LOCUS       NM_011569               1411 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus tektin 1 (Tekt1), transcript variant 2, mRNA.
ACCESSION   NM_011569
VERSION     NM_011569.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1411)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1411)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1411)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (bases 1 to 1411)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 1411)
  AUTHORS   Alrahel,A., Movahedin,M., Mazaheri,Z. and Amidi,F.
  TITLE     Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro
            Three-Dimensional Neonatal Male Mice Testis Culture
  JOURNAL   Iran Biomed J 22 (4), 258-263 (2018)
   PUBMED   29397043
  REMARK    GeneRIF: Tnp1, Tekt1, and Plzf have essential roles in
            spermatogenesis and can be expressed during organ culture of
            testis; with this system, genes can be induced only at the
            molecular level and not beyond meiosis.
REFERENCE   6  (bases 1 to 1411)
  AUTHORS   Haitchi,H.M., Yoshisue,H., Ribbene,A., Wilson,S.J., Holloway,J.W.,
            Bucchieri,F., Hanley,N.A., Wilson,D.I., Zummo,G., Holgate,S.T. and
            Davies,D.E.
  TITLE     Chronological expression of Ciliated Bronchial Epithelium 1 during
            pulmonary development
  JOURNAL   Eur Respir J 33 (5), 1095-1104 (2009)
   PUBMED   19213785
REFERENCE   7  (bases 1 to 1411)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Tekt1 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   8  (bases 1 to 1411)
  AUTHORS   Larsson,M., Norrander,J., Graslund,S., Brundell,E., Linck,R.,
            Stahl,S. and Hoog,C.
  TITLE     The spatial and temporal expression of Tekt1, a mouse tektin C
            homologue, during spermatogenesis suggest that it is involved in
            the development of the sperm tail basal body and axoneme
  JOURNAL   Eur J Cell Biol 79 (10), 718-725 (2000)
   PUBMED   11089920
REFERENCE   9  (bases 1 to 1411)
  AUTHORS   Zhiyong,M.A., Khatlani,T.S., Sasaki,K., Inokuma,H. and Onishi,T.
  TITLE     Cloning of canine cDNA encoding tektin
  JOURNAL   J Vet Med Sci 62 (9), 1013-1016 (2000)
   PUBMED   11039601
REFERENCE   10 (bases 1 to 1411)
  AUTHORS   Norrander,J., Larsson,M., Stahl,S., Hoog,C. and Linck,R.
  TITLE     Expression of ciliary tektins in brain and sensory development
  JOURNAL   J Neurosci 18 (21), 8912-8918 (1998)
   PUBMED   9786996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB572578.1, BY085053.1, BC098181.1 and AV279795.1.
            
            On Aug 14, 2013 this sequence version replaced NM_011569.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF081947.1, BC098181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BB572578.1         3-4
            3-42                BY085053.1         2-41
            43-1408             BC098181.1         1-1366
            1409-1411           AV279795.1         242-244
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 44.03 cM"
     gene            1..1411
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /note="tektin 1"
                     /db_xref="GeneID:21689"
                     /db_xref="MGI:MGI:1333819"
     exon            1..90
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /inference="alignment:Splign:2.1.0"
     exon            91..297
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1364
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /codon_start=1
                     /product="tektin-1"
                     /protein_id="NP_035699.2"
                     /db_xref="CCDS:CCDS36215.1"
                     /db_xref="GeneID:21689"
                     /db_xref="MGI:MGI:1333819"
                     /translation="MAKLLQSPPRFLPEEWYIANKSQYHRAEAQRSQSERLVAESQRL
                     VEEIEKTTRKSQSDVNKKLEQRLEEVRFWKKELDDKLEQLVNQTDDLLTYKTRLERSL
                     ESYKEPLHITEKCLEYREKRVGIDLVHDVVEQELQKEADIIHGVMNLLIRTLEESTEQ
                     IRLNRSAKYNLEKDLRDKFTAITIDDVCFSLNNNSPNINFSEKVVRIEPNSVSLEDWL
                     DFSNANVEKADKQLNNSTALKTLVDQILSQTANDLRRQCEVVDEAFINGLKETKDARN
                     KLADHLAKVMEEIASQEKNIMALENAITQQEGPAKVAHTRLETRTHRPNVELCRDIAQ
                     YRLIKEIQEINHNVARLKETLAQAQTQLKALYRRQLALQEEIQVKENTIYIDQVLCME
                     MRKSIPPRDGDDHGAWEGGIRAEAIC"
     exon            298..463
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /inference="alignment:Splign:2.1.0"
     exon            464..592
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /inference="alignment:Splign:2.1.0"
     exon            593..736
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /inference="alignment:Splign:2.1.0"
     exon            737..959
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1156
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1411
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1385..1390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /note="hexamer: ATTAAA"
     polyA_site      1406
                     /gene="Tekt1"
                     /gene_synonym="MT14"
                     /note="major polyA site"
ORIGIN      
        1 gcagttttct cggctggttc tctcagaacc aggagctctg gttggggtca ggagtgccct
       61 acagaagctt gtgttcttta atgaactaag gactttggaa atcctaaatg gccaagctac
      121 tgcaatctcc acccaggttc cttcctgagg agtggtatat tgctaacaaa agccagtacc
      181 acagagcaga ggcccaaagg tcccaatctg aacgcttggt ggcagagagc cagaggcttg
      241 tggaagaaat tgagaagacc accaggaagt ctcagagcga tgtgaacaag aaacttgagc
      301 agagacttga ggaggtcagg ttctggaaga aggagttaga tgacaaactt gaacagctcg
      361 tgaaccagac ggatgacctg cttacgtaca agacccgcct ggagagatcc ttggagagct
      421 acaaggagcc cctgcacatc acggagaagt gcttggaata cagggagaag cgtgtgggca
      481 tcgatttggt acacgatgtg gtggagcagg agctgcagaa ggaggctgat atcatccacg
      541 gagtcatgaa cctgcttatc cgcacgctgg aagagtcaac agaacagatc aggctgaacc
      601 gctctgccaa gtacaatctg gaaaaggatt tgagggataa gttcacggcc ataactatcg
      661 atgacgtctg cttctcactc aacaataact caccaaatat caatttttct gagaaggttg
      721 tgagaatcga gcccaactca gtgagtctgg aggactggct ggacttctcc aatgccaatg
      781 tggagaaggc agacaaacag ctgaacaatt caacggcgct gaagaccctg gtggaccaaa
      841 tcctgtccca gacagccaat gacctgcgca gacagtgcga agtggtagac gaggcattca
      901 taaatgggct gaaggagacc aaggatgcca ggaacaagct ggctgatcat ctggccaagg
      961 ttatggaaga aattgcttcc caggaaaaaa acatcatggc tcttgaaaat gccatcacgc
     1021 agcaagaagg gccagccaag gtagcacaca cacgcctgga gaccaggacg caccggccga
     1081 acgtggagct gtgtcgagat attgcccagt atcggctgat caaggagatt caggagatca
     1141 accacaatgt tgccaggtta aaggaaaccc tggcccaggc tcagacgcag ctgaaggccc
     1201 tgtaccgcag gcagctggcc ctgcaggagg aaatccaggt gaaggagaac accatctata
     1261 tcgaccaggt gctgtgtatg gagatgagga agtccatccc acctcgagac ggcgacgacc
     1321 atggggcctg ggaggggggc atccgcgcag aggccatctg ctgataggag ccattcagag
     1381 ccttattaaa ctgcatcgta agacaagagt t
//
