LOCUS       NM_183264               1694 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus thymocyte expressed, positive selection associated 1
            (Tespa1), mRNA.
ACCESSION   NM_183264
VERSION     NM_183264.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1694)
  AUTHORS   Yang,R., Yang,M., Wu,Z., Liu,B., Zheng,M., Lu,L. and Wu,S.
  TITLE     Tespa1 deficiency reduces the antitumour immune response by
            decreasing CD8+T cell activity in a mouse Lewis lung cancer model
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110865 (2023)
   PUBMED   37660596
REFERENCE   2  (bases 1 to 1694)
  AUTHORS   Lu,Y., Yang,L., Shen,M., Zhang,Z., Wang,S., Chen,F., Chen,N.,
            Xu,Y., Zeng,H., Chen,M., Chen,S., Wang,F., Hu,M. and Wang,J.
  TITLE     Tespa1 facilitates hematopoietic and leukemic stem cell maintenance
            by restricting c-Myc degradation
  JOURNAL   Leukemia 37 (5), 1039-1047 (2023)
   PUBMED   36997676
  REMARK    GeneRIF: Tespa1 facilitates hematopoietic and leukemic stem cell
            maintenance by restricting c-Myc degradation.
REFERENCE   3  (bases 1 to 1694)
  AUTHORS   Yang,R., Wang,G., Li,L., He,H., Zheng,M., Lu,L. and Wu,S.
  TITLE     Tespa1 plays a role in the modulation of airway hyperreactivity
            through the IL-4/STAT6 pathway
  JOURNAL   J Transl Med 18 (1), 444 (2020)
   PUBMED   33228696
  REMARK    GeneRIF: Tespa1 plays a role in the modulation of airway
            hyperreactivity through the IL-4/STAT6 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1694)
  AUTHORS   Lyu,J., Wang,P., Xu,T., Shen,Y., Cui,Z., Zheng,M., Fu,G. and Lu,L.
  TITLE     Thymic-specific regulation of TCR signaling by Tespa1
  JOURNAL   Cell Mol Immunol 16 (12), 897-907 (2019)
   PUBMED   31316154
  REMARK    GeneRIF: Thymic-specific regulation of TCR signaling by Tespa1.
REFERENCE   5  (bases 1 to 1694)
  AUTHORS   Yao,Y., Huang,W., Li,X., Li,X., Qian,J., Han,H., Sun,H., An,X.,
            Lu,L. and Zhao,H.
  TITLE     Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and
            Attenuates Collagen-Induced Arthritis in Mice
  JOURNAL   Front Immunol 9, 965 (2018)
   PUBMED   29867947
  REMARK    GeneRIF: Our study demonstrates that Tespa1 is essential for T
            cell-dependent B cell responses, and suggests an important role for
            Tespa1 during the development of autoimmune arthritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1694)
  AUTHORS   Liang,J., Lyu,J., Zhao,M., Li,D., Zheng,M., Fang,Y., Zhao,F.,
            Lou,J., Guo,C., Wang,L., Wang,D., Liu,W. and Lu,L.
  TITLE     Tespa1 regulates T cell receptor-induced calcium signals by
            recruiting inositol 1,4,5-trisphosphate receptors
  JOURNAL   Nat Commun 8, 15732 (2017)
   PUBMED   28598420
  REMARK    GeneRIF: Tespa1 functions in T cell development and the regulation
            of TCR-induced Ca(2+) signalling through IP3R1
            Erratum:[Nat Commun. 2018 Mar 12;9:16183. PMID: 29528040]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1694)
  AUTHORS   Wang,D., Zheng,M., Qiu,Y., Guo,C., Ji,J., Lei,L., Zhang,X.,
            Liang,J., Lou,J., Huang,W., Dong,B., Wu,S., Wang,J., Ke,Y., Cao,X.,
            Zhou,Y.T. and Lu,L.
  TITLE     Tespa1 negatively regulates FcepsilonRI-mediated signaling and the
            mast cell-mediated allergic response
  JOURNAL   J Exp Med 211 (13), 2635-2649 (2014)
   PUBMED   25422497
  REMARK    GeneRIF: Loss of Tespa1 in mouse mast cells led to
            hyper-responsiveness to stimulation via FcepsilonRI.
REFERENCE   8  (bases 1 to 1694)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1694)
  AUTHORS   Fujimoto,T., Matsuzaki,H., Tanaka,M. and Shirasawa,S.
  TITLE     Tespa1 protein is phosphorylated in response to store-operated
            calcium entry
  JOURNAL   Biochem Biophys Res Commun 434 (1), 162-165 (2013)
   PUBMED   23541577
  REMARK    GeneRIF: Tespa1 is post-translationally modified upon intracellular
            Ca2+ increase in thymocytes.
REFERENCE   10 (bases 1 to 1694)
  AUTHORS   Wang,D., Zheng,M., Lei,L., Ji,J., Yao,Y., Qiu,Y., Ma,L., Lou,J.,
            Ouyang,C., Zhang,X., He,Y., Chi,J., Wang,L., Kuang,Y., Wang,J.,
            Cao,X. and Lu,L.
  TITLE     Tespa1 is involved in late thymocyte development through the
            regulation of TCR-mediated signaling
  JOURNAL   Nat Immunol 13 (6), 560-568 (2012)
   PUBMED   22561606
  REMARK    GeneRIF: Tespa1 is a component of the TCR signalosome and is
            essential for T-cell selection and maturation through regulation of
            TCR signaling during T-cell development.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152977.1 and AC159473.7.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_183264.5.
            
            On Jan 29, 2008 this sequence version replaced NM_183264.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC152977.1         175769-175886
            119-325             AC159473.7         69518-69724
            326-368             AC159473.7         70589-70631
            369-424             AC159473.7         77086-77141
            425-478             AC159473.7         77825-77878
            479-515             AC159473.7         78692-78728
            516-614             AC159473.7         79178-79276
            615-823             AC159473.7         83021-83229
            824-1694            AC159473.7         84146-85016
FEATURES             Location/Qualifiers
     source          1..1694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.85 cM"
     gene            1..1694
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /note="thymocyte expressed, positive selection associated
                     1"
                     /db_xref="GeneID:67596"
                     /db_xref="MGI:MGI:1914846"
     exon            1..118
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
     exon            119..325
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1539
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /note="thymocyte-expressed positive selection-associated
                     protein 1"
                     /codon_start=1
                     /product="protein TESPA1"
                     /protein_id="NP_899087.2"
                     /db_xref="CCDS:CCDS48735.1"
                     /db_xref="GeneID:67596"
                     /db_xref="MGI:MGI:1914846"
                     /translation="MEASVLSPTSWEKRRAWLRQSRNWQTQVLEEEAAAALQDALDPE
                     PSSLDDVFQEGNPINKIEDWLQGCGCRDTEEGLSEESGQSNYSGYSSHGTSFEDDLSL
                     GAEATLLSTNGNLFSRNFLQTPRLCQLLDLGSSLASSSMTGGTNKTSSSISEILDQVQ
                     EDAEDILFSLGFGHENHKDTSRIPARFFSNPSQAKGINFQLFLKSQVQRMEMEDPCLM
                     LASRFKQVQTLAVTADAFFCLYSYVSKTPVQKFTPSNMFWNFDPTDVPSIRILAPEPE
                     PYSPRERLRRAISKMCLYTGSRDRLSSSYNNPKKNSLDQIVWEVMDRVKGEKIQQDPE
                     HRQALGEESVPPIQNTNPSTSSLPCVSYPKEETQGDMCHAHALARPGPQYHINSTQVR
                     RQLWVLQDINEKPRSAENESPWERKSKARKNLFQRVPVDKNIKSLNLPTIQQKQNQGQ
                     ARHELTNL"
     exon            326..368
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..424
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
     exon            425..478
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..515
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..614
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..823
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1694
                     /gene="Tespa1"
                     /gene_synonym="5830405N20Rik; A430001F24Rik; Itprid3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgaatgag aacagagaga aagtcacagt ctgcgatatg aaactatcac acagccctca
       61 tctctagcac cactcctgag aaagattcaa ccctgtttcg agaactttct tacctctgga
      121 aggcatcagt ttgataggaa ggcctgaaag tgggctcgaa caatggaggc atcggtactg
      181 agccccacat cctgggagaa acgaagggcc tggttacgac agagtcgtaa ctggcaaacc
      241 caggtcctgg aagaggaagc agcagcagct cttcaggatg cactggatcc cgagccttct
      301 agcctggatg atgttttcca ggaagggaat ccaatcaata agattgagga ctggctgcag
      361 ggctgtggtt gtagagacac tgaagagggc ctttctgaag aatcagggca atctaactac
      421 agtggatatt ctagccatgg gacaagcttt gaagatgact tgagtcttgg agcagaggcc
      481 acattactgt ctaccaatgg aaacctcttc tctaggaatt tcctccagac acccaggctt
      541 tgccagttac ttgatcttgg ctctagtttg gcttccagca gcatgactgg tggaaccaac
      601 aaaaccagtt caagcatctc agagattctg gaccaggtac aagaagatgc agaagatatt
      661 cttttcagcc tgggcttcgg gcacgagaac cacaaagaca catctcgtat ccctgcaaga
      721 tttttcagca acccttctca ggccaagggc attaactttc agctcttcct gaagtctcag
      781 gtgcaaagga tggagatgga ggatccctgc ctgatgctgg ccagccggtt taagcaggtg
      841 cagacgctgg ctgtcactgc tgatgctttc ttctgtctct actcctatgt gtctaagaca
      901 cctgtccaaa agttcacacc atccaacatg ttctggaatt tcgacccaac ggatgtgcca
      961 tccatcagga ttctggctcc agagcctgaa ccctactcac ccagagaacg tctcaggaga
     1021 gcaatctcaa aaatgtgcct gtatacaggt tcccgagatc ggctatcatc atcttacaac
     1081 aaccccaaaa agaacagttt ggatcaaatt gtgtgggaag tgatggacag agtgaaagga
     1141 gagaagatcc agcaagaccc tgagcatagg caagcccttg gggaagagtc tgttccccca
     1201 atacaaaata caaatccatc tacttcttcc cttccatgtg tttcctaccc taaagaagaa
     1261 acacagggag acatgtgcca tgctcatgct ctagcaagac caggtccaca gtaccacata
     1321 aactctacac aggtaaggag acagctgtgg gttctacagg acattaatga gaagccacgt
     1381 tcagctgaga atgagagtcc atgggaaaga aaaagcaaag caagaaagaa tctgtttcaa
     1441 agggttcctg tggacaagaa tattaagtca ttgaacttgc ccaccatcca gcagaaacaa
     1501 aaccagggac aagccagaca tgagctgacc aatctttaac tcagcagctt caggatgctt
     1561 cagatttgga gcagatgaga gctcagtttc tcatgaaacg tacatgtact gatgtttttt
     1621 ttaaatgttt ttcatataaa tgaaattgga aaaaaactac acattcttta ataaaatatg
     1681 tcttttgcca agga
//
