LOCUS       NM_011856               9749 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus teneurin transmembrane protein 2 (Tenm2), transcript
            variant 1, mRNA.
ACCESSION   NM_011856 XM_906535
VERSION     NM_011856.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9749)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9749)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9749)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9749)
  AUTHORS   Auclair,G., Borgel,J., Sanz,L.A., Vallet,J., Guibert,S., Dumas,M.,
            Cavelier,P., Girardot,M., Forne,T., Feil,R. and Weber,M.
  TITLE     EHMT2 directs DNA methylation for efficient gene silencing in mouse
            embryos
  JOURNAL   Genome Res 26 (2), 192-202 (2016)
   PUBMED   26576615
REFERENCE   5  (bases 1 to 9749)
  AUTHORS   Delprato,A., Bonheur,B., Algeo,M.P., Rosay,P., Lu,L., Williams,R.W.
            and Crusio,W.E.
  TITLE     Systems genetic analysis of hippocampal neuroanatomy and spatial
            learning in mice
  JOURNAL   Genes Brain Behav 14 (8), 591-606 (2015)
   PUBMED   26449520
REFERENCE   6  (bases 1 to 9749)
  AUTHORS   Ben-Zur,T., Feige,E., Motro,B. and Wides,R.
  TITLE     The mammalian Odz gene family: homologs of a Drosophila pair-rule
            gene with expression implying distinct yet overlapping
            developmental roles
  JOURNAL   Dev Biol 217 (1), 107-120 (2000)
   PUBMED   10625539
REFERENCE   7  (bases 1 to 9749)
  AUTHORS   Rubin,B.P., Tucker,R.P., Martin,D. and Chiquet-Ehrismann,R.
  TITLE     Teneurins: a novel family of neuronal cell surface proteins in
            vertebrates, homologous to the Drosophila pair-rule gene product
            Ten-m
  JOURNAL   Dev Biol 216 (1), 195-209 (1999)
   PUBMED   10588872
REFERENCE   8  (bases 1 to 9749)
  AUTHORS   Ben-Zur,T. and Wides,R.
  TITLE     Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse
            chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human
            chromosome Xq25
  JOURNAL   Genomics 58 (1), 102-103 (1999)
   PUBMED   10331952
REFERENCE   9  (bases 1 to 9749)
  AUTHORS   Oohashi,T., Zhou,X.H., Feng,K., Richter,B., Morgelin,M.,
            Perez,M.T., Su,W.D., Chiquet-Ehrismann,R., Rauch,U. and Fassler,R.
  TITLE     Mouse ten-m/Odz is a new family of dimeric type II transmembrane
            proteins expressed in many tissues
  JOURNAL   J Cell Biol 145 (3), 563-577 (1999)
   PUBMED   10225957
REFERENCE   10 (bases 1 to 9749)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713956.13, AL713915.10, AL713919.11, BX539311.8, BX000433.3 and
            AL645912.18.
            
            On Mar 19, 2014 this sequence version replaced NM_011856.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AL713956.13        119254-119554       c
            302-577             AL713956.13        39981-40256         c
            578-787             AL713915.10        67511-67720         c
            788-1022            AL713919.11        151354-151588       c
            1023-1261           AL713919.11        124389-124627       c
            1262-1384           AL713919.11        72566-72688         c
            1385-1590           AL713919.11        58063-58268         c
            1591-1786           AL713919.11        22484-22679         c
            1787-1888           AL713919.11        14877-14978         c
            1889-2083           BX539311.8         5789-5983           c
            2084-2284           BX000433.3         22845-23045         c
            2285-2467           BX000433.3         20938-21120         c
            2468-2614           AL645912.18        172817-172963       c
            2615-2825           AL645912.18        144458-144668       c
            2826-2945           AL645912.18        138828-138947       c
            2946-3207           AL645912.18        135462-135723       c
            3208-3475           AL645912.18        134416-134683       c
            3476-3619           AL645912.18        129875-130018       c
            3620-3869           AL645912.18        129187-129436       c
            3870-3890           AL645912.18        121024-121044       c
            3891-4123           AL645912.18        117888-118120       c
            4124-4278           AL645912.18        115190-115344       c
            4279-5153           AL645912.18        112865-113739       c
            5154-5329           AL645912.18        107607-107782       c
            5330-5565           AL645912.18        105805-106040       c
            5566-5862           AL645912.18        93243-93539         c
            5863-7477           AL645912.18        89402-91016         c
            7478-7608           AL645912.18        76473-76603         c
            7609-9749           AL645912.18        72754-74894         c
FEATURES             Location/Qualifiers
     source          1..9749
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 21.96 cM"
     gene            1..9749
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="teneurin transmembrane protein 2"
                     /db_xref="GeneID:23964"
                     /db_xref="MGI:MGI:1345184"
     exon            1..301
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..8370
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     teneurin-2; tenascin-M2; protein Odd Oz/ten-m homolog 2;
                     odd Oz/ten-m homolog 2"
                     /codon_start=1
                     /product="teneurin-2 isoform 1"
                     /protein_id="NP_035986.3"
                     /db_xref="CCDS:CCDS24546.1"
                     /db_xref="GeneID:23964"
                     /db_xref="MGI:MGI:1345184"
                     /translation="MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSE
                     TLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGTNFTLAELGICEPSPHRSGYCSDMGI
                     LHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNE
                     NKSDDDNGRPIPPTSSSSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEF
                     SPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLT
                     NRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSS
                     PGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLA
                     YFIAMHLLGLNWQLQPADGHTFNNGVRTGLPGNDDVATVPSGGKVPWSLKNSSIDSGE
                     AEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDF
                     MERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFN
                     TVVLDSVQDCPRNCHGNGECVSGLCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQC
                     YSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCAAGYKGEHCEEVDCLDPTCSSHGV
                     CVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDSGLCSCDPNWMGPDCSVVCSV
                     DCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTID
                     GCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPD
                     CCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGDNPF
                     NSSLVSLIRGQVVTMDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGSALTLHF
                     ERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFF
                     SASPASNPIVPETQVLHEEIELPGTNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIR
                     VHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSL
                     ILWEKRTALLQGFELDPSNLGGWSLDKHHTLNVKSGILHKGTGENQFLTQQPAIITSI
                     MGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLFVGDFNYIRRIFPSRNVTSIL
                     ELRNKEFKHSNSPGHKYYLAVDPVTGSLYVSDTNSRRIYRVKSLSGAKDLAGNSEVVA
                     GTGEQCLPFDEARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIIST
                     LLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQV
                     SIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINRLRQV
                     TTNGEICLLAGAASDCDCKNDVNCICYSGDDAYATDAILNSPSSLAVAPDGTIYIADL
                     GNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTYS
                     ADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLELG
                     LMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIE
                     NSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMAVSFHSEPHV
                     LAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYD
                     RNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMS
                     ERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLHAVTMPS
                     VARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLS
                     KLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRFSEEGM
                     INARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQI
                     ITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTK
                     YTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSARLMPLRYDLRDRITRLG
                     DVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLG
                     HHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGT
                     PLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDV
                     LAGRWTSPDYTMWRNVGKEPAPFNLYMFKNNNPLSNELDLKNYVTDVKSWLVMFGFQL
                     SNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFLALEGQVITKK
                     LHASIREKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYL
                     DKMHYSIEGKDTHYFVKIGAADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRR
                     FTNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGS
                     RLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR"
     exon            302..577
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..787
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1022
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1261
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1384
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1590
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1786
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1888
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2083
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2284
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2467
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2614
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2825
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2945
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3207
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3475
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3619
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3869
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..3890
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4123
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4278
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..5153
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            5154..5329
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            5330..5565
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            5566..5862
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            5863..7477
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            7478..7608
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            7609..9749
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      8603
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="major polyA site"
     regulatory      8947..8952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="hexamer: AATACA"
     polyA_site      8969
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="major polyA site"
     regulatory      9718..9723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="hexamer: AATAAA"
     polyA_site      9749
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="major polyA site"
ORIGIN      
        1 gtgggtgagt gacaggtgcc acaactccag cctccccttt tctaaaagtc gcggagttct
       61 gtttcatctg gaataatgga tgtaaaggac cggcgacatc gctctttgac caggggacgg
      121 tgtggcaaag agtgtcgcta caccagctcc tctctggaca gtgaggactg ccgtgtgccc
      181 actcagaagt cctacagttc cagcgagacc ttgaaggctt atgaccatga cagcagaatg
      241 cactatggaa accgagtcac agacctggtg caccgggagt cggatgagtt ttctagacaa
      301 gggacaaact tcaccctggc agaattggga atctgcgagc cctccccaca ccgaagtggt
      361 tactgttccg acatgggtat cctccaccag ggctactccc tgagcactgg gtctgatgca
      421 gactcggaca ccgagggagg gatgtctcca gaacatgcca tcagactgtg gggacgaggg
      481 ataaaatcca ggcgcagctc tggcttgtcc agccgcgaga actcggccct tactctgact
      541 gactctgaca atgaaaataa atcggatgac gacaatggtc gtcccattcc acctacatcc
      601 tcgtctagcc tcctcccatc tgctcagctg cctagctccc ataatcctcc accagttagc
      661 tgccagatgc cattgctaga cagcaacacc tcccatcaga tcatggacac caaccctgat
      721 gaggaattct cccccaattc atacctgctc agagcatgct cagggcccca gcaagcctcc
      781 agcagtggcc ctccaaacca ccacagccag tcaacactga ggccccctct gccaccccct
      841 cataaccaca ccctgtccca ccaccactcc tcggccaact ccctcaacag gaactcactg
      901 accaatcggc ggagtcaaat ccacgcccca gctcctgcgc ccaacgacct ggccaccacc
      961 ccagagtctg ttcagctcca ggatagctgg gtgctgaaca gtaacgtccc actggagact
     1021 cggcacttcc ttttcaagac gtcgtctgga agcacacccc tgttcagcag ctcttctccg
     1081 ggataccctt tgacctcagg gaccgtttat acaccaccac cccgcctgct gccacggaat
     1141 acattctcca ggaaggcctt caagctgaag aaaccctcca aatactgcag ttggaaatgc
     1201 gctgccctgt ctgccatcgc cgccgccctc ctcttggcca ttttgctggc atatttcata
     1261 gcaatgcatc tgctcggact caattggcaa ctccagccgg cagatggaca cacctttaac
     1321 aatggcgtaa ggaccggctt accaggaaac gatgatgtgg caacagtgcc atctggaggc
     1381 aaagtgccct ggtcattgaa aaacagcagc atagacagtg gcgaagcaga agttggtcgg
     1441 cgggtgacac aggaagtccc accaggggtg ttttggaggt cccagattca catcagtcag
     1501 cctcaattct taaagttcaa catctccctg ggcaaggatg ccctcttcgg tgtctatata
     1561 aggagaggac taccaccgtc tcatgcccag tatgacttca tggaacgcct ggatggaaag
     1621 gagaaatgga gcgtggtcga gtcgcccagg gaacgccgga gcatccagac tctggtgcag
     1681 aacgaggctg tgtttgtgca gtacttggat gtgggcctgt ggcacctggc cttctacaat
     1741 gacggcaagg acaaggagat ggtctccttc aacactgttg tcttagattc agtgcaggac
     1801 tgtccacgga actgtcacgg gaacggcgaa tgcgtgtctg gactgtgtca ctgtttccca
     1861 ggattcctag gtgcagactg tgctaaagct gcctgccctg tactgtgcag cggaaatgga
     1921 cagtattcta aaggaacgtg ccagtgctac agcggctgga aaggtgcaga gtgcgatgtg
     1981 cctatgaacc aatgtatcga tccttcctgt gggggccatg gctcctgcat tgatgggaac
     2041 tgcgtgtgtg ctgctggcta caagggcgag cactgtgagg aagttgattg cttggatcct
     2101 acctgctcca gccatggtgt ctgtgtgaat ggagagtgtc tatgcagccc cggctggggt
     2161 ggtctcaact gtgagctggc gagggtccag tgcccagacc agtgtagtgg gcatggcact
     2221 tacctccctg actccggcct ctgcagctgt gatccgaact ggatgggtcc cgactgctct
     2281 gttgtgtgct cagtagactg tggcactcac ggcgtctgca tcgggggagc ctgccgctgt
     2341 gaagagggct ggacaggcgc agcttgtgac cagcgcgtgt gccacccccg ctgcattgag
     2401 cacgggacct gtaaagatgg caaatgtgaa tgccgagagg gctggaatgg tgaacactgc
     2461 accattgatg gctgccctga tttgtgcaac ggtaacggga gatgcacact gggtcagaac
     2521 agctggcagt gtgtctgcca gaccggctgg agagggcctg gatgcaacgt tgccatggaa
     2581 acctcctgcg ctgataacaa ggataatgag ggagatggcc tggtggactg cctggaccct
     2641 gactgctgcc tacagtcagc ctgtcagaac agcctgctct gccgggggtc tcgggacccc
     2701 ttggacatca ttcagcaagg tcagacagac tggcctgcag tgaagtcctt ctatgaccgc
     2761 atcaagctct tggcaggcaa ggacagcacc cacatcattc ctggagacaa ccccttcaat
     2821 agcagcctgg tgtctctgat ccgaggccaa gtagtaacca tggatgggac tcccttggtg
     2881 ggtgtgaatg tgtcttttgt caagtaccca aaatatggct acaccatcac tcgccaggat
     2941 ggcacgtttg atctgattgc caatgggggt tctgccttga ctcttcactt tgagcgagcc
     3001 cctttcatga gccaggagcg cacagtgtgg ctgccatgga acagcttcta tgccatggac
     3061 accctggtaa tgaagaccga ggaaaactcc atccccagct gtgacctcag tggctttgtc
     3121 cggccagatc caatcatcat ctcctctcct ctgtctacct tcttcagcgc ttcccctgcc
     3181 tcgaacccca ttgtgcctga gacccaggtt cttcatgaag aaattgagct ccctggtacc
     3241 aatgtgaagc tccgttatct cagctctaga actgcagggt acaagtcgct gctgaagatc
     3301 accatgacac agtccacagt gcccttgaac ctcatcaggg ttcacttgat ggttgctgta
     3361 gaggggcatc tcttccagaa gtcattccag gcttctccca acctagccta cacattcatc
     3421 tgggacaaga cagatgctta tggccaaagg gtttatggcc tatcggatgc tgttgtgtct
     3481 gttgggtttg aatatgagac ctgccccagt ctcatcctgt gggagaaaag gacagccctg
     3541 cttcagggat tcgagctgga cccttccaac cttggaggct ggtccctgga caaacaccac
     3601 accctcaatg tgaaaagcgg aatactacac aaagggacag gggagaacca gttcctgacc
     3661 cagcagcctg ccatcatcac gagcatcatg ggcaacggtc gccgcagaag catctcctgt
     3721 cccagctgta atggccttgc tgaaggcaac aaactgttag cccctgtggc cctggctgtg
     3781 gggatcgatg ggagcctctt tgttggtgac ttcaactata tccggcgcat ctttccctct
     3841 cgaaatgtga ccagtatctt ggagttacga aataaagagt ttaaacatag caacagccca
     3901 ggacacaagt attacttggc tgtggacccc gtgaccggct cactctacgt ctctgacacc
     3961 aacagtcgcc gaatctaccg agtcaagtct ctgagcggag ccaaagacct ggctggaaat
     4021 tcggaagttg tggcagggac tggcgaacaa tgtctaccct ttgatgaagc ccgctgtggg
     4081 gatggaggga aggctgtgga cgccaccctc atgagcccca gaggtattgc agtagacaag
     4141 aatgggctta tgtactttgt tgatgccacc atgatccgga aggtggacca aaacggaatc
     4201 atctccaccc tgctgggctc caatgacctc acagctgtcc gaccactgag ctgtgactcg
     4261 agcatggacg tggcccaggt ccgtctagaa tggccgacag acctcgccgt caaccccatg
     4321 gacaactccc tgtacgttct ggagaacaac gtcatcctgc ggatcacgga gaaccaccag
     4381 gtcagcatca tcgcgggacg gcctatgcac tgccaggttc ccggcatcga ctactcgctc
     4441 agcaaactcg ccatccattc tgcgctggaa tcagccagcg ccattgctat ttctcacact
     4501 ggggtgctct acatcactga gacggacgag aagaagatca accgcctacg ccaagtcacc
     4561 accaatggag agatctgcct cttagccggg gcggcctcag actgtgactg caaaaacgat
     4621 gtcaactgca tctgctactc gggagatgac gcttacgcca cggacgccat cctaaactcg
     4681 ccgtcctcct tagccgtggc tccagatggc accatctaca ttgcagacct tgggaatatc
     4741 cggatcaggg cggtcagcaa aaataaaccc gttcttaacg cattcaacca gtatgaggct
     4801 gcatctccgg gagaacagga attgtacgtg ttcaacgctg atggtatcca tcagtacact
     4861 gtgagtctgg tgactgggga gtacttgtac aatttcacat acagcgctga caatgacgtc
     4921 accgagttga ttgacaacaa cgggaattcc ctaaagatcc gccgggacag cagtggcatg
     4981 ccccgccacc tgctcatgcc tgataatcag attatcaccc ttaccgtggg caccaatgga
     5041 ggcctcaaag ccgtgtccac tcagaacctg gagctgggcc tcatgactta tgatgggaac
     5101 actggactcc tagccaccaa gagtgatgaa actggatgga caacttttta tgactatgac
     5161 cacgagggcc gtctgaccaa tgtgacccgc cccacgggcg tagtgaccag tctgcaccgg
     5221 gaaatggaga aatctatcac cattgacatt gagaactcca accgggatga tgacgtcact
     5281 gtgatcacca acctctcctc cgtggaggcc tcctatacag tggtacaaga tcaagtgcga
     5341 aacagctacc agctctgcaa taatggaacc ctgcgggtga tgtacgccaa cggcatggct
     5401 gtcagcttcc acagtgagcc ccacgtcctc gcaggcacca tcacccccac cattgggcgc
     5461 tgcaacatct ctctgcccat ggagaatggc ctgaactcca tcgagtggcg cctgaggaag
     5521 gaacagatca aaggcaaagt caccatcttt gggaggaagc ttcgggtcca cggaaggaat
     5581 ctcctgtcca ttgattatga ccgaaatatc cgaacggaga agatctacga tgaccaccgg
     5641 aaattcaccc tgaggatcat ctatgaccag gtgggccgcc ccttcctgtg gctcccgagc
     5701 agtgggctgg cagccgtcaa tgtctcctac ttcttcaatg ggcgcttggc cggcctccag
     5761 cgaggggcca tgagcgagag gacagacatt gacaagcaag gccggatcgt gtcccgcatg
     5821 ttcgccgacg ggaaagtctg gagctattcc tatcttgaca agtccatggt ccttctgcta
     5881 cagagccaac gtcagtacat atttgaatat gactcctccg atcgcctcca cgcagtcact
     5941 atgcccagtg tcgcccggca cagcatgtcc acgcacacct ccattggtta catccgaaac
     6001 atttacaacc cacccgaaag caatgcatca gtcatctttg actacagtga tgacggccgc
     6061 atcctaaaga catctttctt gggcactggg cgccaggtgt tctacaagta tggaaaactc
     6121 tccaagttat cagagatagt ctacgacagc acagccgtca cctttgggta tgacgagacc
     6181 accggtgtcc tgaagatggt caatctccaa agtgggggtt tctcctgtac catcaggtac
     6241 cgaaaggttg ggccccttgt ggacaagcag atttacaggt tctctgagga aggaatgatc
     6301 aacgccaggt ttgattatac ctatcacgac aatagcttcc gcattgccag catcaaaccc
     6361 gtcattagcg agactcccct tcctgttgac ctctaccgct atgatgagat ttccggcaag
     6421 gtggaacact tcggcaagtt tggggtcatc tactacgaca tcaaccagat catcaccact
     6481 gccgtcatga cgcttagcaa gcactttgac acccatgggc gcatcaagga agtgcaatat
     6541 gagatgttcc ggtccctcat gtactggatg actgtgcaat atgacagtat gggtagggtc
     6601 atcaagaggg aactgaaact agggccctat gccaacacca caaagtacac ctatgactat
     6661 gacggggacg gccagctcca gagtgtggcc gtcaatgacc ggcctacctg gcgctatagc
     6721 tatgacctca atgggaacct gcaccttcta aacccaggaa acagtgctcg cctcatgccc
     6781 ttacgctatg acctccgtga ccggataacc aggctagggg acgtgcagta caaaatcgat
     6841 gacgatggct atttgtgcca gagagggtca gacatctttg aatacaactc caagggcctt
     6901 ctgacaagag catacaacaa ggccagcgga tggagcgtgc agtaccgcta tgacggagtg
     6961 ggccgccggg cttcctacaa gaccaacctg ggccaccacc tacagtactt ctactccgac
     7021 ctccacaacc ccacacgtat cacccatgtt tacaaccact ccaactctga gatcacctcg
     7081 ctctactatg acctccaggg ccacctattt gccatggaga gcagtagtgg tgaagaatac
     7141 tatgtcgcct cagacaacac ggggacccct ctggctgtgt tcagtatcaa tggcctcatg
     7201 atcaagcaac tgcagtacac agcctatggg gagatctact atgactccaa tccagacttc
     7261 cagatggtca ttggcttcca cggaggcctc tatgaccccc tcaccaagct cgtccacttt
     7321 actcaacgtg attatgacgt gctggcagga cggtggacgt cccccgacta caccatgtgg
     7381 aggaacgtgg gcaaggagcc agcccccttc aacctgtaca tgttcaagaa caacaatcct
     7441 ctgagcaatg agctggactt aaagaactac gtgacagacg tgaagagctg gcttgtgatg
     7501 tttggatttc agctcagcaa catcattcct ggattcccga gagccaaaat gtattttgtg
     7561 cctcccccct atgaactgtc agagagtcaa gcaagcgaga acggacagct cattacaggt
     7621 gtccagcaga caactgagag gcataaccag gccttcctgg ctctggaagg acaggtcatc
     7681 actaaaaagc tccatgccag catccgagag aaagcaggcc actggtttgc taccaccaca
     7741 cccatcatcg gcaaaggcat catgtttgcc atcaaagaag ggcgggtgac cacaggagtg
     7801 tctagcatcg ccagtgagga cagccgcaag gtagcatccg tgttgaacaa tgcctactac
     7861 ttagacaaga tgcactacag catcgagggc aaggacacac actactttgt gaagatcggc
     7921 gccgcggatg gtgacctggt cacgctagga accaccattg ggcgcaaggt gctggagagt
     7981 ggggtgaacg tgacggtgtc acagcccacg ctgctggtga atggcaggac tcgaaggttc
     8041 accaacattg agttccagta ctccacgctg ctgctcagta tccgctacgg cctcaccccc
     8101 gacacgctgg acgaagaaaa ggcccgcgtc ctggaccaag cgagacagag agccctgggt
     8161 actgcctggg ccaaggagca gcagaaagcc agggacggga gagagggcag ccgcctgtgg
     8221 acggagggcg agaagcagca actcctgagc acgggacggg tacaaggtta tgagggctat
     8281 tacgtacttc cggtggaaca gtacccggag ctggcagaca gtagcagcaa catccagttc
     8341 ttaagacaga atgagatggg aaagaggtaa caaaataacc tgctgccacc tcttctctgg
     8401 gtggctcagc aggagcaact gtgacctcct ctcctaagga gacgaagacc taacggggca
     8461 ctgaggccgg gctgctttag gatcccaagt ggcaagaaag ctcacatttt ttgagttcaa
     8521 atgctactgt ctaagcgcaa agtccctcat cctgaagtag actagagccc ggccacaaat
     8581 tctgaggaaa aacaaaaact aaaggatgaa cgaacgaacg aacgaatgaa aacacacaca
     8641 aaatgtttca agttccccta aaatatgacc cacttgttcc gggtctaagg cagaaaagag
     8701 acgcagaata gccaaaagga aaggaacaga aaagaaacaa attaaaaaaa aaaaaaagca
     8761 aacaaaaaga caaagacacc gaccatacaa acgaagaaat gaagacgaga aggcctcata
     8821 ttctaatacc tcactcattg acacgtgagc aacacaaaga cattcacaag ggccggcatc
     8881 accagaccag ctgaggacaa ctcagactga cagttggaca aacattgcga cgttttcgtt
     8941 taagcaaata caggtgcatt taaaaaacac gactttgggg gtgatttgtg tgtagcgcct
     9001 ggggagggag ggggcacaaa agcggaggat cgagcactgg aaatactttt taaagaaaaa
     9061 gaaaaacaca agaaaaaaat cagtatcaga agtcaaagcg aaacaatacc gtctggcact
     9121 taactctcag gtcccccact tagtcaggcc tgagctaatt tatttgagcg cagagtgtaa
     9181 aattttaatt caaaatggtg gctatactca ctacacataa atctcataat ctttttgtct
     9241 ttggagattc cattgtggac agtaatacgc agttacaggg tgtagtctgt ttagaatccg
     9301 tagtttgtgg gtatcagttg cggtagagat gcaacatttg tgactctgtt gctaacggtt
     9361 accacttccg atcgccctgt acatacatat gccgtaaggc gcaatcactg tttcagactt
     9421 aaaattatta gtgtgtttgt ttggtccaga aactgagaca atcacatgac agtcaccacg
     9481 aggagagaaa aataaaaaaa taaataaata aataaaaaca aaaaaaaatt ttaaaaagtg
     9541 aagaaaaaaa acacacaaaa aaaaagtcta ataagaactt tggtacagga acttttttgt
     9601 aatatacatg tatgaattgt tcatcgagtt tttatattaa ttttaatttg ctgctaagca
     9661 aagactaggg acaggcaaag ataatttatg gcaaagtgtt taaattgttt atacataaat
     9721 aaagtctcta aaactcctgt ggacactga
//
