LOCUS       NM_017376               4267 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus thyrotroph embryonic factor (Tef), transcript variant
            1, mRNA.
ACCESSION   NM_017376
VERSION     NM_017376.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4267)
  AUTHORS   Valakh,V., Wise,D., Zhu,X.A., Sha,M., Fok,J., Van Hooser,S.D.,
            Schectman,R., Cepeda,I., Kirk,R., O'Toole,S.M. and Nelson,S.B.
  TITLE     A transcriptional constraint mechanism limits the homeostatic
            response to activity deprivation in mammalian neocortex
  JOURNAL   Elife 12, e74899 (2023)
   PUBMED   36749029
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4267)
  AUTHORS   Weger,B.D., Gobet,C., David,F.P.A., Atger,F., Martin,E.,
            Phillips,N.E., Charpagne,A., Weger,M., Naef,F. and Gachon,F.
  TITLE     Systematic analysis of differential rhythmic liver gene expression
            mediated by the circadian clock and feeding rhythms
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33452134
REFERENCE   3  (bases 1 to 4267)
  AUTHORS   Pulido,R.S., Munji,R.N., Chan,T.C., Quirk,C.R., Weiner,G.A.,
            Weger,B.D., Rossi,M.J., Elmsaouri,S., Malfavon,M., Deng,A.,
            Profaci,C.P., Blanchette,M., Qian,T., Foreman,K.L., Shusta,E.V.,
            Gorman,M.R., Gachon,F., Leutgeb,S. and Daneman,R.
  TITLE     Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport
            through Endothelial Circadian Genes
  JOURNAL   Neuron 108 (5), 937-952 (2020)
   PUBMED   32979312
REFERENCE   4  (bases 1 to 4267)
  AUTHORS   Yang,J., Wang,B., Chen,H., Chen,X., Li,J., Chen,Y., Yuan,D. and
            Zheng,S.
  TITLE     Thyrotroph embryonic factor is downregulated in bladder cancer and
            suppresses proliferation and tumorigenesis via the AKT/FOXOs
            signalling pathway
  JOURNAL   Cell Prolif 52 (2), e12560 (2019)
   PUBMED   30515906
  REMARK    GeneRIF: Upregulation of TEF expression significantly retarded
            Bladder Cancer cell growth by inhibiting the G1/S transition via
            regulating AKT/FOXOs signalling.
REFERENCE   5  (bases 1 to 4267)
  AUTHORS   Li,P., Fu,X., Smith,N.A., Ziobro,J., Curiel,J., Tenga,M.J.,
            Martin,B., Freedman,S., Cea-Del Rio,C.A., Oboti,L., Tsuchida,T.N.,
            Oluigbo,C., Yaun,A., Magge,S.N., O'Neill,B., Kao,A., Zelleke,T.G.,
            Depositario-Cabacar,D.T., Ghimbovschi,S., Knoblach,S., Ho,C.Y.,
            Corbin,J.G., Goodkin,H.P., Vicini,S., Huntsman,M.M., Gaillard,W.D.,
            Valdez,G. and Liu,J.S.
  TITLE     Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying
            Focal Epilepsy
  JOURNAL   Neuron 96 (2), 387-401 (2017)
   PUBMED   29024662
REFERENCE   6  (bases 1 to 4267)
  AUTHORS   Fonjallaz,P., Ossipow,V., Wanner,G. and Schibler,U.
  TITLE     The two PAR leucine zipper proteins, TEF and DBP, display similar
            circadian and tissue-specific expression, but have different target
            promoter preferences
  JOURNAL   EMBO J 15 (2), 351-362 (1996)
   PUBMED   8617210
REFERENCE   7  (bases 1 to 4267)
  AUTHORS   Toth,M., Grimsby,J., Buzsaki,G. and Donovan,G.P.
  TITLE     Epileptic seizures caused by inactivation of a novel gene, jerky,
            related to centromere binding protein-B in transgenic mice
  JOURNAL   Nat Genet 11 (1), 71-75 (1995)
   PUBMED   7550318
  REMARK    Erratum:[Nat Genet 1996 Jan;12(1):110]
REFERENCE   8  (bases 1 to 4267)
  AUTHORS   Khatib,Z.A., Inaba,T., Valentine,M. and Look,A.T.
  TITLE     Chromosomal localization and cDNA cloning of the human DBP and TEF
            genes
  JOURNAL   Genomics 23 (2), 344-351 (1994)
   PUBMED   7835883
REFERENCE   9  (bases 1 to 4267)
  AUTHORS   Lossie,A.C., Gordon,D.F. and Camper,S.A.
  TITLE     Localization of thyrotropin-releasing hormone receptor and
            thyrotroph embryonic factor on mouse chromosome 15
  JOURNAL   Mamm Genome 4 (10), 621-623 (1993)
   PUBMED   7903570
REFERENCE   10 (bases 1 to 4267)
  AUTHORS   Drolet,D.W., Scully,K.M., Simmons,D.M., Wegner,M., Chu,K.T.,
            Swanson,L.W. and Rosenfeld,M.G.
  TITLE     TEF, a transcription factor expressed specifically in the anterior
            pituitary during embryogenesis, defines a new class of leucine
            zipper proteins
  JOURNAL   Genes Dev 5 (10), 1739-1753 (1991)
   PUBMED   1916262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY336350.1, AY540631.1, AK147965.1 and BP764162.1.
            
            On Apr 18, 2009 this sequence version replaced NM_017376.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145125.1, AK154472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY336350.1         2-15
            15-1876             AY540631.1         1-1862
            1877-2220           AK147965.1         1810-2153
            2221-2669           AK147965.1         2155-2603
            2670-4240           AK147965.1         2605-4175
            4241-4267           BP764162.1         24-50               c
FEATURES             Location/Qualifiers
     source          1..4267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.25 cM"
     gene            1..4267
                     /gene="Tef"
                     /gene_synonym="2310028D20Rik"
                     /note="thyrotroph embryonic factor"
                     /db_xref="GeneID:21685"
                     /db_xref="MGI:MGI:98663"
     exon            1..307
                     /gene="Tef"
                     /gene_synonym="2310028D20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1062
                     /gene="Tef"
                     /gene_synonym="2310028D20Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thyrotrophic embryonic factor"
                     /codon_start=1
                     /product="thyrotroph embryonic factor isoform 1"
                     /protein_id="NP_059072.1"
                     /db_xref="CCDS:CCDS27672.1"
                     /db_xref="GeneID:21685"
                     /db_xref="MGI:MGI:98663"
                     /translation="MSDAGGGKKPPVEPQAGPGPGRAAGERGLSGSFPLVLKKLMENP
                     PRETRLDKEKGKEKLEEDESAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEF
                     LLENGIPASPTHLAQNLLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSL
                     EKERETPSPIDPSCVEVDVNFNPDPADLVLSSVPGGELFNPRKHRFAEEDLKPQPMIK
                     KAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTE
                     VAELRKEVGKCKTIVSKYETKYGPL"
     exon            308..625
                     /gene="Tef"
                     /gene_synonym="2310028D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..846
                     /gene="Tef"
                     /gene_synonym="2310028D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            847..4244
                     /gene="Tef"
                     /gene_synonym="2310028D20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4223..4228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tef"
                     /gene_synonym="2310028D20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4244
                     /gene="Tef"
                     /gene_synonym="2310028D20Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtccgcggg aggggtgcgg atggagagag gtgggggtgc agtagcgcgt ctgcgcagtg
       61 ctgcccgtgt cagcagctgc ggcgggtcga gccgctccgg cccgtctcgg ggtgcgggcg
      121 ggggaggcga ggcgcacgag tggggcgcag ggcacgatgt ccgacgcggg cggcgggaag
      181 aagccgcctg tggagcctca ggcggggccg ggcccggggc gtgcagctgg agaacggggc
      241 ctgtcgggct ccttccctct ggtcctgaag aagctgatgg agaacccccc gcgcgagacg
      301 cgcctcgata aggaaaaggg gaaggaaaag ctggaggaag acgagtcagc agcagccagt
      361 accatggccg tctctgcctc cctcatgcca cccatctggg acaagaccat cccctacgat
      421 ggcgagtcct tccacctcga gtacatggac ctggatgagt tcctgctgga gaacggcatc
      481 cctgccagcc ccacccacct ggcacagaac ctgctgctgc ctgtggcaga gcttgaagga
      541 aaggagtctg ccagctcttc cacggcatcg ccaccatctt cctctactgc catctttcag
      601 ccctcggaaa ccgtgtccag cacagaatcg tccttggaaa aggagaggga gaccccaagt
      661 cccatcgacc ccagctgtgt ggaggtcgat gtgaacttca accctgaccc tgccgacctg
      721 gtcctctcta gtgtaccagg gggggagctc ttcaaccctc ggaagcacag gtttgcagag
      781 gaggacctga agccccagcc catgatcaaa aaagccaaga aagtctttgt ccctgatgaa
      841 cagaaggatg aaaagtattg gacaagacgt aagaagaaca atgtggcagc taaacgctcc
      901 cgggatgcca ggcgcctgaa ggagaaccag atcaccatcc gggcagcgtt cctggagaag
      961 gagaacacag ccctgcggac ggaggttgcc gagcttcgca aggaggtggg caagtgcaag
     1021 accatcgtgt ccaagtacga gaccaagtac gggcccttgt aacctgtgcc cctgccccgc
     1081 agggcactgc ctgcacctca gacctctgcc tggggcttcc tggaccccac tcgtgtggag
     1141 acttaggact cttcatgggc acatggtggc gtacctgctc taggagcact cacgtctcag
     1201 cttcattata acatggccag cacatgtgat gacttcccca ggggaccaag atcctctccg
     1261 atggggaaca tgagcgaatc tacgtagacg ggtaaatggc ccaagtctct tttgttggat
     1321 gctccagctg aatcagaagg ggccttctgg agtccaggtt ctcttgtaca gagtgctcag
     1381 gctttcctag ccttcccctc agtctccagt ttggactgac aagggctgtc tacagaatga
     1441 gtcatgatta ttgtcaccct aatgtcgtct caggtagcag gtgcatttcc acttggggtg
     1501 tgtctgtcat gtacctcacc ctccccaaaa tctttgagag aaacattcat tcccatctgt
     1561 ctcagagcca ggacatgcta atcctgttag tatagacagg gtggtggacc acacaagtgg
     1621 ggtctctgga tagcctggaa ttagggtggg gctggggctt gtggtagaaa tgcacccaac
     1681 cattcttagc tccaactttt gtcttgtgac tctcaggcct gaagtggccc tggaatcagt
     1741 ttcctctgca tcccacttgc tatggaagag aaatttccag gaagtctggt ctctggggtc
     1801 taattgccag cgcctttgta tctctgggcc attctgaagg ctcatgactt ccactagctt
     1861 ggtctctgat tattttcacc cagtatccct tctcagttct taggtttaag aagaaaacct
     1921 atcacctagg aagcttgagc ttccaggccc cagggtacca cttctgcatg gtgtttagga
     1981 aactggcttc cacagtctcc tgttgtgggc accagaccga ggggttttct cttgggaagc
     2041 tccatggaac ccttgctctg gctcaccaat atacccaggc cagaatctag tgtccctgaa
     2101 ggcagaagag ggcctgccac gtcacagatt agaatccctc cccatgggta tcagcaggcc
     2161 gccgtatatg agttgtattt gctgaagtta cttacagtgc agctctcatg ggacagcagg
     2221 ctctggagac atttacactg gcctgcagtc cctgtggagt cggagggtgc ccacacagct
     2281 ctccccgtgg ggcagagtga tttcttgcag ttttggctcc ctcacagctg cacttttctc
     2341 ttctatttgg ctggattgga catcatggaa ccctctactc atgtgggtca tgagggcacc
     2401 ctccaggagg gtgtgtttgt ttgctcaggg cgggcagcct gtgtgaagga gacagaggtg
     2461 atgagggtgc ttcattatac ttaacactgg ctttatttta aatggtggct tagtttgggg
     2521 cccctatctt ttaagacttt tcataatgat gttaagacca gggcagactg tctactggcc
     2581 atggactgca gccaggagat gccctgcccc tcctgggacc tgcacaccac ctctctgggg
     2641 aacttgacaa aggtccctaa ggctaaggga ggtctccctc ctactaggtc cctgactttg
     2701 actctgtggt tctctaggaa ccgtgtgcac acttgtctct gttgtaacta caaagggcag
     2761 tagcatccag catgtcagtg tctgcccggg ctgcctgcct cctacccacc cagcactatt
     2821 ctctgggctg gctgttcacc cagaggcagt tctcattttg tttctggtgg acaagccttg
     2881 agctgaaaat ctcttcgttt tctttgacta gaaaatgtaa ggtttctgtt ttttaagttt
     2941 tagttttaag gaatggatac ttatctctgg atgccatctg tgttctgacc ctagtgggtg
     3001 ggtgggcctt accgtctccc cttagtcccc gttctgcctt gtggtgccct cctttccttc
     3061 cagaagtagg gagtgggttc tggctcctcc taagtgctta cagagtcact gtctgcttgt
     3121 ttcttggaga agcctctgga atgaaaagcg gcagggaaac aaaccggaag gagcacgcct
     3181 agaggttgac atcttggaga acaaagtgtt cacataagct tggctcctct gttggcttta
     3241 ggacccaagg ctgcacagaa agagttgagc tctgctcttt atcttgctgt ggaagtctcc
     3301 tgactccctc taggagctga cagctgaagc ctgaagctct tgcacttgga tccttgaatt
     3361 ctaaggagta accaggctcc agaagccaac ttctatttgg ctttccgtgg gtttgtctta
     3421 ggatgagaag tgtcatcact tcctaaacat cctgttctca gctatggcag cctcagaaaa
     3481 gacacctgaa tgagttagaa ccctgcagga atgtacattc aagagatgtc ttgataaaga
     3541 actacgtgct tttggaaaga gccacccttt ggaggacctg ttagtcacct ttatcttcag
     3601 cccaaaggct aagttatgtg ggtctgactc ctttggttag ggacagcact agacagtgac
     3661 cctaaccctt ggtccatact ccctgctgtg atggtgctgt ggtctgcttt ccactcaggc
     3721 agctcctaca gtcctccagc ctggggacag atgggaagct ttccaggggc cccccgagag
     3781 gtgtgctccc tgtaagaggg gcctgtaaga ggagctcttg gtttccaggg caaagcccta
     3841 cccacagctt ctttaacatc tgttaattaa gtgcaataaa attttctaga aaaaggcaaa
     3901 gatgatttcc aggtagagat tgctgtcttt tggtgttgga tgccagaaca ccacttggtt
     3961 ttatttttct aagtgcatgt gattggtaga gtgtgtgggc tctgcatcct ccctgggagc
     4021 tgcattccag cagcccctct ccctaccttt gccgtgggaa agaggccagg agaaaagccc
     4081 tttgtcccag ctgcagaggt ggaagcagac agcagccctt tggccttaca tgtgtgtgtg
     4141 tgcctgtgcg agtgtgtccc tgctggtggg ccggagtgat gtgttatgga gggaagttgg
     4201 gaatgtatcc ttttcaaaca aaattaaata ttttgagacg agaaaaaaaa aaaaaaaaaa
     4261 aaaaaaa
//
