LOCUS       NM_001371065            2672 bp    mRNA    linear   ROD 12-OCT-2024
DEFINITION  Mus musculus telomeric repeat binding factor 2 (Terf2), transcript
            variant 5, mRNA.
ACCESSION   NM_001371065 XM_006530836
VERSION     NM_001371065.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Gao,S., Huang,S., Xu,Y., Wang,B., Cheng,P., Lu,Y., Gilson,E. and
            Ye,J.
  TITLE     Role of the telomeric factor TRF2 in post-hypoxic brain damages
  JOURNAL   Redox Biol 75, 103278 (2024)
   PUBMED   39128227
  REMARK    GeneRIF: Role of the telomeric factor TRF2 in post-hypoxic brain
            damages.
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Sullivan,D.I., Bello,F.M., Silva,A.G., Redding,K.M., Giordano,L.,
            Hinchie,A.M., Loughridge,K.E., Mora,A.L., Konigshoff,M.,
            Kaufman,B.A., Jurczak,M.J. and Alder,J.K.
  TITLE     Intact mitochondrial function in the setting of telomere-induced
            senescence
  JOURNAL   Aging Cell 22 (10), e13941 (2023)
   PUBMED   37688329
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Tanno,N., Takemoto,K., Takada-Horisawa,Y., Shimada,R., Fujimura,S.,
            Tani,N., Takeda,N., Araki,K. and Ishiguro,K.I.
  TITLE     FBXO47 is essential for preventing the synaptonemal complex from
            premature disassembly in mouse male meiosis
  JOURNAL   iScience 25 (4), 104008 (2022)
   PUBMED   35310947
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   Sepe,S., Rossiello,F., Cancila,V., Iannelli,F., Matti,V., Cicio,G.,
            Cabrini,M., Marinelli,E., Alabi,B.R., di Lillo,A., Di Napoli,A.,
            Shay,J.W., Tripodo,C. and d'Adda di Fagagna,F.
  TITLE     DNA damage response at telomeres boosts the transcription of
            SARS-CoV-2 receptor ACE2 during aging
  JOURNAL   EMBO Rep 23 (2), e53658 (2022)
   PUBMED   34854526
REFERENCE   5  (bases 1 to 2672)
  AUTHORS   Kaur,P., Barnes,R., Pan,H., Detwiler,A.C., Liu,M., Mahn,C.,
            Hall,J., Messenger,Z., You,C., Piehler,J., Smart,R.C., Riehn,R.,
            Opresko,P.L. and Wang,H.
  TITLE     TIN2 is an architectural protein that facilitates TRF2-mediated
            trans- and cis-interactions on telomeric DNA
  JOURNAL   Nucleic Acids Res 49 (22), 13000-13018 (2021)
   PUBMED   34883513
  REMARK    GeneRIF: TIN2 is an architectural protein that facilitates
            TRF2-mediated trans- and cis-interactions on telomeric DNA.
REFERENCE   6  (bases 1 to 2672)
  AUTHORS   Abmayr,S., Crawford,R.W. and Chamberlain,J.S.
  TITLE     Characterization of ARC, apoptosis repressor interacting with CARD,
            in normal and dystrophin-deficient skeletal muscle
  JOURNAL   Hum Mol Genet 13 (2), 213-221 (2004)
   PUBMED   14645204
REFERENCE   7  (bases 1 to 2672)
  AUTHORS   Smogorzewska,A. and de Lange,T.
  TITLE     Different telomere damage signaling pathways in human and mouse
            cells
  JOURNAL   EMBO J 21 (16), 4338-4348 (2002)
   PUBMED   12169636
REFERENCE   8  (bases 1 to 2672)
  AUTHORS   Zhu,L., Hathcock,K.S., Hande,P., Lansdorp,P.M., Seldin,M.F. and
            Hodes,R.J.
  TITLE     Telomere length regulation in mice is linked to a novel chromosome
            locus
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8648-8653 (1998)
   PUBMED   9671732
REFERENCE   9  (bases 1 to 2672)
  AUTHORS   Sakaguchi,A.Y., Padalecki,S.S., Mattern,V., Rodriguez,A.,
            Leach,R.J., McGill,J.R., Chavez,M. and Giambernardi,T.A.
  TITLE     Chromosomal sublocalization of the transcribed human telomere
            repeat binding factor 2 gene and comparative mapping in the mouse
  JOURNAL   Somat Cell Mol Genet 24 (3), 157-163 (1998)
   PUBMED   10226653
REFERENCE   10 (bases 1 to 2672)
  AUTHORS   Broccoli,D., Smogorzewska,A., Chong,L. and de Lange,T.
  TITLE     Human telomeres contain two distinct Myb-related proteins, TRF1 and
            TRF2
  JOURNAL   Nat Genet 17 (2), 231-235 (1997)
   PUBMED   9326950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123868.4.
            
            On Jun 26, 2019 this sequence version replaced XM_006530836.3.
            
            Transcript Variant: This variant (5) represents the longest
            transcript and encodes the longest isoform (5).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.1090998.1,
                                           SRR7345562.3318040.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               AC123868.4         120284-120710       c
            428-523             AC123868.4         120091-120186       c
            524-654             AC123868.4         118984-119114       c
            655-741             AC123868.4         107145-107231       c
            742-888             AC123868.4         105255-105401       c
            889-989             AC123868.4         103531-103631       c
            990-1379            AC123868.4         100772-101161       c
            1380-1465           AC123868.4         96722-96807         c
            1466-1506           AC123868.4         96037-96077         c
            1507-2672           AC123868.4         93562-94727         c
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.59 cM"
     gene            1..2672
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /note="telomeric repeat binding factor 2"
                     /db_xref="GeneID:21750"
                     /db_xref="MGI:MGI:1195972"
     exon            1..427
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1665
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     telomeric DNA-binding protein; TTAGGG repeat-binding
                     factor 2"
                     /codon_start=1
                     /product="telomeric repeat-binding factor 2 isoform 5"
                     /protein_id="NP_001357994.1"
                     /db_xref="CCDS:CCDS90457.1"
                     /db_xref="GeneID:21750"
                     /db_xref="MGI:MGI:1195972"
                     /translation="MAAGAGTAGPASGPGVVRDPMASQPRKRPSREGGEGGEGERRSN
                     TMAGGGGSSDSSGRAASRRASRSGGRARRGRHEPGLGGAAERGAGEARLEEAVNRWVL
                     KFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGEN
                     LDCSFDMEAELTPLESAINVLEMIKTEFTLTDSMVESSRKLVKEAAVIICIKNKEFEK
                     ASKILKKYMSKDPTTQKLRTDLLNIIREKNLAHPVIQNFSYEVFQQKMLRFLESHLDD
                     TEPYLLTMAKKALKSESAASSTMREEKHPEPVEKPLREPPSRQPQNPPATIGIRTLKA
                     AFKALSTAQDSEAAFAKLDQKDLVLANLASPSSPAHKHKRPRKDEHESAAPAEGEGGS
                     DRQPRNSPMTISRLLLEEDSQSTEPSPGLNSSHKAMSASKPRALNQPHPGEKKPKASK
                     DKWNSPNGLEEKEVWLEEDQLFEVQAPGEDRSSSLTRKQKWTIEESEWVKDGVRKYGE
                     GNWAAISKSYPFVNRTAVMIKDRWRTMKKLGMN"
     exon            428..523
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..654
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..741
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..888
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..989
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1379
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1465
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1506
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..2672
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2651..2656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2672
                     /gene="Terf2"
                     /gene_synonym="TRF2"
                     /note="major polyA site"
ORIGIN      
        1 cccagaagcc cgcgggcggc tcggaacccc gtcggtatca tggctgcggg agccgggaca
       61 gcgggccctg cttccggccc gggcgttgtg cgtgacccga tggcgtcaca gccaaggaaa
      121 cggcccagtc gggagggcgg ggagggcggg gagggcgagc ggcggtcgaa cacgatggcg
      181 ggaggaggcg ggagcagcga tagcagcggg cgggcggcga gccgacgggc atcgcgcagc
      241 ggcgggcggg ctcgacgggg gcgacacgag ccagggttgg gaggcgcggc cgagcggggc
      301 gcgggggaag ctcgcctgga ggaggcggtc aaccgctggg tgctcaagtt ctatttccac
      361 gaggcgctgc gggcctttcg gagtagccgg taccgggact tcaggcagat ccgggacatc
      421 atgcaggcgt tgcttgtcag gcccttgggg aaggagcata cggtgtcccg gttgctgcgg
      481 gttatgcagt gtctgtcgcg cattgaagaa ggagaaaatt tagactgttc ctttgatatg
      541 gaggctgagc tcacaccctt ggaatcagct atcaatgtgc tggagatgat taaaacagag
      601 ttcacactga cagactctat ggttgaatcc agcagaaaac tggtcaagga ggctgctgtc
      661 attatttgta tcaaaaacaa agaatttgaa aaggcttcaa agattttgaa aaaatacatg
      721 tctaaggacc ccacaactca gaagctgaga actgatctcc tgaacattat ccgggaaaag
      781 aacttggccc accctgttat ccagaacttt tcctatgagg tcttccagca gaagatgctg
      841 cgtttcctag agagccacct ggatgacacg gagccctacc tcctcacgat ggctaaaaaa
      901 gctttgaaat ctgaatcagc tgcttcaagt acaatgaggg aagaaaagca cccagagcca
      961 gtggaaaaac cacttagaga gcctccaagc agacagcctc agaaccctcc agccaccatc
     1021 gggatcagga ctctgaaggc agctttcaaa gctctgtcta ctgcacaaga ctcagaggcc
     1081 gcttttgcaa aactggacca gaaagatctg gtacttgcta atctggcatc cccatcatca
     1141 ccagcccaca aacacaagag acccaggaaa gatgaacatg aaagcgcagc tcctgctgag
     1201 ggtgagggag gctcagaccg gcagcccagg aacagtccca tgacaataag cagattgctg
     1261 ttggaggagg acagccagag tactgagccc agcccaggcc tcaactcctc ccacaaggcc
     1321 atgtcagcat ccaagcccag agctctcaac caaccccacc cgggggagaa gaagcccaaa
     1381 gcatccaaag acaagtggaa cagccctaac gggcttgaag aaaaggaagt ttggttggaa
     1441 gaggaccagc tgtttgaagt tcaggcacca ggtgaagaca ggtcatccag tttaacaaga
     1501 aagcagaagt ggaccataga agaaagcgag tgggtgaagg atggagtgcg caaatacggg
     1561 gaaggaaact gggctgccat ttctaaaagt tacccctttg tcaaccgaac agctgtgatg
     1621 attaaagacc gctggcggac catgaaaaaa cttggcatga actgagaaag ggtttcgtag
     1681 ccacaggact cacaagaaca cggttctcaa cagtagcccc tgtgctgtga cgcctctttc
     1741 agaagcggga ctgcgatgag aattgtggca tcatcctcct gagtcggagg tcccgggacc
     1801 ctcccgtcac tgttgctgga gatcatggag ctaaaaagca aagccaggac tagccgtgac
     1861 cacagccgag gcaacaggca ggcccacggc tgggacagtg ccagaagatc attagtgttt
     1921 ccctttagtg ctttgcttca atttgaatcc ctagtattcc gtaaaatctt ccaagaaatg
     1981 atagaatcca ttaggagcac atacgatctc atgacctgta aaaaccagaa atgtgaacgt
     2041 taccgggaat gaatttaatc ctcgttgagt ttcagtacaa aagagctctg tatgttgagc
     2101 ccagatgaga gattttttca gtccctgtgg aatcagattc ttttaaaaaa aaaaaaggaa
     2161 aaaaaactgt tcagctactt gcgaccaccc tggacctgcc tgcctcagcc cccacattga
     2221 tgaatgctag gctacatggc gggttcatcc accacacttc tcacggggtc ggggtcggac
     2281 aagtggtgtt tggttaaatg gtgattgtag ataagcttag ccgccccttc cctcctccgc
     2341 ccaccccttt ctcggagccc ttccttatgc tggactttta aagcgtaaaa atcatttgtt
     2401 gagtatcatg cctaactccc cctgtgatac agttgctccc cgcctccctg gtcttgcttt
     2461 gttcatgtcg tgccccaaac tctgctctcc cttctccttt tgtactgtgt tgtgcttgct
     2521 gtctctcaga cacccttaca gactgtcttt ttagcaaaaa caaaaacaac agaaaaaaaa
     2581 ttgagtcaag tgttttctgt aatctttttt taaatctgag aatgagttgt tcctacttgt
     2641 aacgttcttc attaaagtct tgcttctctc aa
//
