LOCUS       NM_183275               1302 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus transcription elongation factor, mitochondrial (Tefm),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_183275
VERSION     NM_183275.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Jiang,S., Koolmeister,C., Misic,J., Siira,S., Kuhl,I., Silva
            Ramos,E., Miranda,M., Jiang,M., Posse,V., Lytovchenko,O.,
            Atanassov,I., Schober,F.A., Wibom,R., Hultenby,K., Milenkovic,D.,
            Gustafsson,C.M., Filipovska,A. and Larsson,N.G.
  TITLE     TEFM regulates both transcription elongation and RNA processing in
            mitochondria
  JOURNAL   EMBO Rep 20 (6) (2019)
   PUBMED   31036713
  REMARK    GeneRIF: Our data demonstrate that TEFM acts as a general
            transcription elongation factor, necessary for both gene
            transcription and replication primer formation, and loss of TEFM
            affects RNA processing in mammalian mitochondria.
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   Jenne,D.E., Tinschert,S., Dorschner,M.O., Hameister,H., Stephens,K.
            and Kehrer-Sawatzki,H.
  TITLE     Complete physical map and gene content of the human NF1 tumor
            suppressor region in human and mouse
  JOURNAL   Genes Chromosomes Cancer 37 (2), 111-120 (2003)
   PUBMED   12696059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146639.1 and BE949440.1.
            
            On Mar 24, 2007 this sequence version replaced NM_183275.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146639.1, AK003325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1283              AK146639.1         2-1284
            1284-1302           BE949440.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.53 cM"
     gene            1..1302
                     /gene="Tefm"
                     /gene_synonym="1110002N22Rik"
                     /note="transcription elongation factor, mitochondrial"
                     /db_xref="GeneID:68550"
                     /db_xref="MGI:MGI:1915800"
     exon            1..77
                     /gene="Tefm"
                     /gene_synonym="1110002N22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1129
                     /gene="Tefm"
                     /gene_synonym="1110002N22Rik"
                     /codon_start=1
                     /product="transcription elongation factor, mitochondrial"
                     /protein_id="NP_899098.2"
                     /db_xref="CCDS:CCDS36241.1"
                     /db_xref="GeneID:68550"
                     /db_xref="MGI:MGI:1915800"
                     /translation="MAWRTNLACLIKAGGRRWFPVPEYSSLPPVLNNTCSVRKSTAPE
                     KRVASVAACDTDGKEPGNPLDRLFSLEQQASILQVLNTASDKELEAFRLLRGRKSVNI
                     VEHRKKFGPFQRLENLIDVPLIQYKTAVEVCNSILCPENRRRKKSQEKWLLRKFIKPG
                     VEQERLKAVKSIVSIVFGTRRIAWAHLDRRPTVLDWQQTECWKLTNKTYPTSFYLEEI
                     SSVISKIPKADLYILEKSGLSIQNTSLLPILLHFLITEAMLYALLNKTFAEDGQHRVL
                     SINRNAVGKHFDLMIGDTRTSGRELVKQFLSESVLKERPRVFFPQDLLVQYRQKVVKS
                     SYRIEELYDSLLQAVAFYELVFGKDSELKC"
     exon            78..535
                     /gene="Tefm"
                     /gene_synonym="1110002N22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            536..685
                     /gene="Tefm"
                     /gene_synonym="1110002N22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1287
                     /gene="Tefm"
                     /gene_synonym="1110002N22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1269..1274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tefm"
                     /gene_synonym="1110002N22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1286
                     /gene="Tefm"
                     /gene_synonym="1110002N22Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggaac acaggcgtgg gaaagagcct ggcgatggct tggaggacaa accttgcttg
       61 cctcatcaag gccggaggga ggagatggtt tccagtccca gagtactcat ccctgcctcc
      121 agtcctaaat aacacctgct ctgtgaggaa atccactgca cctgagaaac gtgttgccag
      181 tgttgctgct tgtgatacag atggaaagga gcccgggaat ccattggaca ggctcttctc
      241 cctggagcag caggcttcta tcttacaagt gctgaataca gcttctgata aagaactgga
      301 agctttcagg ttgcttcgag gaaggaagtc cgtcaatatt gtagaacaca gaaagaagtt
      361 tgggccgttt cagaggttgg agaatttgat agacgtgccc ttgatccaat ataaaactgc
      421 tgttgaagtt tgtaactcca ttctctgtcc ggagaacaga cggaggaaaa agtcacagga
      481 gaagtggctg ctgagaaagt tcatcaagcc aggtgtagag caagagagac ttaaggcagt
      541 taagagtatc gtatctattg tttttggtac tcgaagaatt gcatgggctc accttgaccg
      601 gagaccgact gtgctggact ggcagcagac tgagtgctgg aaattaacta acaaaacata
      661 cccaacgtcc ttttatctgg aagagatttc ttcagtcatt tcaaagatac ctaaagcaga
      721 tctctacatt ttggaaaaat caggactttc cattcagaac acatctctgc ttcctatact
      781 gttacacttt cttatcacgg aagccatgct gtatgcctta ctcaacaaaa cttttgccga
      841 ggatggccag caccgcgtgc tgagcataaa tcgaaatgcg gtgggcaagc actttgacct
      901 gatgatcggc gacacgagga cgagtgggag ggagctagtg aagcagttcc tctctgagtc
      961 tgtgctgaag gagcggcctc gggtgttctt cccacaggac ctcttagtgc agtacagaca
     1021 gaaggttgtc aagagctcat accggattga agagttgtat gactcattat tacaagctgt
     1081 tgctttttat gagttagttt ttggcaaaga ctcagagctc aaatgttaat gcactcactc
     1141 tagtgttaca cttatttatt aaagcaatgg ttcccatctt ccatgttagt ggaaaacatt
     1201 ttgaatatat tttccatgtt tataaaatct gatttttggc ttaaaaaaaa atgagccaag
     1261 accaaatcaa taaatatttt gtgagataaa aaaaaaaaaa aa
//
