LOCUS       NM_180958               2950 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus telomere repeat binding bouquet formation protein 1
            (Terb1), mRNA.
ACCESSION   NM_180958
VERSION     NM_180958.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2950)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2950)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2950)
  AUTHORS   Zhang,K., Tarczykowska,A., Gupta,D.K., Pendlebury,D.F.,
            Zuckerman,C., Nandakumar,J. and Shibuya,H.
  TITLE     The TERB1 MYB domain suppresses telomere erosion in meiotic
            prophase I
  JOURNAL   Cell Rep 38 (4), 110289 (2022)
   PUBMED   35081355
REFERENCE   4  (bases 1 to 2950)
  AUTHORS   da Cruz,I., Brochier-Armanet,C. and Benavente,R.
  TITLE     The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back
            to the common ancestor of metazoans
  JOURNAL   BMC Evol Biol 20 (1), 55 (2020)
   PUBMED   32408858
  REMARK    GeneRIF: The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres
            dates back to the common ancestor of metazoans.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2950)
  AUTHORS   Wang,Y., Chen,Y., Chen,J., Wang,L., Nie,L., Long,J., Chang,H.,
            Wu,J., Huang,C. and Lei,M.
  TITLE     The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the
            nuclear envelope
  JOURNAL   Nat Commun 10 (1), 564 (2019)
   PUBMED   30718482
  REMARK    GeneRIF: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to
            the nuclear envelope
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2950)
  AUTHORS   Shibuya,H., Hernandez-Hernandez,A., Morimoto,A., Negishi,L.,
            Hoog,C. and Watanabe,Y.
  TITLE     MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging
            Telomere Cap
  JOURNAL   Cell 163 (5), 1252-1266 (2015)
   PUBMED   26548954
  REMARK    Erratum:[Cell. 2018 May 3;173(4):1058. doi:
            10.1016/j.cell.2018.04.025.. PMID: 29727665]
REFERENCE   7  (bases 1 to 2950)
  AUTHORS   Daniel,K., Trankner,D., Wojtasz,L., Shibuya,H., Watanabe,Y.,
            Alsheimer,M. and Toth,A.
  TITLE     Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated
            protein
  JOURNAL   BMC Cell Biol 15, 17 (2014)
   PUBMED   24885367
  REMARK    GeneRIF: The coiled-coil-domain containing protein 79 (CCDC79) is a
            meiosis specific telomere-associated protein in mice.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2950)
  AUTHORS   Shibuya,H., Ishiguro,K. and Watanabe,Y.
  TITLE     The TRF1-binding protein TERB1 promotes chromosome movement and
            telomere rigidity in meiosis
  JOURNAL   Nat Cell Biol 16 (2), 145-156 (2014)
   PUBMED   24413433
REFERENCE   9  (bases 1 to 2950)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 2950)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029754.1 and AC130543.3.
            
            On Jan 7, 2010 this sequence version replaced NM_180958.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029754.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849380 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-849               AK029754.1         2-850
            850-850             AC130543.3         58452-58452
            851-2588            AK029754.1         852-2589
            2589-2950           AC130543.3         106314-106675
FEATURES             Location/Qualifiers
     source          1..2950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2950
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /note="telomere repeat binding bouquet formation protein
                     1"
                     /db_xref="GeneID:320022"
                     /db_xref="MGI:MGI:2443187"
     exon            1..86
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            87..193
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            194..250
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..2526
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /note="coiled-coil domain-containing protein 79;
                     coiled-coil domain containing 79"
                     /codon_start=1
                     /product="telomere repeats-binding bouquet formation
                     protein 1"
                     /protein_id="NP_851289.2"
                     /db_xref="CCDS:CCDS22580.1"
                     /db_xref="GeneID:320022"
                     /db_xref="MGI:MGI:2443187"
                     /translation="MESEKPKKTQEMKTDLKLLLECLKYHMGNPLSQKEVLITIHSVC
                     KQNSDAGIYFREIGGLMFIINLAKSSEQSLVKEAALYTLGSIAEENVYCQQSLCTSEL
                     FQDLTGLLTNDDSNTNLKRMSVYVLLVLVSNNRNGQTLVREVGCIEVLSQMFRTVLSN
                     YELNLSDNSVFQSYLLWSSVCSTLCVCVNNPQNDENQMLCCSLFPCVNEWLMNCMRPE
                     VIRPICSFIGLTLANNTHAQNCFVSSGGLDVLCQVLVQLESDSHNTLSSAKLAVIVTK
                     TMDACITDNSAAFTVVLSKYHIVSTLLALLLHESLDSREKFSIILAIGHCTEDCEKNQ
                     YELLKNNGLPLMIQALTEFKNEDLSKAATYVLHNCKKITGKLSLSLGQNSFGENEIEL
                     KDISEKETLREHWKAAKEILCRIKQFEKGGKEEKQQNRSGHYKDNTPSMKVNIQTNLK
                     RLCADSTGGTRAEDKDINQSRELRSYKPSEIMSKACANENQLTTRKKNTNPVHPFCKE
                     KGQSKIVHETTPSCAQNLDKEKTFDQKDSVSQSSDQVLKHLPHTVKNRKQVPETDPFT
                     LCLDIIDREVGIQATDSCSRMLKYTCSGCIVARKLLNSRNFSKFLHSCAYQCVHHKVI
                     MEAEDKYKNELRKTFICAKKILLTPCRRRQLCKESTASEELKIVHQKPDSKKLPGLEA
                     QALNTSIPEAMERRSPVPGQSGLHKKRRIRKDFTKEEVNYLFHGVKTMGNHWNSILWS
                     FPFQKGRRAVDLAHKYHRLIKGPSCAAL"
     exon            251..361
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            362..490
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            491..622
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            623..683
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            684..799
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            800..922
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1075
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1210
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1336
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1491
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1844
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1906
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1999
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2149
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2215
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2338
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2950
                     /gene="Terb1"
                     /gene_synonym="4930532D21Rik; Ccdc79"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcaggcgt cgtggtctag gctgccacag ggacgagctg gtgtgggcct gacaggggct
       61 ctgggttcca gggtggagag gccaagctct ttaggtgagc caggcctccg gagcctggag
      121 cgagagcgag ggagccataa cccacggaaa gacggtggac ccggaggctg ggaatcccgg
      181 gcgagccgtg aggatgaaat ataagggaaa aagacaagca tggaaagtga gaagccaaag
      241 aaaacacaag aaatgaagac tgacctgaag ttactgttgg aatgtctgaa gtatcacatg
      301 ggcaaccctt tgtcacaaaa ggaagttttg atcacgattc attcagtttg taaacaaaac
      361 agtgatgcag gtatttattt ccgggaaatt ggtggtttga tgtttataat aaaccttgca
      421 aagtcaagtg agcagagctt ggtaaaagaa gcagccttat acacattagg atctattgca
      481 gaagaaaatg tttactgtca gcaatctttg tgtacttcag aattatttca agatttaacc
      541 gggctcttaa ctaatgatga ttcaaacaca aatttgaaaa gaatgtctgt ctatgttctt
      601 ttggttctgg tttcaaataa tagaaatgga caaactcttg tgagagaagt gggttgtatt
      661 gaagttctgt cacagatgtt caggacagtt ctttccaatt atgagttgaa tttgtcagat
      721 aatagtgttt tccagagcta tctgctatgg tcgtctgtgt gcagtactct gtgtgtatgt
      781 gtcaacaatc ctcaaaatga tgagaatcaa atgctttgtt gttcactttt tccatgtgtt
      841 aatgaatggc taatgaactg catgagacct gaggtaattc gacctatatg ctcatttatt
      901 ggacttactc ttgcaaataa tacacacgct cagaactgct ttgtctcttc gggtggactg
      961 gatgttttgt gtcaagttct tgtgcagctg gagtctgatt cacacaatac tctttccagt
     1021 gctaagcttg cagtcatagt gacaaagacc atggatgcat gtattactga taactcagct
     1081 gcttttacag tggtattatc caagtaccac attgtttcta cacttctggc attactgctt
     1141 catgaaagtc ttgattcaag agaaaaattt agcatcatac ttgccattgg tcactgcaca
     1201 gaggattgtg agaaaaatca gtatgaactt ttaaaaaaca atgggcttcc attgatgata
     1261 caagccttaa ctgagtttaa gaatgaagac ctaagcaaag ctgccactta cgtgcttcac
     1321 aactgcaaaa aaattactgg gaaattatct ctaagtctag gacagaattc ttttggtgaa
     1381 aatgaaattg aactaaagga cataagcgaa aaagagactc ttagagagca ctggaaggca
     1441 gcaaaggaaa ttctatgcag aataaaacaa tttgaaaaag gagggaaaga ggagaagcaa
     1501 caaaacagga gtggacacta taaggataat accccatcta tgaaagtaaa catacagacc
     1561 aatttgaaac gtctctgtgc agatagtact ggaggtacca gagcagaaga taaggatata
     1621 aaccagtcta gagagcttcg cagctataag cccagtgaaa tcatgtctaa agcttgtgca
     1681 aatgaaaacc aactgacgac tcggaagaag aacacaaatc cagttcatcc tttctgtaag
     1741 gagaaagggc agagtaagat tgtacatgaa accactccaa gctgtgctca aaacttagac
     1801 aaggaaaaaa cctttgacca aaaggattct gtttctcaat cgagtgacca ggtccttaaa
     1861 catctgcctc atactgtcaa aaatagaaag caggtaccag aaacagatcc atttacattg
     1921 tgtttagaca taatagatag agaagttggt attcaagcaa ctgacagctg ttccagaatg
     1981 ttaaaatata cgtgctcagg ttgcatagta gcaagaaaac tcctcaacag ccgaaatttt
     2041 agcaagtttt tgcactcatg tgcataccag tgtgttcacc ataaagtcat tatggaagct
     2101 gaagacaaat ataaaaatga actaaggaaa acatttatct gtgcaaaaaa aattttgctg
     2161 actccctgta gaagaagaca actttgtaaa gaatctactg cctctgaaga actaaaaatt
     2221 gttcatcaaa aaccagatag taaaaaactt ccaggtttgg aggcacaggc cttaaatacc
     2281 agcattccag aggctatgga aagaagatca ccagttccag gccagagtgg actacataaa
     2341 aaaagaagaa ttcgtaaaga ctttaccaaa gaagaagtaa attatctttt ccatggagtt
     2401 aaaacaatgg gaaatcattg gaattcaatt ttgtggtctt tcccctttca gaaaggacga
     2461 agggctgtag accttgctca caaataccac aggctgatca aaggccccag ctgtgcagcc
     2521 ctgtgactgg aggagattcg gtcctttgtt tggactctta aaatagaatt tcttaggaga
     2581 taaaatatgt taaaatttct ccttaactct tgtgagacgg ggaatgatga aacagaaata
     2641 gtttaagtta aatgattttt gtgatataaa ctcttcaaaa tgatacaata atttataaag
     2701 caagtgcatt ttcagtgtgg aaattagaat ccctccgtga ggtcaaatgt aatgtgcctt
     2761 tacttttcct tatggtcaaa gaccagcctt taaacatcac ttagcattgt attgccacaa
     2821 atactgtgtg agacgctgca tttcagtatt tttgtctagt gccaaagtcc accttagtac
     2881 tgataagttt ctcaagctgt tcagctaagg ctcacaccca acaaataaac agatggcatt
     2941 ttgttaattg
//
