LOCUS       NM_133905               3552 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus terminal nucleotidyltransferase 2 (Tent2), transcript
            variant 1, mRNA.
ACCESSION   NM_133905
VERSION     NM_133905.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3552)
  AUTHORS   Mansur,F., Alarcon,J.M., Stackpole,E.E., Wang,R. and Richter,J.D.
  TITLE     Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels,
            alternative RNA processing, and synaptic plasticity but not
            hippocampal-dependent behaviours
  JOURNAL   RNA Biol 18 (7), 962-971 (2021)
   PUBMED   32954964
  REMARK    GeneRIF: Noncanonical cytoplasmic poly(A) polymerases regulate RNA
            levels, alternative RNA processing, and synaptic plasticity but not
            hippocampal-dependent behaviours.
REFERENCE   2  (bases 1 to 3552)
  AUTHORS   Kleaveland,B., Shi,C.Y., Stefano,J. and Bartel,D.P.
  TITLE     A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain
  JOURNAL   Cell 174 (2), 350-362 (2018)
   PUBMED   29887379
REFERENCE   3  (bases 1 to 3552)
  AUTHORS   Mansur,F., Ivshina,M., Gu,W., Schaevitz,L., Stackpole,E., Gujja,S.,
            Edwards,Y.J. and Richter,J.D.
  TITLE     Gld2-catalyzed 3' monoadenylation of miRNAs in the hippocampus has
            no detectable effect on their stability or on animal behavior
  JOURNAL   RNA 22 (10), 1492-1499 (2016)
   PUBMED   27495319
  REMARK    GeneRIF: In Gld2 knockout mice there are detectable alterations in
            specific miRNA monoadenylation in the hippocampus, but no
            detectable effect on miRNA stability and no overt change in animal
            behavior.
REFERENCE   4  (bases 1 to 3552)
  AUTHORS   Cragle,C. and MacNicol,A.M.
  TITLE     Musashi protein-directed translational activation of target mRNAs
            is mediated by the poly(A) polymerase, germ line development
            defective-2
  JOURNAL   J Biol Chem 289 (20), 14239-14251 (2014)
   PUBMED   24644291
REFERENCE   5  (bases 1 to 3552)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   6  (bases 1 to 3552)
  AUTHORS   Udagawa,T., Swanger,S.A., Takeuchi,K., Kim,J.H., Nalavadi,V.,
            Shin,J., Lorenz,L.J., Zukin,R.S., Bassell,G.J. and Richter,J.D.
  TITLE     Bidirectional control of mRNA translation and synaptic plasticity
            by the cytoplasmic polyadenylation complex
  JOURNAL   Mol Cell 47 (2), 253-266 (2012)
   PUBMED   22727665
  REMARK    GeneRIF: poly(A) polymerase Gld2, deadenylase PARN, and translation
            inhibitory factor neuroguidin (Ngd) are components of a dendritic
            CPEB-associated polyadenylation apparatus
REFERENCE   7  (bases 1 to 3552)
  AUTHORS   Katoh,T., Sakaguchi,Y., Miyauchi,K., Suzuki,T., Kashiwabara,S.,
            Baba,T. and Suzuki,T.
  TITLE     Selective stabilization of mammalian microRNAs by 3' adenylation
            mediated by the cytoplasmic poly(A) polymerase GLD-2
  JOURNAL   Genes Dev 23 (4), 433-438 (2009)
   PUBMED   19240131
  REMARK    GeneRIF: identified GLD-2, which is a regulatory cytoplasmic
            poly(A) polymerase, as responsible for the 3'-terminal adenylation
            of miR-122 after unwinding of the miR-122/miR-122* duplex
REFERENCE   8  (bases 1 to 3552)
  AUTHORS   Nakanishi,T., Kumagai,S., Kimura,M., Watanabe,H., Sakurai,T.,
            Kimura,M., Kashiwabara,S. and Baba,T.
  TITLE     Disruption of mouse poly(A) polymerase mGLD-2 does not alter
            polyadenylation status in oocytes and somatic cells
  JOURNAL   Biochem Biophys Res Commun 364 (1), 14-19 (2007)
   PUBMED   17927953
  REMARK    GeneRIF: We found an association of mGLD-2 with cytoplasmic
            polyadenylation components, CPEB and CPSF described in Xenopus
            oocytes
REFERENCE   9  (bases 1 to 3552)
  AUTHORS   Nakanishi,T., Kubota,H., Ishibashi,N., Kumagai,S., Watanabe,H.,
            Yamashita,M., Kashiwabara,S., Miyado,K. and Baba,T.
  TITLE     Possible role of mouse poly(A) polymerase mGLD-2 during oocyte
            maturation
  JOURNAL   Dev Biol 289 (1), 115-126 (2006)
   PUBMED   16325797
  REMARK    GeneRIF: mGLD-2 may act in the ooplasm on the progression of
            metaphase I to metaphase II during oocyte maturation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120347.7, AC121991.3 and AC130217.4.
            
            On Mar 28, 2018 this sequence version replaced NM_133905.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016629.1, SRR1660817.153152.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC120347.7         27419-27742         c
            325-498             AC121991.3         94485-94658
            499-588             AC121991.3         95064-95153
            589-826             AC121991.3         96645-96882
            827-941             AC121991.3         105149-105263
            942-1033            AC121991.3         105351-105442
            1034-1112           AC121991.3         106243-106321
            1113-1182           AC121991.3         109069-109138
            1183-1259           AC121991.3         112494-112570
            1260-1388           AC121991.3         112907-113035
            1389-1432           AC130217.4         197667-197710       c
            1433-1569           AC130217.4         192947-193083       c
            1570-1661           AC130217.4         188706-188797       c
            1662-1741           AC130217.4         186903-186982       c
            1742-3552           AC130217.4         183877-185687       c
FEATURES             Location/Qualifiers
     source          1..3552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.81 cM"
     gene            1..3552
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /note="terminal nucleotidyltransferase 2"
                     /db_xref="GeneID:100715"
                     /db_xref="MGI:MGI:2140950"
     exon            1..324
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            325..498
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..1816
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /EC_number="2.7.7.19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     poly(A) RNA polymerase GLD2; cytoplasmic poly(A)
                     polymerase; PAP-associated domain-containing protein 4;
                     PAP associated domain containing 4"
                     /codon_start=1
                     /product="poly(A) RNA polymerase GLD2 isoform 1"
                     /protein_id="NP_598666.1"
                     /db_xref="CCDS:CCDS26686.1"
                     /db_xref="GeneID:100715"
                     /db_xref="MGI:MGI:2140950"
                     /translation="MFPNSILGRPPFTPTHQQHNNFFALSPTLYSHQQLIDAQFNFQN
                     VDLSRAVSLQPLTYGTVSPIQTSTSPLFRGRKRISDEKAFPLDGKRQRFHSPHQEPTI
                     INQLVPLSGDRRYSMPPLFHTHYIPDIVRCVPPLREIPLLEPREITLPEAKDKLSQQI
                     LELFETCQQQASDLKKKELCRAQLQREIQLLFPQSRLFLVGSSLNGFGARSSDGDLCL
                     VVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCV
                     EFDLNVNNTVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHDINDASRGTLSSYSLV
                     LMVLHYLQTLPEPILPSLQKIYPESFSTSVQLHLVHHAPCNVPPYLSKNESSLGDLLL
                     GFLKYYATEFDWNTQMISVREAKAIPRPDDMEWRNKYICVEEPFDGTNTARAVHEKQK
                     FDMIKDQFLKSWQRLKNKRDLNSVLPLRAATLKR"
     exon            499..588
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            589..826
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            827..941
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1033
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1112
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1182
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1259
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1388
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1432
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1569
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1661
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1741
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..3552
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1847..1852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /note="hexamer: AATAAA"
     polyA_site      1872
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /note="major polyA site"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /note="hexamer: AATAAA"
     polyA_site      3130
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
     regulatory      3529..3534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
                     /note="hexamer: AATAAA"
     polyA_site      3552
                     /gene="Tent2"
                     /gene_synonym="8030446C20Rik; GLD-2; Gld2; Papd4"
ORIGIN      
        1 tttccggggt cacgttgatc ttccgggtcc tgtgacaggg ttgtctacgc cgccttttcg
       61 gcgacttttt agtcttccgc cttttttttt ttttcctccc ccacccccct ttctttttgt
      121 tgtcgccacc cccagccttc cacggccgcg cgggcctggc cttaggctcg tgactctccg
      181 ccgccctgcc cgcccgagct gggcctcgct gcgccgggcc gctggctgct cctacctctg
      241 cctgctcggg cggcagctcc ggcctgggag cgtgttggcg ggcagtgccg ctgggccccg
      301 ctcggccctt cggcgtggac gccggtagaa gaatacatgt ttacctttag tgaacaagag
      361 catgttccca aactcaattt tgggtcgtcc acccttcact ccaacccacc aacagcataa
      421 taacttcttt gctctctcac caactcttta ttcacaccag caacttatag atgcacaatt
      481 caactttcaa aatgtagact tgtctagagc tgtgtcctta cagcccctga catatggaac
      541 tgtcagtcca atacagacct caacatctcc attatttcga ggaaggaaga gaataagcga
      601 tgaaaaagct tttcctcttg atggtaaacg gcagcgtttc cattcacccc accaagagcc
      661 aactataatc aaccagctag tgcctttatc aggtgacaga agatattcca tgccaccgtt
      721 gtttcacacg cactatatac cagatatagt cagatgtgtt ccacctcttc gagaaattcc
      781 actgttagaa cctcgagaaa tcacactgcc tgaggccaaa gataagttga gtcagcagat
      841 actagagttg tttgaaactt gtcagcagca agcaagtgac ttgaagaaga aagaactctg
      901 tagagcacag ctgcagagag agatccagct gctcttccca caaagcagac tttttctcgt
      961 tggatcatct ttgaatggat ttggtgcccg aagcagtgat ggcgatttat gcttagttgt
     1021 taaagaagaa ccatgttttt tccaggtaaa tcagaagact gaagcacgac atatactcac
     1081 cttagtccat aagcacttct gtactagact gtctggctat attgagagac ctcagctgat
     1141 tcgagcaaaa gtgccaattg tgaagttcag ggataaagtc agttgtgtgg aattcgactt
     1201 aaatgtaaac aataccgttg gaattagaaa tacattcctt ctcagaacct atgcatacct
     1261 tgaaaatcga gttcgtccat tagtgctggt gattaagaag tgggcaagtc accatgacat
     1321 caatgatgcc agtcgtggca cattaagcag ctatagtctt gtattgatgg ttttgcacta
     1381 tttacaaacc ctacctgaac ccatccttcc atccctccaa aaaatttacc cagaatcatt
     1441 tagtacttct gtccagctgc accttgttca tcatgcccca tgtaatgtcc ctccttacct
     1501 ctcaaagaat gaatcaagtc ttggggacct cttactgggc tttctgaaat attatgctac
     1561 agaatttgac tggaacactc agatgatttc agttcgtgaa gccaaagcca tcccaaggcc
     1621 tgatgatatg gaatggagaa ataaatacat ctgtgttgaa gaaccttttg atggaactaa
     1681 taccgccaga gctgtgcatg agaagcagaa gtttgatatg atcaaggatc aatttttaaa
     1741 gtcatggcag agattgaaaa acaagagaga tctgaacagt gtgctgcctt tgagagctgc
     1801 taccctgaaa agataactgg tctctaattc ttcaattctt ccaagaaata aagaacaaca
     1861 gatctatcat aattcatttt gtttacctcc atcatggttt atttttaatg ttcttgtttt
     1921 catgttttat ttttaaaagg acatatataa agattgcata ttttattatg acatttccta
     1981 ataaactctt tgatttaaga aaatgtattt ttgaaaatgt ttacatctct tagtagtatt
     2041 atggcatgac ttttcagcat aaaatatatt ttgagaaatt acctgaacta ataaggtttt
     2101 gatatattct caagtacttg taccacatac ttatcctgag aactacgtgg gattttgcaa
     2161 agatcctagt acttagtata actggcagca gcagcagcag tctagctcag ttctagtcaa
     2221 gtaaagattc aagtcagcta ttcagttact tgaagcaaat gaaatctttg attcagtgcg
     2281 atcactgtgg cgtcttgaaa tactggacag ttgccttcag tcttcactcg actccctggg
     2341 acactgtctg aggggtggct gtactgttta tagcacttca caactgactt tgatagactc
     2401 tggaggttgc tttagatttt gtgttgaaac aatacatttt gcactgttgt aacaggaaca
     2461 ctaacaacag ttagtgactt gtttatggac tatttgaaag tctctgactt aaatattttg
     2521 gaaaaaatgg agtttcttct gctttctgat agcacagtga acctgtgcac tgtggcttcg
     2581 cctgttttcc tggttttatt ttcctcatga taggaaacag cagaaaacgg aaacatcaac
     2641 gttgagatta tatcctactt gtagaatcag atttccgtgg attataatct aaactggaat
     2701 ttttaggcag taagccacta caaagtgttt tagataagac aataaagtta taaataaaag
     2761 tttaatgttt atacaaaaat cttttttagt atttctcttc cacatgaaag tagtagttca
     2821 gatgcaagct aagctgttta ataagattgt ttttagttta tgtaaatact tgtaaattgg
     2881 tcagtacctg tattgtacat ttaaatataa aaagtaatct tgaaggcagt tttaactttt
     2941 tcaaagattg caaacttctt gtaggcctac agtggtacaa tttgtaccac taaactattt
     3001 tttgcagacc aattaaaaaa ctaaaacttt cactttgttt gacttacaaa gggtgcatat
     3061 tttctttttt ctttttaagt ttaaattttt gtatgctgtc aaatggaata aagtttatat
     3121 ctggacattg ttgaggtgtt atttttctgt gcagttgttt ttgtgatatt aaggctgtaa
     3181 ttatcttaac tgatcggaac ctaatcgtgc ttgattattg aatgcgaaga gtgtctggga
     3241 cgaagctcat ctggagcctg tgaaccacat tacttctgtg ttataattag gattagagct
     3301 ttctctatgg gtcagttttt tagaatactg atctgtagta cttttgatgc agtttaaaaa
     3361 aatttacata tgattttttt tcttggaaac atttctaaga tttatcccac attgtgcagc
     3421 gctttctcag agtgtattga gtataacagt tcagtgtgac ctcaggtaat gtttgtcaat
     3481 catagtccct tggggacggg tgttctactc tgcagcacta tggcatttaa taaagcctca
     3541 gactttgccg ta
//
