LOCUS       NM_001160379            5450 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus terminal nucleotidyltransferase 5A (Tent5a),
            transcript variant 2, mRNA.
ACCESSION   NM_001160379 XM_135029 XM_918327 XM_925654 XM_994662
VERSION     NM_001160379.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5450)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5450)
  AUTHORS   Matern,M.S., Durruthy-Durruthy,R., Birol,O., Darmanis,S.,
            Scheibinger,M., Groves,A.K. and Heller,S.
  TITLE     Transcriptional dynamics of delaminating neuroblasts in the mouse
            otic vesicle
  JOURNAL   Cell Rep 42 (6), 112545 (2023)
   PUBMED   37227818
REFERENCE   3  (bases 1 to 5450)
  AUTHORS   Liudkovska,V., Krawczyk,P.S., Brouze,A., Guminska,N., Wegierski,T.,
            Cysewski,D., Mackiewicz,Z., Ewbank,J.J., Drabikowski,K., Mroczek,S.
            and Dziembowski,A.
  TITLE     TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the
            innate immune response in animals
  JOURNAL   Sci Adv 8 (46), eadd9468 (2022)
   PUBMED   36383655
REFERENCE   4  (bases 1 to 5450)
  AUTHORS   Gewartowska,O., Aranaz-Novaliches,G., Krawczyk,P.S., Mroczek,S.,
            Kusio-Kobialka,M., Tarkowski,B., Spoutil,F., Benada,O.,
            Kofronova,O., Szwedziak,P., Cysewski,D., Gruchota,J., Szpila,M.,
            Chlebowski,A., Sedlacek,R., Prochazka,J. and Dziembowski,A.
  TITLE     Cytoplasmic polyadenylation by TENT5A is required for proper bone
            formation
  JOURNAL   Cell Rep 35 (3), 109015 (2021)
   PUBMED   33882302
  REMARK    GeneRIF: Cytoplasmic polyadenylation by TENT5A is required for
            proper bone formation.
REFERENCE   5  (bases 1 to 5450)
  AUTHORS   Doyard,M., Bacrot,S., Huber,C., Di Rocco,M., Goldenberg,A.,
            Aglan,M.S., Brunelle,P., Temtamy,S., Michot,C., Otaify,G.A.,
            Haudry,C., Castanet,M., Leroux,J., Bonnefont,J.P., Munnich,A.,
            Baujat,G., Lapunzina,P., Monnot,S., Ruiz-Perez,V.L. and
            Cormier-Daire,V.
  TITLE     FAM46A mutations are responsible for autosomal recessive
            osteogenesis imperfecta
  JOURNAL   J Med Genet 55 (4), 278-284 (2018)
   PUBMED   29358272
  REMARK    GeneRIF: By RT-PCR analysis, we detected specific expression of
            FAM46A in human osteoblasts andinterestingly, a nonsense mutation
            in Fam46a has been recently identified in an ENU-derived
            (N-ethyl-N-nitrosourea) mouse model characterised by decreased body
            length, limb, rib, pelvis, and skull deformities and reduced
            cortical thickness in long bones.
REFERENCE   6  (bases 1 to 5450)
  AUTHORS   Diener,S., Bayer,S., Sabrautzki,S., Wieland,T., Mentrup,B.,
            Przemeck,G.K., Rathkolb,B., Graf,E., Hans,W., Fuchs,H., Horsch,M.,
            Schwarzmayr,T., Wolf,E., Klopocki,E., Jakob,F., Strom,T.M., Hrabe
            de Angelis,M. and Lorenz-Depiereux,B.
  TITLE     Exome sequencing identifies a nonsense mutation in Fam46a
            associated with bone abnormalities in a new mouse model for
            skeletal dysplasia
  JOURNAL   Mamm Genome 27 (3-4), 111-121 (2016)
   PUBMED   26803617
REFERENCE   7  (bases 1 to 5450)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   8  (bases 1 to 5450)
  AUTHORS   Sabrautzki,S., Rubio-Aliaga,I., Hans,W., Fuchs,H., Rathkolb,B.,
            Calzada-Wack,J., Cohrs,C.M., Klaften,M., Seedorf,H., Eck,S.,
            Benet-Pages,A., Favor,J., Esposito,I., Strom,T.M., Wolf,E.,
            Lorenz-Depiereux,B. and Hrabe de Angelis,M.
  TITLE     New mouse models for metabolic bone diseases generated by
            genome-wide ENU mutagenesis
  JOURNAL   Mamm Genome 23 (7-8), 416-430 (2012)
   PUBMED   22527485
  REMARK    Erratum:[Mamm Genome. 2014 Dec;25(11-12):648]
REFERENCE   9  (bases 1 to 5450)
  AUTHORS   Etokebe,G.E., Kuchler,A.M., Haraldsen,G., Landin,M., Osmundsen,H.
            and Dembic,Z.
  TITLE     Family-with-sequence-similarity-46, member A (Fam46a) gene is
            expressed in developing tooth buds
  JOURNAL   Arch Oral Biol 54 (11), 1002-1007 (2009)
   PUBMED   19740458
  REMARK    GeneRIF: expressed in ameloblasts' nuclei of tooth germs and might
            act together with morphogenetic factors important for the formation
            of enamel in mouse tooth
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135132.1 and AC159809.2.
            
            On or before May 24, 2009 this sequence version replaced
            XM_925654.3, XM_918327.2, XM_135029.8, XM_994662.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding region and initiates translation at an alternate start
            codon, compared to variant 1. The encodes isoform 92) has a
            distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135132.1, CX234358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-779               AK135132.1         3-781
            780-5450            AC159809.2         36668-41338         c
FEATURES             Location/Qualifiers
     source          1..5450
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.04 cM"
     gene            1..5450
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /note="terminal nucleotidyltransferase 5A"
                     /db_xref="GeneID:212943"
                     /db_xref="MGI:MGI:2670964"
     exon            1..108
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /inference="alignment:Splign:2.1.0"
     exon            109..655
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1432
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /EC_number="2.7.7.19"
                     /note="isoform 2 is encoded by transcript variant 2;
                     family with sequence similarity 46, member A"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 5A isoform 2"
                     /protein_id="NP_001153851.1"
                     /db_xref="CCDS:CCDS81046.1"
                     /db_xref="GeneID:212943"
                     /db_xref="MGI:MGI:2670964"
                     /translation="MAEGEGYFAMAEDELTGGPYIPLGGDFGGGGSSFGDRCSDYCES
                     PTAHCNVLNWEQVQRLDGILSETIPIHGRGNFPTLELQPSLIVKVVRRRLEEKGIGVR
                     DVRLNGSAASHVLHQDSGLGYKDLDLIFCADLRGEEEFQTVKDVVLDCLLDFLPEGVN
                     KEKITPLTLKEAYVQKMVKVCNDSDRWSLISLSNNSGKNVELKFVDSLRRQFEFSVDS
                     FQIKLDSLLLFYECSENPMTETFHPTIIGESVYGDFHEAFDHLCNKIIATRNPEEIRG
                     GGLLKYCNLLVRGFRPASEEIKTLQRYMCSRFFIDFSDIGEQQRKLESYLQNHFVGLE
                     DRKYDYLMTLHGVVNESTVCLMGHERRQTLNLITMLAIRVLADQNVIPNVANVTCYYQ
                     PAPYVADANFSNYYIAQVQPVFTCQQQTYSTWLPCN"
     exon            656..5450
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1495
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /note="major polyA site"
     regulatory      4838..4843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /note="hexamer: AATAAA"
     polyA_site      4864
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
     regulatory      5422..5427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /note="hexamer: AATAAA"
     polyA_site      5450
                     /gene="Tent5a"
                     /gene_synonym="BAP014; D930050G01Rik; Fam46a"
                     /note="major polyA site"
ORIGIN      
        1 ggagaagtcg cgggccgctg ccgggagcgc actcgcagct cctgcgaagt gtgtccgcct
       61 cgcggttcct cgctcgcctg cgctcctaga aggggcggcc gcctccagga ctgaccaagg
      121 ccaagtggct ttcggagggc actacatggc cgagggcgaa gggtactttg ccatggcaga
      181 ggacgagctg accggcggcc cttacatccc cctgggtggt gacttcggcg gcggcggcag
      241 cagcttcggc gaccgctgct cggactattg cgaaagcccc acggcgcact gcaatgtgct
      301 gaactgggag caagtgcagc ggttggacgg cattctgagc gagaccatcc cgatccacgg
      361 gcgcggcaac ttccccacgc tcgagctgca gccaagcctg attgtgaagg tggtgaggag
      421 gcgcctggaa gagaagggca taggtgtccg cgacgtgcgc ctcaacggct cagccgccag
      481 tcacgtcctg caccaggaca gtggcctagg ctacaaggac ctggacctca tcttctgcgc
      541 tgacctgcgt ggggaagagg agtttcagac tgtgaaggac gtcgttctgg attgcctgtt
      601 agacttcttg cccgaagggg tgaacaagga gaagatcaca ccgctcactc tcaaggaggc
      661 ttatgtgcag aaaatggtta aagtgtgcaa tgattctgac cggtggagcc ttatatccct
      721 gtcaaacaac agtggcaaaa atgtggagct gaagtttgtg gattccctgc ggaggcagtt
      781 tgaattcagt gtagattctt ttcaaatcaa attagactct cttctcctct tttacgagtg
      841 ttcagagaac ccgatgactg agacatttca ccccaccatc atcggtgaga gtgtctatgg
      901 tgatttccac gaagcctttg atcacctttg caacaagatc attgccacca ggaacccaga
      961 ggaaataaga gggggaggcc tgcttaagta ctgcaatctc ttagtgcggg gcttcaggcc
     1021 tgcctccgag gagatcaaga ccctccagag gtacatgtgt tcccggtttt ttattgactt
     1081 ctcagacatc ggagagcagc agagaaagct ggagtcctac ttgcagaacc acttcgtggg
     1141 cttggaagac cgcaagtatg actatctcat gacccttcat ggagtggtaa acgagagtac
     1201 ggtgtgcctg atgggacatg aaaggaggca gactttaaac cttatcacca tgctggcaat
     1261 ccgggtgcta gctgaccaaa atgtcattcc taatgtggct aatgtcactt gctattacca
     1321 gccggccccc tatgttgcag atgctaactt tagcaattac tacattgcac aagttcagcc
     1381 cgtgttcaca tgccagcagc agacatactc tacttggtta ccctgcaact aagaatgttt
     1441 aaaaaatgtc ccatggggaa gccatttcaa gtaagacagg ggggaaaaaa agaaagaaag
     1501 agagaaagaa aaaaaaagaa aggaagaaaa attatgacac aacaccaaaa agggaagtga
     1561 cccagtccta attagggatg tgtttagtgc acggaggact tgctcctgat tttaaagttg
     1621 gcaatgcttt tggatctttc catcagtaca ggagcaggat ctcaactgtc accctcccta
     1681 gccacccacc tcacctatgg tctctaccca attggatggt atcttgaaac aaacgaggcc
     1741 tgttggtaaa aagcagccag attctcccaa aataacaaga gaattttaaa aaaggaaaaa
     1801 aaaaaaggct tgattttgac aatatgggtt tgcagtagct actcccatag ctctgccata
     1861 gggaagagaa tggtggacaa acttttcaga tggcattcac aaatgggaaa ccacagagga
     1921 ggaaagcctt gcctatcaca cgaggaggtc agaaagtaac aggggaaagc agggctacta
     1981 tactagaagg tattaccgtc tgttttgaag caagtgctct ctttggaatg atcctgtttt
     2041 cctcagagaa acagctcaat ccaaaccaac agtccaaacc gaccaacagt cagtcgatgc
     2101 tgtcctcgta acaaacagca gaacttaagg atgacacgac ccgttaattc cagcttcgtg
     2161 cgtagcttgc gtttttttta attattatta ttattttaaa tgtgaagacg caagcaaaaa
     2221 acagctgtag ccaagaaaac atgctcaagg accaaagatt taacagataa aaattcccaa
     2281 gcagaagaga tagaatagga tatataaaga gttactatat ttgttacaca ccaatacaca
     2341 tcaaagtgcc tgttgctttc agaagatttg aagtggaaaa ggttatttta tggtttaata
     2401 attattttat tttatcaggg actcaagaaa aaaaaataaa acaacatata agcttgtgaa
     2461 tggtggagga aatgccctat tttttttttt ttttttggca aatacctata taaagttgat
     2521 attgtttggt gtgatgttat cataggtacg tatatattgt ttgtgtgtat acacacacac
     2581 atatatgtga tatgtatgta tgtatatata cacacactac tttgtctatg atctaaaata
     2641 atgtatcaaa taggaaaaat ttaaatatag tgctttttat gtttttggta ggatcttaga
     2701 agacatgggc aaactgcaat gatgacttaa aacccataaa aaaataagac aagtggaggt
     2761 aaatgagtaa tatatttgta ggaaaagcag agattacaca tttatagtga gttttttctt
     2821 attttcagtg agccagagaa cttcacaaat ggaagaatat ttggtagcat actttttaat
     2881 tgacttactt gacattttga gagtctgaac ccctccccct taaataaatg gaatcacata
     2941 ccttcaaggc ttagaacttg tggatcatgg accagagata ggataactaa atccataaac
     3001 tgcggaaaaa aaattctgga acctgaacac tacttcctaa tatttaaatg aaaatacaaa
     3061 tgagtgcatt ctacattttg gaccactaga atttaataaa tgtgaaatga ccatttttaa
     3121 agagtatttg cacaattaca taaagtttat atataggata tctatattat atatacatat
     3181 atatacattt tataaattta tccgatatga aatatgtttg atctggttgt cacactgcat
     3241 agaaatatgt agtactgcac cttaaattaa atcacgttgt attcgctcaa acccagcttt
     3301 agttttctct cccaggagac catttgtgta cctttgtgtc gtgaactgat attttcatgt
     3361 tcagcgacag ctaaacttaa ctcctgtccc agctctgtag accttgatct ctgaaaaata
     3421 acatttcaaa aaaatgaaac aaatgcatta aaaaccttcc cttattgttg tgaaacaatc
     3481 acacagtccc ctggaacctt agtgaatgac tgctaggtat ggtcattcct ttgcagagcc
     3541 agtcagtgac agagatgcta gggtgaatgt aactctctca ccttggcaat gaatgatgtt
     3601 atctcagcat ctctcagctt ctgctggaca gattagtcca ggttcatctg tctggaccac
     3661 ccttctgtgc atctgtatct gaagccttaa cagcaaccag attggctctg attggacagc
     3721 ttccctgaga atcctcacta agctgccaca gcccccaaca ctgccactct cttttataag
     3781 gaactgatct tactcccatg gtggtccagt tttccccttc actgccctgc atttgaaaaa
     3841 tcatacacaa agtcccagga aaccttgttc agcttgcagc tgaagtctgg aactcaccta
     3901 tcagaaacca cagtccagcc cacttagctc tcctgcaagt tcccctggac tgctggggcg
     3961 ggggacagag gcttttctgg tgacctggtt tctgctcatg ctaactctgc aaatatgagt
     4021 tgtccactgt tttgaaaagt ctggagatct tgggctctgc catagtagca gcctgctgtt
     4081 aactgacagc acaggttttt gtttgaaggg gccttattag aaaataatgt ttatcattta
     4141 ctttctcaag tattttctat tccttgcttg cttacttagc tgcaagctaa gtcaaaagaa
     4201 cttagtcaaa agaaccagca cgcaacattc agatagaaca ggctgtgttc aaggcaactt
     4261 ttggcattta ctttaaccct tatataattt atttctattt tgtgcatact atagtcctgt
     4321 gcatatgtag ttgaacatgc aagggaatat gtgtctctct ttgtggatgt gtggcctaaa
     4381 attctgaatg tcagagcaaa ggacagctct ctctgcatct aatcagtgcc cacggtttgt
     4441 ttgctcttgt gtttgtctgg cctagtgtac tgttactttg aaacagggag aagtcttgcc
     4501 ttctgaaggt tcttctcacg tgtccagtct ggcatgtcag agaacactta gcctgtgact
     4561 gtgtcctttt acaaagttta cttcatctgc agtaaattca actgcctcaa gaactcttac
     4621 agggggatgg actttccaaa gttgaacgga gcgcttgcgc tctttggtat agttaggctg
     4681 ttttgacctg ggtccaaaaa agcacaagga tgggcagaat actcaatcca atcaggaagt
     4741 gaaatgaaaa gtgaacatac tgtttttgcc accccttctg tttgctgtcg ttggttgctt
     4801 tactgtgcat atccttgttt taatgcaatg cttgttaaat aaatattgtg aactattttg
     4861 taaatgaaat gtattatgtt aaaagctgtc agcagctgtc aaaaataagc ttttgttgtg
     4921 aaagaaaaat gtgtgttaga taaaaacaaa acaaaacaaa aaaagtcaaa aatatcctgt
     4981 tttcatatat agcacctatt tgaatatact ctttctttaa tatttctttt agcatcacca
     5041 tttcagtgct gtggagggat ctccgtgtca cgtgttgtca tggtaatggc ttgctaagaa
     5101 atcagtgata accgtacaaa gtgggcggtg ctgaggggct tggggatcct tgctgcaaag
     5161 ctttgcagaa tgtaagaggc tctgtttacc cttggccctc cctcccacct ccctacaacc
     5221 attgcctgct ctgagttgtc ctatgacagc aagatgcacc ctgggtcact cttggaacgt
     5281 tttgacaatt gtgtgtcaca ggcagtaaaa agagttgata gaaaatggac tcttcaaaac
     5341 tgacatgttc gcagcagtgc tagagggaac agattgtgaa ttttgtttac agcatccaat
     5401 atttggattt ttgtttttgt aaataaaaag aagttatttt tttctattga
//
