LOCUS       NM_183137               2784 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus TEPSIN, adaptor related protein complex 4 accessory
            protein (Tepsin), mRNA.
ACCESSION   NM_183137
VERSION     NM_183137.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2784)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2784)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2784)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   4  (bases 1 to 2784)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2784)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868415.1, AK019105.1, BY084429.1, BC094318.1, BC049110.1 and
            BY665064.1.
            
            On Nov 17, 2006 this sequence version replaced NM_183137.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019105.1, AK154660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BB868415.1         2-32
            32-271              AK019105.1         3-242
            272-408             BY084429.1         242-378
            409-1021            AK019105.1         380-992
            1022-1074           BC094318.1         1511-1563
            1075-1431           AK019105.1         1047-1403
            1432-2770           BC049110.1         1368-2706
            2771-2784           BY665064.1         343-356
FEATURES             Location/Qualifiers
     source          1..2784
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.96 cM"
     gene            1..2784
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /note="TEPSIN, adaptor related protein complex 4 accessory
                     protein"
                     /db_xref="GeneID:78777"
                     /db_xref="MGI:MGI:1926027"
     exon            1..106
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1780
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /note="tetra-epsin; protein C17orf56 homolog; ENTH domain
                     containing 2; ENTH domain-containing protein 2"
                     /codon_start=1
                     /product="AP-4 complex accessory subunit tepsin"
                     /protein_id="NP_898960.2"
                     /db_xref="CCDS:CCDS36387.1"
                     /db_xref="GeneID:78777"
                     /db_xref="MGI:MGI:1926027"
                     /translation="MAAVPPLRDRLSFLHRLPILLKGTSDDSIPCPGYLFEEIAKISH
                     ESLGSSQCLLEYLLNRLDSSSGHVKLKVLKILLYLCGHGSSSFLLILRRNSALIQEAT
                     AFSGPPDPLHGNSLYQKVRAAAQDLGSTLFSDAVPQPPSQPPQIPPPAGMGAQARPLS
                     ALQGFGYTKESSRTGSAGETFLSTIQRAAEVVANAVRPGPDNPCTKGPLPYGDSYQPA
                     VTPSASHTHPNPGNLLPGAILGARAVRHQPGQAGGGWDELDSSPSSQNSSCTSNLSRA
                     SDSGSRSGSDSHSGTSREPGDLAERAEATPPNDCQQELNLVRTVTQGPRVFLSREETQ
                     HFIKECGLLNCEAVLELLLRQLVGTSECEQMRALCAIASFGSADLLPQEHVLLLCRQQ
                     LQELGAGSPGPVTNKATKILRHFEASCGQQLPTLRLCAQPNSAAAPVGPADLLTSPVP
                     APGSQVFLQPLSSATVVPRSPVLFPSPNTLPPSALEEPSEVRTQLVCSSEQGTESEQR
                     LENTDTPEDSSSPLPWSPNSLFAGMELVACPRLPCHSSQDLQTDLQKVTTEAPVSEPS
                     AFAFLNM"
     exon            107..179
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            180..271
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..365
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..433
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            434..509
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..581
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..785
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..960
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1074
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1153
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1288
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..2779
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /note="hexamer: AATAAA"
     polyA_site      2770
                     /gene="Tepsin"
                     /gene_synonym="2410002I01Rik; Enthd2"
                     /note="major polyA site"
ORIGIN      
        1 gacgattgga ggatcgaagc ctggcggaag cggggcagtt tgggaggtta cctggaccat
       61 ggcagctgtg ccgcccctgc gggaccgctt gagcttcttg cataggctcc ccatcctgtt
      121 gaaggggacc tcagatgata gcatcccatg tccaggctac ctgtttgaag agatcgccaa
      181 gatttcccac gagtcactag gcagcagcca gtgcctgctg gagtacctcc tgaaccgtct
      241 ggacagcagc tccggccacg tgaagctcaa ggtgctaaag atcttgcttt acctgtgtgg
      301 tcatggctct tcctccttcc tcctcatcct caggagaaac tctgctctca tccaagaagc
      361 cacggctttc tcagggcctc cagatcctct tcacggaaat agcttgtacc agaaggtgcg
      421 ggcggctgcc caggacctgg gtagcaccct gttctcagat gccgtgccac agcctccatc
      481 gcagccacct cagatcccgc ctcccgcagg catgggcgcc caggccagac ctcttagtgc
      541 cctgcaaggc ttcggctaca cgaaggagag cagccggaca ggctccgcag gtgaaacctt
      601 cctctccacc atccagaggg ccgcagaggt agtggctaat gctgtgcgtc ctggacctga
      661 taatccttgt accaagggac ccttgccgta tggtgattcc taccagcctg cagtgacacc
      721 ttcagctagc cacacacatc ccaaccctgg gaatctactc cctggggcca tcctgggggc
      781 cagagctgtg agacaccagc ccgggcaggc tgggggcggc tgggatgagc tggacagcag
      841 tcctagttcc cagaattcct cctgcaccag caacctgagc agggcctcgg actcgggcag
      901 tcggtctggc agtgacagcc actctggcac cagccgggag ccaggcgacc tggcagaaag
      961 ggctgaggcc acgcccccaa atgactgcca gcaagaactg aatctagtga ggactgtgac
     1021 acaggggcca cgtgtcttcc tgagccgtga ggagacgcag cacttcatca aagagtgtgg
     1081 cctgctcaac tgtgaggcag tgctggagct gctcctgcgc cagctggtcg ggaccagtga
     1141 gtgcgagcag atgagggcgc tgtgtgccat cgcgtccttt gggagtgctg acctcctgcc
     1201 tcaggagcac gtcctcctcc tgtgccgaca gcagctgcag gaacttggcg cgggcagccc
     1261 tggacctgtg accaacaaag ccaccaagat cctgagacat tttgaagcct cctgtggaca
     1321 acagctccct accctaaggc tctgtgccca gcccaactct gcagctgccc ctgtgggccc
     1381 agctgacctg ctgaccagcc ccgtgcctgc ccctgggagc caggtcttcc tccagcctct
     1441 cagctccgcc acagtggtac ccaggagtcc tgtgctcttt ccatccccca ataccttacc
     1501 tccgtctgct ctggaggagc ccagcgaggt ccgaacccaa ttggtgtgtt ctagtgaaca
     1561 ggggacagaa tctgagcaga ggctggagaa cacagacacc ccagaggata gctccagtcc
     1621 gctcccgtgg agtcccaact ctttgtttgc tggcatggag ctggtggctt gcccccgcct
     1681 gccttgccac agctcgcagg acctccagac agatttacag aaggtgacca cagaagctcc
     1741 ggtttcagag ccatcagctt ttgcattttt aaacatgtga ctttctgggc ccagctgtac
     1801 agcgtcccct ctggtcctca tataaaaggc cccaggacct tatggtctcc tgtcctcgtg
     1861 ttcaccaagg agccatcctt tggtgtcctc tggctgtccc ttcgccctct ggccccttcc
     1921 tttcaactag gaaactggta cagcggcctt tgagccaggt gagccctgga tgggcctccc
     1981 agtgctcaga acagtcactg aagaagggat ctgggccctt agtgctgacc agccaacatg
     2041 gaggtgtgga aaatacagtc aactggtgcc tcagaagatg tccgcacacc cattgcttct
     2101 tgggaattga ctctgagact ggcttctctc ttcctcccag caagacccac acagaccttc
     2161 ttagcggtct gtccatagct ggagaccacc ttgtacatct gcagggcagg acgtccccag
     2221 ggctgtcgac cacagcccct ccgccccatg ctgctctgtc cctaggaggc tgaacactga
     2281 ctacaactcc cacccccaac tcccaggcta cctcagtccc agttggacct gtcccattgc
     2341 taggtgctgg caatgattgt atggacttga attcctatgg tgacagctgg ccagtagcaa
     2401 ggctgccggg ctgaccttgg gtaccctggg caagccctgt gggcctgacc ctcagaaatg
     2461 agcacttgag agggttggaa acaccaactt ggctcacagt taggttctga tctctggtcc
     2521 ttcctctggg aggtcaaagt agctgggagc cacagccttg aggatagggg ggctgggcgg
     2581 gtacctttgg ttctcagagt ttcctcagac aagtgccctg tggccgtttc cagtgtcagt
     2641 cactgtaggg cccagcgctg gatgccagct tgccacagtt ttctgtagga cacgggagag
     2701 agtcgtccca tctcagaaga acctgtggag atgcaatgtg cactttctca ataaacacat
     2761 gtttacactg cttgtgccaa aaaa
//
