LOCUS       NM_009354               4335 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus telomerase reverse transcriptase (Tert), transcript
            variant 1, mRNA.
ACCESSION   NM_009354
VERSION     NM_009354.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4335)
  AUTHORS   Mishima,M., Takai,A., Takeda,H., Iguchi,E., Nakano,S., Fujii,Y.,
            Ueno,M., Ito,T., Teramura,M., Eso,Y., Shimizu,T., Maruno,T.,
            Hidema,S., Nishimori,K., Marusawa,H., Hatano,E. and Seno,H.
  TITLE     TERT upregulation promotes cell proliferation via degradation of
            p21 and increases carcinogenic potential
  JOURNAL   J Pathol 264 (3), 318-331 (2024)
   PUBMED   39329419
  REMARK    GeneRIF: TERT upregulation promotes cell proliferation via
            degradation of p21 and increases carcinogenic potential.
REFERENCE   2  (bases 1 to 4335)
  AUTHORS   Shim,H.S., Iaconelli,J., Shang,X., Li,J., Lan,Z.D., Jiang,S.,
            Nutsch,K., Beyer,B.A., Lairson,L.L., Boutin,A.T., Bollong,M.J.,
            Schultz,P.G. and DePinho,R.A.
  TITLE     TERT activation targets DNA methylation and multiple aging
            hallmarks
  JOURNAL   Cell 187 (15), 4030-4042 (2024)
   PUBMED   38908367
  REMARK    GeneRIF: TERT activation targets DNA methylation and multiple aging
            hallmarks.
REFERENCE   3  (bases 1 to 4335)
  AUTHORS   Kumar,A., Nagasaka,Y., Jayananthan,V., Zidan,A., Heisler-Taylor,T.,
            Ambati,J., Tamiya,S. and Kerur,N.
  TITLE     Therapeutic targeting of telomerase ameliorates experimental
            choroidal neovascularization
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167156 (2024)
   PUBMED   38582267
REFERENCE   4  (bases 1 to 4335)
  AUTHORS   Xu,X., Mo,L., Liao,Y., Zhang,K.S., Zhang,H., Liu,L., Liu,Y.,
            Tang,A., Yang,P. and Liu,X.
  TITLE     An association between elevated telomerase reverse transcriptase
            expression and the immune tolerance disruption of dendritic cells
  JOURNAL   Cell Commun Signal 22 (1), 284 (2024)
   PUBMED   38783329
  REMARK    GeneRIF: An association between elevated telomerase reverse
            transcriptase expression and the immune tolerance disruption of
            dendritic cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4335)
  AUTHORS   Liu,M.Y., Fan,Y., Ni,N., Yu,T., Mao,Z., Huang,H., Zhang,J.,
            Tang,Y., He,H., Meng,F., You,Y. and Zhou,Q.G.
  TITLE     TERT mediates the U-shape of glucocorticoids effects in modulation
            of hippocampal neural stem cells and associated brain function
  JOURNAL   CNS Neurosci Ther 30 (2), e14577 (2024)
   PUBMED   38421107
  REMARK    GeneRIF: TERT mediates the U-shape of glucocorticoids effects in
            modulation of hippocampal neural stem cells and associated brain
            function.
REFERENCE   6  (bases 1 to 4335)
  AUTHORS   Yuan,X., Ishibashi,S., Hatakeyama,S., Saito,M., Nakayama,J.,
            Nikaido,R., Haruyama,T., Watanabe,Y., Iwata,H., Iida,M.,
            Sugimura,H., Yamada,N. and Ishikawa,F.
  TITLE     Presence of telomeric G-strand tails in the telomerase catalytic
            subunit TERT knockout mice
  JOURNAL   Genes Cells 4 (10), 563-572 (1999)
   PUBMED   10583505
REFERENCE   7  (bases 1 to 4335)
  AUTHORS   Greenberg,R.A., O'Hagan,R.C., Deng,H., Xiao,Q., Hann,S.R.,
            Adams,R.R., Lichtsteiner,S., Chin,L., Morin,G.B. and DePinho,R.A.
  TITLE     Telomerase reverse transcriptase gene is a direct target of c-Myc
            but is not functionally equivalent in cellular transformation
  JOURNAL   Oncogene 18 (5), 1219-1226 (1999)
   PUBMED   10022128
REFERENCE   8  (bases 1 to 4335)
  AUTHORS   Martin-Rivera,L., Herrera,E., Albar,J.P. and Blasco,M.A.
  TITLE     Expression of mouse telomerase catalytic subunit in embryos and
            adult tissues
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10471-10476 (1998)
   PUBMED   9724727
REFERENCE   9  (bases 1 to 4335)
  AUTHORS   Zhu,L., Hathcock,K.S., Hande,P., Lansdorp,P.M., Seldin,M.F. and
            Hodes,R.J.
  TITLE     Telomere length regulation in mice is linked to a novel chromosome
            locus
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8648-8653 (1998)
   PUBMED   9671732
REFERENCE   10 (bases 1 to 4335)
  AUTHORS   Greenberg,R.A., Allsopp,R.C., Chin,L., Morin,G.B. and DePinho,R.A.
  TITLE     Expression of mouse telomerase reverse transcriptase during
            development, differentiation and proliferation
  JOURNAL   Oncogene 16 (13), 1723-1730 (1998)
   PUBMED   9582020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133783.1, AF051911.1 and BC082327.1.
            
            On Apr 13, 2018 this sequence version replaced NM_009354.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF051911.1, AF073311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AK133783.1         2-91
            91-3516             AF051911.1         1-3426
            3517-4335           BC082327.1         2929-3747
FEATURES             Location/Qualifiers
     source          1..4335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.12 cM"
     gene            1..4335
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /note="telomerase reverse transcriptase"
                     /db_xref="GeneID:21752"
                     /db_xref="MGI:MGI:1202709"
     exon            1..338
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..3488
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /EC_number="2.7.7.49"
                     /note="isoform 1 is encoded by transcript variant 1;
                     telomerase catalytic subunit; telomerase reverse
                     transcriptase beta"
                     /codon_start=1
                     /product="telomerase reverse transcriptase isoform 1"
                     /protein_id="NP_033380.1"
                     /db_xref="CCDS:CCDS26633.1"
                     /db_xref="GeneID:21752"
                     /db_xref="MGI:MGI:1202709"
                     /translation="MTRAPRCPAVRSLLRSRYREVWPLATFVRRLGPEGRRLVQPGDP
                     KIYRTLVAQCLVCMHWGSQPPPADLSFHQVSSLKELVARVVQRLCERNERNVLAFGFE
                     LLNEARGGPPMAFTSSVRSYLPNTVIETLRVSGAWMLLLSRVGDDLLVYLLAHCALYL
                     LVPPSCAYQVCGSPLYQICATTDIWPSVSASYRPTRPVGRNFTNLRFLQQIKSSSRQE
                     APKPLALPSRGTKRHLSLTSTSVPSAKKARCYPVPRVEEGPHRQVLPTPSGKSWVPSP
                     ARSPEVPTAEKDLSSKGKVSDLSLSGSVCCKHKPSSTSLLSPPRQNAFQLRPFIETRH
                     FLYSRGDGQERLNPSFLLSNLQPNLTGARRLVEIIFLGSRPRTSGPLCRTHRLSRRYW
                     QMRPLFQQLLVNHAECQYVRLLRSHCRFRTANQQVTDALNTSPPHLMDLLRLHSSPWQ
                     VYGFLRACLCKVVSASLWGTRHNERRFFKNLKKFISLGKYGKLSLQELMWKMKVEDCH
                     WLRSSPGKDRVPAAEHRLRERILATFLFWLMDTYVVQLLRSFFYITESTFQKNRLFFY
                     RKSVWSKLQSIGVRQHLERVRLRELSQEEVRHHQDTWLAMPICRLRFIPKPNGLRPIV
                     NMSYSMGTRALGRRKQAQHFTQRLKTLFSMLNYERTKHPHLMGSSVLGMNDIYRTWRA
                     FVLRVRALDQTPRMYFVKADVTGAYDAIPQGKLVEVVANMIRHSESTYCIRQYAVVRR
                     DSQGQVHKSFRRQVTTLSDLQPYMGQFLKHLQDSDASALRNSVVIEQSISMNESSSSL
                     FDFFLHFLRHSVVKIGDRCYTQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQRDGLL
                     LRFVDDFLLVTPHLDQAKTFLSTLVHGVPEYGCMINLQKTVVNFPVEPGTLGGAAPYQ
                     LPAHCLFPWCGLLLDTQTLEVFCDYSGYAQTSIKTSLTFQSVFKAGKTMRNKLLSVLR
                     LKCHGLFLDLQVNSLQTVCINIYKIFLLQAYRFHACVIQLPFDQRVRKNLTFFLGIIS
                     SQASCCYAILKVKNPGMTLKASGSFPPEAAHWLCYQAFLLKLAAHSVIYKCLLGPLRT
                     AQKLLCRKLPEATMTILKAAADPALSTDFQTILD"
     exon            339..1662
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1858
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2039
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2219
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2378
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2480
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2566
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2680
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2752
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2941
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3068
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3130
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3255
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3384
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..4318
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4298..4303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /note="hexamer: AATAAA"
     polyA_site      4318
                     /gene="Tert"
                     /gene_synonym="EST2; TCS1; TP2; TR; TRT"
                     /note="major polyA site"
ORIGIN      
        1 gttcccagcc tcatcttttt cgtcgtggac tctcagtggc ctgggtcctg gctgttttct
       61 aagcacaccc ttgcatcttg gttcccgcac gtgggaggcc catcccggcc ttgagcacaa
      121 tgacccgcgc tcctcgttgc cccgcggtgc gctctctgct gcgcagccga taccgggagg
      181 tgtggccgct ggcaaccttt gtgcggcgcc tggggcccga gggcaggcgg cttgtgcaac
      241 ccggggaccc gaagatctac cgcactttgg ttgcccaatg cctagtgtgc atgcactggg
      301 gctcacagcc tccacctgcc gacctttcct tccaccaggt gtcatccctg aaagagctgg
      361 tggccagggt tgtgcagaga ctctgcgagc gcaacgagag aaacgtgctg gcttttggct
      421 ttgagctgct taacgaggcc agaggcgggc ctcccatggc cttcactagt agcgtgcgta
      481 gctacttgcc caacactgtt attgagaccc tgcgtgtcag tggtgcatgg atgctactgt
      541 tgagccgagt gggcgacgac ctgctggtct acctgctggc acactgtgct ctttatcttc
      601 tggtgccccc cagctgtgcc taccaggtgt gtgggtctcc cctgtaccaa atttgtgcca
      661 ccacggatat ctggccctct gtgtccgcta gttacaggcc cacccgaccc gtgggcagga
      721 atttcactaa ccttaggttc ttacaacaga tcaagagcag tagtcgccag gaagcaccga
      781 aacccctggc cttgccatct cgaggtacaa agaggcatct gagtctcacc agtacaagtg
      841 tgccttcagc taagaaggcc agatgctatc ctgtcccgag agtggaggag ggaccccaca
      901 ggcaggtgct accaacccca tcaggcaaat catgggtgcc aagtcctgct cggtcccccg
      961 aggtgcctac tgcagagaaa gatttgtctt ctaaaggaaa ggtgtctgac ctgagtctct
     1021 ctgggtcggt gtgctgtaaa cacaagccca gctccacatc tctgctgtca ccaccccgcc
     1081 aaaatgcctt tcagctcagg ccatttattg agaccagaca tttcctttac tccaggggag
     1141 atggccaaga gcgtctaaac ccctcattcc tactcagcaa cctccagcct aacttgactg
     1201 gggccaggag actggtggag atcatctttc tgggctcaag gcctaggaca tcaggaccac
     1261 tctgcaggac acaccgtcta tcgcgtcgat actggcagat gcggcccctg ttccaacagc
     1321 tgctggtgaa ccatgcagag tgccaatatg tcagactcct caggtcacat tgcaggtttc
     1381 gaacagcaaa ccaacaggtg acagatgcct tgaacaccag cccaccgcac ctcatggatt
     1441 tgctccgcct gcacagcagt ccctggcagg tatatggttt tcttcgggcc tgtctctgca
     1501 aggtggtgtc tgctagtctc tggggtacca ggcacaatga gcgccgcttc tttaagaact
     1561 taaagaagtt catctcgttg gggaaatacg gcaagctatc actgcaggaa ctgatgtgga
     1621 agatgaaagt agaggattgc cactggctcc gcagcagccc ggggaaggac cgtgtccccg
     1681 ctgcagagca ccgtctgagg gagaggatcc tggctacgtt cctgttctgg ctgatggaca
     1741 catacgtggt acagctgctt aggtcattct tttacatcac agagagcaca ttccagaaga
     1801 acaggctctt cttctaccgt aagagtgtgt ggagcaagct gcagagcatt ggagtcaggc
     1861 aacaccttga gagagtgcgg ctacgggagc tgtcacaaga ggaggtcagg catcaccagg
     1921 acacctggct agccatgccc atctgcagac tgcgcttcat ccccaagccc aacggcctgc
     1981 ggcccattgt gaacatgagt tatagcatgg gtaccagagc tttgggcaga aggaagcagg
     2041 cccagcattt cacccagcgt ctcaagactc tcttcagcat gctcaactat gagcggacaa
     2101 aacatcctca ccttatgggg tcttctgtac tgggtatgaa tgacatctac aggacctggc
     2161 gggcctttgt gctgcgtgtg cgtgctctgg accagacacc caggatgtac tttgttaagg
     2221 cagatgtgac cggggcctat gatgccatcc cccagggtaa gctggtggag gttgttgcca
     2281 atatgatcag gcactcggag agcacgtact gtatccgcca gtatgcagtg gtccggagag
     2341 atagccaagg ccaagtccac aagtccttta ggagacaggt caccaccctc tctgacctcc
     2401 agccatacat gggccagttc cttaagcatc tgcaggattc agatgccagt gcactgagga
     2461 actccgttgt catcgagcag agcatctcta tgaatgagag cagcagcagc ctgtttgact
     2521 tcttcctgca cttcctgcgt cacagtgtcg taaagattgg tgacaggtgc tatacgcagt
     2581 gccagggcat cccccagggc tccagcctat ccaccctgct ctgcagtctg tgtttcggag
     2641 acatggagaa caagctgttt gctgaggtgc agcgggatgg gttgctttta cgttttgttg
     2701 atgactttct gttggtgacg cctcacttgg accaagcaaa aaccttcctc agcaccctgg
     2761 tccatggcgt tcctgagtat gggtgcatga taaacttgca gaagacagtg gtgaacttcc
     2821 ctgtggagcc tggtaccctg ggtggtgcag ctccatacca gctgcctgct cactgcctgt
     2881 ttccctggtg tggcttgctg ctggacactc agactttgga ggtgttctgt gactactcag
     2941 gttatgccca gacctcaatt aagacgagcc tcaccttcca gagtgtcttc aaagctggga
     3001 agaccatgcg gaacaagctc ctgtcggtct tgcggttgaa gtgtcacggt ctatttctag
     3061 acttgcaggt gaacagcctc cagacagtct gcatcaatat atacaagatc ttcctgcttc
     3121 aggcctacag gttccatgca tgtgtgattc agcttccctt tgaccagcgt gttaggaaga
     3181 acctcacatt ctttctgggc atcatctcca gccaagcatc ctgctgctat gctatcctga
     3241 aggtcaagaa tccaggaatg acactaaagg cctctggctc ctttcctcct gaagccgcac
     3301 attggctctg ctaccaggcc ttcctgctca agctggctgc tcattctgtc atctacaaat
     3361 gtctcctggg acctctgagg acagcccaaa aactgctgtg ccggaagctc ccagaggcga
     3421 caatgaccat ccttaaagct gcagctgacc cagccctaag cacagacttt cagaccattt
     3481 tggactaacc ctgtctcctt ccgctagatg aacatgggca ttgtagcctc agcactcctg
     3541 gatccacgtc acaagaggga ctggtcagtt gtgaggctag gtcatcctcc aaacctctgt
     3601 gtcatgggtg gtatgggaga ttgtcccagt gccttgtttc ctgtaacagg cttgatttct
     3661 ttcctgatgc cctcagggag gcagatccta tcccttttag tggcagggat ccactagcac
     3721 cagcacatga ggagtgcacc cagtgcacat gggcactggg acagtggaca ggtgtgagat
     3781 tcctgggccc tggagtcttt tcacacctaa ccatggagcc tgtcccagta catcagagtg
     3841 cctcggagat gaaaaaggac atcgagccag tgacctaaat tacagcctga atatactctg
     3901 aattcatgtg actgccttag ctacttctct actgctgtgt agtaaaacac caagccaact
     3961 tataaaagca ggattttcct actggagcag cagctgagag tttacatctt gatccataag
     4021 cacaaaagca caagacagag agagagagag agagagagag agagagagag agagagagag
     4081 agagagagag agagagtcag tcagtcagtc taacaaataa ctaagaaagg tgaagggtga
     4141 tgaagtccac agggatcacg ctagggatgt tccatgcctt ctctgaagct aagattcctt
     4201 ggcagcgttt gacagtaacc atagtgggta cctactgaga tcactataaa gataaaatag
     4261 ggggaagcgt atttgtactg aactggaaaa acatacaaat aaagagtaaa tcatggaaaa
     4321 aaaaaaaaaa aaaaa
//
