LOCUS       NM_001290702            9656 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus teneurin transmembrane protein 2 (Tenm2), transcript
            variant 2, mRNA.
ACCESSION   NM_001290702
VERSION     NM_001290702.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9656)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9656)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9656)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9656)
  AUTHORS   Auclair,G., Borgel,J., Sanz,L.A., Vallet,J., Guibert,S., Dumas,M.,
            Cavelier,P., Girardot,M., Forne,T., Feil,R. and Weber,M.
  TITLE     EHMT2 directs DNA methylation for efficient gene silencing in mouse
            embryos
  JOURNAL   Genome Res 26 (2), 192-202 (2016)
   PUBMED   26576615
REFERENCE   5  (bases 1 to 9656)
  AUTHORS   Delprato,A., Bonheur,B., Algeo,M.P., Rosay,P., Lu,L., Williams,R.W.
            and Crusio,W.E.
  TITLE     Systems genetic analysis of hippocampal neuroanatomy and spatial
            learning in mice
  JOURNAL   Genes Brain Behav 14 (8), 591-606 (2015)
   PUBMED   26449520
REFERENCE   6  (bases 1 to 9656)
  AUTHORS   Ben-Zur,T., Feige,E., Motro,B. and Wides,R.
  TITLE     The mammalian Odz gene family: homologs of a Drosophila pair-rule
            gene with expression implying distinct yet overlapping
            developmental roles
  JOURNAL   Dev Biol 217 (1), 107-120 (2000)
   PUBMED   10625539
REFERENCE   7  (bases 1 to 9656)
  AUTHORS   Rubin,B.P., Tucker,R.P., Martin,D. and Chiquet-Ehrismann,R.
  TITLE     Teneurins: a novel family of neuronal cell surface proteins in
            vertebrates, homologous to the Drosophila pair-rule gene product
            Ten-m
  JOURNAL   Dev Biol 216 (1), 195-209 (1999)
   PUBMED   10588872
REFERENCE   8  (bases 1 to 9656)
  AUTHORS   Ben-Zur,T. and Wides,R.
  TITLE     Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse
            chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human
            chromosome Xq25
  JOURNAL   Genomics 58 (1), 102-103 (1999)
   PUBMED   10331952
REFERENCE   9  (bases 1 to 9656)
  AUTHORS   Oohashi,T., Zhou,X.H., Feng,K., Richter,B., Morgelin,M.,
            Perez,M.T., Su,W.D., Chiquet-Ehrismann,R., Rauch,U. and Fassler,R.
  TITLE     Mouse ten-m/Odz is a new family of dimeric type II transmembrane
            proteins expressed in many tissues
  JOURNAL   J Cell Biol 145 (3), 563-577 (1999)
   PUBMED   10225957
REFERENCE   10 (bases 1 to 9656)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713956.13, AL713915.10, AL713919.11, BX539311.8, BX000433.3 and
            AL645912.18.
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region but maintains reading frame, compared to variant
            1. The encoded isoform (2) is shorter, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141361.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AL713956.13        119254-119554       c
            302-577             AL713956.13        39981-40256         c
            578-787             AL713915.10        67511-67720         c
            788-1022            AL713919.11        151354-151588       c
            1023-1261           AL713919.11        124389-124627       c
            1262-1467           AL713919.11        58063-58268         c
            1468-1663           AL713919.11        22484-22679         c
            1664-1765           AL713919.11        14877-14978         c
            1766-1960           BX539311.8         5789-5983           c
            1961-2161           BX000433.3         22845-23045         c
            2162-2374           BX000433.3         20911-21123         c
            2375-2521           AL645912.18        172817-172963       c
            2522-2732           AL645912.18        144458-144668       c
            2733-2852           AL645912.18        138828-138947       c
            2853-3114           AL645912.18        135462-135723       c
            3115-3382           AL645912.18        134416-134683       c
            3383-3526           AL645912.18        129875-130018       c
            3527-3776           AL645912.18        129187-129436       c
            3777-3797           AL645912.18        121024-121044       c
            3798-4030           AL645912.18        117888-118120       c
            4031-4185           AL645912.18        115190-115344       c
            4186-5060           AL645912.18        112865-113739       c
            5061-5236           AL645912.18        107607-107782       c
            5237-5472           AL645912.18        105805-106040       c
            5473-5769           AL645912.18        93243-93539         c
            5770-7384           AL645912.18        89402-91016         c
            7385-7515           AL645912.18        76473-76603         c
            7516-9656           AL645912.18        72754-74894         c
FEATURES             Location/Qualifiers
     source          1..9656
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 21.96 cM"
     gene            1..9656
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="teneurin transmembrane protein 2"
                     /db_xref="GeneID:23964"
                     /db_xref="MGI:MGI:1345184"
     exon            1..301
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..8277
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     teneurin-2; tenascin-M2; protein Odd Oz/ten-m homolog 2;
                     odd Oz/ten-m homolog 2"
                     /codon_start=1
                     /product="teneurin-2 isoform 2"
                     /protein_id="NP_001277631.1"
                     /db_xref="GeneID:23964"
                     /db_xref="MGI:MGI:1345184"
                     /translation="MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSE
                     TLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGTNFTLAELGICEPSPHRSGYCSDMGI
                     LHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNE
                     NKSDDDNGRPIPPTSSSSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEF
                     SPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLT
                     NRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSS
                     PGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLA
                     YFIVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALF
                     GVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLW
                     HLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGLCHCFPGFLGADCAKAAC
                     PVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCAAGYKGE
                     HCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDSGLC
                     SCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCK
                     DGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPG
                     CNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWP
                     AVKSFYDRIKLLAGKDSTHIIPGDNPFNSSLVSLIRGQVVTMDGTPLVGVNVSFVKYP
                     KYGYTITRQDGTFDLIANGGSALTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEE
                     NSIPSCDLSGFVRPDPIIISSPLSTFFSASPASNPIVPETQVLHEEIELPGTNVKLRY
                     LSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWDKT
                     DAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHTL
                     NVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAV
                     GIDGSLFVGDFNYIRRIFPSRNVTSILELRNKEFKHSNSPGHKYYLAVDPVTGSLYVS
                     DTNSRRIYRVKSLSGAKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAVDATLMSPRGI
                     AVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTD
                     LAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESA
                     SAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCICYSGDD
                     AYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQEL
                     YVFNADGIHQYTVSLVTGEYLYNFTYSADNDVTELIDNNGNSLKIRRDSSGMPRHLLM
                     PDNQIITLTVGTNGGLKAVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGR
                     LTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNS
                     YQLCNNGTLRVMYANGMAVSFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRK
                     EQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWL
                     PSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSM
                     VLLLQSQRQYIFEYDSSDRLHAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFD
                     YSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSG
                     GFSCTIRYRKVGPLVDKQIYRFSEEGMINARFDYTYHDNSFRIASIKPVISETPLPVD
                     LYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMY
                     WMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGN
                     LHLLNPGNSARLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRA
                     YNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLY
                     YDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDF
                     QMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWRNVGKEPAPFNLYMFKNN
                     NPLSNELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENGQ
                     LITGVQQTTERHNQAFLALEGQVITKKLHASIREKAGHWFATTTPIIGKGIMFAIKEG
                     RVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGAADGDLVTLGTT
                     IGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARV
                     LDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQY
                     PELADSSSNIQFLRQNEMGKR"
     exon            302..577
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..787
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1022
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1261
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1467
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1663
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1765
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1960
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2161
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2374
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2521
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2732
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2852
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3114
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3382
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3526
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3776
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3797
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..4030
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            4031..4185
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..5060
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            5061..5236
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            5237..5472
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            5473..5769
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            5770..7384
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            7385..7515
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     exon            7516..9656
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      8510
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="major polyA site"
     regulatory      8854..8859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="hexamer: AATACA"
     polyA_site      8876
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="major polyA site"
     regulatory      9625..9630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="hexamer: AATAAA"
     polyA_site      9656
                     /gene="Tenm2"
                     /gene_synonym="Odz2; Odz3; Ten-2; Ten-m2"
                     /note="major polyA site"
ORIGIN      
        1 gtgggtgagt gacaggtgcc acaactccag cctccccttt tctaaaagtc gcggagttct
       61 gtttcatctg gaataatgga tgtaaaggac cggcgacatc gctctttgac caggggacgg
      121 tgtggcaaag agtgtcgcta caccagctcc tctctggaca gtgaggactg ccgtgtgccc
      181 actcagaagt cctacagttc cagcgagacc ttgaaggctt atgaccatga cagcagaatg
      241 cactatggaa accgagtcac agacctggtg caccgggagt cggatgagtt ttctagacaa
      301 gggacaaact tcaccctggc agaattggga atctgcgagc cctccccaca ccgaagtggt
      361 tactgttccg acatgggtat cctccaccag ggctactccc tgagcactgg gtctgatgca
      421 gactcggaca ccgagggagg gatgtctcca gaacatgcca tcagactgtg gggacgaggg
      481 ataaaatcca ggcgcagctc tggcttgtcc agccgcgaga actcggccct tactctgact
      541 gactctgaca atgaaaataa atcggatgac gacaatggtc gtcccattcc acctacatcc
      601 tcgtctagcc tcctcccatc tgctcagctg cctagctccc ataatcctcc accagttagc
      661 tgccagatgc cattgctaga cagcaacacc tcccatcaga tcatggacac caaccctgat
      721 gaggaattct cccccaattc atacctgctc agagcatgct cagggcccca gcaagcctcc
      781 agcagtggcc ctccaaacca ccacagccag tcaacactga ggccccctct gccaccccct
      841 cataaccaca ccctgtccca ccaccactcc tcggccaact ccctcaacag gaactcactg
      901 accaatcggc ggagtcaaat ccacgcccca gctcctgcgc ccaacgacct ggccaccacc
      961 ccagagtctg ttcagctcca ggatagctgg gtgctgaaca gtaacgtccc actggagact
     1021 cggcacttcc ttttcaagac gtcgtctgga agcacacccc tgttcagcag ctcttctccg
     1081 ggataccctt tgacctcagg gaccgtttat acaccaccac cccgcctgct gccacggaat
     1141 acattctcca ggaaggcctt caagctgaag aaaccctcca aatactgcag ttggaaatgc
     1201 gctgccctgt ctgccatcgc cgccgccctc ctcttggcca ttttgctggc atatttcata
     1261 gtgccctggt cattgaaaaa cagcagcata gacagtggcg aagcagaagt tggtcggcgg
     1321 gtgacacagg aagtcccacc aggggtgttt tggaggtccc agattcacat cagtcagcct
     1381 caattcttaa agttcaacat ctccctgggc aaggatgccc tcttcggtgt ctatataagg
     1441 agaggactac caccgtctca tgcccagtat gacttcatgg aacgcctgga tggaaaggag
     1501 aaatggagcg tggtcgagtc gcccagggaa cgccggagca tccagactct ggtgcagaac
     1561 gaggctgtgt ttgtgcagta cttggatgtg ggcctgtggc acctggcctt ctacaatgac
     1621 ggcaaggaca aggagatggt ctccttcaac actgttgtct tagattcagt gcaggactgt
     1681 ccacggaact gtcacgggaa cggcgaatgc gtgtctggac tgtgtcactg tttcccagga
     1741 ttcctaggtg cagactgtgc taaagctgcc tgccctgtac tgtgcagcgg aaatggacag
     1801 tattctaaag gaacgtgcca gtgctacagc ggctggaaag gtgcagagtg cgatgtgcct
     1861 atgaaccaat gtatcgatcc ttcctgtggg ggccatggct cctgcattga tgggaactgc
     1921 gtgtgtgctg ctggctacaa gggcgagcac tgtgaggaag ttgattgctt ggatcctacc
     1981 tgctccagcc atggtgtctg tgtgaatgga gagtgtctat gcagccccgg ctggggtggt
     2041 ctcaactgtg agctggcgag ggtccagtgc ccagaccagt gtagtgggca tggcacttac
     2101 ctccctgact ccggcctctg cagctgtgat ccgaactgga tgggtcccga ctgctctgtt
     2161 gaagtgtgct cagtagactg tggcactcac ggcgtctgca tcgggggagc ctgccgctgt
     2221 gaagagggct ggacaggcgc agcttgtgac cagcgcgtgt gccacccccg ctgcattgag
     2281 cacgggacct gtaaagatgg caaatgtgaa tgccgagagg gctggaatgg tgaacactgc
     2341 accattggta ggcaaacggc aggcaccgaa acagatggct gccctgattt gtgcaacggt
     2401 aacgggagat gcacactggg tcagaacagc tggcagtgtg tctgccagac cggctggaga
     2461 gggcctggat gcaacgttgc catggaaacc tcctgcgctg ataacaagga taatgaggga
     2521 gatggcctgg tggactgcct ggaccctgac tgctgcctac agtcagcctg tcagaacagc
     2581 ctgctctgcc gggggtctcg ggaccccttg gacatcattc agcaaggtca gacagactgg
     2641 cctgcagtga agtccttcta tgaccgcatc aagctcttgg caggcaagga cagcacccac
     2701 atcattcctg gagacaaccc cttcaatagc agcctggtgt ctctgatccg aggccaagta
     2761 gtaaccatgg atgggactcc cttggtgggt gtgaatgtgt cttttgtcaa gtacccaaaa
     2821 tatggctaca ccatcactcg ccaggatggc acgtttgatc tgattgccaa tgggggttct
     2881 gccttgactc ttcactttga gcgagcccct ttcatgagcc aggagcgcac agtgtggctg
     2941 ccatggaaca gcttctatgc catggacacc ctggtaatga agaccgagga aaactccatc
     3001 cccagctgtg acctcagtgg ctttgtccgg ccagatccaa tcatcatctc ctctcctctg
     3061 tctaccttct tcagcgcttc ccctgcctcg aaccccattg tgcctgagac ccaggttctt
     3121 catgaagaaa ttgagctccc tggtaccaat gtgaagctcc gttatctcag ctctagaact
     3181 gcagggtaca agtcgctgct gaagatcacc atgacacagt ccacagtgcc cttgaacctc
     3241 atcagggttc acttgatggt tgctgtagag gggcatctct tccagaagtc attccaggct
     3301 tctcccaacc tagcctacac attcatctgg gacaagacag atgcttatgg ccaaagggtt
     3361 tatggcctat cggatgctgt tgtgtctgtt gggtttgaat atgagacctg ccccagtctc
     3421 atcctgtggg agaaaaggac agccctgctt cagggattcg agctggaccc ttccaacctt
     3481 ggaggctggt ccctggacaa acaccacacc ctcaatgtga aaagcggaat actacacaaa
     3541 gggacagggg agaaccagtt cctgacccag cagcctgcca tcatcacgag catcatgggc
     3601 aacggtcgcc gcagaagcat ctcctgtccc agctgtaatg gccttgctga aggcaacaaa
     3661 ctgttagccc ctgtggccct ggctgtgggg atcgatggga gcctctttgt tggtgacttc
     3721 aactatatcc ggcgcatctt tccctctcga aatgtgacca gtatcttgga gttacgaaat
     3781 aaagagttta aacatagcaa cagcccagga cacaagtatt acttggctgt ggaccccgtg
     3841 accggctcac tctacgtctc tgacaccaac agtcgccgaa tctaccgagt caagtctctg
     3901 agcggagcca aagacctggc tggaaattcg gaagttgtgg cagggactgg cgaacaatgt
     3961 ctaccctttg atgaagcccg ctgtggggat ggagggaagg ctgtggacgc caccctcatg
     4021 agccccagag gtattgcagt agacaagaat gggcttatgt actttgttga tgccaccatg
     4081 atccggaagg tggaccaaaa cggaatcatc tccaccctgc tgggctccaa tgacctcaca
     4141 gctgtccgac cactgagctg tgactcgagc atggacgtgg cccaggtccg tctagaatgg
     4201 ccgacagacc tcgccgtcaa ccccatggac aactccctgt acgttctgga gaacaacgtc
     4261 atcctgcgga tcacggagaa ccaccaggtc agcatcatcg cgggacggcc tatgcactgc
     4321 caggttcccg gcatcgacta ctcgctcagc aaactcgcca tccattctgc gctggaatca
     4381 gccagcgcca ttgctatttc tcacactggg gtgctctaca tcactgagac ggacgagaag
     4441 aagatcaacc gcctacgcca agtcaccacc aatggagaga tctgcctctt agccggggcg
     4501 gcctcagact gtgactgcaa aaacgatgtc aactgcatct gctactcggg agatgacgct
     4561 tacgccacgg acgccatcct aaactcgccg tcctccttag ccgtggctcc agatggcacc
     4621 atctacattg cagaccttgg gaatatccgg atcagggcgg tcagcaaaaa taaacccgtt
     4681 cttaacgcat tcaaccagta tgaggctgca tctccgggag aacaggaatt gtacgtgttc
     4741 aacgctgatg gtatccatca gtacactgtg agtctggtga ctggggagta cttgtacaat
     4801 ttcacataca gcgctgacaa tgacgtcacc gagttgattg acaacaacgg gaattcccta
     4861 aagatccgcc gggacagcag tggcatgccc cgccacctgc tcatgcctga taatcagatt
     4921 atcaccctta ccgtgggcac caatggaggc ctcaaagccg tgtccactca gaacctggag
     4981 ctgggcctca tgacttatga tgggaacact ggactcctag ccaccaagag tgatgaaact
     5041 ggatggacaa ctttttatga ctatgaccac gagggccgtc tgaccaatgt gacccgcccc
     5101 acgggcgtag tgaccagtct gcaccgggaa atggagaaat ctatcaccat tgacattgag
     5161 aactccaacc gggatgatga cgtcactgtg atcaccaacc tctcctccgt ggaggcctcc
     5221 tatacagtgg tacaagatca agtgcgaaac agctaccagc tctgcaataa tggaaccctg
     5281 cgggtgatgt acgccaacgg catggctgtc agcttccaca gtgagcccca cgtcctcgca
     5341 ggcaccatca cccccaccat tgggcgctgc aacatctctc tgcccatgga gaatggcctg
     5401 aactccatcg agtggcgcct gaggaaggaa cagatcaaag gcaaagtcac catctttggg
     5461 aggaagcttc gggtccacgg aaggaatctc ctgtccattg attatgaccg aaatatccga
     5521 acggagaaga tctacgatga ccaccggaaa ttcaccctga ggatcatcta tgaccaggtg
     5581 ggccgcccct tcctgtggct cccgagcagt gggctggcag ccgtcaatgt ctcctacttc
     5641 ttcaatgggc gcttggccgg cctccagcga ggggccatga gcgagaggac agacattgac
     5701 aagcaaggcc ggatcgtgtc ccgcatgttc gccgacggga aagtctggag ctattcctat
     5761 cttgacaagt ccatggtcct tctgctacag agccaacgtc agtacatatt tgaatatgac
     5821 tcctccgatc gcctccacgc agtcactatg cccagtgtcg cccggcacag catgtccacg
     5881 cacacctcca ttggttacat ccgaaacatt tacaacccac ccgaaagcaa tgcatcagtc
     5941 atctttgact acagtgatga cggccgcatc ctaaagacat ctttcttggg cactgggcgc
     6001 caggtgttct acaagtatgg aaaactctcc aagttatcag agatagtcta cgacagcaca
     6061 gccgtcacct ttgggtatga cgagaccacc ggtgtcctga agatggtcaa tctccaaagt
     6121 gggggtttct cctgtaccat caggtaccga aaggttgggc cccttgtgga caagcagatt
     6181 tacaggttct ctgaggaagg aatgatcaac gccaggtttg attataccta tcacgacaat
     6241 agcttccgca ttgccagcat caaacccgtc attagcgaga ctccccttcc tgttgacctc
     6301 taccgctatg atgagatttc cggcaaggtg gaacacttcg gcaagtttgg ggtcatctac
     6361 tacgacatca accagatcat caccactgcc gtcatgacgc ttagcaagca ctttgacacc
     6421 catgggcgca tcaaggaagt gcaatatgag atgttccggt ccctcatgta ctggatgact
     6481 gtgcaatatg acagtatggg tagggtcatc aagagggaac tgaaactagg gccctatgcc
     6541 aacaccacaa agtacaccta tgactatgac ggggacggcc agctccagag tgtggccgtc
     6601 aatgaccggc ctacctggcg ctatagctat gacctcaatg ggaacctgca ccttctaaac
     6661 ccaggaaaca gtgctcgcct catgccctta cgctatgacc tccgtgaccg gataaccagg
     6721 ctaggggacg tgcagtacaa aatcgatgac gatggctatt tgtgccagag agggtcagac
     6781 atctttgaat acaactccaa gggccttctg acaagagcat acaacaaggc cagcggatgg
     6841 agcgtgcagt accgctatga cggagtgggc cgccgggctt cctacaagac caacctgggc
     6901 caccacctac agtacttcta ctccgacctc cacaacccca cacgtatcac ccatgtttac
     6961 aaccactcca actctgagat cacctcgctc tactatgacc tccagggcca cctatttgcc
     7021 atggagagca gtagtggtga agaatactat gtcgcctcag acaacacggg gacccctctg
     7081 gctgtgttca gtatcaatgg cctcatgatc aagcaactgc agtacacagc ctatggggag
     7141 atctactatg actccaatcc agacttccag atggtcattg gcttccacgg aggcctctat
     7201 gaccccctca ccaagctcgt ccactttact caacgtgatt atgacgtgct ggcaggacgg
     7261 tggacgtccc ccgactacac catgtggagg aacgtgggca aggagccagc ccccttcaac
     7321 ctgtacatgt tcaagaacaa caatcctctg agcaatgagc tggacttaaa gaactacgtg
     7381 acagacgtga agagctggct tgtgatgttt ggatttcagc tcagcaacat cattcctgga
     7441 ttcccgagag ccaaaatgta ttttgtgcct cccccctatg aactgtcaga gagtcaagca
     7501 agcgagaacg gacagctcat tacaggtgtc cagcagacaa ctgagaggca taaccaggcc
     7561 ttcctggctc tggaaggaca ggtcatcact aaaaagctcc atgccagcat ccgagagaaa
     7621 gcaggccact ggtttgctac caccacaccc atcatcggca aaggcatcat gtttgccatc
     7681 aaagaagggc gggtgaccac aggagtgtct agcatcgcca gtgaggacag ccgcaaggta
     7741 gcatccgtgt tgaacaatgc ctactactta gacaagatgc actacagcat cgagggcaag
     7801 gacacacact actttgtgaa gatcggcgcc gcggatggtg acctggtcac gctaggaacc
     7861 accattgggc gcaaggtgct ggagagtggg gtgaacgtga cggtgtcaca gcccacgctg
     7921 ctggtgaatg gcaggactcg aaggttcacc aacattgagt tccagtactc cacgctgctg
     7981 ctcagtatcc gctacggcct cacccccgac acgctggacg aagaaaaggc ccgcgtcctg
     8041 gaccaagcga gacagagagc cctgggtact gcctgggcca aggagcagca gaaagccagg
     8101 gacgggagag agggcagccg cctgtggacg gagggcgaga agcagcaact cctgagcacg
     8161 ggacgggtac aaggttatga gggctattac gtacttccgg tggaacagta cccggagctg
     8221 gcagacagta gcagcaacat ccagttctta agacagaatg agatgggaaa gaggtaacaa
     8281 aataacctgc tgccacctct tctctgggtg gctcagcagg agcaactgtg acctcctctc
     8341 ctaaggagac gaagacctaa cggggcactg aggccgggct gctttaggat cccaagtggc
     8401 aagaaagctc acattttttg agttcaaatg ctactgtcta agcgcaaagt ccctcatcct
     8461 gaagtagact agagcccggc cacaaattct gaggaaaaac aaaaactaaa ggatgaacga
     8521 acgaacgaac gaatgaaaac acacacaaaa tgtttcaagt tcccctaaaa tatgacccac
     8581 ttgttccggg tctaaggcag aaaagagacg cagaatagcc aaaaggaaag gaacagaaaa
     8641 gaaacaaatt aaaaaaaaaa aaaagcaaac aaaaagacaa agacaccgac catacaaacg
     8701 aagaaatgaa gacgagaagg cctcatattc taatacctca ctcattgaca cgtgagcaac
     8761 acaaagacat tcacaagggc cggcatcacc agaccagctg aggacaactc agactgacag
     8821 ttggacaaac attgcgacgt tttcgtttaa gcaaatacag gtgcatttaa aaaacacgac
     8881 tttgggggtg atttgtgtgt agcgcctggg gagggagggg gcacaaaagc ggaggatcga
     8941 gcactggaaa tactttttaa agaaaaagaa aaacacaaga aaaaaatcag tatcagaagt
     9001 caaagcgaaa caataccgtc tggcacttaa ctctcaggtc ccccacttag tcaggcctga
     9061 gctaatttat ttgagcgcag agtgtaaaat tttaattcaa aatggtggct atactcacta
     9121 cacataaatc tcataatctt tttgtctttg gagattccat tgtggacagt aatacgcagt
     9181 tacagggtgt agtctgttta gaatccgtag tttgtgggta tcagttgcgg tagagatgca
     9241 acatttgtga ctctgttgct aacggttacc acttccgatc gccctgtaca tacatatgcc
     9301 gtaaggcgca atcactgttt cagacttaaa attattagtg tgtttgtttg gtccagaaac
     9361 tgagacaatc acatgacagt caccacgagg agagaaaaat aaaaaaataa ataaataaat
     9421 aaaaacaaaa aaaaatttta aaaagtgaag aaaaaaaaca cacaaaaaaa aagtctaata
     9481 agaactttgg tacaggaact tttttgtaat atacatgtat gaattgttca tcgagttttt
     9541 atattaattt taatttgctg ctaagcaaag actagggaca ggcaaagata atttatggca
     9601 aagtgtttaa attgtttata cataaataaa gtctctaaaa ctcctgtgga cactga
//
