LOCUS       NM_009352               2268 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus telomeric repeat binding factor 1 (Terf1), transcript
            variant 1, mRNA.
ACCESSION   NM_009352
VERSION     NM_009352.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2268)
  AUTHORS   Pineiro-Hermida S, Martinez P, Bosso G, Flores JM, Saraswati S,
            Connor J, Lemaire R and Blasco MA.
  TITLE     Consequences of telomere dysfunction in fibroblasts, club and basal
            cells for lung fibrosis development
  JOURNAL   Nat Commun 13 (1), 5656 (2022)
   PUBMED   36202783
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2268)
  AUTHORS   Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R, Fujimura S, Tani
            N, Takeda N, Araki K and Ishiguro KI.
  TITLE     FBXO47 is essential for preventing the synaptonemal complex from
            premature disassembly in mouse male meiosis
  JOURNAL   iScience 25 (4), 104008 (2022)
   PUBMED   35310947
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2268)
  AUTHORS   Solek P, Mytych J, Tabecka-Lonczynska A and Koziorowski M.
  TITLE     Molecular Consequences of Depression Treatment: A Potential In
            Vitro Mechanism for Antidepressants-Induced Reprotoxic Side Effects
  JOURNAL   Int J Mol Sci 22 (21), 11855 (2021)
   PUBMED   34769286
  REMARK    GeneRIF: Molecular Consequences of Depression Treatment: A
            Potential In Vitro Mechanism for Antidepressants-Induced Reprotoxic
            Side Effects.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2268)
  AUTHORS   Chen B, Zhu G, Yan A, He J, Liu Y, Li L, Yang X, Dong C and Kee K.
  TITLE     IGSF11 is required for pericentric heterochromatin dissociation
            during meiotic diplotene
  JOURNAL   PLoS Genet 17 (9), e1009778 (2021)
   PUBMED   34491997
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2268)
  AUTHORS   Beier F, Foronda M, Martinez P and Blasco MA.
  TITLE     Conditional TRF1 knockout in the hematopoietic compartment leads to
            bone marrow failure and recapitulates clinical features of
            dyskeratosis congenita
  JOURNAL   Blood 120 (15), 2990-3000 (2012)
   PUBMED   22932806
  REMARK    GeneRIF: Loss of TRF1 leads to bone marrow failure and
            recapitulates clinical features of dyskeratosis congenita.
REFERENCE   6  (bases 1 to 2268)
  AUTHORS   Iwano T, Tachibana M, Reth M and Shinkai Y.
  TITLE     Importance of TRF1 for functional telomere structure
  JOURNAL   J Biol Chem 279 (2), 1442-1448 (2004)
   PUBMED   14559908
  REMARK    GeneRIF: TRF1 interacts with other telomere-binding molecules and
            integrates into the functional telomere structure
REFERENCE   7  (bases 1 to 2268)
  AUTHORS   Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T
            and de Lange T.
  TITLE     Targeted deletion reveals an essential function for the telomere
            length regulator Trf1
  JOURNAL   Mol Cell Biol 23 (18), 6533-6541 (2003)
   PUBMED   12944479
  REMARK    GeneRIF: Here we show that targeted deletion of exon 1 of the mouse
            gene encoding Trf1 causes early (day 5 to 6 postcoitus) embryonic
            lethality.These data suggest that murine Trf1 has an essential
            function that is independent of telomere length regulation
REFERENCE   8  (bases 1 to 2268)
  AUTHORS   Smith S and de Lange T.
  TITLE     TRF1, a mammalian telomeric protein
  JOURNAL   Trends Genet 13 (1), 21-26 (1997)
   PUBMED   9009844
  REMARK    Review article
REFERENCE   9  (bases 1 to 2268)
  AUTHORS   Broccoli D, Chong L, Oelmann S, Fernald AA, Marziliano N, van
            Steensel B, Kipling D, Le Beau MM and de Lange T.
  TITLE     Comparison of the human and mouse genes encoding the telomeric
            protein, TRF1: chromosomal localization, expression and conserved
            protein domains
  JOURNAL   Hum Mol Genet 6 (1), 69-76 (1997)
   PUBMED   9002672
REFERENCE   10 (bases 1 to 2268)
  AUTHORS   Chong L, van Steensel B, Broccoli D, Erdjument-Bromage H, Hanish J,
            Tempst P and de Lange T.
  TITLE     A human telomeric protein
  JOURNAL   Science 270 (5242), 1663-1667 (1995)
   PUBMED   7502076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB652245.1, BC034866.1,
            BG073357.2 and AC109269.17.
            
            [WARNING] On May 3, 2023 this sequence was replaced by NM_009352.4.
            
            On Nov 13, 2013 this sequence version replaced NM_009352.2.
            
            Summary: This gene encodes a protein that binds to repeats in
            telomeres to form a nucleoprotein complex that protects against the
            degradation of chromosomal ends. The encoded protein regulates the
            length of telomeres and is an integral structural component of the
            functional telomere. This protein is thought to play a role in
            spindle formation in mitosis. Mutations in this gene are associated
            with bone marrow failure. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034866.1, U65586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BB652245.1         2-13
            13-1645             BC034866.1         1-1633
            1646-2121           BG073357.2         1-476               c
            2122-2268           AC109269.17        74748-74894         c
FEATURES             Location/Qualifiers
     source          1..2268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 4.88 cM"
     gene            1..2268
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /note="telomeric repeat binding factor 1"
                     /db_xref="GeneID:21749"
                     /db_xref="MGI:MGI:109634"
     exon            1..312
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1298
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TTAGGG repeat-binding factor 1"
                     /codon_start=1
                     /product="telomeric repeat-binding factor 1 isoform 1"
                     /protein_id="NP_033378.1"
                     /db_xref="CCDS:CCDS14827.1"
                     /db_xref="GeneID:21749"
                     /db_xref="MGI:MGI:109634"
                     /translation="MAETVSSAARDAPSREGWTDSDSPEQEEVGDDAELLQCQLQLGT
                     PREMENAELVAEVEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRDSAEAIIHGLHRL
                     TAYQLKTVYICQFLTRVASGKALDAQFEVDERITPLESALMIWNSIEKEHDKLHDEIK
                     NLIKIQAVAVCMEIGSFKEAEEVFERIFGDPEFYTPLERKLLKIISQKDVFHSLFQHF
                     SYSCMMEKIQSYVGDVLSEKSSTFLMKAATKVVENEKARTQASKDRPDATNTGMDTEV
                     GLNKEKSVNGQQSTETEPLVDTVSSIRSHKNALSQLKHRRAPSDFSRNEARTGTLQCE
                     TTMERNRRTSGRNRLCVSENQPDTDDKSGRRKRQTWLWEEDRILKCGVKKYGEGNWAK
                     ILSHYKFNNRTSVMLKDRWRTMKRLKLIS"
     exon            313..408
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..530
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..617
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..767
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..880
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..940
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1029
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1136
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..2268
                     /gene="Terf1"
                     /gene_synonym="Pin2; Trbf1; Trf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgaggca cggcgagcgc tttcggttta acatggcgga gacggtctcc tcagcggccc
       61 gggacgcgcc gagccgtgag ggctggacag attcggattc tccagagcag gaggaggtgg
      121 gagacgacgc ggagctgctc cagtgccagc ttcagctggg gaccccgaga gagatggaga
      181 acgcggagct tgtggctgag gtggaggccg tggctgcggg ctggatgctc gacttcctct
      241 gcctgtctct gtgccgagcc ttccgtgacg gccgctccga ggactttcgt cgtactcgtg
      301 acagcgccga ggctattatt catggactac acagacttac agcttaccaa ttgaaaactg
      361 tgtatatatg tcagtttttg acaagagttg catctggaaa ggcccttgat gcacagtttg
      421 aagttgatga gcgtattaca cccttggaat cagccctgat gatttggaac tcaattgaaa
      481 aggaacatga caaactgcat gacgaaataa agaatttaat taaaattcag gctgtagctg
      541 tttgtatgga aattggcagc tttaaggaag cagaagaagt atttgaaaga atatttggtg
      601 atccagaatt ttacacgcct ttagaaagga agttacttaa gataatctct cagaaggatg
      661 tgttccactc ccttttccaa cacttcagct atagctgcat gatggagaaa attcagagtt
      721 atgtgggtga tgtgttaagt gaaaaatcat caacttttct aatgaaggca gcaacaaaag
      781 tagtggaaaa tgagaaagcg aggacacaag cgtctaagga taggccagat gccaccaaca
      841 ctggaatgga cactgaagtt ggtttgaata aagagaaaag tgttaatggc cagcagtcta
      901 cagaaactga acccttagtg gatacagtat cctcaataag gtctcacaag aacgccttat
      961 cgcagttaaa acacagacgt gctccatcag atttcagtag gaacgaagca agaacaggaa
     1021 ctcttcagtg tgaaacaacg atggaaagga accgaagaac cagtggaagg aatagattgt
     1081 gtgtctcaga gaatcagcca gacactgatg acaaaagtgg acgcaggaaa agacagacat
     1141 ggctttggga agaagacaga attttgaagt gtggtgtaaa gaaatatgga gagggaaatt
     1201 gggctaaaat actatcccat tataagttca acaaccgaac aagtgtcatg ttaaaagata
     1261 gatggagaac aatgaagaga ctgaaactga ttagctgaga cactggaggc tggatgggtt
     1321 tgattcagct taatacaagg ataaatactt ggatcactac actttgttta caatttcctg
     1381 gtcagtaatg ataaagcatt atggtggtgg tggggcagtg aggaggggga agagaaagag
     1441 agtttttgtt tttttggttt ttgtttgttt gtttgtttgt ttgtttttta gaggagattt
     1501 gtgctttaaa tctatgtcat cattattttc tgaatcttta tttttgtaaa atatagatat
     1561 gttgaaccct accaaattca gtaccccatc ccatattctg ttttaataca aaagagtcta
     1621 ataagattaa atgaatatat gactatttac ggtttgttct attccatgtc tataaactaa
     1681 cctcacaaaa tgccacctag cattgagttt tctgaagaac ttaattggaa taatccttga
     1741 tgtgacttta ctgctggatc tatggctaat gtactactta ctaaagatct attactagag
     1801 aggtattcaa aacaactcat gagttctaac aagcctagct tggcttctct caaaagtttc
     1861 atttaaagga agttgagttt tcaccaaaaa tgtattcatt gcaatattta atcaaagact
     1921 aattaataat tagcatttga gttttatgtg ccatatttaa caagtaaaaa ataagtctcg
     1981 gccgggtgtg gtggcgcagg cctttaatcc cagcactcgg gaggcagagg caggtagatt
     2041 tctgagtttg aggccagcct ggtcttcaga gtgagttcca ggacagccag ggctacacag
     2101 agaaaccttg tctcaaaaac caaaaaaaaa aaaagtctca acctattgaa atatttatga
     2161 gaaagtcagc attgtgtatt tccttcaaag tgttgtgcat tgctttcctg ttctcttgaa
     2221 tttgctgcct tatatatata ataaacagaa gcattagtgg ttgctgta
//
