LOCUS       NM_001253857           14354 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus tet methylcytosine dioxygenase 1 (Tet1), transcript
            variant 1, mRNA.
ACCESSION   NM_001253857 XM_011243509
VERSION     NM_001253857.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 14354)
  AUTHORS   Foong,Y.H., Caldwell,B., Thorvaldsen,J.L., Krapp,C., Mesaros,C.A.,
            Zhou,W., Kohli,R.M. and Bartolomei,M.S.
  TITLE     TET1 displays catalytic and non-catalytic functions in the adult
            mouse cortex
  JOURNAL   Epigenetics 19 (1), 2374979 (2024)
   PUBMED   38970823
  REMARK    GeneRIF: TET1 displays catalytic and non-catalytic functions in the
            adult mouse cortex.
REFERENCE   2  (bases 1 to 14354)
  AUTHORS   Mulet,I., Grueso-Cortina,C., Cortes-Cano,M., Gerovska,D., Wu,G.,
            Iakab,S.A., Jimenez-Blasco,D., Curtabbi,A., Hernansanz-Agustin,P.,
            Ketchum,H., Manjarres-Raza,I., Wunderlich,F.T., Bolanos,J.P.,
            Dawlaty,M.M., Hopf,C., Enriquez,J.A., Arauzo-Bravo,M.J. and
            Tapia,N.
  TITLE     TET3 regulates terminal cell differentiation at the metabolic level
  JOURNAL   Nat Commun 15 (1), 9749 (2024)
   PUBMED   39557858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 14354)
  AUTHORS   Kong,Y., Ji,J., Zhan,X., Yan,W., Liu,F., Ye,P., Wang,S. and Tai,J.
  TITLE     Tet1-mediated 5hmC regulates hippocampal neuroinflammation via wnt
            signaling as a novel mechanism in obstructive sleep apnoea leads to
            cognitive deficit
  JOURNAL   J Neuroinflammation 21 (1), 208 (2024)
   PUBMED   39169375
  REMARK    GeneRIF: Tet1-mediated 5hmC regulates hippocampal neuroinflammation
            via wnt signaling as a novel mechanism in obstructive sleep apnoea
            leads to cognitive deficit.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14354)
  AUTHORS   Yang,Y., Rivera,L., Fang,S., Cavalier,M., Suris,A., Zhou,Y. and
            Huang,Y.
  TITLE     Maternal high-fat diet alters Tet-mediated epigenetic regulation
            during heart development
  JOURNAL   iScience 27 (9), 110631 (2024)
   PUBMED   39262804
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14354)
  AUTHORS   Zhang,X., Gao,X., Liu,Z., Shao,F., Yu,D., Zhao,M., Qin,X. and
            Wang,S.
  TITLE     Microbiota regulates the TET1-mediated DNA hydroxymethylation
            program in innate lymphoid cell differentiation
  JOURNAL   Nat Commun 15 (1), 4792 (2024)
   PUBMED   38839760
  REMARK    GeneRIF: Microbiota regulates the TET1-mediated DNA
            hydroxymethylation program in innate lymphoid cell differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 14354)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 14354)
  AUTHORS   Lorsbach,R.B., Moore,J., Mathew,S., Raimondi,S.C., Mukatira,S.T.
            and Downing,J.R.
  TITLE     TET1, a member of a novel protein family, is fused to MLL in acute
            myeloid leukemia containing the t(10;11)(q22;q23)
  JOURNAL   Leukemia 17 (3), 637-641 (2003)
   PUBMED   12646957
REFERENCE   8  (bases 1 to 14354)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 14354)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 14354)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166359.3.
            
            On or before Jun 22, 2017 this sequence version replaced
            XM_011243509.2, NM_001253857.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.92363.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC166359.3         180479-180631       c
            154-2135            AC166359.3         171459-173440       c
            2136-2189           AC166359.3         158115-158168       c
            2190-4392           AC166359.3         131483-133685       c
            4393-4483           AC166359.3         126845-126935       c
            4484-4577           AC166359.3         126201-126294       c
            4578-4789           AC166359.3         115856-116067       c
            4790-4940           AC166359.3         112780-112930       c
            4941-5036           AC166359.3         112246-112341       c
            5037-5126           AC166359.3         109691-109780       c
            5127-5264           AC166359.3         107743-107880       c
            5265-5511           AC166359.3         106885-107131       c
            5512-14354          AC166359.3         97877-106719        c
FEATURES             Location/Qualifiers
     source          1..14354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.48 cM"
     gene            1..14354
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="tet methylcytosine dioxygenase 1"
                     /db_xref="GeneID:52463"
                     /db_xref="MGI:MGI:1098693"
     exon            1..153
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            154..2135
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..6392
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /EC_number="1.14.11.80"
                     /note="isoform 1 is encoded by transcript variant 1; CXXC
                     finger 6; methylcytosine dioxygenase TET1; ten-eleven
                     translocation 1 gene protein homolog; CXXC-type zinc
                     finger protein 6; tet oncogene 1"
                     /codon_start=1
                     /product="methylcytosine dioxygenase TET1 isoform 1"
                     /protein_id="NP_001240786.1"
                     /db_xref="CCDS:CCDS56706.1"
                     /db_xref="GeneID:52463"
                     /db_xref="MGI:MGI:1098693"
                     /translation="MSRSRPAKPSKSVKTKLQKKKDIQMKTKTSKQAVRHGASAKAVN
                     PGKPKQLIKRRDGKKETEDKTPTPAPSFLTRAGAARMNRDRNQVLFQNPDSLTCNGFT
                     MALRRTSLSWRLSQRPVVTPKPKKVPPSKKQCTHNIQDEPGVKHSENDSVPSQHATVS
                     PGTENGEQNRCLVEGESQEITQSCPVFEERIEDTQSCISASGNLEAEISWPLEGTHCE
                     ELLSHQTSDNECTSPQECAPLPQRSTSEVTSQKNTSNQLADLSSQVESIKLSDPSPNP
                     TGSDHNGFPDSSFRIVPELDLKTCMPLDESVYPTALIRFILAGSQPDVFDTKPQEKTL
                     ITTPEQVGSHPNQVLDATSVLGQAFSTLPLQWGFSGANLVQVEALGKGSDSPEDLGAI
                     TMLNQQETVAMDMDRNATPDLPIFLPKPPNTVATYSSPLLGPEPHSSTSCGLEVQGAT
                     PILTLDSGHTPQLPPNPESSSVPLVIAANGTRAEKQFGTSLFPAVPQGFTVAAENEVQ
                     HAPLDLTQGSQAAPSKLEGEISRVSITGSADVKATAMSMPVTQASTSSPPCNSTPPMV
                     ERRKRKACGVCEPCQQKANCGECTYCKNRKNSHQICKKRKCEVLKKKPEATSQAQVTK
                     ENKRPQREKKPKVLKTDFNNKPVNGPKSESMDCSRRGHGEEEQRLDLITHPLENVRKN
                     AGGMTGIEVEKWAPNKKSHLAEGQVKGSCDANLTGVENPQPSEDDKQQTNPSPTFAQT
                     IRNGMKNVHCLPTDTHLPLNKLNHEEFSKALGNNSSKLLTDPSNCKDAMSVTTSGGEC
                     DHLKGPRNTLLFQKPGLNCRSGAEPTIFNNHPNTHSAGSRPHPPEKVPNKEPKDGSPV
                     QPSLLSLMKDRRLTLEQVVAIEALTQLSEAPSESSSPSKPEKDEEAHQKTASLLNSCK
                     AILHSVRKDLQDPNVQGKGLHHDTVVFNGQNRTFKSPDSFATNQALIKSQGYPSSPTA
                     EKKGAAGGRAPFDGFENSHPLPIESHNLENCSQVLSCDQNLSSHDPSCQDAPYSQIEE
                     DVAAQLTQLASTINHINAEVRNAESTPESLVAKNTKQKHSQEKRMVHQKPPSSTQTKP
                     SVPSAKPKKAQKKARATPHANKRKKKPPARSSQENDQKKQEQLAIEYSKMHDIWMSSK
                     FQRFGQSSPRSFPVLLRNIPVFNQILKPVTQSKTPSQHNELFPPINQIKFTRNPELAK
                     EKVKVEPSDSLPTCQFKTESGGQTFAEPADNSQGQPMVSVNQEAHPLPQSPPSNQCAN
                     IMAGAAQTQFHLGAQENLVHQIPPPTLPGTSPDTLLPDPASILRKGKVLHFDGITVVT
                     EKREAQTSSNGPLGPTTDSAQSEFKESIMDLLSKPAKNLIAGLKEQEAAPCDCDGGTQ
                     KEKGPYYTHLGAGPSVAAVRELMETRFGQKGKAIRIEKIVFTGKEGKSSQGCPVAKWV
                     IRRSGPEEKLICLVRERVDHHCSTAVIVVLILLWEGIPRLMADRLYKELTENLRSYSG
                     HPTDRRCTLNKKRTCTCQGIDPKTCGASFSFGCSWSMYFNGCKFGRSENPRKFRLAPN
                     YPLHNYYKRITGMSSEGSDVKTGWIIPDRKTLISREEKQLEKNLQELATVLAPLYKQM
                     APVAYQNQVEYEEVAGDCRLGNEEGRPFSGVTCCMDFCAHSHKDIHNMHNGSTVVCTL
                     IRADGRDTNCPEDEQLHVLPLYRLADTDEFGSVEGMKAKIKSGAIQVNGPTRKRRLRF
                     TEPVPRCGKRAKMKQNHNKSGSHNTKSFSSASSTSHLVKDESTDFCPLQASSAETSTC
                     TYSKTASGGFAETSSILHCTMPSGAHSGANAAAGECTGTVQPAEVAAHPHQSLPTADS
                     PVHAEPLTSPSEQLTSNQSNQQLPLLSNSQKLASCQVEDERHPEADEPQHPEDDNLPQ
                     LDEFWSDSEEIYADPSFGGVAIAPIHGSVLIECARKELHATTSLRSPKRGVPFRVSLV
                     FYQHKSLNKPNHGFDINKIKCKCKKVTKKKPADRECPDVSPEANLSHQIPSRVASTLT
                     RDNVVTVSPYSLTHVAGPYNRWV"
     exon            2136..2189
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..4392
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            4393..4483
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..4577
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            4578..4789
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            4790..4940
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            4941..5036
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            5037..5126
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            5127..5264
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            5265..5511
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     exon            5512..14354
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6494..6499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="hexamer: AAGAAA"
     polyA_site      6520
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="major polyA site"
     regulatory      6633..6638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="hexamer: AATAAA"
     polyA_site      6663
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="major polyA site"
     regulatory      8093..8098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="hexamer: TATAAA"
     polyA_site      8117
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
     regulatory      10754..10759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="hexamer: ATTAAA"
     polyA_site      10772
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
     regulatory      11447..11452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="hexamer: AATATA"
     polyA_site      11466
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
     regulatory      14329..14334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
                     /note="hexamer: AATAAA"
     polyA_site      14354
                     /gene="Tet1"
                     /gene_synonym="2510010B09Rik; Cxxc6; D10Ertd17e; LCX;
                     mKIAA1676"
ORIGIN      
        1 cactctgcaa ctggtttgta caatcccggg gtctgtattc gcccctggac gtcctctccc
       61 tccctggtca tgtacctcta cctgcctctt ctacgggaac attcgcggag cagctcccca
      121 acccgggtgc tcgggccctg accgtgccgg atgaccccaa actcaggtga ccaagcttgg
      181 caacacctcc agattctcct caaaaggaag attttgcaaa ggaccaatga cactgtgccc
      241 cgcatccttg catctttact tactctgcag ccatgtctcg gtcccgcccc gcaaagcctt
      301 ccaaatcagt caaaacaaag ctacagaaaa agaaagacat ccagatgaag acgaagacat
      361 caaagcaggc tgtcagacat ggggcatcag cgaaggcagt gaaccccgga aaaccgaagc
      421 aattaattaa aagaagagat ggtaagaagg aaacggaaga caaaaccccg acaccggcgc
      481 cgagttttct gacgcgagcc ggggccgccc gaatgaatcg ggatcgaaac caagttcttt
      541 ttcagaaccc agactcctta acttgcaacg ggtttacaat ggctcttcga agaacctctc
      601 ttagctggcg actctcccag cgcccagtag tcacacccaa acctaagaaa gtaccacctt
      661 caaagaagca gtgtacacat aatatccagg acgagccggg ggtaaagcac tctgaaaatg
      721 attcagtccc cagccaacac gctaccgtgt ccccaggcac agagaatggt gaacagaaca
      781 ggtgtttagt tgaaggggag agccaagaga taacccagtc ttgccctgta tttgaggaaa
      841 gaatagaaga tacccaaagc tgtatttccg catctgggaa cctggaagca gaaatttctt
      901 ggccactgga agggacacat tgtgaagaac tactttctca tcagacatct gataatgagt
      961 gcacttcccc tcaagagtgt gctccattgc cccaaagatc aacttccgaa gttacctctc
     1021 agaaaaacac tagcaatcag ttagcagact tgagctcaca agtagagtct atcaagctgt
     1081 ctgatccttc tccgaatcct acgggaagcg accataatgg ctttccagac tccagtttta
     1141 ggatcgttcc tgaattggac ctgaaaacct gcatgcctct tgatgagtct gtgtatccca
     1201 cagctctgat aagattcatc ttggcaggct cacagccgga tgtctttgat actaagcccc
     1261 aagaaaaaac ccttataaca accccagaac aagtgggaag ccacccaaat caagttctgg
     1321 atgccacctc tgtcctagga caggccttta gtactcttcc acttcagtgg ggattttctg
     1381 gtgctaactt agttcaagtt gaggccctgg gcaagggttc agactcacca gaggatcttg
     1441 gtgctattac tatgctaaac caacaagaaa ctgtggctat ggatatggat aggaatgcta
     1501 ccccggacct gcctatcttc cttcctaagc ctccaaacac agttgctacc tacagtagcc
     1561 ctcttttagg gcctgagccc cacagctcta cctcctgtgg gcttgaagtc caaggtgcta
     1621 ccccgatttt aactttggac tcaggacaca ctccccaact cccaccaaac cctgagtcaa
     1681 gttcagtacc tctggtaata gctgcaaacg gtacgcgagc tgagaagcag tttggtacca
     1741 gccttttccc agccgtccca caagggttta cagtcgcagc cgagaatgaa gtccagcatg
     1801 ccccattaga tcttacccag ggttctcagg ctgctcccag caaactggaa ggagagattt
     1861 ctcgggtcag catcactggc tcagctgatg tcaaagccac agcgatgtcc atgccggtta
     1921 cacaggccag tacctcttct cccccatgta attctacgcc gccaatggtg gagaggagga
     1981 agcgcaaggc ctgtggggtc tgtgagccgt gccagcagaa ggccaactgt ggggagtgca
     2041 cctactgcaa gaatcgaaag aacagccacc agatctgtaa gaagaggaaa tgcgaggtgc
     2101 tcaaaaagaa gccagaggcc acctcacagg cacaggttac aaaagaaaac aagaggcccc
     2161 agagggaaaa gaagcccaaa gttttaaaga cagactttaa caacaaacca gtaaatggcc
     2221 ccaaatcaga gtccatggac tgcagtagac gtggtcatgg ggaagaagag caaaggttgg
     2281 atttgatcac acatcccctt gaaaatgtaa ggaagaatgc aggcggcatg acgggaattg
     2341 aggtggagaa gtgggcgcca aacaagaaat cacacttagc agagggtcaa gtcaaaggaa
     2401 gctgtgatgc caatttaact ggggtggaaa acccccagcc ctctgaagat gacaagcagc
     2461 aaaccaaccc ttctccgaca tttgcccaga ccataaggaa cggcatgaaa aatgtacact
     2521 gtttacccac tgacacacac cttccgctca acaaattgaa tcatgaggaa tttagcaagg
     2581 cgttgggaaa taattcctct aaattgctga ctgatccctc aaactgcaag gatgccatga
     2641 gtgtcaccac ctccgggggg gagtgtgatc atctcaaggg gccaaggaac accctgctct
     2701 tccagaagcc tggcttgaac tgcaggtctg gtgcagaacc caccatcttt aataatcacc
     2761 ctaatacaca cagcgctggg agtcgacctc accctcctga gaaggtaccc aacaaagaac
     2821 ccaaagatgg ctctccggtt cagccaagtc ttctatccct aatgaaggac aggagattaa
     2881 cgctggaaca agtggtagcc atagaagccc tgactcagct ctcagaagcg ccctcagaga
     2941 gctcctcccc atccaagccg gagaaggatg aagaagcgca tcagaaaacg gctagtctgc
     3001 ttaacagttg caaggctatc cttcattcgg tgagaaaaga cctccaagac ccaaacgttc
     3061 aaggaaaggg ccttcaccat gacactgttg tctttaatgg ccagaacaga acattcaagt
     3121 cacctgatag tttcgctact aaccaagcac ttataaaatc acaaggatat ccaagttcac
     3181 ctacagctga gaagaaaggc gctgctggtg ggagagctcc ctttgatggt tttgagaatt
     3241 cacatccatt gcccatagaa agtcacaatc ttgaaaactg cagtcaggta ctaagctgcg
     3301 atcagaattt gagttcccat gacccatcat gccaggatgc accctacagt caaattgaag
     3361 aagatgtcgc agcacaattg acccaacttg catccacgat taatcacatc aacgccgagg
     3421 tcaggaatgc tgaaagtaca ccagaaagcc ttgttgcaaa gaacacaaag caaaaacaca
     3481 gtcaggagaa acgcatggta catcagaagc caccctctag tacacaaact aaacccagtg
     3541 taccatcagc aaagccaaag aaggcccaga aaaaggcaag agcgacccca cacgcaaaca
     3601 agcggaaaaa gaaaccccca gcccgaagct ctcaagaaaa tgatcagaag aagcaagagc
     3661 agctagctat agagtatagt aaaatgcatg acatttggat gtcatctaag tttcaaaggt
     3721 ttggccagtc tagtccacgt agttttcctg ttctgttgag aaatattcct gtctttaacc
     3781 aaatattaaa gcccgtgact cagagtaaaa caccctcaca acataatgag ttatttcctc
     3841 ctatcaatca gataaaattc acaagaaacc ctgaattggc aaaggagaaa gtgaaggttg
     3901 aaccatcaga ttctctgcca acatgccaat tcaagacaga atccggtggg cagacatttg
     3961 cagagccggc agataattct cagggacagc ccatggtgag tgtcaatcag gaagctcacc
     4021 ctctgcccca gtccccacca tctaaccagt gtgctaatat aatggctggt gctgcccaaa
     4081 cacagtttca tctaggcgct caagagaacc tggtgcatca gataccacca ccgacgttgc
     4141 ctggtacctc ccctgacaca ctcttgccag acccagcatc aatcctcagg aaagggaaag
     4201 tgttacattt cgatggaatt acagttgtta cggagaagcg tgaagctcaa acatcaagca
     4261 atggaccact gggtcccacc acagacagtg cacagtcaga atttaaagag agcatcatgg
     4321 acttacttag caagcctgca aaaaacctga tagctggatt gaaggaacag gaagctgcac
     4381 cctgtgactg tgatggaggt acacaaaaag aaaaaggccc atattataca caccttgggg
     4441 caggaccaag tgtggctgct gtcagggagc tcatggagac taggtttggc cagaagggga
     4501 aggcaatccg gattgagaag atagtgttca cggggaagga agggaagagc tctcagggct
     4561 gcccggtcgc caagtgggtg atcagaagaa gtggtcctga agagaagctt atttgtttgg
     4621 ttcgtgagcg tgtagaccat cactgttcga cggctgtgat agttgtcctt atcctgctgt
     4681 gggaaggtat ccctcgcctg atggctgacc gcctgtacaa agagctcact gagaacttga
     4741 ggtcctacag cggacatccc acagaccgaa gatgtaccct caacaaaaag cgtacctgca
     4801 cctgtcaagg catcgaccca aaaacctgcg gagcgtcctt ctcctttggc tgttcgtgga
     4861 gcatgtattt caacggctgt aagtttggga ggagtgaaaa ccccagaaaa ttcagacttg
     4921 ctccaaacta ccccttacat aactactata agagaattac tggaatgagt tctgaaggaa
     4981 gtgacgtgaa aaccgggtgg atcattccag accgcaagac cctcataagc agagaggaaa
     5041 aacagcttga aaagaattta caagaattgg ctacagtatt agctccactt tacaagcaga
     5101 tggctccagt tgcttatcaa aatcaggtgg aatatgaaga agttgctgga gactgtcgac
     5161 ttggaaatga agaggggcgt cctttctctg gtgtcacctg ttgcatggat ttttgtgccc
     5221 attctcacaa ggacattcac aacatgcaca acggaagcac cgtggtgtgt acgttgattc
     5281 gagcagatgg ccgtgacaca aattgtcccg aggatgaaca actccacgtc ctgccactat
     5341 accggcttgc agacactgat gaatttggct ccgtggaagg gatgaaggcc aaaatcaaat
     5401 ctggggccat ccaagtcaat gggccaacca ggaagaggcg actacgtttt actgagcctg
     5461 ttcctcgatg tgggaagagg gccaaaatga agcagaacca caataaatca ggttcacaca
     5521 acactaagag cttttcatca gcctcatcta cttctcacct agtgaaagac gaatctacag
     5581 acttctgtcc cctgcaggct tcctccgcag aaacatctac ctgtacgtac agtaaaacag
     5641 cctcaggtgg gtttgcagaa acaagtagta ttctccactg cacaatgcct tctggagcac
     5701 acagtggtgc taatgcagct gctggggaat gtactggaac ggtgcagcct gccgaggtgg
     5761 ctgctcatcc tcaccagtct cttcccacag ccgattctcc cgttcatgct gagcctctca
     5821 ctagtccatc tgagcagcta acttctaacc agtcaaacca gcagctccct ctcctcagca
     5881 attctcagaa actggcttcc tgtcaggtgg aagatgagcg gcaccctgaa gcggatgagc
     5941 ctcagcaccc cgaggacgat aacttgcctc aacttgatga attctggtca gacagtgagg
     6001 agatctacgc cgatccttcc tttggtggcg tggcgatagc acccattcac ggctcggtgc
     6061 tcattgagtg cgctcggaag gagcttcatg ctaccacctc tttgcgctcc cccaaacgag
     6121 gggtcccttt tcgtgtgtcc cttgtattct accagcacaa aagcctaaac aagcctaatc
     6181 atggttttga tatcaacaaa attaagtgta aatgcaaaaa agtaacgaaa aaaaagcccg
     6241 cagaccggga gtgtcctgat gtatcccccg aagccaattt atcacaccaa attccttctc
     6301 gagttgcatc aaccttaacc cgagacaatg ttgttaccgt gtccccatac tctctcactc
     6361 atgttgcggg accctacaat cgttgggtct aaaggcttct ctcatgtaat gcctttgcta
     6421 atgtggtgta gtgggtattt ttgtttgttt gtttgttttc ttttgttttt ttgttttttc
     6481 cggtgctgtt aaaaagaaag tcattctgtt gtttactgta gctttgtttc gcccatttca
     6541 actccgacgt aaatattaaa aaaaaaaaaa gggtgaatac ttaactgtga ttacattttg
     6601 agaattggta gaaggtgaac attttcagca aaaataaact ttttatagtt ttaaatactt
     6661 aaaggaacat cttggttagg tgttggccat gctagaacca tagagtctgg tgctttcccc
     6721 cgggtttgtt tactattcag agggtttata acaggttcct gcaataagaa gtaaagacca
     6781 agatgtagtg ttaactctac acagttcctg gtgctttaac cacatcaaca cacggagtga
     6841 tgagctgagt gattgttttc tggtgccatt gctcaagcct cttccaatca ttgccatcgt
     6901 gtctgcacat ttctttgaag taaaccaatg aaatgctttt tctcttaaaa catttctcct
     6961 atataaagta gttctctatt ctcatgatgg ttggaagctg ttcgctaact ataaatgtat
     7021 atattttaaa aagcactttc tacttttaag agtaacttga aatagtatag tagcagaatc
     7081 ctattgtcta ttatgtgtgc atatttgaat accagagaag tcatttgttc ttgctctgta
     7141 gagtcccatc ccgttaacct cagcctgtac tcaaataaca cacggcttct gttctttact
     7201 tatagaatag agggtctcta aaaaaaaaaa tttaaataca agatgctacc aatatcaatt
     7261 ttccctcttt aactagaaaa aatattgtct tctgaagtca cctcgtcaat taactatatg
     7321 acccaattac aggtgttttc aaaggaaaag gaggcaaatt gggatcagtc aaaagttccc
     7381 agtgtttcaa gattagaaaa tacataatta agagacatgt ccttcccaaa tgagaaggaa
     7441 atattctata gagataattg aggggacatg cttgcgttag cattgtcacc cttaccctgg
     7501 agttccatgg taatattgag agccaaacta ttcattaata gtgccctatc aggtttagga
     7561 aaatgggaac ccaaacttgc ttagtaatcc tctattgaag gtcacaactg aaatcagcat
     7621 cctgattact ttgtgttcca gtgttctgcc cattgtttaa ttgacttctt tatataccaa
     7681 gaatgatttc cccaaacaaa aaagcctaga accaagcgac ctttctgaga gatccaaatg
     7741 cacaggtgct attgccattg cttgggttga agtctttgga tctggattag gattcctgtc
     7801 cttcagggac cctgatggtg cttctcagag atgccacaag aagcccacaa ctaccacaat
     7861 cttggtgcaa atgtaagccg ttgcagtaaa ctccttaggg aataacttat taaacacaat
     7921 acatggtgca aagtgtcagc ctctgactga ggcacgttca ggaagaggaa gggactgtaa
     7981 ataagaacgt gtccactgac tttcatccca tcctgcacag ggagctggat gctcttggga
     8041 tccatacaca tgtggatctg agttagtgtt ctgtgtgcct tagagttctg tttataaacc
     8101 tttttttaag tttcttatgt cggtatgtga atgtggtcct ttcttgctgt gtctgcttca
     8161 gttaggtatt tatttgttag tgtagaccat cagaaatcct ccctcatgag ttaacctttg
     8221 aggtttcaga ccttatctag aaatcatttt cttgccatta tgggatagaa tcgcctcttc
     8281 ctgcctttat ttgtccattc atctgtccgc tcgattagtt tgttttccct tgaattaccc
     8341 cttatcacac aaacttataa cgaatgcttg gaactgcttt ctaagaacat aacaaactac
     8401 ctataaatga agagctacag taatatatat tcaagctgat gtgtttttaa tgataaggcc
     8461 acattcttgg tgcttaatca gttgaataca ccaatgttga tgaatgggac tgttggtgtt
     8521 tatgaatcta gttgcagttt gacaaaataa gtacatgaaa ctaaccactt tcaacaaaaa
     8581 tgttgtcatt ccatcgctag agttagcatc agagatggag tgcctcagcc aacagccctc
     8641 tgtggggact tcattatatt actttcatgg tctctgatgt gctttgtagg catcctctac
     8701 ttggttggtg ttctactgca ccatctgctg gctatacacg gctttaagaa tggactttct
     8761 taaaaacaaa atacaaccgg acagtggtag agcatgcctt taatcccagt acttgggagg
     8821 cagaggcagg tggatttctg agctcgagga cagccagggc tacacagaga aaccctgtct
     8881 caaaaagaca aaaagtaaaa tacattggtt tgagatgaca gtcacttatc tgacaatctt
     8941 tctacacctc tactgtttta attagattgc gttcctctga cctcgtttgt ggagctctga
     9001 ctaagactgt tctcgctgtg aacattggat acattgttat atgacttcca cagtagccct
     9061 ggtgatgcta caattcattc ctgcctgctt tagaattaga catcacctgc cctcttaaaa
     9121 ccatttttgg tgggttttgg ttttatgaga ctggatctct atgtagttcc ggctgtcctg
     9181 gaactcatgt agcagaccag gctatcctag aattcacaga actatcttcc tgctcctacc
     9241 tatgtgctgg gattaaagtt gtcctcctcc actctcctag ttcttttgtt cttgtgcttg
     9301 tcagcctcgt gtatatcctg tttccagttc tctacaaagt accaaataag accaggtact
     9361 aaagagactg ttatcactgt cattgaaata tagtgtttgg acttgaggat aatagaggca
     9421 aatttttggg aacaagtcca catcttaagt gatttcccaa gcataacgtt gcatttgtga
     9481 gacacagaac ttcattaggt gaaaaccgta agccattcac ttccattcac cccgttaaac
     9541 agttaactga gtggctatta ttctgtaaat gatgtactgg cttgattcac atgaggtaac
     9601 ctactacttc tgattatcat ttcacaagaa catgtacaaa actaacccca aattattcat
     9661 tcatatatat aaaatgagac ttctgtgtgg ggtggagcta tcaagctatc atgtcatcac
     9721 atgacctctt ctatcgattg tgggtgcatt tacctttgtg ccaaacaagt aagtgtatgc
     9781 aaccttaaca caaagctacc ctgagtttca ccccctcaat gcatgggaat ctttttgagt
     9841 ctagatttaa tacaactgag tttcatctat actagaaatg tataacaaga attatgacaa
     9901 aggatagtgt ggtggctgtt gctgcaccaa tagtctcctt agaaggcaga gctcaatccc
     9961 tgagttctcg ggacagacag cgcctaattg cttgagggcc attctgctct tagagctgtt
    10021 caagacaaac tacttttctc actcagagag gattatatta ctaagaactt atcttgattt
    10081 ttgtccaagt caaaaataaa acaactttct gtcctctggt gaggttcagg acaagaaaga
    10141 cattggtgag attaggtcaa gattgccttt actgtctatc ctaggctttg ccaggagaac
    10201 ctatgacatt aacctactaa ctcttcccga tgcagaaggc aatccttgtc tctgccattc
    10261 cctctggaac ctagtattag gaataaatac ccaaggagtt cttgaggact ggctgtggga
    10321 accattgagg gaagcatgcc ttcactgtat atactctgta gccgcggttg cacagtccct
    10381 actgcccctc ccctacttca gtgctggcag ctcactgtga tgtggccgtc accataaaca
    10441 ggcgcgctgc ttcacttctc tgtgctggtc acgttggcat atttagccat gtggtgtggt
    10501 cattgcttag tggtttgaga tgactaagtt tttttttttt tttcaaatga aatgggtgtt
    10561 tcatattgta tttcatcaga aaacagtggc aattgtgaag accatttaga tagtcactgt
    10621 atcctcccac aaaacctaat tctgtatatt ttcttcaaaa ttgttaaaat tcctaagcat
    10681 ggttttttaa gttttgtttt gtttttttgg ttggttggtt gatttgtctt tgtgtaatag
    10741 aagttgggct tttattaaat tgtgagcctg gacttcctta agaatctcat ggtggcgtat
    10801 agcacagttt tgaactatgg ctaaggatgt tgagaacgtc tttttccctt tctttgcttc
    10861 tggaactggg tctcactata cagacctggc caggacaaag atcaagttgc tcttgaacct
    10921 gcaagggttc tttctgacct ctggctgtgc cactcttagt ttctctggtg ctgggattga
    10981 accaggcctt tttgtgtgtc tggtaaacac catcaacatt ccctcccatc ctagaccttg
    11041 gggttttttc cgtagggaat catcatttgt gtttgttttc agctctacaa aatcttagca
    11101 tgctgccaaa tccttttctg aaccttctgg ttcaggtgat ctcttattga ttgctagggt
    11161 atagacacag ggctccctgc ccagctaatg tacatttgta ttagcccagc tcttttctca
    11221 gataatcagt ttgttcaaaa tatgtgttac tcataaatct cacattgacc ctgagacccc
    11281 agtgatcaaa attaccttgt ggcagtctgt aatgtttcca gcttcaaaat tacaaggtta
    11341 ataatttatt tattcctttt ctacattcag atttccttat gattaaaaat cttctgtact
    11401 cctgtatgta caccctggct ccaccaccca gatcatccca tatgcaaata tatctgatta
    11461 gttccagttt tccatttctc tgccttcctt ttgcctcagc accttggctt atctttttca
    11521 accatgtgtc ataaagtcta acaccatgct tggctcaagt gtgtgtgatc ccaactgctt
    11581 gagggactga gacaggatga tagaaagaaa aggaacacca gcagggcgca gagctgcctg
    11641 ccatagagtt catgaaagag tggtgcttgc caaccttgct ggaagcaatc cctagtactg
    11701 cagaaaggac caaggatgtg tatgcagaac ttttcaatta ggagtaagta caacttaagt
    11761 ttcatattcc cattcttttg gccttttcca tctccagctg ctaaaattga aacctgcaag
    11821 gcagttttag tcactggatc ttatatgcag acagagtttc ttttccttct cctcattttc
    11881 aacaatctca ttctgttgat gggagcctgt ttcctaaggt aaattaactc tagaagttct
    11941 tcagctgtac tcgtccctta ataatggccc tgatgtactg caagtaggat cctgtctcca
    12001 accccagctc agacagtaca gccccacatc cttacacata atctagtttc aaacataagt
    12061 ccttggtgat gagctaccag aatccctggt gaggaagtca tggggattaa tagttcttgt
    12121 ctgccctctt ctaattttaa ctgaaaatag gtgatctttt gacaataaat aggacatgaa
    12181 caaaaaacaa aaaacaaaaa agcttagcat ctctccctag gtgtgatgtg cccatctata
    12241 attcagctcc cggggaggca gaagaaatgg gatgggatca tgtcttcaga gctctttgtg
    12301 ggatttctca ccagtactga actcagaaag cagttcagcc gccagcgaga atagccagga
    12361 gcttactcca tgtcacacag caagtcaagt aatacgagtg aaatgtagtt gcctgcatgt
    12421 atgtgtgtgc cttgtgtgtt gtctaagtag agctgatagg agaaaaacag aaaacttata
    12481 agcctgtttc atttccgttg tttagccagc tgttgcacat atgaaagatc tcaaatcctt
    12541 atttatgcat caaagcttag gtttatggtt ttgtgagtgt gtgtgtgtgt gtgtgtgtgt
    12601 gtgtttaaaa caggttcaca atgttgctct agctggcctg gaagatgctg ttctgtcctc
    12661 aggttgcttt ggtcctacgt cagggactgc aggtgtaaac ctctccattc agtgataata
    12721 agcagagaga gagagagaga gagcgtgcgc atcctgttgc cattaatagg aagacacttt
    12781 caccaagtaa ttttctaaat aggaatttta aagcccctca taatcaaagt ttaatatatt
    12841 taagtatgct gaaatgaagg tttcttgaag gagatggtgc tagctgaaca attttagttc
    12901 ctagcccttc attataaata tgcaaaattg ttgataacag gttttattaa ctctggatta
    12961 tatcttttgt cttgttgggt gtttggcttt ttgttcgtcc tggtgtgtga gtgttccctc
    13021 tgctttgctg gtagccatat caatctttgg agcaagtatc ctagagttaa gagtgctgag
    13081 atgtatttgt aaagttccta gtgatttgtc tataggttat tttaacaacc tctctatata
    13141 gaggtatatt ttgactatag tgatacattc tttggcacaa atataaggga agaggccaaa
    13201 gaaccgtgaa tattcagtat ggcctcctct tacgttggtg agtcgtcttg ccaacatcag
    13261 tttgtgctgt gataaaacgg ctgactgact atatttgact ttacaaacac agctcatagg
    13321 aaagattaaa tatttttatt gcgatgtatg gtcatatttt ttttagcttt atggagttaa
    13381 cattgtgata ggtgctttaa gagaaatatt tttccagaaa tggttttata gctaaactat
    13441 gggcagcttt tgcattgtga tgtgtgggtc gatggctcta tttgggttac taggaaatca
    13501 tgaagtgttc cctatggaga tacctgtccg catccatggc agagagatca gcatgaagtc
    13561 tcagttgact cccttttctc tcatagagtg agctagcacg taaatgacca tgtgtggcat
    13621 tacttggttt acaggactca gcgggctggt tagcggtggt gggaataagg catcaattca
    13681 cattcctcac cacatacagt ggggctgagt ccgtttccag tctcttatgt gaaggcctcc
    13741 ccagcagtcc ctggaagagg ctcgctgttc attttgatgg ttacaattct accgttgcat
    13801 ctcagtaatt gaaggctttt atctttggaa atgctgttaa aattccaaaa accagtttag
    13861 ttcttcacct atgaggaaaa tagttaaagc acttcatgac attaaaggga aagagaatcc
    13921 tatacccatg atagtttcaa tacctaatca atattgagtc ctctgcacag aatgggacgc
    13981 ttcgtagcag tacttgaata cctgtgagtt ggaattgcat gttacttgaa agatctaatt
    14041 aagctaaatt ttggtgcaca gcagttgtac atgatttcat gtttatgtag caaaatacat
    14101 tgaaatgtac taggattgaa acataaatgt aaaaatagtt gtggaaattg tcttattttc
    14161 cttatgtctc atttgtttaa agcataaatt ttcttttaaa aaattctaac taaggataaa
    14221 ggaatactgt aattgaagat atattttaaa tctttgtcat gttttttttt ttaaagctat
    14281 tgcaaattgt atcattcctg actatataga actttgtggg tggtataaaa taaattttat
    14341 acttctattt tgca
//
