LOCUS       NP_035986               2764 aa            linear   ROD 12-JUN-2024
DEFINITION  teneurin-2 isoform 1 [Mus musculus].
ACCESSION   NP_035986 XP_911628
VERSION     NP_035986.3
DBSOURCE    REFSEQ: accession NM_011856.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2764)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2764)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2764)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2764)
  AUTHORS   Auclair,G., Borgel,J., Sanz,L.A., Vallet,J., Guibert,S., Dumas,M.,
            Cavelier,P., Girardot,M., Forne,T., Feil,R. and Weber,M.
  TITLE     EHMT2 directs DNA methylation for efficient gene silencing in mouse
            embryos
  JOURNAL   Genome Res 26 (2), 192-202 (2016)
   PUBMED   26576615
REFERENCE   5  (residues 1 to 2764)
  AUTHORS   Delprato,A., Bonheur,B., Algeo,M.P., Rosay,P., Lu,L., Williams,R.W.
            and Crusio,W.E.
  TITLE     Systems genetic analysis of hippocampal neuroanatomy and spatial
            learning in mice
  JOURNAL   Genes Brain Behav 14 (8), 591-606 (2015)
   PUBMED   26449520
REFERENCE   6  (residues 1 to 2764)
  AUTHORS   Ben-Zur,T., Feige,E., Motro,B. and Wides,R.
  TITLE     The mammalian Odz gene family: homologs of a Drosophila pair-rule
            gene with expression implying distinct yet overlapping
            developmental roles
  JOURNAL   Dev Biol 217 (1), 107-120 (2000)
   PUBMED   10625539
REFERENCE   7  (residues 1 to 2764)
  AUTHORS   Rubin,B.P., Tucker,R.P., Martin,D. and Chiquet-Ehrismann,R.
  TITLE     Teneurins: a novel family of neuronal cell surface proteins in
            vertebrates, homologous to the Drosophila pair-rule gene product
            Ten-m
  JOURNAL   Dev Biol 216 (1), 195-209 (1999)
   PUBMED   10588872
REFERENCE   8  (residues 1 to 2764)
  AUTHORS   Ben-Zur,T. and Wides,R.
  TITLE     Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse
            chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human
            chromosome Xq25
  JOURNAL   Genomics 58 (1), 102-103 (1999)
   PUBMED   10331952
REFERENCE   9  (residues 1 to 2764)
  AUTHORS   Oohashi,T., Zhou,X.H., Feng,K., Richter,B., Morgelin,M.,
            Perez,M.T., Su,W.D., Chiquet-Ehrismann,R., Rauch,U. and Fassler,R.
  TITLE     Mouse ten-m/Odz is a new family of dimeric type II transmembrane
            proteins expressed in many tissues
  JOURNAL   J Cell Biol 145 (3), 563-577 (1999)
   PUBMED   10225957
REFERENCE   10 (residues 1 to 2764)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713956.13, AL713915.10, AL713919.11, BX539311.8, BX000433.3 and
            AL645912.18.
            
            On Jul 27, 2007 this sequence version replaced NP_035986.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2764
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 21.96 cM"
     Protein         1..2764
                     /product="teneurin-2 isoform 1"
                     /note="teneurin-2; tenascin-M2; protein Odd Oz/ten-m
                     homolog 2; odd Oz/ten-m homolog 2"
                     /calculated_mol_wt=306422
     Region          10..374
                     /region_name="Ten_N"
                     /note="Teneurin Intracellular Region; pfam06484"
                     /db_xref="CDD:461932"
     Region          580..602
                     /region_name="EGF_2"
                     /note="EGF-like domain; pfam07974"
                     /db_xref="CDD:400365"
     Region          644..789
                     /region_name="C_rich_MXAN6577"
                     /note="MXAN_6577-like cysteine-rich domain; NF041328"
                     /db_xref="CDD:469225"
     Region          797..830
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          833..863
                     /region_name="acid_disulf_rpt"
                     /note="acidic double-disulfide repeat; NF033662"
                     /db_xref="CDD:411265"
     Region          1230..1560
                     /region_name="NHL"
                     /note="NHL repeat unit of beta-propeller proteins;
                     cl18310"
                     /db_xref="CDD:302697"
     Region          1230..1269
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271323"
     Region          1281..1324
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271323"
     Region          1348..1386
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271323"
     Region          1402..1443
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271323"
     Region          1466..1499
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271323"
     Region          1521..2458
                     /region_name="RhsA"
                     /note="Uncharacterized conserved protein RhaS, contains 28
                     RHS repeats [General function prediction only]; COG3209"
                     /db_xref="CDD:442442"
     Region          1534..1560
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271323"
     Region          2680..2757
                     /region_name="Tox-GHH"
                     /note="GHH signature containing HNH/Endo VII superfamily
                     nuclease toxin; pfam15636"
                     /db_xref="CDD:464783"
     CDS             1..2764
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /coded_by="NM_011856.4:76..8370"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24546.1"
                     /db_xref="GeneID:23964"
                     /db_xref="MGI:MGI:1345184"
ORIGIN      
        1 mdvkdrrhrs ltrgrcgkec rytsssldse dcrvptqksy sssetlkayd hdsrmhygnr
       61 vtdlvhresd efsrqgtnft laelgiceps phrsgycsdm gilhqgysls tgsdadsdte
      121 ggmspehair lwgrgiksrr ssglssrens altltdsdne nksdddngrp ipptssssll
      181 psaqlpsshn pppvscqmpl ldsntshqim dtnpdeefsp nsyllracsg pqqasssgpp
      241 nhhsqstlrp plppphnhtl shhhssansl nrnsltnrrs qihapapapn dlattpesvq
      301 lqdswvlnsn vpletrhflf ktssgstplf sssspgyplt sgtvytpppr llprntfsrk
      361 afklkkpsky cswkcaalsa iaaalllail layfiamhll glnwqlqpad ghtfnngvrt
      421 glpgnddvat vpsggkvpws lknssidsge aevgrrvtqe vppgvfwrsq ihisqpqflk
      481 fnislgkdal fgvyirrglp pshaqydfme rldgkekwsv vesprerrsi qtlvqneavf
      541 vqyldvglwh lafyndgkdk emvsfntvvl dsvqdcprnc hgngecvsgl chcfpgflga
      601 dcakaacpvl csgngqyskg tcqcysgwkg aecdvpmnqc idpscgghgs cidgncvcaa
      661 gykgehceev dcldptcssh gvcvngeclc spgwgglnce larvqcpdqc sghgtylpds
      721 glcscdpnwm gpdcsvvcsv dcgthgvcig gacrceegwt gaacdqrvch prciehgtck
      781 dgkcecregw ngehctidgc pdlcngngrc tlgqnswqcv cqtgwrgpgc nvametscad
      841 nkdnegdglv dcldpdcclq sacqnsllcr gsrdpldiiq qgqtdwpavk sfydriklla
      901 gkdsthiipg dnpfnsslvs lirgqvvtmd gtplvgvnvs fvkypkygyt itrqdgtfdl
      961 ianggsaltl hferapfmsq ertvwlpwns fyamdtlvmk teensipscd lsgfvrpdpi
     1021 iissplstff saspasnpiv petqvlheei elpgtnvklr ylssrtagyk sllkitmtqs
     1081 tvplnlirvh lmvaveghlf qksfqaspnl aytfiwdktd aygqrvygls davvsvgfey
     1141 etcpslilwe krtallqgfe ldpsnlggws ldkhhtlnvk sgilhkgtge nqfltqqpai
     1201 itsimgngrr rsiscpscng laegnkllap valavgidgs lfvgdfnyir rifpsrnvts
     1261 ilelrnkefk hsnspghkyy lavdpvtgsl yvsdtnsrri yrvkslsgak dlagnsevva
     1321 gtgeqclpfd earcgdggka vdatlmsprg iavdknglmy fvdatmirkv dqngiistll
     1381 gsndltavrp lscdssmdva qvrlewptdl avnpmdnsly vlennvilri tenhqvsiia
     1441 grpmhcqvpg idyslsklai hsalesasai aishtgvlyi tetdekkinr lrqvttngei
     1501 cllagaasdc dckndvncic ysgddayatd ailnspssla vapdgtiyia dlgnirirav
     1561 sknkpvlnaf nqyeaaspge qelyvfnadg ihqytvslvt geylynftys adndvtelid
     1621 nngnslkirr dssgmprhll mpdnqiitlt vgtngglkav stqnlelglm tydgntglla
     1681 tksdetgwtt fydydhegrl tnvtrptgvv tslhremeks itidiensnr dddvtvitnl
     1741 ssveasytvv qdqvrnsyql cnngtlrvmy angmavsfhs ephvlagtit ptigrcnisl
     1801 pmenglnsie wrlrkeqikg kvtifgrklr vhgrnllsid ydrnirteki yddhrkftlr
     1861 iiydqvgrpf lwlpssglaa vnvsyffngr laglqrgams ertdidkqgr ivsrmfadgk
     1921 vwsysyldks mvlllqsqrq yifeydssdr lhavtmpsva rhsmsthtsi gyirniynpp
     1981 esnasvifdy sddgrilkts flgtgrqvfy kygklsklse ivydstavtf gydettgvlk
     2041 mvnlqsggfs ctiryrkvgp lvdkqiyrfs eegminarfd ytyhdnsfri asikpviset
     2101 plpvdlyryd eisgkvehfg kfgviyydin qiittavmtl skhfdthgri kevqyemfrs
     2161 lmywmtvqyd smgrvikrel klgpyanttk ytydydgdgq lqsvavndrp twrysydlng
     2221 nlhllnpgns arlmplrydl rdritrlgdv qykidddgyl cqrgsdifey nskglltray
     2281 nkasgwsvqy rydgvgrras yktnlghhlq yfysdlhnpt rithvynhsn seitslyydl
     2341 qghlfamess sgeeyyvasd ntgtplavfs inglmikqlq ytaygeiyyd snpdfqmvig
     2401 fhgglydplt klvhftqrdy dvlagrwtsp dytmwrnvgk epapfnlymf knnnplsnel
     2461 dlknyvtdvk swlvmfgfql sniipgfpra kmyfvpppye lsesqaseng qlitgvqqtt
     2521 erhnqaflal egqvitkklh asirekaghw fatttpiigk gimfaikegr vttgvssias
     2581 edsrkvasvl nnayyldkmh ysiegkdthy fvkigaadgd lvtlgttigr kvlesgvnvt
     2641 vsqptllvng rtrrftnief qystlllsir ygltpdtlde ekarvldqar qralgtawak
     2701 eqqkardgre gsrlwtegek qqllstgrvq gyegyyvlpv eqypeladss sniqflrqne
     2761 mgkr
//
