTRQPTPHSPYPSSAHTSDIYGDTNHVNFYPTSSHASGSYLNPSNYMNPYLGLLNQN
                     NQYAPFPYNGSVPVDNGSPFLGSYSPQAQSRDLHRYPNQDHLTNQNLPPIHTLHQQTF
                     GDSPSKYLSYGNQNMQRDAFTTNSTLKPNVHHLATFSPYPTPKMDSHFMGAASRSPYS
                     HPHTDYKTSEHHLPSHTIYSYTAAASGSSSSHAFHNKENDNIANGLSRVLPGFNHDRT
                     ASAQELLYSLTGSSQEKQPEVSGQDAAAVQEIEYWSDSEHNFQDPCIGGVAIAPTHGS
                     ILIECAKCEVHATTKVNDPDRNHPTRISLVLYRHKNLFLPKHCLALWEAKMAEKARKE
                     EECGKNGSDHVSQKNHGKQEKREPTGPQEPSYLRFIQSLAENTGSVTTDSTVTTSPYA
                     FTQVTGPYNTFV"
     exon            3543..3621
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3715
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3924
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4075
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4165
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4303
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4667
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     exon            4668..9181
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9151..9156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /note="hexamer: AATAAA"
     polyA_site      9176
                     /gene="Tet2"
                     /gene_synonym="Ayu17-449; E130014J05Rik; mKIAA1546"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgcct gagagccggc cccgccgagc ctagagaaca gacgtcaaac tgccttatga
       61 atattgatgc ggaggcgagg ctgctttcgt agaggagcag aaggaagcaa gatggctgcc
      121 ctgtaggatt tgttagaaag gagacccggc tgcgacggcg gtggactgcg aggctgaggg
      181 accagaacca ggctggtata cattcagcag cttgccctcc caagactctt catgttcctt
      241 gttcctgttc cgctacggtg cttggaagca ggagatgggc tccctcacgg tcaacaggac
      301 atgatccagg aggagcagtg agggacggtg ctgctggatt cattcaaagg gcagccttgt
      361 ggatggcccc gaagcaagcc tgatggaaca ggacagaacc acccatgctg agggcaccag
      421 actgagtcca ttcctgatag caccaccttc tcccatcagc catacagaac ctctggctgt
      481 caaactccag aatggaagcc cgttagcaga gagacctcat ccagaagtaa atggagacac
      541 caagtggcaa tcttcccaaa gctgttatgg aatatcccac atgaaaggca gccagagcag
      601 tcatgagagt ccacatgaag acagagggta ttccaggtgc ttacagaatg gagggataaa
      661 acgcacagtc agtgaaccat ctctctctgg gctccatcca aacaagatat tgaaactaga
      721 ccaaaaagct aagggagaaa gcaatatctt cgaggaaagc caagaaagaa accacggtaa
      781 aagcagccgt cagccaaatg tctccggact aagtgataat ggagagcccg tgacctcgac
      841 cacccaggaa agttcaggtg cagatgcttt cccaacacgg aactacaatg gagttgaaat
      901 tcaggttctc aacgagcagg aaggggaaaa aggcaggagc gttacattac ttaaaaacaa
      961 gattgtgcta atgcctaatg gtgctacagt ttctgcccat tctgaggaga acacacgtgg
     1021 tgaactcctg gaaaaaacac agtgttatcc agattgtgtc tccattgccg tgcagagtac
     1081 cgcatctcat gtaaacaccc ctagcagtca ggctgctatc gagttgtccc acgagatccc
     1141 tcaaccatcg cttacctcag cgcagatcaa tttctcccag acctcaagct tgcagctgcc
     1201 tccagagcca gctgcaatgg tgactaaggc ctgtgatgct gataatgcca gtaaaccagc
     1261 tatagtacca ggtacctgtc cttttcagaa agcagaacac caacaaaagt cagctttgga
     1321 cataggccca tctcgtgcag aaaacaaaac catccaagga agcatggagc tatttgctga
     1381 agaatactat cctagttccg accggaattt gcaagcttcg catggcagct ctgaacagta
     1441 ttcaaagcaa aaggaaacca atggtgctta cttcaggcaa agctcgaagt tccctaaaga
     1501 ttccatctct cccactactg tgaccccacc gtcacaatca cttcttgctc cccgtcttgt
     1561 tcttcagcct cctttagaag gaaaaggcgc tctaaatgat gtagctttgg aagaacacca
     1621 tgactacccc aaccgaagca accgaactct tttaagggaa gggaaaatag accatcaacc
     1681 caagacatca tctagccaga gtctgaatcc atctgtacat acacccaacc cccccttgat
     1741 gcttccagaa cagcatcaga atgattgtgg ctcaccgagc cctgaaaagt caagaaaaat
     1801 gtcagaatat ctcatgtatt acctgccaaa tcatggccac agtggaggtt tacaagaaca
     1861 tagccaatac ctgatggggc acagggagca agagattccg aaggatgcaa acgggaaaca
     1921 aacgcaaggc tctgtacagg cagcacctgg ctggatagaa ctgaaagccc cgaatttgca
     1981 tgaagcactc catcagacaa aacgcaagga tatatccttg cactcagtcc tccactctca
     2041 gaccggccct gtcaatcaga tgagctccaa acagtccact ggcaatgtca acatgccagg
     2101 aggattccaa aggctacctt acctccagaa aacagcccag ccagagcaga aggcacaaat
     2161 gtaccaagtg caagtgaacc aaggaccgtc tccaggtatg ggggaccaac atcttcagtt
     2221 ccagaaagct ttataccagg agtgcatccc caggacagat ccgtcatctg aggctcaccc
     2281 gcaagcaccg agcgttcctc agtatcattt ccagcaaaga gtaaatccct ccagtgataa
     2341 gcatttgagt caacaggcca cagagactca acggttatca ggctttttac aacatactcc
     2401 tcagacgcag gcatcacaaa caccagcatc ccagaactca aatttccctc aaatctgcca
     2461 gcagcagcag cagcagcagt tacagaggaa gaataaagag caaatgcctc agactttctc
     2521 tcatctccaa ggtagcaatg ataagcaaag agaaggctcg tgctttggcc agattaaagt
     2581 ggaagaaagc ttttgtgtcg gaaatcagta ctccaaatca agtaatttcc aaactcacaa
     2641 taatacccaa ggggggttgg agcaagtaca aaatataaat aaaaattttc cttattcgaa
     2701 gatcttaaca ccaaattcga gcaacttaca gattctccct tcaaatgaca cacacccggc
     2761 ttgtgagcgg gaacaagctc tacatcccgt aggaagtaag acctcaaacc tgcagaacat
     2821 gcagtatttc ccgaataatg tgaccccaaa tcaggacgtt caccggtgct ttcaggaaca
     2881 agcgcagaag cctcagcaag cttcgtctct acaggggctt aaggacagaa gccagggtga
     2941 gtctccagcc ccaccagctg aggcagctca acagaggtat ttggtgcata atgaagcaaa
     3001 ggcactccct gtgcctgagc aaggaggaag tcagacacag acccctcctc agaaggacac
     3061 tcagaagcac gctgccttaa ggtggcttct cttacagaag caagaacagc agcaaacaca
     3121 gcaatcccag cctggtcata accagatgct taggccaatc aagactgagc ctgtatccaa
     3181 accttcttcc tatagatacc ccttgtcacc gccacaagaa aatatgtcca gcaggataaa
     3241 gcaagagatc tcctctccaa gccgtgacaa tgggcagcca aagagcatca ttgagaccat
     3301 ggaacagcac ctgaagcagt ttcagctcaa gtcactctgt gactataagg ctctgactct
     3361 caagtcacag aaacacgtga aagtgccaac agatatccag gctgcagaat cggagaacca
     3421 cgcccgagct gcagagcctc aagcaaccaa aagcacagat tgttctgttc tcgacgatgt
     3481 ttcagaatca gatactcctg gtgaacaaag tcagaatggc aaatgtgaag gatgcaatcc
     3541 agacaaagat gaagctcctt attataccca tctaggagct ggtcctgatg tggcagctat
     3601 tagaacactc atggaagaaa ggtatggaga gaagggtaaa gctattagga ttgaaaaagt
     3661 catatatact ggtaaagaag gcaagagctc tcagggatgt cctattgcta aatgggtata
     3721 tcggagatcg agtgaggagg agaaactact gtgtttggta cgagtgcgac ctaatcacac
     3781 atgtgagacg gcggtgatgg taattgccat catgttgtgg gacggaatcc caaagctact
     3841 cgcatcagaa ctctactcag aacttacaga tatcttgggc aagtgtggca tatgcaccaa
     3901 ccgtcgctgt tctcagaatg aaactagaaa ctgttgttgt cagggtgaga atccagagac
     3961 ctgtggtgcc tccttttctt ttggttgttc ttggagcatg tactataatg gatgtaagtt
     4021 tgccagaagc aagaaaccaa ggaaatttag gctacatgga gctgagccaa aagaggaaga
     4081 gagactaggt tctcatttgc aaaacctggc tactgtcatt gctccaatat acaagaagct
     4141 tgcacccgat gcatacaata atcaggttga atttgaacac caagccccag actgctgttt
     4201 gggtctgaag gaaggccggc cattctcagg agtcactgca tgtttggact tctctgctca
     4261 ttcccacaga gaccagcaga acatgccaaa tggcagtaca gtggtggtca ccctcaatag
     4321 agaagacaat cgagaagtcg gagctaagcc tgaggatgag cagttccacg tgctgcctat
     4381 gtacatcatc gcccctgagg atgagtttgg gagtacggaa ggccaggaga agaagatacg
     4441 gatggggtcc attgaggttc tgcagtcatt tcggaggaga agggtcataa ggataggaga
     4501 gctgcccaag agttgcaaga agaaagcgga gcccaagaaa gccaagacca agaaagcagc
     4561 tcgaaagcgt tcctctctgg agaactgctc cagtaggact gagaagggaa agtcttcctc
     4621 acatacaaag ctgatggaaa atgcaagcca tatgaaacaa atgacagcac aaccgcagct
     4681 ttcgggcccg gtcatccggc agccaccaac actccagagg caccttcagc aagggcagag
     4741 gccacagcag ccgcagccac ctcagccgca gccgcagacg acacctcagc cacagccaca
     4801 gccacagcat atcatgcccg gtaactctca gtctgttggt tctcattgtt ctggatccac
     4861 cagtgtctac acgagacagc ctactcctca cagtccttat cccagctcag cacacacctc
     4921 agatatttat ggagatacca accatgtgaa cttttacccc acttcatctc atgcctcggg
     4981 ttcatatttg aatccttcta attacatgaa cccctacctt gggcttttga atcagaataa
     5041 ccaatatgca ccttttccat acaatgggag tgtgccagtg gacaatggtt cccctttctt
     5101 aggttcttat tccccccagg ctcagtccag ggatctacat agatatccaa accaggacca
     5161 tctcaccaat cagaacttac cacccatcca cacccttcac caacagacgt ttggggacag
     5221 tccctctaag tacttaagtt atggaaacca aaatatgcag agagatgcct tcactactaa
     5281 ctccacccta aaaccaaatg tacaccacct agcaacgttt tctccttacc ccacccccaa
     5341 gatggatagt catttcatgg gagctgcctc cagatcacca tacagccacc cacacactga
     5401 ctacaaaacc agtgagcatc atctaccctc tcacacgatc tacagctaca cggcagcagc
     5461 ttcggggagc agttccagcc acgccttcca caacaaggag aatgacaaca tagccaatgg
     5521 gctctcaaga gtgcttccag ggtttaatca tgatagaact gcttctgccc aagaactatt
     5581 atacagtctg actggcagca gtcaggagaa gcagcctgag gtgtcaggcc aggatgcagc
     5641 tgctgtgcag gaaattgagt attggtcaga tagtgagcac aactttcagg atccttgcat
     5701 tggaggggtg gctatagctc caactcatgg gtcaattctt attgagtgtg caaagtgtga
     5761 ggttcatgcc acaaccaaag taaacgatcc cgaccggaat caccccacca ggatctcact
     5821 tgtactgtat aggcataaga atttgtttct accaaaacat tgtttggctc tctgggaagc
     5881 caaaatggct gaaaaggccc ggaaagagga agagtgcgga aagaatggat cagaccacgt
     5941 gtctcagaaa aatcatggca aacaggaaaa gcgtgagccc acagggccac aggaacccag
     6001 ttacctgcgt ttcatccagt ctcttgctga gaacacaggg tctgtgacta cggattctac
     6061 cgtgactaca tcaccatatg ctttcactca ggtcacaggg ccttacaaca catttgtatg
     6121 acgctggcca ttaggccaga ccaccaagga cgacctgtga gcagtatgtc tttcatggca
     6181 tgggccgtag ggacaggtca cagcatctgt gacaaatgca gtgtgtgttt gtgtgtatgt
     6241 ttattggggg ggggctgtca gctcaccagc aaaatagttt attttatcat tatatttaat
     6301 ctctcccgtg gtccatggtg gcattcagga agagcatcct atgcaagggc acagtgggaa
     6361 ggaagcgctg gacatttgtc ttgaaaacca ctggttctct tattggctga ggtcatgcgt
     6421 gtgccatgcc cctcagcact ctacacgtaa ctgcttctag tactcagcgt gtgtaaccgt
     6481 gggacacagc gctgtagtag agcagttgca ggatcatctg gtgctgacgt atgatgtact
     6541 gaagaaatac tggaactaag actttttaac atgcaggttt tttactgtaa tcttaataac
     6601 ttatttatca aagtagctac agaaagctta agtgaataat ggcaaaacac tgaatctgtt
     6661 tgggtgttaa cattaaatgg tgctacaaat ggtgttttta atagctgaaa aatcaatgcc
     6721 ttctatcatc tagccagtgt ggtcgagggc cctggaggca ctggggtacc tctgatttta
     6781 catttctatc ttaattattc agcttagttt ttaaaatgtg gacatttcaa aggcctctgg
     6841 attgtagtta tccaccgatg tccttgtagg actataatgt atagatatgc acacttacac
     6901 atgtgtactg aaatatttta agttgtgtct tagaaaagca ctttgcctac ctaagctttg
     6961 gcaacttggg caatgctaag gtactaaaac ataaaaacaa aacaaaaaaa agtttacttt
     7021 catttaggat taaaagtggt tttgttttgt ttccttttaa ggaaacattt gctttgctct
     7081 tagccactat cggctgatga gcagtatcag gcctgttaca atccaaaccg aagctgaatg
     7141 gatatgctag tccacagaaa acaaataaca gtttttggtg ctcaccttac ttgctatcct
     7201 gtaaaacggt ggtagggcaa gctcatccct cctgcgtata cagcttaaga acgtctgtta
     7261 attgcaggtg ataattagcc ttggtgctgc agacagagca aagcttgccc acttaagtcc
     7321 atgttgtccc acacacagac ctgtatgttc ttcagaacag caggctgcct ttgtgttcat
     7381 tacatgcttt gtggtgtctt ttcttagcta agtgttatat ataccaggaa ggttgagtgg
     7441 actgaaaccc gcagaagttg agaagacatg gttaagtcca taggactcta ctggttacag
     7501 agcaaccaac aaaaaccgaa agagaatagg cagctggttt atggtgattt taaacattaa
     7561 tttgtattaa aaggtaaaaa agagttgtat agtaaattaa attgtaaaac aacctttttt
     7621 aatgcaatgc tttagtattt tagtactgta aaaaattaaa tatatacata tgtgtatata
     7681 tatattatat atatatatat aatatatgag attgaagaaa aattcacatc acgatggtgc
     7741 tacccagatt gctccacata gatcttaatg tgagctaaga atccattcaa agttggagtg
     7801 gtgttcctac ttgtcgtcat acctcaacac tagctaggca atgggatact gagctaacag
     7861 tggaggctta gagcattgta gaccaccatt tttctttttt tttttttttt taaatctttg
     7921 tattaagaca taccattttt aaatacttga tttcttagca agtataactt gaatctcaaa
     7981 ctttttgttc taaaaattca gggatatttc agctcattct ccttatgcta acatgtcatc
     8041 tgtttatgca aagttgtcgg ttaatatatt cgctttcaga ggattgcaat ccctcgtagt
     8101 ttgcttgtat atgtactgat aactgaaaac taattttata aattttgtca cctttcaatt
     8161 gtaaattttg gagagttggc attcagcaga gtaaaaagtg taaaatagga agccctgagc
     8221 tggcagaggg agatgggggg tacaagacat cgccggtaat ggcttctgat ctagtgacga
     8281 ggacagcttt ggactgcagc tggacagtcc tagaagctgg tggtgtgctg tgcaatagga
     8341 ctgttgttac attgtggcct aaatacagtg ttgcttacta gctttgcaaa tagctttgcg
     8401 tcagtggaga cctttgtaat ttaccatcag tcacatttgt cactaaaaac tttcagaatg
     8461 tctgccttgc acacacacac acacacacac acacacacaa aaacaaaaac cacaaggttt
     8521 ccaaaccatg atgttgagtc cacatcaggt tcctgcaagg tgtgcttggc aatttttttt
     8581 tttttttttt gagccagcca tccctaagga atatttgctt tacatgtcac ccactgtcat
     8641 ttgtcaaact gctggccaac aggagtagta agtgtggttt gagaggatgg gtggtgtagg
     8701 gaggaaggca gtgacatccc acctctgtcc attagatcaa gtgggaggca gatctgtgat
     8761 ttgcttctat aggaacagct tgactacata gccatactcg atacaagtgc ttctgcttgg
     8821 tgtcaacatt acttgaatga atttttcatc ttgattgacg cacagtgatg tatagttcac
     8881 tttacaaggt agtttggtta acttgttagg gttttttttt tttttttggt tttgtttttt
     8941 gtttttttgc agtttgacac taagataatg aacttctgtg tgcatttttc tatgctttat
     9001 tttttaatgt agcttacttc ctgagatttt ggctttgttt atacaatctg agggtggtta
     9061 taaatactgt aagtattgta atgttatgaa tgcagtttat tttaaagctg tttattatat
     9121 cattcctgat aacgccatgt gagtgttttt aataaaattt atatttattt aatgcactca
     9181 aaaaaaaaaa aaaaaaaaa
//
