LOCUS       NM_134118               1190 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus trans-2,3-enoyl-CoA reductase (Tecr), transcript
            variant 1, mRNA.
ACCESSION   NM_134118
VERSION     NM_134118.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1190)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1190)
  AUTHORS   Honda,A., Nozumi,M., Ito,Y., Natsume,R., Kawasaki,A., Nakatsu,F.,
            Abe,M., Uchino,H., Matsushita,N., Ikeda,K., Arita,M., Sakimura,K.
            and Igarashi,M.
  TITLE     Very-long-chain fatty acids are crucial to neuronal polarity by
            providing sphingolipids to lipid rafts
  JOURNAL   Cell Rep 42 (10), 113195 (2023)
   PUBMED   37816355
REFERENCE   3  (bases 1 to 1190)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   4  (bases 1 to 1190)
  AUTHORS   Sultana,D.A., Tomita,S., Hamada,M., Iwanaga,Y., Kitahama,Y.,
            Khang,N.V., Hirai,S., Ohigashi,I., Nitta,S., Amagai,T.,
            Takahashi,S. and Takahama,Y.
  TITLE     Gene expression profile of the third pharyngeal pouch reveals role
            of mesenchymal MafB in embryonic thymus development
  JOURNAL   Blood 113 (13), 2976-2987 (2009)
   PUBMED   19164599
REFERENCE   5  (bases 1 to 1190)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   6  (bases 1 to 1190)
  AUTHORS   Yu,A.C., Sun,C.X., Li,Q., Liu,H.D., Wang,C.R., Zhao,G.P., Jin,M.,
            Lau,L.T., Fung,Y.W. and Liu,S.
  TITLE     Identification of a mouse synaptic glycoprotein gene in cultured
            neurons
  JOURNAL   Neurochem Res 30 (10), 1289-1294 (2005)
   PUBMED   16341590
  REMARK    GeneRIF: Results describe the sequence and distribution of mouse
            synaptic glycoprotein homolog 2.
REFERENCE   7  (bases 1 to 1190)
  AUTHORS   Moon,Y.A. and Horton,J.D.
  TITLE     Identification of two mammalian reductases involved in the
            two-carbon fatty acyl elongation cascade
  JOURNAL   J Biol Chem 278 (9), 7335-7343 (2003)
   PUBMED   12482854
REFERENCE   8  (bases 1 to 1190)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY278351.1, AK010984.1 and BE994003.1.
            
            On Apr 3, 2009 this sequence version replaced NM_134118.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019984.1, AK010984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BY278351.1         1-48
            49-1075             AK010984.1         23-1049
            1076-1190           BE994003.1         1-115               c
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.22 cM"
     gene            1..1190
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /note="trans-2,3-enoyl-CoA reductase"
                     /db_xref="GeneID:106529"
                     /db_xref="MGI:MGI:1915408"
     exon            1..152
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1064
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /EC_number="1.3.1.93"
                     /note="isoform 1 is encoded by transcript variant 1; TER;
                     synaptic glycoprotein SC2; glycoprotein, synaptic 2;
                     very-long-chain enoyl-CoA reductase"
                     /codon_start=1
                     /product="very-long-chain enoyl-CoA reductase isoform 1"
                     /protein_id="NP_598879.1"
                     /db_xref="CCDS:CCDS40403.1"
                     /db_xref="GeneID:106529"
                     /db_xref="MGI:MGI:1915408"
                     /translation="MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWY
                     PARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIY
                     LLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRN
                     IFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAVFVICQLGNFSIHMALRDL
                     RPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFT
                     QMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL"
     exon            153..203
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            204..255
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..300
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..404
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..520
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..626
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..699
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..743
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..801
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..890
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..936
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1174
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1155..1160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /note="hexamer: AATAAA"
     polyA_site      1174
                     /gene="Tecr"
                     /gene_synonym="2410016D23Rik; A230102P12Rik; D17Ertd178e;
                     Gpsn2; SC2"
                     /note="major polyA site"
ORIGIN      
        1 gggacgcacg catagagggg ggcggagccg gagtccggga gtgctgctcc ccgagtgtgt
       61 gtggagctgg gtggtgtttg gtgcggtacg gcggccactc agttgcagca gagcaggtgc
      121 catcctgtgg aagaaccatg aagcactacg aggtggagat tcgggatgca aagacgaggg
      181 agaagctgtg cttcctggac aaggtagagc ctcaggccac catttctgaa atcaagaccc
      241 ttttcaccaa gacacacccg cagtggtatc ctgcccgcca gtccctccgc ctggacccca
      301 aggggaagtc cctgaaagat gaagatgtct tacagaagct tcctgtgggc accacagcca
      361 cactctactt ccgggacctc ggggcccaga tcagctgggt gacggtcttc ctgacggagt
      421 atgccgggcc ccttttcatc tacctgctct tctacttccg ggtacccttc atttatggcc
      481 gcaaatacga ctttacgtcc agtcggcata cggtggtgca cctcgcctgc atgtgccact
      541 cgttccacta catcaagcgc ctgctggaga ctctcttcgt gcaccgattc tctcacggaa
      601 ccatgccttt gcgaaacatc ttcaaaaact gcacctacta ttggggcttt gctgcatgga
      661 tggcttatta catcaaccac cctctctaca caccccctac ctatggagtt cagcaggtta
      721 agctggcact ggccgttttt gtgatctgcc agcttgggaa cttctccatc cacatggctc
      781 ttcgggacct tcggcctgct gggtcgaaaa ccaggaagat cccatacccc accaagaacc
      841 ccttcacctg gctgttcctg ttggtgtcct gtcccaacta cacttatgag gtgggctcct
      901 ggattggctt tgccatcttg actcagtgtg tcccagtggc cctcttctcc ctggtgggct
      961 tcacccagat gactatctgg gccaagggca aacaccgcag ctacctgaag gagttccgcg
     1021 actacccgcc cctgcgcatg cccattattc ccttcctgct ctgagcagct cctcacggct
     1081 ctgcccagta atactctcca cccctcactg cccctgtcct gatgtgtggc tggccatggc
     1141 tctccagcag caacaataaa acctgcttac ccaaaaaaaa aaaaaaaaaa
//
