LOCUS       NM_021344               1031 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus tescalcin (Tesc), transcript variant 1, mRNA.
ACCESSION   NM_021344 XM_914312
VERSION     NM_021344.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1031)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1031)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1031)
  AUTHORS   Takamatsu,G., Katagiri,C., Tomoyuki,T., Shimizu-Okabe,C.,
            Nakamura,W., Nakamura-Higa,M., Hayakawa,T., Wakabayashi,S.,
            Kondo,T., Takayama,C. and Matsushita,M.
  TITLE     Tescalcin is a potential target of class I histone deacetylase
            inhibitors in neurons
  JOURNAL   Biochem Biophys Res Commun 482 (4), 1327-1333 (2017)
   PUBMED   27939885
  REMARK    GeneRIF: TESC has an important role in mediating the
            neuroprotective effect of class I histone deacetylase inhibitors,
            and may also be involved in the development of brain and
            neurodegenerative diseases through epigenetic mechanisms
REFERENCE   4  (bases 1 to 1031)
  AUTHORS   Miyai,M., Hamada,M., Moriguchi,T., Hiruma,J., Kamitani-Kawamoto,A.,
            Watanabe,H., Hara-Chikuma,M., Takahashi,K., Takahashi,S. and
            Kataoka,K.
  TITLE     Transcription Factor MafB Coordinates Epidermal Keratinocyte
            Differentiation
  JOURNAL   J Invest Dermatol 136 (9), 1848-1857 (2016)
   PUBMED   27208706
  REMARK    Review article
REFERENCE   5  (bases 1 to 1031)
  AUTHORS   Nicholson,T.B., Singh,A.K., Su,H., Hevi,S., Wang,J., Bajko,J.,
            Li,M., Valdez,R., Goetschkes,M., Capodieci,P., Loureiro,J.,
            Cheng,X., Li,E., Kinzel,B., Labow,M. and Chen,T.
  TITLE     A hypomorphic lsd1 allele results in heart development defects in
            mice
  JOURNAL   PLoS One 8 (4), e60913 (2013)
   PUBMED   23637775
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1031)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   7  (bases 1 to 1031)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
REFERENCE   8  (bases 1 to 1031)
  AUTHORS   Gutierrez-Ford,C., Levay,K., Gomes,A.V., Perera,E.M., Som,T.,
            Kim,Y.M., Benovic,J.L., Berkovitz,G.D. and Slepak,V.Z.
  TITLE     Characterization of tescalcin, a novel EF-hand protein with a
            single Ca2+-binding site: metal-binding properties, localization in
            tissues and cells, and effect on calcineurin
  JOURNAL   Biochemistry 42 (49), 14553-14565 (2003)
   PUBMED   14661968
  REMARK    GeneRIF: Tescalcin shares sequence and functional homology with
            calcineurin-B homologous protein (CHP), and like CHP can inhibit
            the phosphatase activity of calcineurin A.
REFERENCE   9  (bases 1 to 1031)
  AUTHORS   Mailander,J., Muller-Esterl,W. and Dedio,J.
  TITLE     Human homolog of mouse tescalcin associates with Na(+)/H(+)
            exchanger type-1
  JOURNAL   FEBS Lett 507 (3), 331-335 (2001)
   PUBMED   11696366
REFERENCE   10 (bases 1 to 1031)
  AUTHORS   Perera,E.M., Martin,H., Seeherunvong,T., Kos,L., Hughes,I.A.,
            Hawkins,J.R. and Berkovitz,G.D.
  TITLE     Tescalcin, a novel gene encoding a putative EF-hand Ca(2+)-binding
            protein, Col9a3, and renin are expressed in the mouse testis during
            the early stages of gonadal differentiation
  JOURNAL   Endocrinology 142 (1), 455-463 (2001)
   PUBMED   11145610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE979843.1, CX242767.1 and AC114993.18.
            
            On Oct 12, 2017 this sequence version replaced NM_021344.3.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107679.1, GQ856259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                BE979843.1         1-98
            99-736              CX242767.1         1-638
            737-859             CX242767.1         640-762
            860-1031            AC114993.18        66331-66502         c
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 57.84 cM"
     gene            1..1031
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /note="tescalcin"
                     /db_xref="GeneID:57816"
                     /db_xref="MGI:MGI:1930803"
     exon            1..245
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..832
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /note="TSC; CHP3"
                     /codon_start=1
                     /product="calcineurin B homologous protein 3"
                     /protein_id="NP_067319.2"
                     /db_xref="CCDS:CCDS19608.1"
                     /db_xref="GeneID:57816"
                     /db_xref="MGI:MGI:1930803"
                     /translation="MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRK
                     ENFNNVPDLELNPIRSKIVRAFFDNRNLRKGSSGLADEINFEDFLTIMSYFRPIDTTL
                     GEEQVELSRKEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADG
                     AMMEAASVCVGQMEPDQVYEGITFEDFLKIWQGIDIETKMHIRFLNMETIALCH"
     exon            246..315
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..396
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..536
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..598
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..706
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..754
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1031
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1005..1010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /note="hexamer: AATAAA"
     polyA_site      1023
                     /gene="Tesc"
                     /gene_synonym="1010001A17Rik; 2410011K10Rik; TE-1"
                     /note="major polyA site"
ORIGIN      
        1 cggccgcgag ggaagcgggc gagcgctagg accgcgccgc tccgcctccc gccgctataa
       61 gaggccgctc gagccccacg cggaaccggc tccgcgccgc tgtccccgcg tccccacccg
      121 gctccaacgc agcgcagccc aggcagtccc cggcctgcgt ggggcgcccg gggccccgcg
      181 gcgcaccatg ggcgctgccc actcggcgtc cgaggaggtg cgggagctcg agggcaagac
      241 cggcttctcc tcggaccaga tagagcagct gcatcggagg ttcaagcagc taagcgggga
      301 ccagcccacc attcgcaagg agaacttcaa caatgtccct gacctggagc tcaacccgat
      361 ccgatccaaa atcgtccgtg ccttcttcga caacaggaac ctgcgaaagg gatccagcgg
      421 tctggccgat gagatcaact ttgaggactt cctgactatc atgtcctact tccggcccat
      481 cgacaccacc ctgggcgagg aacaggtgga gctgtcacga aaggagaagc tgaaatttct
      541 gtttcatatg tatgattcgg acagtgacgg ccgcatcacc ctggaagagt atagaaatgt
      601 ggtggaggag ctgctctcgg gaaaccctca cattgaaaag gagtcggctc ggtccattgc
      661 agacggggcc atgatggagg cggccagcgt gtgcgtgggg cagatggaac cggaccaggt
      721 gtacgagggg atcacctttg aggacttcct gaagatctgg cagggcatcg acatcgagac
      781 caagatgcac attcgtttcc tcaacatgga gaccatcgcc ctctgccact gacctgctgc
      841 ctgctgcccg tgcaagggag ggggtggctg gaagctgggg gtgaccgagg acggatgttc
      901 agccctatgc ctgggcttct gtgacaatca gtaacccttc ttcagttatc ctcctcgtgg
      961 ggtgtggtgt gtgggactcc gatattttta tctctaatgg tgacaataaa ggtttcctaa
     1021 tgagtccggc a
//
