LOCUS       NM_001324548            7341 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus tectorin alpha (Tecta), transcript variant 2, mRNA.
ACCESSION   NM_001324548 XM_006510150
VERSION     NM_001324548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7341)
  AUTHORS   Underhill,A., Webb,S., Grandi,F.C., Jeng,J.Y., de Monvel,J.B.,
            Plion,B., Carlton,A.J., Amariutei,A.E., Voulgari,N., De Faveri,F.,
            Ceriani,F., Mustapha,M., Johnson,S.L., Safieddine,S., Kros,C.J. and
            Marcotti,W.
  TITLE     MYO7A is required for the functional integrity of the
            mechanoelectrical transduction complex in hair cells of the adult
            cochlea
  JOURNAL   Proc Natl Acad Sci U S A 122 (1), e2414707122 (2025)
   PUBMED   39746042
REFERENCE   2  (bases 1 to 7341)
  AUTHORS   Kersbergen,C.J., Babola,T.A., Kanold,P.O. and Bergles,D.E.
  TITLE     Preservation of developmental spontaneous activity enables early
            auditory system maturation in deaf mice
  JOURNAL   PLoS Biol 21 (6), e3002160 (2023)
   PUBMED   37368868
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7341)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   4  (bases 1 to 7341)
  AUTHORS   Kersbergen,C.J., Babola,T.A., Rock,J. and Bergles,D.E.
  TITLE     Developmental spontaneous activity promotes formation of sensory
            domains, frequency tuning and proper gain in central auditory
            circuits
  JOURNAL   Cell Rep 41 (7), 111649 (2022)
   PUBMED   36384119
REFERENCE   5  (bases 1 to 7341)
  AUTHORS   Ebeid,M., Barnas,K., Zhang,H., Yaghmour,A., Noreikaite,G. and
            Bjork,B.C.
  TITLE     PRDM16 expression and function in mammalian cochlear development
  JOURNAL   Dev Dyn 251 (10), 1666-1683 (2022)
   PUBMED   35451126
REFERENCE   6  (bases 1 to 7341)
  AUTHORS   Legan,P.K., Lukashkina,V.A., Goodyear,R.J., Kossi,M., Russell,I.J.
            and Richardson,G.P.
  TITLE     A targeted deletion in alpha-tectorin reveals that the tectorial
            membrane is required for the gain and timing of cochlear feedback
  JOURNAL   Neuron 28 (1), 273-285 (2000)
   PUBMED   11087000
REFERENCE   7  (bases 1 to 7341)
  AUTHORS   Rau,A., Legan,P.K. and Richardson,G.P.
  TITLE     Tectorin mRNA expression is spatially and temporally restricted
            during mouse inner ear development
  JOURNAL   J Comp Neurol 405 (2), 271-280 (1999)
   PUBMED   10023815
REFERENCE   8  (bases 1 to 7341)
  AUTHORS   Verhoeven,K., Van Laer,L., Kirschhofer,K., Legan,P.K., Hughes,D.C.,
            Schatteman,I., Verstreken,M., Van Hauwe,P., Coucke,P., Chen,A.,
            Smith,R.J., Somers,T., Offeciers,F.E., Van de Heyning,P.,
            Richardson,G.P., Wachtler,F., Kimberling,W.J., Willems,P.J.,
            Govaerts,P.J. and Van Camp,G.
  TITLE     Mutations in the human alpha-tectorin gene cause autosomal dominant
            non-syndromic hearing impairment
  JOURNAL   Nat Genet 19 (1), 60-62 (1998)
   PUBMED   9590290
  REMARK    Erratum:[Nat Genet 1999 Apr;21(4):449]
REFERENCE   9  (bases 1 to 7341)
  AUTHORS   Hughes,D.C., Legan,P.K., Steel,K.P. and Richardson,G.P.
  TITLE     Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9
            and human chromosome 11: a candidate for human autosomal dominant
            nonsyndromic deafness
  JOURNAL   Genomics 48 (1), 46-51 (1998)
   PUBMED   9503015
REFERENCE   10 (bases 1 to 7341)
  AUTHORS   Legan,P.K., Rau,A., Keen,J.N. and Richardson,G.P.
  TITLE     The mouse tectorins. Modular matrix proteins of the inner ear
            homologous to components of the sperm-egg adhesion system
  JOURNAL   J Biol Chem 272 (13), 8791-8801 (1997)
   PUBMED   9079715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156631.2.
            
            On Feb 24, 2020 this sequence version replaced NM_001324548.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138426.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC156631.2         137838-138121       c
            285-349             AC156631.2         136387-136451       c
            350-483             AC156631.2         133107-133240       c
            484-771             AC156631.2         130023-130310       c
            772-909             AC156631.2         126341-126478       c
            910-1075            AC156631.2         125833-125998       c
            1076-1488           AC156631.2         122169-122581       c
            1489-2059           AC156631.2         115668-116238       c
            2060-2652           AC156631.2         113166-113758       c
            2653-3226           AC156631.2         111021-111594       c
            3227-3828           AC156631.2         104842-105443       c
            3829-4390           AC156631.2         97080-97641         c
            4391-4590           AC156631.2         90158-90357         c
            4591-4974           AC156631.2         86071-86454         c
            4975-5261           AC156631.2         83577-83863         c
            5262-5542           AC156631.2         81803-82083         c
            5543-5653           AC156631.2         78432-78542         c
            5654-5856           AC156631.2         77083-77285         c
            5857-6020           AC156631.2         75989-76152         c
            6021-6269           AC156631.2         75280-75528         c
            6270-6432           AC156631.2         70582-70744         c
            6433-6520           AC156631.2         69483-69570         c
            6521-6637           AC156631.2         69098-69214         c
            6638-7341           AC156631.2         67796-68499         c
FEATURES             Location/Qualifiers
     source          1..7341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 23.63 cM"
     gene            1..7341
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /note="tectorin alpha"
                     /db_xref="GeneID:21683"
                     /db_xref="MGI:MGI:109575"
     exon            1..284
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            285..349
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..6738
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; alpha-tectorin; [a]-tectorin"
                     /codon_start=1
                     /product="alpha-tectorin isoform 2 preproprotein"
                     /protein_id="NP_001311477.1"
                     /db_xref="CCDS:CCDS85660.1"
                     /db_xref="GeneID:21683"
                     /db_xref="MGI:MGI:109575"
                     /translation="MNYSSLLRIWVSFIFALVRHQAQPRELMYPFWQNDTRTPKVDDG
                     SSSEIKLAIPVFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFIAPFWAD
                     VHNGIRGEIYYRETMDPAILRRATKDIRKYFKDMTTFSATWVFIVTWEEVTFYGGSST
                     TPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTN
                     FFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEIDPANGCTSRGQFLRRGEVFWDD
                     LNCTIKCRCLDFNNEIYCQEASCSPYEVCEPKGRFFYCSPVETSTCVVFGEPHYHTFD
                     GFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRGGSAVSWVKELSVEVNGYKILI
                     PKGSYGKVKVNDLVTSLPVTLELGAVKIYQSGMSTAVETDFGLLVTFDGQHYASISIP
                     GSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCGSGCVDNCT
                     QCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDATAFVHSCVYDLCSVRDNGTLLCQ
                     AIQAYALVCQALGIPIGDWRIQTGCVSTVRCPSFSHYSVCTSSCPDTCSDLTASQNCA
                     TPCTEGCECNEGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQCLCEEGGD
                     VYCFNKTCRSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGAAYAFPSELSYTLL
                     KTCPERPEYLEIDINKKKPDAGPAWLRGVRILVADQEVKIGGVGALEVKLNGQDVELP
                     FFHPSGRLEIHRNKNSTTVESKGVVSVQYSDVGLLYIRLSTMYFNCTGGLCGFFNANA
                     SDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGI
                     INDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVG
                     PWRTYDFCPLECPENSHFEECMTCTETCETLALGPICVDSCSEGCQCDEGYALQGSQC
                     VPRSECGCNFEGHQLATNETFWVDQDCQIFCYCNGTDNSVHCETIPCRDDEYCMEESG
                     LYYCQPRTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTGSRPISDSFPKFIVTAK
                     NEDRDPSLALWVKQVDVNVFGYSIVIHRAYKHTVLVNNERLYLPLKLGQGKINIFSFG
                     FHVVVETDFGLKVVYDWKTFLSITVPRSMQNGTYGLCGRYNGNPDDDLEMPMGLPALS
                     INEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAGFAKCHSKVNP
                     TFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTSCSVTCPPNSHY
                     ESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLNGKSCILPHNCGCYSDGKYYEP
                     KQLFWNGDCTRRCRCFRRNLIQCDPRQCKSDEECALRSGVRGCFSTKTSYCLAAGGGV
                     FRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNLTIISPVYFYINEE
                     QILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNVIKISI
                     SERLQNKVCGLCGNFNGDMTDDYVTLRGKPVVSSVVLAQSWKTNGMQKSCNELQFSQY
                     AATCDNVHIQAMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNHKKFQLC
                     GSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELDNGGELCGCIEP
                     PPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRINDRQCSGIEGEDFIS
                     FQINNTKGNCGNIVQSNGTHIMYKNTIWIESANNTGNIITRDRTINVEFSCAYELDIK
                     ISLDSVVKPMLSVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLYVGV
                     FVVGADSTHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIGIEENGVSLTCR
                     FHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKINCPQNSRIATDYSKEHKEQIISVGP
                     IRRKRLDWCEDNGGCEQICTSRVDGPLCSCVTGSLQEDGRSCRASNSSVELQVWTLLL
                     IMTQISLWHLIYKSGATS"
     exon            350..483
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            484..771
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            772..909
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1075
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1488
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..2059
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2652
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..3226
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3828
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..4390
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4590
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            4591..4974
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            4975..5261
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            5262..5542
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            5543..5653
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            5654..5856
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            5857..6020
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            6021..6269
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            6270..6432
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            6433..6520
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            6521..6637
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     exon            6638..7341
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7321..7326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /note="hexamer: AATAAA"
     polyA_site      7341
                     /gene="Tecta"
                     /gene_synonym="Tctna"
                     /note="major polyA site"
ORIGIN      
        1 aggaaaagag cctctccgcg caatcctgaa actgatcttc agatttacct ctccttaatc
       61 aatagagagc aacttgattg caactcaaca ctcccccgac tctagtgcag gactaactga
      121 atttttggtt ttaagagtat gggattcgga cgtgatttca gggatcagaa ataattggca
      181 gccacgcgag gagaactgac gtgaattctt atacctaatt ttccgggctc accaagattt
      241 gacttaatac ttttcactca attcctccag tctccacaga acaggatgaa ttattcatca
      301 ttacttagaa tttgggtctc tttcatcttc gctcttgttc ggcaccaagc tcagcccagg
      361 gagctcatgt atccattttg gcagaatgac acgagaaccc ctaaagtaga tgacggaagc
      421 tcctctgaga ttaagttggc catccccgtc ttcttctttg gtgttcctta ccgcaccgtc
      481 tatgtcaata acaatggtgt tgtttccttc aacgtgctag tgagccagtt tacaccagag
      541 tcctttcccc tgacggacgg gagggccttc attgctccat tctgggcaga tgtgcacaat
      601 ggaattcggg gtgagatcta ttacagagaa accatggacc ccgccatcct gagaagagcc
      661 accaaggaca tcaggaagta cttcaaagac atgaccacct tctctgccac ttgggttttc
      721 attgtgacct gggaggaagt cacgttttac ggaggcagca gtaccacgcc tgtgaacacc
      781 ttccaggctg tgctggtatc cgacggctcc tacacattca cgctctttaa ttactatgag
      841 atcaactgga cgactgggac agccagcggt ggcgaccctc taacaggcct tggaggtgtg
      901 atggcacagg caggatttaa tggtggaaac ctcacgaatt tcttcagtct tccgggatca
      961 aggacccctg agattgtaaa tattcaagag accacaaatg tcaatgttcc aggacgctgg
     1021 gcatttaaag ttgacgggaa ggaaattgac ccggccaatg gctgcacctc tagaggacag
     1081 ttccttcgtc gaggggaggt gttttgggat gacctgaact gtaccatcaa gtgtcgctgt
     1141 ctggatttca acaatgagat ctactgtcag gaggcctcct gtagccccta cgaggtgtgc
     1201 gaacccaagg gtcggttctt ctactgcagc ccagtggaga ccagtacctg tgtggtattc
     1261 ggggagccac actaccacac ctttgatggc ttcctcttcc acttccaagg ctcgtgtgct
     1321 tacctgttgg cccgacagtg tctacaaacc tccagcctcc ccttcttcag tgtggaggcc
     1381 aagaacgagc accgaggggg ctctgctgtc tcgtgggtaa aggagctctc tgtcgaggtc
     1441 aatggctaca agattctcat tcctaaagga agctatggga aagtcaaggt taatgaccta
     1501 gtgacttctt tgcccgtcac cttagagttg ggggcggtga aaatctacca gagtggcatg
     1561 tctactgccg tggaaacaga ttttgggctc ttagtgacgt ttgacggcca gcactacgcc
     1621 tccatttcca tcccaggctc ttacataaac tctacctgtg gcctatgcgg gaactacaac
     1681 aaaaatccac tggatgactt cctccgcccc gatggcaggc ccgccatgtc ggtgctggac
     1741 ctaggagaga gctggcgtgt ctaccatgct gactggaagt gtggctctgg ctgtgtagac
     1801 aattgtactc agtgtgatgc agccactgag gccctctact ttggttctga ctactgcggc
     1861 ttcctcaaca agacggatgg ccccctgtgg gagtgcggca ctgttgtgga tgccacggct
     1921 tttgtacaca gctgtgtgta cgacctgtgc agtgtgaggg acaacggcac gctcctctgc
     1981 caagccattc aggcctacgc cttggtgtgc caagcccttg gcatcccaat cggagactgg
     2041 agaatccaaa ctgggtgtgt gtctaccgtg cggtgcccaa gcttcagcca ttactctgta
     2101 tgtaccagta gctgtccgga cacctgctcg gacctgacgg cctctcagaa ctgtgccact
     2161 ccatgcacgg aaggttgcga gtgcaacgag ggctttgtcc tcagcaccag ccagtgtgtc
     2221 cctttgcaca agtgcggctg tgacttcgat ggccactact ataccatggg cgagttcttc
     2281 tgggccaccg ccaattgtac agtgcagtgc ttatgcgaag agggagggga tgtctactgc
     2341 ttcaacaaga cctgccggag tggggaggtg tgtgctgtgg aggacggtta ccagggctgc
     2401 ttccccaagc gggagacggt gtgcctgctc agccagaacc aggtactaca cacatttgat
     2461 ggcgccgcct acgcattccc atccgagtta tcatataccc tactcaagac ctgccctgag
     2521 cgtcctgagt acttggaaat tgacatcaac aagaagaagc ctgatgcagg gccagcttgg
     2581 ctccggggtg ttcggatcct cgtggctgac caagaggtca agataggagg cgtcggggct
     2641 ttggaagtca agctaaatgg tcaagatgtg gaattaccct ttttccatcc ttcggggagg
     2701 ttggagattc acagaaacaa gaacagcaca actgtggagt ccaagggtgt ggtgtccgtc
     2761 cagtactccg atgtgggact actgtacatc cgactgtcca ccatgtactt caactgtact
     2821 ggaggcctgt gtggcttctt caatgccaat gccagtgatg agttctgcct tcctaatggc
     2881 aaatgcacag acaacctggc ggtgttcttg gagagctgga caacatttga ggaaatctgc
     2941 aatggcgagt gtggggacct gctgaaggcc tgcaacaatg actccgagct gctcaagttc
     3001 taccggagcc gctcccggtg tggtatcatc aacgacccct ccaacagctc cttcctggag
     3061 tgccatgggg tggttaatgt caccgcctac taccgcacct gcctgtttcg cctgtgccag
     3121 agcggaggca atgagtcaga gctgtgtgat tctgtggccc gctatgccag tgcttgcaag
     3181 aatgcagatg tggaggtggg cccctggagg acctatgact tctgccctct agaatgcccg
     3241 gagaacagcc attttgagga gtgtatgaca tgtacagaga cctgcgagac cctggccttg
     3301 ggccccatct gtgtggacag ctgctctgag ggatgccagt gtgatgaagg ttatgccctg
     3361 cagggcagcc agtgtgtccc tcggagcgag tgcggctgca actttgaggg gcatcaactt
     3421 gccaccaatg agaccttctg ggtagaccag gactgccaga tcttctgcta ctgcaatggc
     3481 acagacaaca gtgtccactg tgagaccatt ccctgcaggg acgatgaata ctgtatggaa
     3541 gagagtggct tgtactactg ccagccccgt actgatgctt cctgtatcgt ctcaggctat
     3601 ggtcactacc tcacctttga tggctaccca tttgacttcc agaccagttg tcctcttatc
     3661 ctctgcacca caggaagcag accaatctca gactctttcc ccaagttcat tgtaacagcc
     3721 aagaatgagg accgggaccc atctctagcc ttgtgggtga agcaggtgga cgtgaacgtg
     3781 tttggctaca gcattgtgat acaccgggct tacaagcaca ctgtgttggt caacaatgag
     3841 cggttgtacc tgcccctgaa gttaggacaa gggaagataa acatcttttc attcggcttt
     3901 catgtggttg tggagactga ctttggcctg aaggtcgtgt atgactggaa gaccttcctg
     3961 tccattaccg tcccccggag catgcagaac ggcacctatg gcctctgtgg acgctacaat
     4021 ggcaaccccg atgatgacct tgagatgccc atggggctgc ctgcactgag tatcaacgag
     4081 tttggccaga gctgggtgaa gagagacacc ttctgccagg tgggctgtgg ggaccgctgc
     4141 ccatcctgtg ccaaagtgga aggtttctcc aaagtacagc agctgtgcag cctgatcccc
     4201 aaccagaatg ctggctttgc caaatgtcac agcaaagtca accccacctt cttctacaaa
     4261 aactgcctgt ttgactcctg tatcgatggg ggtgccgtgc agacagcctg cagctggtta
     4321 caaaactatg ccagcacttg ccagactcaa ggaatcgcag tgaccggctg gaggaactac
     4381 acgtcctgtt cggttacctg cccccccaac agccactatg agagctgtgt gagcgtctgc
     4441 cagccccgct gcgcagccat ccgcctgaag agtgactgta atcactactg cgtagagggc
     4501 tgccagtgtg atgcaggcta cgtcctcaat ggcaagagct gcatcttgcc ccacaactgt
     4561 ggctgctact cagatggcaa atactatgag cccaagcagc tattctggaa tggggactgc
     4621 acgcggcgct gccgctgttt caggcgcaac ctgatccagt gtgacccacg ccaatgcaag
     4681 tcagatgagg agtgcgccct gcgcagtggg gtgcgcggct gcttcagcac caaaacctcc
     4741 tactgcctag cggcaggggg tggtgtcttc cgcacgttcg atggtgcctt cctgcgcttc
     4801 cctgccaact gcgccttcgt gctctcaacc atctgccaga aattgccaga catctccttc
     4861 cagctcatca tcaacttcga caagtggtcc tcgcccaacc tcactatcat ctcaccggtc
     4921 tatttctaca ttaacgaaga gcagattctc atcaacgatc ggaacactgt caaggtgaat
     4981 ggcacacaag taaatgttcc atttataacg ggcttggcaa ccaaaatcta cagcagcgag
     5041 gggtttctgg tgatcgacac cagtcccgac atccagatat attacaatgg ttttaacgtc
     5101 attaaaatca gcatcagtga gaggctacag aacaaagtgt gtgggctctg tgggaacttc
     5161 aatggagaca tgactgacga ctacgtgacc ttgcggggga aacccgtggt gagcagcgtg
     5221 gtgctggccc agagctggaa gaccaatggc atgcagaaga gctgcaacga gctacagttc
     5281 tcacagtatg cagccacatg tgacaatgtg cacatccagg ccatgcaggg tgacggctac
     5341 tgcctgaaac tcaccgacat gaagggcttc ttccagccct gctatgggct ccttgatccc
     5401 ctcccgttct acgagtcctg ttacctggat ggctgctaca accacaagaa gttccagctg
     5461 tgtggctccc tggctgccta cggggaggcc tgccgctcct tcggcatcct tagcaccgag
     5521 tggattgaga aagagaattg ctcaggagtg gttgaagacc cttgtgtggg ggcggattgt
     5581 cccaacagga cctgcgagct ggacaacgga ggagaattat gtggctgcat tgagccaccc
     5641 ccctatggaa acaattccca tgacatcatc gacgcggagg tgacctgcaa ggcagcccag
     5701 atggaagtgt ccatatctaa gtgcaagctc ttccagctgg gctttgagag agagggtgtg
     5761 agaatcaatg accggcagtg ctctggcatc gagggcgagg attttatctc ctttcaaatc
     5821 aacaacacca aagggaactg tgggaacatc gtgcagtcca atggcactca tatcatgtat
     5881 aaaaacacaa tctggattga aagtgccaac aacactggca acatcatcac gagggaccgc
     5941 acgatcaatg tggaattttc atgcgcttat gagctagata tcaagatctc cttagactct
     6001 gtcgtgaagc ctatgctaag tgtcatcaac ctgacagttc cgacccagga gggcagcttc
     6061 accaccaaga tggcactcta taaaaatgct tcctacaaac acccttaccg ccaaggggaa
     6121 gttgtgctga caactcggga tgtgctgtac gtgggcgtct ttgtggtcgg agctgactct
     6181 acacacttga ttctcacact caacaaatgc tacgccaccc cctcccgaga cagcaacgac
     6241 aagcttcggt acttcatcat cgaaggagga tgtcagaaca tcaaagacaa caccattggc
     6301 atagaggaga acggagtgtc cctaacctgt cgtttccacg tcaccgtctt caagttcatc
     6361 ggagactacg atgaagttca tcttcactgt gcagtgtccc tctgtgactc agagaaatac
     6421 tcttgcaaga ttaattgccc acaaaattcc aggatcgcca cagattattc aaaagagcac
     6481 aaagaacaga tcatttcagt gggacccatt aggagaaaaa ggctggactg gtgtgaagac
     6541 aacggcggct gtgagcagat ctgcaccagc cgggtcgacg ggcctctgtg cagctgtgtg
     6601 accggatccc tgcaagaaga tggaaggagc tgcagagcct ctaattcttc agtggaactt
     6661 caagtttgga cacttcttct catcatgacc cagatctcac tgtggcattt gatctataaa
     6721 tcaggcgcaa cctcataacg aactcagggt gctttcttca gtccctgtag gtataaaagt
     6781 gtgtgtcccc aagtcaaaac agcctctcac actcacgcca ccttcctcca gcagtcagat
     6841 ctggaggaca ccaacgttcc tggctcctct tccacagtat gcaatagtgg tttctcaaag
     6901 ccaatgggag gaaagcacgc tcttaccctc aatgccaaac agctggcact gggtacctag
     6961 gttcaggcca gaagccagcc agggaaagct ctggctacag aagtctgatg ggaaagctgg
     7021 ccagaaaagt tggtctgtcc cgcgctgttt ctggaacacc gtggttatag gcaaggctat
     7081 tgctgtgact ttgaattaaa gttgcgtctc tctctgtgga gcctcgccaa cactgccctc
     7141 agctcacttt gcttagctcc tccccctcct gctgtggcct ccaccttgcc gtgccagctt
     7201 cagtcactgg agatgatgtt tgtagacctg gagaacctca ccctgcccgt cccgatcctc
     7261 aaacccagcc cttcacattt tacaaatcaa ccaaataatt tttaatgtgt tttatcctta
     7321 aataaacttt gtgttcaagt a
//
