LOCUS       NM_001357262            1542 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus tektin 2 (Tekt2), transcript variant 2, mRNA.
ACCESSION   NM_001357262 XM_017320190
VERSION     NM_001357262.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Yamaguchi,A., Kaneko,T., Inai,T. and Iida,H.
  TITLE     Molecular cloning and subcellular localization of Tektin2-binding
            protein 1 (Ccdc 172) in rat spermatozoa
  JOURNAL   J Histochem Cytochem 62 (4), 286-297 (2014)
   PUBMED   24394471
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Alten,L., Schuster-Gossler,K., Beckers,A., Groos,S., Ulmer,B.,
            Hegermann,J., Ochs,M. and Gossler,A.
  TITLE     Differential regulation of node formation, nodal ciliogenesis and
            cilia positioning by Noto and Foxj1
  JOURNAL   Development 139 (7), 1276-1284 (2012)
   PUBMED   22357932
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Durcan,T.M., Halpin,E.S., Rao,T., Collins,N.S., Tribble,E.K.,
            Hornick,J.E. and Hinchcliffe,E.H.
  TITLE     Tektin 2 is required for central spindle microtubule organization
            and the completion of cytokinesis
  JOURNAL   J Cell Biol 181 (4), 595-603 (2008)
   PUBMED   18474621
  REMARK    GeneRIF: Tek2-dependent organization of the central spindle during
            anaphase is essential for proper midbody formation and the
            segregation of daughter cells after cytokinesis.
REFERENCE   7  (bases 1 to 1542)
  AUTHORS   Iida,H., Honda,Y., Matsuyama,T., Shibata,Y. and Inai,T.
  TITLE     Tektin 4 is located on outer dense fibers, not associated with
            axonemal tubulins of flagella in rodent spermatozoa
  JOURNAL   Mol Reprod Dev 73 (7), 929-936 (2006)
   PUBMED   16596631
REFERENCE   8  (bases 1 to 1542)
  AUTHORS   Tanaka,H., Iguchi,N., Toyama,Y., Kitamura,K., Takahashi,T.,
            Kaseda,K., Maekawa,M. and Nishimune,Y.
  TITLE     Mice deficient in the axonemal protein Tektin-t exhibit male
            infertility and immotile-cilium syndrome due to impaired inner arm
            dynein function
  JOURNAL   Mol Cell Biol 24 (18), 7958-7964 (2004)
   PUBMED   15340058
  REMARK    GeneRIF: Tektin-t participates in dynein inner arm formation or
            attachment and that the loss of Tektin-t results in impaired
            motility of both flagella and cilia.
REFERENCE   9  (bases 1 to 1542)
  AUTHORS   Yoshida,T., Izawa,D., Nakayama,T., Nakahara,K., Kakizaki,M.,
            Imai,T., Suzuki,R., Miyasaka,M. and Yoshie,O.
  TITLE     Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor
  JOURNAL   FEBS Lett 458 (1), 37-40 (1999)
   PUBMED   10518929
REFERENCE   10 (bases 1 to 1542)
  AUTHORS   Iguchi,N., Tanaka,H., Fujii,T., Tamura,K., Kaneko,Y., Nojima,H. and
            Nishimune,Y.
  TITLE     Molecular cloning of haploid germ cell-specific tektin cDNA and
            analysis of the protein in mouse testis
  JOURNAL   FEBS Lett 456 (2), 315-321 (1999)
   PUBMED   10456331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY084876.1, AL606976.25, BY094167.1, AK006205.1 and BG083070.2.
            
            On Oct 25, 2017 this sequence version replaced XM_017320190.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1993417.1,
                                           SRR5189685.128456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               BY084876.1         2-274
            274-274             AL606976.25        41767-41767         c
            275-401             BY094167.1         253-379
            402-463             AK006205.1         102-163
            464-959             BG083070.2         15-510
            960-1540            AK006205.1         659-1239
            1541-1542           AL606976.25        39039-39040         c
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 60.37 cM"
     gene            1..1542
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /note="tektin 2"
                     /db_xref="GeneID:24084"
                     /db_xref="MGI:MGI:1346335"
     exon            1..44
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            45..114
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            115..320
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1457
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /note="testicular tektin"
                     /codon_start=1
                     /product="tektin-2"
                     /protein_id="NP_001344191.1"
                     /db_xref="CCDS:CCDS18651.1"
                     /db_xref="GeneID:24084"
                     /db_xref="MGI:MGI:1346335"
                     /translation="MATLSFKPSERYRLSDWRTNSYLLSTNAERQRDASHQIRQEARI
                     LRNETNNQIVWDEHDNRTRLAERIDTVNRWKETLDKCLTDLDAEIDSLAQAKESAEQN
                     LQAKNLPLDVAIECLTLRESRRDIDVVRDPVEEELLKEVEVIEATKKVLQEKISQAFQ
                     HLCLLQEIRQQLNSDHRDKMETLEIDRGCLSLNLTSPNISLKVNPTRIPKDSTTLQQW
                     DEFTRFNKNRAEAEMKASIELREAIALAIAQTNNELDAQRVATEFTFRKRLREMESFY
                     SELKWQEKNTLEEIAELQGDIRRLEEDLRRKMMNLKLAHTRLESRTYRSNVELCRDQT
                     QYGLIDEVHQLEATINTMKQKLAQTQNALDALFKHLARIQADIACKTNTLLLDTKCMD
                     TRRKLTVPAEKFVPQVDTFTRTTNRTLSPLKICQLELT"
     exon            321..446
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            447..652
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            653..796
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            797..911
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1019
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1163
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1243
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1542
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1523..1528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /note="hexamer: AATAAA"
     polyA_site      1542
                     /gene="Tekt2"
                     /gene_synonym="tektin-t"
                     /note="major polyA site"
ORIGIN      
        1 aggagttctc agacctgggc cctgagggcg tgaggggaaa ccaggctcca gggctttgtg
       61 cctgaagaca gaccactgag gaaatacagc ttgattgcta atacctcaca ggaggtggcg
      121 atctggaaca ggcctaaggg gttcagacct tcgtctcctt agccatggcg acactaagtt
      181 tcaagcccag cgaacgctac cggctctccg actggcgcac caacagctac ctattgtcca
      241 ccaatgcaga gcggcagcga gatgcttccc accaaatccg ccaggaggcc cggatccttc
      301 gcaatgagac aaacaatcag attgtatggg atgaacatga caataggacc cgcctggctg
      361 agaggatcga cactgtcaac cggtggaagg agacgctgga caagtgtctg acagatttag
      421 atgctgagat cgatagcttg gcacaggcca aagaatcggc ggagcaaaac ctgcaggcca
      481 agaacctgcc cctggatgtg gccatcgagt gcctgactct gcgagagagc cggcgagaca
      541 ttgatgtggt gagggaccct gtggaggaag agctgctgaa agaggtggaa gtcattgaag
      601 ccaccaagaa ggtcctacag gagaagatca gccaggcctt ccagcacctc tgtctcctgc
      661 aggaaattcg gcagcaactc aactctgacc accgggacaa aatggagaca ctggagatcg
      721 acaggggctg cctctctctc aacctcactt ccccaaacat ctctctgaaa gtcaacccca
      781 cacgcatccc caaagactcc accacactgc agcagtggga tgaatttact cgattcaaca
      841 agaaccgggc agaggccgaa atgaaagcgt ccatagagtt gagggaagcc attgccctag
      901 ctattgctca gaccaacaat gaactggacg ctcagagggt tgcaacagaa ttcaccttca
      961 ggaagcggct tcgggaaatg gagagttttt acagtgagct caagtggcaa gagaaaaata
     1021 ccttagaaga gatagccgag ctgcagggag acattcggcg cctggaggag gacctgcgta
     1081 gaaagatgat gaacttgaag cttgcacata cccggctgga gtccagaacc taccggtcca
     1141 atgtggagct ctgccgggac cagacacagt atggcctcat tgatgaagtc caccagttag
     1201 aggcaaccat caataccatg aagcagaagc tggcccaaac acagaacgct ttggatgccc
     1261 tgttcaagca cctggcccgg atacaggctg atatcgcgtg caagaccaac accctgctct
     1321 tggacaccaa gtgtatggac acccgacgca agctgacggt gccggctgag aaatttgtgc
     1381 cccaggtgga caccttcacg cgcacgacaa accgcacact gagtccactc aaaatctgcc
     1441 agctggagct aacctaggct ttggcggctg agggaagaca caagattggt gggagggggg
     1501 agtagtgagg ggacagtaaa ataataaaaa tggagttctc aa
//
