LOCUS       NM_020584               3599 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus telomeric repeat binding factor 2, interacting protein
            (Terf2ip), mRNA.
ACCESSION   NM_020584
VERSION     NM_020584.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3599)
  AUTHORS   Wang,Y., Liu,S., Ni,M., Chen,Y., Chen,R., Wang,J., Jiang,W.,
            Zhou,T., Fan,S., Chang,J., Xu,X., Zhang,Y., Yu,Y., Li,X. and Li,C.
  TITLE     Terf2ip deficiency accelerates non-alcoholic steatohepatitis
            through regulating lipophagy and fatty acid oxidation via
            Sirt1/AMPK pathway
  JOURNAL   Free Radic Biol Med 220, 78-91 (2024)
   PUBMED   38697492
  REMARK    GeneRIF: Terf2ip deficiency accelerates non-alcoholic
            steatohepatitis through regulating lipophagy and fatty acid
            oxidation via Sirt1/AMPK pathway.
REFERENCE   2  (bases 1 to 3599)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3599)
  AUTHORS   Stock,A.J., McDevitt,R.A., Puligilla,C., Wang,Y., Zhang,Y.,
            Wang,K., Sun,C., Becker,K.G., Lehrmann,E., Wood,W.H. 3rd, Gong,Y.,
            Aqdas,M., Sung,M.H., Hoffmann,V., Liu,C., Gorospe,M.,
            Harrington,L., Ferrucci,L. and Liu,Y.
  TITLE     Aberrant expression and localization of the RAP1 shelterin protein
            contribute to age-related phenotypes
  JOURNAL   PLoS Genet 18 (11), e1010506 (2022)
   PUBMED   36441670
  REMARK    GeneRIF: Aberrant expression and localization of the RAP1 shelterin
            protein contribute to age-related phenotypes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3599)
  AUTHORS   Barry,R.M., Sacco,O., Mameri,A., Stojaspal,M., Kartsonis,W.,
            Shah,P., De Ioannes,P., Hofr,C., Cote,J. and Sfeir,A.
  TITLE     Rap1 regulates TIP60 function during fate transition between
            two-cell-like and pluripotent states
  JOURNAL   Genes Dev 36 (5-6), 313-330 (2022)
   PUBMED   35210222
  REMARK    GeneRIF: Rap1 regulates TIP60 function during fate transition
            between two-cell-like and pluripotent states.
REFERENCE   5  (bases 1 to 3599)
  AUTHORS   Cai,Y., Liu,H., Song,E., Wang,L., Xu,J., He,Y., Zhang,D., Zhang,L.,
            Cheng,K.K., Jin,L., Wu,M., Liu,S., Qi,D., Zhang,L., Lopaschuk,G.D.,
            Wang,S., Xu,A. and Xia,Z.
  TITLE     Deficiency of telomere-associated repressor activator protein 1
            precipitates cardiac aging in mice via p53/PPARalpha signaling
  JOURNAL   Theranostics 11 (10), 4710-4727 (2021)
   PUBMED   33754023
  REMARK    GeneRIF: Deficiency of telomere-associated repressor activator
            protein 1 precipitates cardiac aging in mice via p53/PPARalpha
            signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3599)
  AUTHORS   Celli,G.B. and de Lange,T.
  TITLE     DNA processing is not required for ATM-mediated telomere damage
            response after TRF2 deletion
  JOURNAL   Nat Cell Biol 7 (7), 712-718 (2005)
   PUBMED   15968270
REFERENCE   7  (bases 1 to 3599)
  AUTHORS   Liu,D., O'Connor,M.S., Qin,J. and Songyang,Z.
  TITLE     Telosome, a mammalian telomere-associated complex formed by
            multiple telomeric proteins
  JOURNAL   J Biol Chem 279 (49), 51338-51342 (2004)
   PUBMED   15383534
REFERENCE   8  (bases 1 to 3599)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 3599)
  AUTHORS   Tarsounas,M., Munoz,P., Claas,A., Smiraldo,P.G., Pittman,D.L.,
            Blasco,M.A. and West,S.C.
  TITLE     Telomere maintenance requires the RAD51D recombination/repair
            protein
  JOURNAL   Cell 117 (3), 337-347 (2004)
   PUBMED   15109494
REFERENCE   10 (bases 1 to 3599)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY129872.1, AK148537.1 and AK148508.1.
            
            On Nov 22, 2007 this sequence version replaced NM_020584.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148508.1, AK148537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY129872.1         1-39
            40-3593             AK148537.1         2-3555
            3594-3599           AK148508.1         3553-3558
FEATURES             Location/Qualifiers
     source          1..3599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 58.29 cM"
     gene            1..3599
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
                     /note="telomeric repeat binding factor 2, interacting
                     protein"
                     /db_xref="GeneID:57321"
                     /db_xref="MGI:MGI:1929871"
     exon            1..784
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1305
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
                     /note="TRF2-interacting telomeric protein Rap1; RAP1
                     homolog; TRF2-interacting telomeric protein 1;
                     TERF2-interacting telomeric protein 1; repressor/activator
                     protein 1 homolog"
                     /codon_start=1
                     /product="telomeric repeat-binding factor 2-interacting
                     protein 1"
                     /protein_id="NP_065609.2"
                     /db_xref="CCDS:CCDS52678.1"
                     /db_xref="GeneID:57321"
                     /db_xref="MGI:MGI:1929871"
                     /translation="MAEAMDLGKDPNGPTHSSTLFVREDGSAMSFYVRPSSAKRRLST
                     LILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVDRNEKLDLEAYRLG
                     LTEQASDPKPGASTEGSTEPEPQPLTGRIAYTDAEDVAILTYVKENARSPSSVTGNAL
                     WKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGNAPVSPSSQKLKRKAEQDPEAAD
                     SGEPQNKRAPDLPEEECVKGEIKENGEADNKLFEEAAPEFGEAVVDESPDFEIHITMC
                     DGDPPTPEEDSETQPDEEEEEPKVSTQEVGTAIKVIRQLMEKFNLDLSTVTQALLKNS
                     GELEATSSFLESGRRPDGYPIWCRQDDLDLQKDDDDTKNALVKKFGAQNVARRIEFRK
                     K"
     exon            785..909
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..3599
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2245..2250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
                     /note="hexamer: AATAAA"
     polyA_site      2272
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
                     /note="major polyA site"
     regulatory      3580..3585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
                     /note="hexamer: AATAAA"
     polyA_site      3598
                     /gene="Terf2ip"
                     /gene_synonym="Rap1"
ORIGIN      
        1 gggaaagagg gcgggccctc ggccggactc tcgctgcgca ggcgcagtgc tgggctcctc
       61 cggcggagag tccgtcttag tggtgtcgtt tctgcgcttt acttgtacag cggggcgaca
      121 ggtatggcgg aggcgatgga tctgggtaaa gaccccaatg ggcccactca ctcctccact
      181 ctgttcgtga gagaagacgg cagcgccatg tcgttttacg tgcggcccag ctcggccaag
      241 cgccggctgt cgacgctcat cctgcacggc ggcggcaccg tgtgtcgggt gcaggaaccc
      301 ggagccgtgc ttctcgccca gcccggggag gcgctggccg aggcttcggg cgacttcatc
      361 tccacgcagt acatcctaga ctgcgtggat cgcaacgaga agctggacct ggaggcctat
      421 cggctgggcc tgacggagca ggcgtccgat ccgaagcccg gggcttccac cgagggctcc
      481 acggaaccgg agccgcagcc cctgaccggg cgcatcgcct acaccgacgc ggaagatgtg
      541 gccatcctga cctacgtgaa ggagaacgcc cgttcgccca gctcggtcac aggcaatgcc
      601 ttgtggaaag cgatggagaa gagctcgctc acgcagcact cctggcagtc gctcaaggac
      661 cgctacctca agcacctacg gggtcaggag cacaagtacc tgctcgggaa cgccccggtc
      721 agcccgtcct cccagaagct caaacggaag gcggagcagg accccgaggc cgcggatagc
      781 ggagagccac agaacaagag agcgccagac ttgcctgagg aggagtgtgt gaaaggagag
      841 atcaaggaga atggagaggc agacaacaag ctgtttgagg aagccgctcc ggagttcgga
      901 gaagccgtgg tggatgagag ccctgacttt gaaatacata taacgatgtg tgatggtgat
      961 ccacccacac ccgaggaaga ctcagaaaca cagccagacg aggaggaaga agaaccaaaa
     1021 gtttctacgc aagaagtggg aactgccatt aaggtgatcc ggcagctaat ggagaagttc
     1081 aacttggatc tatcaacagt tacacaggcc ttgctgaaga acagtggtga gctggaggcc
     1141 acgtcctcct tcttagagtc ggggcggaga cccgacggtt atcccatttg gtgcagacaa
     1201 gatgacttag atttgcagaa ggacgatgac gacacgaaaa atgcactggt caaaaagttt
     1261 ggagctcaga acgttgctcg gaggattgaa ttccgaaaga aataaacaga caagaggatg
     1321 gaaaagatag gtgatgatgt aagcacctgt gaccattgac accgaccagc aggcgatcgt
     1381 gtcagcacca gtggccagtg accccgccgg tgctgctgta gccacgcagt gtaatgtagc
     1441 aggataaaac aaaagacact ggaattagag ccgtccatgg caagtatccc ctgtttatga
     1501 taggcaaatc taagccagag aggttggtct gtgtactagt catttttgga tggactgtgt
     1561 cccccgttgt acaggtgcca ggagccaagt gacaaagtca aagttggaaa tgaaagggca
     1621 tttgacttgg tgagggaata attcttgtct tttggcagaa gttgctttag ctggagggtc
     1681 ccaaaccaag agtctagaag aacgatttag ttgcagagct tgtaccatga ctcccaaact
     1741 atcccatccc ccagggacct ctggattctg tgttgactga gttgaaaaac cccatagtca
     1801 tcttgctata aatctttgaa atctcttctt cttccttggc tgttgctttt tgactctgag
     1861 tcaagtctct atagaacata cttgcttact taccactcag ttttgtgtac ataaagccct
     1921 aggcttgaag gagcttccat cctttgtaca ttataaatga tgtcatgtac aaacttcaca
     1981 gtcaagaatc aaaggaaaaa atcaagttac acacacacac acacacacac acacacacac
     2041 agtcttaaaa ctctgttcta gaaggctgtg attcagtgtc tcacccttgt agctatcctc
     2101 ggacactgtt ggttggatac tgttaattgt gatatgtcaa ttttaaaatt atgtggaaca
     2161 tacgttttct gctgaaaatt atgctagact taaaattgag tggccttggt ccactttgct
     2221 gtgttgtttt tgtcattgaa aataaataaa actttgtgtt gagtcttgtc aacaagcatt
     2281 ttctttgatt ttatatagga aacagtttag gtaaattttc attttagaat taataagcct
     2341 tgaaaagatg atcctctagg tggagtgaag ggaggatgtg tctcagtcag ggtttgtata
     2401 cctgcacaaa acaccatgac caagaagcaa gttggggagg aaagggttta ttcagtttac
     2461 acttccacat tgctgttcat caccaaagga agtcaggact ggacctcaca cagggcagga
     2521 acctggaggc aggaactgat gcagaggcca tggaaggtgc tggttcctgg attgctttcc
     2581 ctggcttgct cagcttttct tcttgtagaa cccaaaccac ccaacagccc tccccctttg
     2641 atcaataatt gagaaaatgc cttacagctg gatctcgtga agccgtttcc tcaaaggagg
     2701 ctcctttccc tgtgaaaact ccagcttgtg tcaggttgac gcacaaaacc agccggtacc
     2761 gtgtgcatca gaactatgaa aagaggcaga atcagttgaa attctgcgag ttgaagagaa
     2821 gcaagccaga ggtgtgtcac aggtgtgagc cccatctcca gcagtctgga cactcaaact
     2881 tcacactcac caacaggaat ctgatacgtg tctacgcgaa gcattctaga gttaatgtct
     2941 tagttttagg taatcttaaa acttagtttt agtttttagt ttacctaaaa ctagtcttag
     3001 ttttaggtaa tcaaaggatg tgagaacaga ggtctcctgt ttaccaccta agtgtatttt
     3061 ggaactagat gcactgaaaa aaaaaaggtt gtttgtttag agagaggaac ttatgtcttc
     3121 tactttctaa aaaacttcta gtagagtctg gtataagtga aatgtttaac ctgagccctt
     3181 ttctgaggat gttttaggca tgtgacacac gtcagtaatg taattctcac tactctggtg
     3241 actaagatgg gaattgagag gggttatatg gtacgatttg tttaaaatgt gtactctttt
     3301 tgataggact ctaaaatggt tcaaaattaa ctgtcttaag ggctggagag atggctcagt
     3361 ggttaagagc actgtctgct cttccagagg tcctgagttc aaatcccagc aaccacatgg
     3421 tggctcacaa ccatctgtaa tggggtccga tgcacacttc tggtgtgtgt ctgaagacag
     3481 ctactgtgta ctcgtataaa taaaaataaa tctttaaaaa aaaaaagaaa attctgtttt
     3541 tgtaaaaaaa aaaaagacag ctacagtgta cttacatata ataaataaat ctttaaaag
//
