LOCUS       NM_001113460            2661 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus tec protein tyrosine kinase (Tec), transcript variant
            1, mRNA.
ACCESSION   NM_001113460
VERSION     NM_001113460.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Sandner,L., Alteneder,M., Zhu,C., Hladik,A., Hogler,S., Rica,R.,
            Van Greuningen,L.W., Sharif,O., Sakaguchi,S., Knapp,S., Kenner,L.,
            Trauner,M., Ellmeier,W. and Boucheron,N.
  TITLE     The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation,
            Pathogenicity, and Plasticity in T-Cell-Driven Intestinal
            Inflammation
  JOURNAL   Front Immunol 12, 750466 (2021)
   PUBMED   35003062
  REMARK    GeneRIF: The Tyrosine Kinase Tec Regulates Effector Th17
            Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven
            Intestinal Inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Fuhriman,J.M., Winge,M.C.G., Haberstock-Debic,H., Funk,J.O.,
            Bradshaw,J.M. and Marinkovich,M.P.
  TITLE     ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse
            Models of Psoriasis
  JOURNAL   J Invest Dermatol 138 (4), 864-871 (2018)
   PUBMED   29129599
  REMARK    GeneRIF: Inhibition of ITK and RLK attenuated psoriasis-associated
            signaling pathways, indicating that PRN694 is an effective
            psoriasis therapeutic.
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Wang,F., Zhang,W., Wang,C., Fang,X., Cheng,H., Liu,S. and Chen,X.L.
  TITLE     Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory
            mediators production in LPS-stimulated RAW264.7 macrophages via
            NF-kappaB pathway
  JOURNAL   Oncotarget 8 (21), 34099-34110 (2017)
   PUBMED   28415764
  REMARK    GeneRIF: Results suggest that Tec kinase involves in acute
            inflammation process in LPS-stimulated RAW264.7 macrophages cells
            via NF-kappaB pathway.
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   de Bruijn,M.J., Rip,J., van der Ploeg,E.K., van Greuningen,L.W.,
            Ta,V.T., Kil,L.P., Langerak,A.W., Rimmelzwaan,G.F., Ellmeier,W.,
            Hendriks,R.W. and Corneth,O.B.
  TITLE     Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell
            Receptor Signaling
  JOURNAL   J Immunol 198 (8), 3058-3068 (2017)
   PUBMED   28275136
  REMARK    GeneRIF: these data indicate that in mature B cells, Tec and Btk
            may compete for activation of the Akt signaling pathway, whereby
            the activating capacity of Btk is limited by the presence of Tec
            kinase.
REFERENCE   5  (bases 1 to 2661)
  AUTHORS   Tampella,G., Kerns,H.M., Niu,D., Singh,S., Khim,S., Bosch,K.A.,
            Garrett,M.E., Moguche,A., Evans,E., Browning,B., Jahan,T.A.,
            Nacht,M., Wolf-Yadlin,A., Plebani,A., Hamerman,J.A., Rawlings,D.J.
            and James,R.G.
  TITLE     The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for
            the Regulation of Inhibitory Signals in Murine Macrophages
  JOURNAL   J Immunol 195 (1), 246-256 (2015)
   PUBMED   26026062
  REMARK    GeneRIF: Btk, Tec, Bmx are required for TLR-dependent signaling in
            many types of myeloid cells while being tissue-specific.
REFERENCE   6  (bases 1 to 2661)
  AUTHORS   Machide,M., Mano,H. and Todokoro,K.
  TITLE     Interleukin 3 and erythropoietin induce association of Vav with Tec
            kinase through Tec homology domain
  JOURNAL   Oncogene 11 (4), 619-625 (1995)
   PUBMED   7651724
REFERENCE   7  (bases 1 to 2661)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   8  (bases 1 to 2661)
  AUTHORS   Mano,H., Mano,K., Tang,B., Koehler,M., Yi,T., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G. and Ihle,J.N.
  TITLE     Expression of a novel form of Tec kinase in hematopoietic cells and
            mapping of the gene to chromosome 5 near Kit
  JOURNAL   Oncogene 8 (2), 417-424 (1993)
   PUBMED   7678927
REFERENCE   9  (bases 1 to 2661)
  AUTHORS   Mano,H., Ishikawa,F., Nishida,J., Hirai,H. and Takaku,F.
  TITLE     A novel protein-tyrosine kinase, tec, is preferentially expressed
            in liver
  JOURNAL   Oncogene 5 (12), 1781-1786 (1990)
   PUBMED   2284097
REFERENCE   10 (bases 1 to 2661)
  AUTHORS   Wilks,A.F., Kurban,R.R., Hovens,C.M. and Ralph,S.J.
  TITLE     The application of the polymerase chain reaction to cloning members
            of the protein tyrosine kinase family
  JOURNAL   Gene 85 (1), 67-74 (1989)
   PUBMED   2482828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ047828.1, AK168460.1, AK139329.1 and AC099698.14.
            
            On Oct 23, 2013 this sequence version replaced NM_001113460.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154457.1, SRR7345562.2020934.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CJ047828.1         2-6
            6-143               AK168460.1         2-139
            144-2656            AK139329.1         53-2565
            2657-2661           AC099698.14        167319-167323       c
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.44 cM"
     gene            1..2661
                     /gene="Tec"
                     /note="tec protein tyrosine kinase"
                     /db_xref="GeneID:21682"
                     /db_xref="MGI:MGI:98662"
     exon            1..55
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            56..142
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            143..328
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            329..433
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            434..515
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            516..644
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            645..685
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            686..858
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            859..924
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            925..979
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1059
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1193
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1268
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1440
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1657
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1722
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1841
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1999
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2661
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2617..2622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tec"
                     /note="hexamer: TATAAA"
     polyA_site      2641
                     /gene="Tec"
                     /note="major polyA site"
ORIGIN      
        1 tccgcagttt ggacgtcgct ctgtcttggc ttgtctcggc acgcgctccg tcaaggtgtc
       61 ggacgacact gaggacacag aggatgtccg aagaatgaaa tgagcagatg gaactttgaa
      121 ggctgagtca acgggcagag ggaatccgga gatcgtcaat ggcaggagaa agagcaacca
      181 gaagaccgag atgaatttca acactatcct agaagagatt cttattaaaa ggtcccagca
      241 gaaaaagaag acatcaccct taaactacaa agagagactt tttgtactta caaaatccgt
      301 gttgagctac tatgagggtc gagcggagaa gaaatacaga aagggcgtca ttgatatttc
      361 caaaatcaag tgtgtggaga tagtgaagaa cgatgatggt gtcattccct gtcaaaataa
      421 atttccattc caggttgttc atgatgctaa tacactttat atttttgcac ctagtccaca
      481 aagcagggac cgatgggtga agaagttaaa agaagaaata aagaacaaca ataatatcat
      541 gattaaatac catcctaaat tctgggcaga tgggagttac cagtgttgta gacaaacaga
      601 aaaactagca cccggatgtg agaagtacaa tctttttgag agtagtataa gaaagaccct
      661 gcctcccgcg ccagaaataa agaagagaag gcctcctcca ccaattcccc cagaggaaga
      721 aaatactgaa gaaatcgttg tagcgatgta tgacttccaa gcgacggaag cacatgacct
      781 caggttagag agaggccaag agtatatcat cctggaaaag aatgacctcc attggtggag
      841 agcgagagat aagtatggga gtgaaggata tatcccaagt aattacgtca cagggaagaa
      901 atccaacaac ttagatcaat atgagtggta ctgcagaaat accaacagaa gcaaagcaga
      961 acagctcctc agaacggaag ataaagaagg tggttttatg gtgagagact ccagtcaacc
     1021 aggcttgtac actgtctccc tttacacaaa gtttggggga gaaggctcat caggtttcag
     1081 gcattatcac ataaaggaaa cagcaacatc cccaaagaag tattacctgg cagagaagca
     1141 tgctttcggg tccattcctg agatcattga atatcacaag cacaatgcgg cagggcttgt
     1201 caccaggctg cggtacccgg tcagtacaaa ggggaagaac gctcccacta ctgccggctt
     1261 cagctatgat aagtgggaga ttaacccatc agagctgacc tttatgagag agttggggag
     1321 cggactgttt ggagtggtga ggcttggcaa gtggcgggcc cagtacaaag tggccatcaa
     1381 agctatccgg gaaggcgcca tgtgtgaaga ggatttcata gaggaagcta aagtcatgat
     1441 gaagctgaca caccccaagc tggtacagct ctatggtgta tgcacccagc agaagcccat
     1501 ctacatcgtt accgagttca tggaacgggg ctgccttctg aatttcctcc ggcagagaca
     1561 aggccatttc agcagagaca tgctgctaag catgtgtcaa gatgtctgtg aagggatgga
     1621 gtacctggag agaaacagct tcatccacag agacctggct gccagaaatt gtctagtgaa
     1681 tgaagcagga gttgtcaaag tatctgattt tggaatggcc aggtacgttc tggatgatca
     1741 gtacacaagt tcttctggcg ccaagttccc tgtgaagtgg tgtcccccag aagtgtttaa
     1801 ttacagccgc tttagcagca agtcagacgt ctggtcgttt ggtgtgctaa tgtgggaaat
     1861 attcacagaa ggcaggatgc cctttgagaa gaacaccaat tacgaagtgg taaccatggt
     1921 gactcgtggc caccgcctcc accggccaaa gctggcttcc aaatatttgt atgaggtgat
     1981 gctgagatgc tggcaagaga gaccagaggg aaggccttcc tttgaagact tgctgcgtac
     2041 gatagatgaa ctagttgaat gtgaagaaac ttttggaaga tgaatggtgg ccccagtttc
     2101 caaggcaaga ggaagaaatg gtgtgccatc ggaacgcaat tctcttggca cctgggagta
     2161 tagactgctc tgcttacaac acgggagccc cagcgcatct gctgctgatc cagcctgagc
     2221 tcagtggctg ctttgccggc tgcacagatg gtctctcaga gctggtgact tgaagcactc
     2281 attttgctca tttcttcaag ggtttgagtg ccagccatgt ataccaggct ctgtgcccag
     2341 gcctcaggag atgaacatgg gactatgcta gctgatgcta gcagaaagcc agggtggttg
     2401 tgatggggac gagtcatgtc ccagcgtctc ttccatgccc tttggctttt acataaacct
     2461 gggcctggag tgttgtctac cactgagttc taggaaaagc aggaacccac ctggatacgt
     2521 agtaatcctc tgttttggaa acatctcttt ccaaacttgt tcttagtagt atgcttaaaa
     2581 atttgtatat tgtatatatt gtaaatacat ataatatata aagttatata tttataagta
     2641 acatacgttt atctctttag c
//
