LOCUS       NM_001142952            2054 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus terminal nucleotidyltransferase 5C (Tent5c), mRNA.
ACCESSION   NM_001142952 XR_001536 XR_002338 XR_005163
VERSION     NM_001142952.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Liudkovska,V., Krawczyk,P.S., Brouze,A., Guminska,N., Wegierski,T.,
            Cysewski,D., Mackiewicz,Z., Ewbank,J.J., Drabikowski,K., Mroczek,S.
            and Dziembowski,A.
  TITLE     TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the
            innate immune response in animals
  JOURNAL   Sci Adv 8 (46), eadd9468 (2022)
   PUBMED   36383655
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Mroczek,S., Chlebowska,J., Kulinski,T.M., Gewartowska,O.,
            Gruchota,J., Cysewski,D., Liudkovska,V., Borsuk,E., Nowis,D. and
            Dziembowski,A.
  TITLE     The non-canonical poly(A) polymerase FAM46C acts as an
            onco-suppressor in multiple myeloma
  JOURNAL   Nat Commun 8 (1), 619 (2017)
   PUBMED   28931820
  REMARK    GeneRIF: FAM46C protein is strongly induced during activation of
            primary splenocytes and that B lymphocytes isolated from newly
            generated FAM46C KO mice proliferate faster than those isolated
            from their WT littermates.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY170905.1 and BC046309.1.
            
            On or before Jan 2, 2009 this sequence version replaced
            XR_005163.1, XR_002338.2, XR_001536.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046309.1, BC120717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143, SAMN02146468
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BY170905.1         1-53
            54-2054             BC046309.1         48-2048
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.71 cM"
     gene            1..2054
                     /gene="Tent5c"
                     /gene_synonym="4930431B09Rik; Fam46c"
                     /note="terminal nucleotidyltransferase 5C"
                     /db_xref="GeneID:74645"
                     /db_xref="MGI:MGI:1921895"
     exon            1..99
                     /gene="Tent5c"
                     /gene_synonym="4930431B09Rik; Fam46c"
                     /inference="alignment:Splign:2.1.0"
     exon            100..2029
                     /gene="Tent5c"
                     /gene_synonym="4930431B09Rik; Fam46c"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1302
                     /gene="Tent5c"
                     /gene_synonym="4930431B09Rik; Fam46c"
                     /EC_number="2.7.7.19"
                     /note="DN-384L23.3; protein FAM46C; putative
                     nucleotidyltransferase FAM46C; family with sequence
                     similarity 46, member C"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 5C"
                     /protein_id="NP_001136424.1"
                     /db_xref="CCDS:CCDS51017.1"
                     /db_xref="GeneID:74645"
                     /db_xref="MGI:MGI:1921895"
                     /translation="MAEEGSSTKDSESFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTL
                     EITLKDIVQTVRGRLEEAGINVQDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTE
                     AEFQLVRDVVLCSLLNFLPEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNK
                     NGRNVELKFVDSIRRQFEFSVDSFQIILDSLLFFYDCSGNPISEHFHPTVIGESMYGD
                     FEEAFDHLQNRLIATKNPEEIRGGGLLKYSNLLVRDFRPADQEEIKTLERYMCSRFFI
                     DFPDILEQQRKLETYLQNHFSDEERSKYDYLMILRRVVNESTVCLMGHERRQTLNLIS
                     LLALRVLAEQNIIPSATNVTCYYQPAPYVSDGNFNNYYIAHPPITYSQPYPTWLPCN"
     regulatory      1872..1877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tent5c"
                     /gene_synonym="4930431B09Rik; Fam46c"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="Tent5c"
                     /gene_synonym="4930431B09Rik; Fam46c"
                     /note="major polyA site"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tent5c"
                     /gene_synonym="4930431B09Rik; Fam46c"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="Tent5c"
                     /gene_synonym="4930431B09Rik; Fam46c"
                     /note="major polyA site"
ORIGIN      
        1 tcgccgcagc tgtctagggg ccgcagtctc cgctccgctc ctgctggggg ctgcccacgc
       61 caaccacctg cctcagtcac ctcctcttcc aacgcccagc ttcccctggc cagaacatcc
      121 cctaagatgg cagaggaggg cagcagtacc aaggactctg agtccttcag cgtgctcaac
      181 tgggatcagg ttagccggct gcacgaggtc ctgactgagg tcgtgcccat ccacgggcga
      241 ggcaactttc caaccttgga gataaccctg aaggacattg tccagactgt ccgaggccgg
      301 ctggaggagg caggcatcaa cgtgcaggac gtccggctga acggctctgc agccggccac
      361 gttttggtca aagacaacgg cttgggttgc aaagatctgg atctgatctt tcacgtggct
      421 ctccccacag aggcggaatt tcagctggtg agagatgtgg ttctgtgctc ccttctgaac
      481 tttctgccag agggcgtgaa taagctcaaa atcagccccg tcaccctgaa ggaggcgtac
      541 gtgcagaagc tggtgaaggt ttgcacagac acagaccgct ggagcctgat ttccctctcc
      601 aacaagaacg ggaggaacgt ggagctcaag tttgtcgact ccatccggcg gcagtttgag
      661 ttcagcgtgg actctttcca gatcatccta gattctttgc tctttttcta tgactgctcc
      721 ggcaatccca tctccgagca tttccacccc acagtgatcg gggagagtat gtacggggat
      781 tttgaggaag cctttgacca tcttcagaac aggctgatcg ccaccaagaa ccctgaagaa
      841 atccgaggtg ggggtctcct taagtacagc aacctccttg tgcgggactt caggcctgcc
      901 gaccaggagg agatcaagac cctggagcgt tacatgtgct ccagattttt catcgacttc
      961 cccgacatcc tggaacagca gaggaagctg gagacctacc ttcagaacca cttctcggac
     1021 gaggagagaa gcaagtacga ctacctcatg attctccgca gggttgtgaa cgagagcacc
     1081 gtgtgcctca tggggcacga acgcaggcag accctgaacc tcatctctct cctggccttg
     1141 cgtgtgctgg cagaacaaaa catcatcccc agtgccacca acgtcacctg ttactaccag
     1201 ccagctcctt acgtcagtga tggcaacttc aacaactatt acattgcgca ccctccaatt
     1261 acctacagcc agccttatcc tacatggctg ccctgtaact aacctgaaga cctgagggtt
     1321 tccacagtgg gaactcggtt agggcagggg ctctcaggta ggagagcctc tttctagatg
     1381 taggtgtttg gctttcgaag gggaactcag ctccgactct gtttttcttt ttgtacccat
     1441 tggaataggt ccacagacta tcgtgagcca accctaaaag gacccatagt tgagtgccac
     1501 tcagggagat gcaataggag gcgtgacttc tcaccatctt tctaagatag tcactaacat
     1561 gtcactcccc agacattagc acatgggatc tgagctcggc acagtctctg agattggggg
     1621 agtcggacag cgtatgaaaa gtgttccagg cgctctcctc agctgagttc tcggtagatt
     1681 ctacaggctc tctcattcag gattctcagc agtcatgtga gagatgcact gatagtctct
     1741 cactgggtca cttctagtca gctccccaaa ctgataaacc gtgagggtgc tctttgtgac
     1801 tgaattttca ctcacgggac taagttgtgt ctgtctagtc cccatcggca gagctgagaa
     1861 tttcattcat caataaacca aagccaatag ctggagactt gagatctggt tggaagtggt
     1921 ttatggtata tgctgtgctt tatcaaggaa ttatgagata ttgtggagaa aaaaaaatga
     1981 cctttttctt gaaatgtaac ttgaaaacaa aataaaatgt ggaacataaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaa
//
