LOCUS       NM_001290549            4699 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus TEK receptor tyrosine kinase (Tek), transcript variant
            2, mRNA.
ACCESSION   NM_001290549 XM_006502929
VERSION     NM_001290549.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4699)
  AUTHORS   Li,C., Zhang,M., Du,Y., Liu,S., Li,D., Zhang,S., Ji,F., Zhang,J.
            and Jiao,J.
  TITLE     Compromised cell competition exhausts neural stem cells pool
  JOURNAL   Cell Prolif 57 (12), e13710 (2024)
   PUBMED   39010274
REFERENCE   2  (bases 1 to 4699)
  AUTHORS   Schwakopf,J., Romero,C.O., Lopez,N.N., Millar,J.C., Vetter,M.L. and
            Bosco,A.
  TITLE     Schlemm's canal-selective Tie2/TEK knockdown induces sustained
            ocular hypertension in adult mice
  JOURNAL   Exp Eye Res 248, 110114 (2024)
   PUBMED   39368692
REFERENCE   3  (bases 1 to 4699)
  AUTHORS   Sekimoto,A., Takaso,Y., Saruyama,H., Ookawa,M., Yamamoto,M.,
            Toyohara,T., Saigusa,D., Fukuuchi,T., Otsuka,M., Fushiki,Y.,
            Yamakoshi,S., Tanaka,K., Ikeda,T., Tanaka,T., Takahashi,N.,
            Mishima,E. and Sato,E.
  TITLE     Impacts of low birthweight on kidney development and
            intergenerational growth of the offspring
  JOURNAL   iScience 27 (11), 111159 (2024)
   PUBMED   39524353
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4699)
  AUTHORS   Wang,W., Wang,Y., Su,L., Zhang,M., Zhang,T., Zhao,J., Ma,H.,
            Zhang,D., Ji,F., Jiao,R.D., Li,H., Xu,Y., Chen,L. and Jiao,J.
  TITLE     Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and
            Myelination During Brain Development
  JOURNAL   Adv Sci (Weinh) 11 (38), e2308508 (2024)
   PUBMED   39136074
REFERENCE   5  (bases 1 to 4699)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   6  (bases 1 to 4699)
  AUTHORS   Huang,L., Turck,C.W., Rao,P. and Peters,K.G.
  TITLE     GRB2 and SH-PTP2: potentially important endothelial signaling
            molecules downstream of the TEK/TIE2 receptor tyrosine kinase
  JOURNAL   Oncogene 11 (10), 2097-2103 (1995)
   PUBMED   7478529
REFERENCE   7  (bases 1 to 4699)
  AUTHORS   Henkemeyer,M., Rossi,D.J., Holmyard,D.P., Puri,M.C., Mbamalu,G.,
            Harpal,K., Shih,T.S., Jacks,T. and Pawson,T.
  TITLE     Vascular system defects and neuronal apoptosis in mice lacking ras
            GTPase-activating protein
  JOURNAL   Nature 377 (6551), 695-701 (1995)
   PUBMED   7477259
REFERENCE   8  (bases 1 to 4699)
  AUTHORS   Wheatley,S.C., Isacke,C.M. and Crossley,P.H.
  TITLE     Restricted expression of the hyaluronan receptor, CD44, during
            postimplantation mouse embryogenesis suggests key roles in tissue
            formation and patterning
  JOURNAL   Development 119 (2), 295-306 (1993)
   PUBMED   7507029
REFERENCE   9  (bases 1 to 4699)
  AUTHORS   Horita,K., Yagi,T., Kohmura,N., Tomooka,Y., Ikawa,Y. and Aizawa,S.
  TITLE     A novel tyrosine kinase, hyk, expressed in murine embryonic stem
            cells
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1747-1753 (1992)
   PUBMED   1282811
REFERENCE   10 (bases 1 to 4699)
  AUTHORS   Dumont,D.J., Yamaguchi,T.P., Conlon,R.A., Rossant,J. and
            Breitman,M.L.
  TITLE     tek, a novel tyrosine kinase gene located on mouse chromosome 4, is
            expressed in endothelial cells and their presumptive precursors
  JOURNAL   Oncogene 7 (8), 1471-1480 (1992)
   PUBMED   1630810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772277.13 and AL954716.16.
            
            On Mar 14, 2014 this sequence version replaced XM_006502929.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter by an amino acid, compared to
            isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X67553.1, X71426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AL772277.13        87857-88260
            405-716             AL772277.13        129384-129695
            717-827             AL772277.13        147179-147289
            828-980             AL772277.13        147695-147847
            981-1112            AL772277.13        152853-152984
            1113-1253           AL772277.13        153381-153521
            1254-1382           AL772277.13        159856-159984
            1383-1534           AL954716.16        3529-3680
            1535-1679           AL954716.16        10701-10845
            1680-1835           AL954716.16        11115-11270
            1836-1970           AL954716.16        13329-13463
            1971-2258           AL954716.16        20562-20849
            2259-2558           AL954716.16        33066-33365
            2559-2710           AL954716.16        35168-35319
            2711-2921           AL954716.16        36814-37024
            2922-3032           AL954716.16        38767-38877
            3033-3223           AL954716.16        42333-42523
            3224-3337           AL954716.16        43016-43129
            3338-3408           AL954716.16        47058-47128
            3409-3449           AL954716.16        48050-48090
            3450-3546           AL954716.16        48868-48964
            3547-3646           AL954716.16        56487-56586
            3647-4699           AL954716.16        57369-58421
FEATURES             Location/Qualifiers
     source          1..4699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 43.34 cM"
     gene            1..4699
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /note="TEK receptor tyrosine kinase"
                     /db_xref="GeneID:21687"
                     /db_xref="MGI:MGI:98664"
     exon            1..404
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..3721
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; angiopoietin-1 receptor; p140 TEK;
                     tyrosine-protein kinase receptor TEK; endothelial-specific
                     receptor tyrosine kinase; tunica interna endothelial cell
                     kinase; tyrosine-protein kinase receptor TIE-2;
                     endothelial tyrosine kinase; tyrosine kinase with Ig and
                     EGF homology domains-2"
                     /codon_start=1
                     /product="angiopoietin-1 receptor isoform 2 precursor"
                     /protein_id="NP_001277478.1"
                     /db_xref="CCDS:CCDS71421.1"
                     /db_xref="GeneID:21687"
                     /db_xref="MGI:MGI:98664"
                     /translation="MDSLAGLVLCGVSLLLYGVVEGAMDLILINSLPLVSDAETSLTC
                     IASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFC
                     EGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGS
                     FIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGP
                     DCSRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGPEGCKS
                     YVFCLPDPYGCSCATGWRGLQCNEACPSGYYGPDCKLRCHCTNEEICDRFQGCLCSQG
                     WQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDGTV
                     LQPNDFNYTDRFSVAIFTVNRVLPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHA
                     PNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIEVTNEIFTLNYLEPR
                     TDYELCVQLARPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFT
                     NSEDEFYVEVERRSLQTTSDQQNIKVPGNLTSVLLSNLVPREQYTVRARVNTKAQGEW
                     SEELRAWTLSDILPPQPENIKISNITDSTAMVSWTIVDGYSISSIIIRYKVQGKNEDQ
                     HIDVKIKNATVTQYQLKGLEPETTYHVDIFAENNIGSSNPAFSHELRTLPHSPASADL
                     GGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAFQNREEPAVQFNSGT
                     LALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK
                     EYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRK
                     SRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE
                     NYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIV
                     SLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV
                     SLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA"
     exon            405..716
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..827
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..980
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1112
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1253
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1382
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1534
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1679
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1835
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1970
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2258
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2558
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2710
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2921
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3032
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3223
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3337
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3408
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3449
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3546
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3646
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..4699
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4640..4645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /note="hexamer: AATAAA"
     polyA_site      4662
                     /gene="Tek"
                     /gene_synonym="Cd202b; Hyk; STK1; Tie-2; Tie2"
                     /note="major polyA site"
ORIGIN      
        1 agttaaggca ggagcaggag ccggagcagg agcagaagat aagccttgga tgaagggcaa
       61 gatggatagg gctcgctctg ccccaagccc tgctgatacc aagtgccttt aagatacagc
      121 ctttcccatc ctaatctgca aaggaaacag gaaaaaggaa cttaaccctc cctgtgctca
      181 gacagaaatg agactgttac cgcctgcttc tgtggtgttt ctccttgccg ccaacttgta
      241 aacaagagcg agtggaccat gcgagcggga agtcgcaaag ttgtgagttg ttgaaagctt
      301 cccagggact catgctcatc tgtggacgct ggatggggag atctggggaa gtatggactc
      361 tttagccggc ttagttctct gtggagtcag cttgctcctt tatggagtag tagaaggcgc
      421 catggacctg atcttgatca attccctacc tcttgtgtct gatgccgaaa catccctcac
      481 ctgcattgcc tctgggtggc acccccatga gcccatcacc ataggaaggg actttgaagc
      541 cttaatgaac cagcaccaag atccactgga ggttactcaa gatgtgacca gagaatgggc
      601 gaaaaaagtt gtttggaaga gagaaaaggc cagtaagatt aatggtgctt atttctgtga
      661 aggtcgagtt cgaggacagg ctataaggat acggaccatg aagatgcgtc aacaagcatc
      721 cttcctacct gctactttaa ctatgaccgt ggacagggga gataatgtga acatatcttt
      781 caaaaaggtg ttaattaaag aagaagatgc agtgatttac aaaaatggct ccttcatcca
      841 ctcagtgccc cggcatgaag tacctgatat tttagaagtt cacttgccgc atgctcagcc
      901 ccaggatgct ggtgtgtact cggccaggta cataggagga aacctgttca cctcagcctt
      961 caccaggctg attgttcgga gatgtgaagc tcagaagtgg gggcccgact gtagccgtcc
     1021 ttgtactact tgcaagaaca atggagtctg ccatgaagat accggggaat gcatttgccc
     1081 tcctgggttt atggggagaa catgtgagaa agcttgtgag ccgcacacat ttggcaggac
     1141 ctgtaaagaa aggtgtagtg gaccagaagg atgcaagtct tatgtgttct gtctcccaga
     1201 cccttacggg tgttcctgtg ccacaggctg gagggggttg cagtgcaatg aagcatgccc
     1261 atctggttac tacggaccag actgtaagct caggtgccac tgtaccaatg aagagatatg
     1321 tgatcggttc caaggatgcc tctgctctca aggatggcaa gggctgcagt gtgagaaaga
     1381 aggcaggcca aggatgactc cacagataga ggatttgcca gatcacattg aagtaaacag
     1441 tggaaaattt aaccccatct gcaaagcctc tgggtggcca ctacctacta gtgaagaaat
     1501 gaccctagtg aagccagatg ggacagtgct ccaaccaaat gacttcaact atacagatcg
     1561 tttctcagtg gccatattca ctgtcaaccg agtcttacct cctgactcag gagtctgggt
     1621 ctgcagtgtg aacacagtgg ctgggatggt ggaaaagcct ttcaacattt ccgtcaaagt
     1681 tcttccagag cccctgcacg ccccaaatgt gattgacact ggacataact ttgctatcat
     1741 caatatcagc tctgagcctt actttgggga tggacccatc aaatccaaga agcttttcta
     1801 taaacctgtc aatcaggcct ggaaatacat tgaagtgacg aatgagattt tcactctcaa
     1861 ctacttggag ccgcggactg actacgagct gtgtgtgcag ctggcccgtc ctggagaggg
     1921 tggagaaggg catcctgggc ctgtgagacg atttacaaca gcgtctatcg gactccctcc
     1981 tccaagaggt ctcagtctcc tgccaaaaag ccagacagct ctaaatttga cttggcaacc
     2041 gatatttaca aactcagaag atgaatttta tgtggaagtc gagaggcgat ccctgcaaac
     2101 aacaagtgat cagcagaaca tcaaagtgcc tgggaacctg acctcggtgc tactgagcaa
     2161 cttagtcccc agggagcagt acacagtccg agctagagtc aacaccaagg cgcaggggga
     2221 gtggagtgaa gaactcaggg cctggaccct tagtgacatt ctccctcctc aaccagaaaa
     2281 catcaagatc tccaacatca ctgactccac agctatggtt tcttggacaa tagtggatgg
     2341 ctattcgatt tcttccatca tcatccggta taaggttcag ggcaaaaatg aagaccagca
     2401 cattgatgtg aagatcaaga atgctaccgt tactcagtac cagctcaagg gcctagagcc
     2461 agagactaca taccatgtgg atatttttgc tgagaacaac ataggatcaa gcaacccagc
     2521 cttttctcat gaactgagga cgcttccaca ttccccagcc tctgcagacc tcggaggggg
     2581 aaagatgcta ctcatagcca tccttgggtc ggctggaatg acttgcatca ccgtgctgtt
     2641 ggcgtttctg attatgttgc aactgaagag agcaaatgtc caaaggagaa tggctcaggc
     2701 attccagaac agagaagaac cagctgtgca gtttaactca ggaactctgg cccttaacag
     2761 gaaggccaaa aacaatccgg atcccacaat ttatcctgtg cttgactgga atgacatcaa
     2821 gtttcaagac gtgatcggag agggcaactt tggccaggtt ctgaaggcac gcatcaagaa
     2881 ggatgggtta cggatggatg ccgccatcaa gaggatgaaa gagtatgcct ccaaagatga
     2941 tcacagggac ttcgcaggag aactggaggt tctttgtaaa cttggacacc atccaaacat
     3001 cattaatctc ttgggagcat gtgaacaccg aggctatttg tacctagcta ttgagtatgc
     3061 cccgcatgga aacctcctgg acttcctgcg taagagcaga gtgctagaga cagaccctgc
     3121 ttttgccatc gccaacagta cagcttccac actgtcctcc caacagcttc ttcattttgc
     3181 tgcagatgtg gcccggggga tggactactt gagccagaaa cagtttatcc acagggacct
     3241 ggctgccaga aacattttag ttggtgaaaa ctacatagcc aaaatagcag attttggatt
     3301 gtcacgaggt caagaagtgt atgtgaaaaa gacaatggga aggctcccag tgcgttggat
     3361 ggcaatcgaa tcactgaact atagtgtcta tacaaccaac agtgatgtct ggtcctatgg
     3421 tgtattgctc tgggagattg ttagcttagg aggcaccccc tactgcggca tgacgtgcgc
     3481 ggagctctat gagaagctac cccagggcta caggctggag aagcccctga actgtgatga
     3541 tgaggtgtat gatctaatga gacagtgctg gagggagaag ccttatgaga gaccatcatt
     3601 tgcccagata ttggtgtcct taaacaggat gctggaagaa cggaagacat acgtgaacac
     3661 cacactgtat gagaagttta cctatgcagg aattgactgc tctgcggaag aagcagccta
     3721 gagcagaact cttcatgtac aacggccatt tctcctcact ggcgcgagag cgccttgaca
     3781 cctgtaccaa gcaagccacc cactgccaag agatgtgata tataagtgta tatattgtgc
     3841 tgtgtttggg accctcctca tacagctcgt gcggatctgc agtgtgttct gactctaatg
     3901 tgactgtata tactgctcgg agtaagaatg tgctaagatc agaatgcctg ttcgtggttt
     3961 catataatat atttttctaa aagcatagat tgcacaggaa ggtatgagta caaatactgt
     4021 aatgcataac ttgttattgt cctagatgtg tttgatattt ttcctttaca actgaatgct
     4081 ataaaagtgt tttgctgtgt acacataaga tactgttcgt taaaataagc attcccttga
     4141 cagcacagga agaaaagcga gggaaatgta tggattatat taaatgtggg ttactacaca
     4201 agaggccgaa cattccaagt agcagaagag agggtctctc aactctgctc ctcacctgca
     4261 gaagccagtt tgtttggcca tgtgacaatt gtcctgtgtt tttatagcac ccaaatcatt
     4321 ctaaaatatg aacatctaaa aactttgcta ggagactaag aacctttgga gagatagata
     4381 taagtacggt caaaaaacaa aactgtggga cttacattta ttttctatag taatctgttg
     4441 tacattttaa gaagtaaaac taggaattta ggagtgatgt gtgacatttc tgacatggag
     4501 ttaccatccc cacatgtatc acatactgtc atattcccac atgtatcaca catgtattgt
     4561 aaaattttgt agttttgatc acttgtgaat ttactgttga tgtggtagcc acctgctgca
     4621 atggttcctc ttgtaggtga ataaatgtct tgtctaccca cactcttccc aggattgtgt
     4681 ctcataaaaa tatatttgg
//
