LOCUS       NM_011571               3620 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus testis specific protein kinase 1 (Tesk1), mRNA.
ACCESSION   NM_011571 XM_973123
VERSION     NM_011571.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3620)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3620)
  AUTHORS   Fang,Q., Zhang,Y., Da,P., Shao,B., Pan,H., He,Z., Cheng,C., Li,D.,
            Guo,J., Wu,X., Guan,M., Liao,M., Zhang,Y., Sha,S., Zhou,Z.,
            Wang,J., Wang,T., Su,K., Chai,R. and Chen,F.
  TITLE     Deletion of Limk1 and Limk2 in mice does not alter cochlear
            development or auditory function
  JOURNAL   Sci Rep 9 (1), 3357 (2019)
   PUBMED   30833597
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3620)
  AUTHORS   Wang,L., Buckley,A.F. and Spurney,R.F.
  TITLE     Regulation of cofilin phosphorylation in glomerular podocytes by
            testis specific kinase 1 (TESK1)
  JOURNAL   Sci Rep 8 (1), 12286 (2018)
   PUBMED   30115939
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3620)
  AUTHORS   Morita,R., Kihira,M., Nakatsu,Y., Nomoto,Y., Ogawa,M., Ohashi,K.,
            Mizuno,K., Tachikawa,T., Ishimoto,Y., Morishita,Y. and Tsuji,T.
  TITLE     Coordination of Cellular Dynamics Contributes to Tooth Epithelium
            Deformations
  JOURNAL   PLoS One 11 (9), e0161336 (2016)
   PUBMED   27588418
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3620)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3620)
  AUTHORS   Chandramouli,S., Yu,C.Y., Yusoff,P., Lao,D.H., Leong,H.F.,
            Mizuno,K. and Guy,G.R.
  TITLE     Tesk1 interacts with Spry2 to abrogate its inhibition of ERK
            phosphorylation downstream of receptor tyrosine kinase signaling
  JOURNAL   J Biol Chem 283 (3), 1679-1691 (2008)
   PUBMED   17974561
REFERENCE   7  (bases 1 to 3620)
  AUTHORS   Toshima,J., Toshima,J.Y., Suzuki,M., Noda,T. and Mizuno,K.
  TITLE     Cell-type-specific expression of a TESK1 promoter-linked lacZ gene
            in transgenic mice
  JOURNAL   Biochem Biophys Res Commun 286 (3), 566-573 (2001)
   PUBMED   11511097
REFERENCE   8  (bases 1 to 3620)
  AUTHORS   Toshima,J., Nakagawara,K., Mori,M., Noda,T. and Mizuno,K.
  TITLE     Structural organization and chromosomal localization of the mouse
            tesk1 (testis-specific protein kinase 1) gene
  JOURNAL   Gene 206 (2), 237-245 (1998)
   PUBMED   9469938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099699.1, AK144302.1 and BB325506.1.
            
            On Apr 21, 2009 this sequence version replaced NM_011571.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099699.1, AB003494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3318              BC099699.1         1-3318
            3319-3608           AK144302.1         2902-3191
            3609-3620           BB325506.1         300-311
FEATURES             Location/Qualifiers
     source          1..3620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.04 cM"
     gene            1..3620
                     /gene="Tesk1"
                     /note="testis specific protein kinase 1"
                     /db_xref="GeneID:21754"
                     /db_xref="MGI:MGI:1201675"
     exon            1..1362
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1159..3042
                     /gene="Tesk1"
                     /EC_number="2.7.12.1"
                     /note="testicular protein kinase 1"
                     /codon_start=1
                     /product="dual specificity testis-specific protein kinase
                     1"
                     /protein_id="NP_035701.3"
                     /db_xref="CCDS:CCDS18094.1"
                     /db_xref="GeneID:21754"
                     /db_xref="MGI:MGI:1201675"
                     /translation="MAGERPPLRGPGPGEAPGEGPGGAGGGPGRGRPSSYRALRSAVS
                     SLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRL
                     RHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIAQGLRY
                     LHAKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYW
                     MAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGND
                     CPLPFLLLAIHCCSMEPSTRAPFTEITQHLEQILEQQPEATPLAKPPLTKAPLTYNQG
                     SVPRGGPSATLPRPDPRLSRSRSDLFLPPSPESPPSWGDNLTRVNPFSLREDLRGGKI
                     KLLDTPCKPATPLPLVPPSPLTSTQLPLVTTPDILVQPETPVRRCRSLPSSPELPRRM
                     ETALPGPGPSPMGPTEERMDCEGSSPEPEPPGLAPQLPLAVATDNFISTCSSASQPWS
                     PRSGPPLNNNPPAVVVNSPQGWAREPWNRAQHSLPRAAALERTEPSPPPSAPREPEEG
                     LPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPG
                     ARS"
     exon            1363..1484
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1533
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1680
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1763
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1854
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1938
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2028
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2158
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..3620
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3299..3304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tesk1"
                     /note="hexamer: AATAAA"
     polyA_site      3339
                     /gene="Tesk1"
                     /note="major polyA site"
     regulatory      3588..3593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tesk1"
                     /note="hexamer: AATAAA"
     polyA_site      3609
                     /gene="Tesk1"
                     /note="major polyA site"
ORIGIN      
        1 aagccacgtc ccgagaccgg gcgtgcgcac tccgaggatc ccaaccgctg tagaggcctc
       61 tgcacctcct cctctggact gagggggcac actggcgtct accgacgtgg ggcgcaacct
      121 gccgaaaggg gtcacaccgc tgggcgctag cgaggggagg agtcaccttg agaggagggg
      181 tcacaatgac tagccgagtc actctgccag gtctctttta gtgagaggaa cacaaagagg
      241 agggggtgca gcactgaggg gctcggggaa cacacggatg tagcagtgtc atccgtagga
      301 aaggtccccc gaaggagagc gggctccgag gggcagcggc ctttgagggg gcgggatcct
      361 gccgagggcg gggcctcctt gcaggtgcag gcgtctccga agagagggtt attaggacaa
      421 agaagtaaga gggtggtcac cggatcgagc gtcggaatct caactttact tagggggatg
      481 gagatggagt gagaaggagt cgagcaggtc agggatgcga aggccagagg ctccctacag
      541 ccctggatac tgcgatcgga gaagacaggt gttagcgagc cccgagattt agagtgtcgg
      601 ggtcagaaac ccccctgaaa tggacagtcg gagtcggacg cagaccgggc aggcagcgtg
      661 gtcgatccgt ggagcccagg gcgcaggaga attagcgcca gcagtcaacc ctcaagtcgt
      721 cctgtgattc acgccccggc ctacgcgcgg gggacgcacc tgagggggcg tggccgggcc
      781 gcagcccggg ctccaaggag ttaaccgcag accgggccgg gccccgcccc gggcaggccg
      841 cacagcctga gcccggcggc gaagcggagc agcagccgcc cgcggggagc ccgccgccgg
      901 cgcccgggag cgccgccgcc gcccggccca ggcccaggcc caggccccgc gcagagcgga
      961 gagccgcggc gttccaccgg gcccaactcg ccggcgcggc gggggcgggc ccaggacctt
     1021 cggcaggtcc tccaggagtc caccgggcgg gagtcccggc ccccgggatc gggttgggcc
     1081 ggcgcccatg gcgagcgcgg cctgcccggg tcccggggat ccggccatgt gaagcaggcc
     1141 ggggctgggg gcccggccat ggccggggaa cggccgccgc tgcggggccc cgggcccgga
     1201 gaggctccgg gggaggggcc ggggggcgca ggcggaggcc cgggccgggg ccggccctcc
     1261 tcctaccggg ccctccgcag cgccgtgtcc agccttgcgc gtgtggacga tttcgactgc
     1321 gcagagaaga tcggggccgg tttcttctct gaggtctaca aggttcggca ccgacagtcg
     1381 ggacaagtca tggtgctgaa gatgaacaag ctccccagta accggagcaa cacgctaagg
     1441 gaggtgcagc tgatgaaccg gctccggcac cctaacatcc tcaggttcat gggggtctgt
     1501 gtgcaccaag ggcagctgca cgcgcttaca gagtatatga atgggggcac cctggaacag
     1561 ctgctcagct ccccagaacc cctctcctgg ccagtcaggc tccacctagc cctggacatt
     1621 gcacaaggcc tacggtacct acacgccaaa ggtgtgtttc accgagacct cacatccaag
     1681 aactgtctgg tccgaaggga agaccgaggc ttcacagctg ttgtgggtga cttcggactg
     1741 gctgagaaga ttcctgtgta tagggaaggg acaaggaagg agcccttggc tgtggtgggc
     1801 tccccgtact ggatggctcc agaggtgttg cggggagagc tgtatgatga gaaggccgat
     1861 gtcttcgcct tcgggatcgt cctctgtgag ctcatcgccc gagtgcctgc agaccctgac
     1921 tacctacccc gcactgagga ctttggcctg gatgtgcctg ctttccgaac tttggtggga
     1981 aatgactgtc cgctaccttt cctgcttctg gccatccact gctgcagcat ggaacccagc
     2041 acccgggccc cttttactga aatcacccag cacctggaac agatcctgga gcagcagcct
     2101 gaggccacgc ccctcgccaa gccacccctc accaaggctc ccttgacata caatcagggg
     2161 tctgttccaa gaggaggtcc ctctgccaca cttcccaggc cagacccccg gctctcccga
     2221 agccggtcag acctcttcct gccaccttcg ccagaatcac cccccagctg gggggacaat
     2281 ctaacacgag tcaacccctt ctcactgcgg gaagacctca ggggtggcaa gatcaagctg
     2341 ctggacacac cctgcaagcc ggccactcca ctgcccctgg ttccaccatc accacttacc
     2401 tctacccagc tgcccttagt gaccactcca gacatcctgg tccagcctga gacccctgtc
     2461 cgccgctgtc gctcactacc ttcatcccct gagcttcccc gacggatgga gactgcactg
     2521 ccaggtcctg gcccttcccc catgggcccg actgaggaga ggatggactg cgagggcagc
     2581 agccctgagc cagagccccc aggcctggct ccccagctgc ctctggctgt ggccactgac
     2641 aacttcatca gtacttgttc ctcagcctcg cagccctggt ctcctagatc aggacctccc
     2701 ctcaacaata atccccctgc tgtggtggtg aattccccac aagggtgggc tagggagccc
     2761 tggaaccggg cacagcatag ccttccccgg gcagcagccc tggagcggac agagccctca
     2821 ccgcccccat cagctccccg ggagccggag gaggggctgc cctgccctgg ctgctgcctt
     2881 ggcccgttca gctttggctt tctatccatg tgcccccgcc ctaccccagc tgttgcccgc
     2941 taccgcaact tgaactgtga ggcgggcagt cttctctgcc accgagggca tcatgccaag
     3001 ccacccacac ccagcctgca gctgcctggg gcacgctctt agcagtgagg cctgtgagct
     3061 caggcttcca accttggcct tcgggatacc ctgtaaggac agtgcacttg ctggacaatg
     3121 ccagccccag atgggctgac tagctcttct ccccgtatag gggagcctca gcatggtctc
     3181 aatggacaga gcacctccta gccgacccct gggttcactg tcccattggg atcaccgaac
     3241 tagacacagc attgctgaca cacaggacta acacgtgcaa agtatttaaa aatatttcaa
     3301 taaaactgcc tggctggctc cgggccatcc atccactcag cggagcgccc tcccctgacc
     3361 catctctagt ttgggaagtt cttaaggaag gtcaagtctt ttctggaggc ttctttactc
     3421 ttcccaagag aagtccagtt tctggagcag ctttcaagca agcagcaggt catcccttag
     3481 ctgggcatgc ccgagagtga gggagtgctg gaggaatagc agtcttaaaa attggcaggc
     3541 cgtaggttaa ggatgtaggt cacaaggtct tgttcaagtg tctggaaaat aaagcatcag
     3601 tgagcttcag ttgactgtca
//
