LOCUS       NM_198600               4583 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus terminal nucleotidyltransferase 4A (Tent4a),
            transcript variant 1, mRNA.
ACCESSION   NM_198600 XM_127464
VERSION     NM_198600.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4583)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4583)
  AUTHORS   Juriloff,D.M., Harris,M.J. and Dewell,S.L.
  TITLE     A digenic cause of cleft lip in A-strain mice and definition of
            candidate genes for the two loci
  JOURNAL   Birth Defects Res A Clin Mol Teratol 70 (8), 509-518 (2004)
   PUBMED   15329828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122484.3.
            
            On Feb 10, 2022 this sequence version replaced NM_198600.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059846.1, SRR1660817.79851.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-965               AC122484.3         65354-66318         c
            966-1089            AC122484.3         47646-47769         c
            1090-1136           AC122484.3         46831-46877         c
            1137-1257           AC122484.3         44756-44876         c
            1258-1365           AC122484.3         42486-42593         c
            1366-1494           AC122484.3         41429-41557         c
            1495-1708           AC122484.3         38782-38995         c
            1709-1835           AC122484.3         36472-36598         c
            1836-1936           AC122484.3         35501-35601         c
            1937-2109           AC122484.3         34772-34944         c
            2110-2268           AC122484.3         34057-34215         c
            2269-2433           AC122484.3         32339-32503         c
            2434-4583           AC122484.3         29827-31976         c
FEATURES             Location/Qualifiers
     source          1..4583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 35.55 cM"
     gene            1..4583
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /note="terminal nucleotidyltransferase 4A"
                     /db_xref="GeneID:210106"
                     /db_xref="MGI:MGI:2682295"
     exon            1..965
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..2628
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /EC_number="2.7.7.19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polymerase (DNA directed) sigma; DNA polymerase sigma; PAP
                     associated domain containing 7; PAP-associated
                     domain-containing protein 7; TRAMP-like complex
                     polyadenylate polymerase; non-canonical poly(A) RNA
                     polymerase PAPD7; terminal guanylyltransferase"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 4A isoform 1"
                     /protein_id="NP_941002.3"
                     /db_xref="CCDS:CCDS26622.1"
                     /db_xref="GeneID:210106"
                     /db_xref="MGI:MGI:2682295"
                     /translation="MDPRVAWIQPEQKGPANALWMQIWETSQGVGRGGSGFASYFCLN
                     SPALDTAAAPGAAGRAAPAAGGPGPAPAASSPPPAPGPAALPPALLTALGPAADSARR
                     LHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSTSLGRAGSGRTFFSFADGAAHAHP
                     GPRGSTPAGSPPQHQFHPGRRKRENKASTYGLNYLLSGSRAATLSGGGGPGAQAARPG
                     TPWKSRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLWPTADVQI
                     FGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIK
                     LTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTG
                     GISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGG
                     AYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAV
                     SPLARSYPNRDSESTLGRIIKVTQEVIDYRRWIKEKWGSRILPSPDLDNRIKIKERIT
                     TCNGEQMQSREPSSPYTQRLTLSLSSPQLLSSGSSASSVSSLSGSDIDSDTPPCTTPS
                     VYQFSLQAPTTLMASLPTALPMPSSKPQPAASRTLIMTTNNQTRVTIPPPTLGVAPVP
                     CRQAGVDGTTSLKAVHSVTSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHNHTQGG
                     GYSSVGSGAVRPPVGNRGHHQYNRTGWRRKKHAHTRDSLPVSLSR"
     exon            966..1089
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1136
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1257
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1365
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1494
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1708
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1835
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1936
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2109
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2268
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2433
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..4583
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4566..4571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /note="hexamer: AATAAA"
     polyA_site      4583
                     /gene="Tent4a"
                     /gene_synonym="LAK-1; Papd7; POLK; Pols; TRF4; TRF4-1"
                     /note="major polyA site"
ORIGIN      
        1 accgcccctt cgatggcctc tccctgccgc ccgcacgcta cgccgccgcc gccgcggccc
       61 cctcgccctc cccgcgccgc ctgagccacc gggaccgcag ctgcgccgcg cgccccaccg
      121 agcgccgccc gcgcccatcc gcgcgcaccg gagcgcggcc caggcccgtc cgtccgtccg
      181 tccgcgcggc cggcccgggg cgcggcgggg cggggcgcgg cgggggcggg gcgcggcggg
      241 cgacgcgggc cccgcggggg cggcgcgtgg atggatccgc gcgtggcctg gatccagccg
      301 gagcagaagg ggccggccaa tgccctgtgg atgcagatct gggagacctc gcagggcgtg
      361 ggccgtggcg gctccggctt cgcgtcctac ttctgcctca actcgccggc gctggacacg
      421 gcggccgcgc ccggggcggc ggggcgcgca gcaccagcag caggaggccc ggggccggcg
      481 cccgccgcct cgtccccgcc gccggcgccc ggccccgccg cgctgccccc ggcgctgctt
      541 accgcgctag ggcccgcggc ggacagcgca agacgcttgc acaagtcccc gtcgctgtcg
      601 tcgtcgtcgt cctcgtcgtc gtccaacgcc gagtcgggca ccgagagtcc cggctgctcg
      661 tcgtcgtcct ccagcagcac ctcgctcggc cgcgccggca gcggccgcac cttcttcagc
      721 ttcgccgacg gtgctgccca cgcacacccg ggcccacgcg gctccacgcc cgccggctcg
      781 ccgccgcagc accagttcca cccgggtcgg cggaaacgcg agaacaaggc cagcacgtat
      841 ggcctcaact acctgctgtc gggcagccgc gcggccacgc tgagcggagg gggcggcccc
      901 ggggcccagg cggcgcggcc cggcacgccg tggaagagcc gcgcgtacag cccgggcatc
      961 cagggacttc atgaggagat aatcgacttt tataacttca tgtccccttg tcctgaagaa
     1021 gcagccatga gaagggaggt ggtgaaacgg atcgaaactg tggtgaaaga cctctggccc
     1081 acagctgatg tgcagatatt tggcagcttt agtacaggcc tctatcttcc aacaagtgac
     1141 atagacctgg ttgtctttgg aaagtgggaa cgccctccat tacagttgtt ggaacaagcc
     1201 ctccggaagc acaacgtggc tgagccgtgc tccatcaaag ttcttgacaa agctacagtg
     1261 cccatcataa agctcacaga tcaggagact gaagttaaag tcgacatcag ctttaacatg
     1321 gagactggcg tgcgggcggc agagttcatc aagaattaca tgaagaagta ctcgctactg
     1381 ccatacttga ttttagtgct gaaacagttc ctgctgcaga gggacctgaa tgaggtcttc
     1441 acaggcggga tcagctccta cagcctcatc ctaatggcca tcagctttct gcagttacat
     1501 ccaagaatcg atgcccggag agctgatgaa aacctgggaa tgcttcttgt agaatttttt
     1561 gaactttatg gaagaaattt taattactta aaaactggta ttagaataaa agaaggaggt
     1621 gcctatatcg ccaaagaaga gatcatgaaa gccatgacca gtgggtaccg accatcgatg
     1681 ctgtgcattg aggacccctt actgcctgga aatgatgttg gacggagttc ctatggggcc
     1741 atgcaggtga agcaggtgtt tgactacgct tacattgtgc tcagccacgc tgtgtcaccg
     1801 ctcgccaggt cttaccccaa cagggattct gaaagtactt taggaagaat catcaaagtc
     1861 acccaggaag tgatcgacta ccggaggtgg atcaaagaaa agtggggtag cagaatcctc
     1921 ccgtctccag accttgacaa caggattaag ataaaggaga gaattaccac gtgcaatggg
     1981 gagcagatgc agagccggga gcccagctcc ccttacaccc agcgcctgac tctgtccctg
     2041 tccagtcccc agctgctgtc ttcaggctct tctgcttctt ctgtgtcctc actttctgga
     2101 agtgacattg actccgacac accgccctgc accacaccca gtgtttatca gttcagcctg
     2161 caagcaccca ctaccctgat ggccagcctg cccacagcct tgccaatgcc cagcagcaaa
     2221 ccccagcctg ctgcttccag aacgttgatc atgacaacaa acaaccagac cagggttact
     2281 atccctccac caaccctcgg agtcgcccct gttccttgca gacaggctgg tgtcgacgga
     2341 accacatctt tgaaggctgt tcacagtgta acttccccag ccattccctc ggcatccccc
     2401 aacccactgt ctagtcctca tctgtatcac aagcagcaca atggcatgaa actgtccatg
     2461 aaaggctccc acaaccacac tcagggtggc ggctacagct ctgtgggcag tggagctgtg
     2521 aggcctcctg taggcaaccg aggacatcat cagtacaacc gcaccggctg gaggagaaaa
     2581 aagcacgcac acacaaggga cagcctgccc gtgagtctca gcagataatg gtcctgactg
     2641 actgcccaaa ggcctcgctc gggcaccaca ggggagccga gaccagcatc cagcacctcc
     2701 accgctgtct gccaagcgca gcccagcact ggtcactctg catgtttgtg tggtggccgc
     2761 atccatctta cagaacagct ccttgtgctc atctgtgaag ccttactaca tgtggatgtg
     2821 cgtctgcctg cctagaagtc ttcatctgtg cccagcaggg cggcctagga gtgtcaggga
     2881 ctggatgtgc ggctgtgcag ccgggtcagc taggtggcca tttggggttc tcatcgtgtc
     2941 tgtcacaggc agagacgcca agccctgctc cgtgtcttct gacggagtgg gcaggctgct
     3001 gttttactgc cctcatgtct tgtttgaaaa tttgggactg tttttctatg taaatattga
     3061 aaacttatga tttgtgcaat aactcagata ttttttattt aatttcatat tttcacataa
     3121 gttatattta agggaggagg gaattttttt taaaacacgc ttaaatcctt tcccaatttg
     3181 cattttctaa gttgggttcc tcgtgttggc tggttatctg atagcatcct gacatgaaca
     3241 ccgtgaggag ggaggggcct gtgggctttg tttttatgtc ttttcttttg gtcagatgca
     3301 gtgaaggagc caagtcaact tgatagttct gtgaggccag tgtgtacctg gcagcctggc
     3361 tgtcggcctt gggcctttgt cctctctgac cacgagttct gacattttgg tttgggtttt
     3421 taaaaactag acaccaaatc cagcatttaa agtgccagaa gtaagaacct ctaagaggag
     3481 aagaggttgt cacgtcgtat aaatcgtaaa gaatcgtgac tctgggcgtg cttcggtcat
     3541 taagtgacgt ggtctagagt cacgggcctg gtgagtatcg ttacagacaa tggcacccag
     3601 atttaggaat gtggagaaag ggattttgtt gattccattg aggaatctgc ataggtatgc
     3661 actcgttctg ttaagagcaa atatctgaaa aggacctccg ttgtccaggc acatgggggt
     3721 attttaatgt atcacaggag agcacagccc cagtgtgggc ccaggagcgg ctggtgcctg
     3781 gcgtcagaag catacaggta tactatgcaa gtgtattctg ccacaaccac tgtctttgtt
     3841 actttttttg aacaagaatc catccattgc ctgaccctga ttctcaagca ccacggttgt
     3901 cctggagtgc ttgcagttgt aggccctctg acttctgctt ctaaaacggg ggtctggacc
     3961 tgctgcacac cacaggcagg ttgcttcttg tccaccagta cagagtgtca agccgagtgc
     4021 tgtgccacct gattgacatg cagcagtgga aattctgaat ggatgtctga gtgacattgg
     4081 acacctcgcc aaggacaagc tctgtgtgtc tgggtctgcc tcctgctgcc gtggtgaggc
     4141 tgttgactct gggaggcatt ccagagcaga ggagcacatg ggtctgcagc tcatgaggat
     4201 tggagtcatc cagaatattt aaaattattt aaattgtgaa gcctgttgct aaagaatatt
     4261 tatgaacact ggtccatagc ctgtactaat ttacacatta gcaatattga ctgtatctgc
     4321 attaaggagc caccgtgggg ccgttcgagt gacccgcaga tgtgcgtttt aaagttctgt
     4381 catccacagg cacaggtatg tgtccgtctc cgtcatggtg aaccagatga attggcctgg
     4441 cgaccactgt ggccatatgc tacagtttac aaaatgatac catgtttaaa ttttctgtgc
     4501 ggacaacaat gtggacacta aaattaacat atttttatgt aaagtttttc tattctttga
     4561 tctttaataa actttagatg cta
//
