LOCUS       NM_011567               3076 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus TEA domain family member 4 (Tead4), transcript variant
            1, mRNA.
ACCESSION   NM_011567 XM_132891
VERSION     NM_011567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3076)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 3076)
  AUTHORS   Zhu,M., Meglicki,M., Lamba,A., Wang,P., Royer,C., Turner,K.,
            Jauhar,M.A., Jones,C., Child,T., Coward,K., Na,J. and
            Zernicka-Goetz,M.
  TITLE     Tead4 and Tfap2c generate bipotency and a bistable switch in
            totipotent embryos to promote robust lineage diversification
  JOURNAL   Nat Struct Mol Biol 31 (6), 964-976 (2024)
   PUBMED   38789684
  REMARK    GeneRIF: Tead4 and Tfap2c generate bipotency and a bistable switch
            in totipotent embryos to promote robust lineage diversification.
REFERENCE   3  (bases 1 to 3076)
  AUTHORS   Wu,X., Shi,Y., Hu,B., Zhao,P., Li,S., Xiao,L., Wang,S. and Zhang,K.
  TITLE     TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but
            not in cattle
  JOURNAL   Reproduction 167 (3), e230322 (2024)
   PUBMED   38206180
  REMARK    GeneRIF: TEAD4 regulates KRT8 and YAP in preimplantation embryos in
            mice but not in cattle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3076)
  AUTHORS   Dos Santos,M., Shah,A.M., Zhang,Y., Bezprozvannaya,S., Chen,K.,
            Xu,L., Lin,W., McAnally,J.R., Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3076)
  AUTHORS   Zhang,H., Ren,C., Liu,Q., Wang,Q. and Wang,D.
  TITLE     TFAP2C exacerbates psoriasis-like inflammation by promoting Th17
            and Th1 cells activation through regulating TEAD4 transcription
  JOURNAL   Allergol Immunopathol (Madr) 51 (3), 124-134 (2023)
   PUBMED   37169570
  REMARK    GeneRIF: TFAP2C exacerbates psoriasis-like inflammation by
            promoting Th17 and Th1 cells activation through regulating TEAD4
            transcription.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3076)
  AUTHORS   Hsu,D.K., Guo,Y., Alberts,G.F., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Peifley,K.A. and Winkles,J.A.
  TITLE     Identification of a murine TEF-1-related gene expressed after
            mitogenic stimulation of quiescent fibroblasts and during myogenic
            differentiation
  JOURNAL   J Biol Chem 271 (23), 13786-13795 (1996)
   PUBMED   8662936
REFERENCE   7  (bases 1 to 3076)
  AUTHORS   Yockey,C.E., Smith,G., Izumo,S. and Shimizu,N.
  TITLE     cDNA cloning and characterization of murine transcriptional
            enhancer factor-1-related protein 1, a transcription factor that
            binds to the M-CAT motif
  JOURNAL   J Biol Chem 271 (7), 3727-3736 (1996)
   PUBMED   8631987
REFERENCE   8  (bases 1 to 3076)
  AUTHORS   Blanar,M.A., Crossley,P.H., Peters,K.G., Steingrimsson,E.,
            Copeland,N.G., Jenkins,N.A., Martin,G.R. and Rutter,W.J.
  TITLE     Meso1, a basic-helix-loop-helix protein involved in mammalian
            presomitic mesoderm development
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 5870-5874 (1995)
   PUBMED   7597044
REFERENCE   9  (bases 1 to 3076)
  AUTHORS   Burgess,R., Cserjesi,P., Ligon,K.L. and Olson,E.N.
  TITLE     Paraxis: a basic helix-loop-helix protein expressed in paraxial
            mesoderm and developing somites
  JOURNAL   Dev Biol 168 (2), 296-306 (1995)
   PUBMED   7729571
REFERENCE   10 (bases 1 to 3076)
  AUTHORS   Burglin,T.R.
  TITLE     The TEA domain: a novel, highly conserved DNA-binding motif
  JOURNAL   Cell 66 (1), 11-12 (1991)
   PUBMED   2070413
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D87965.1, D87966.1, BC130257.1
            and AB221623.1.
            
            On Feb 3, 2007 this sequence version replaced NM_011567.1.
            
            Summary: This gene product is a member of the transcriptional
            enhancer factor (TEF) family of transcription factors, which
            contain the TEA/ATTS DNA-binding domain. It is preferentially
            expressed in the skeletal muscle, and binds to the M-CAT regulatory
            element found in promoters of muscle-specific genes to direct their
            gene expression. This factor may play a role in the embryonic
            development of skeletal muscle. Alternatively spliced transcripts
            encoding distinct isoforms, which are translated through the use of
            a non-AUG (AUU) initiation codon, have been described for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform (a,
            also known as ETFR-2a), and initiates translation from a non-AUG
            (AUU) codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87966.1, AK133915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 8920920
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 D87965.1           1-5
            6-745               D87966.1           1-740
            746-895             BC130257.1         181-330
            896-1264            D87966.1           891-1259
            1265-1854           AB221623.1         566-1155
            1855-3076           D87966.1           1850-3071
FEATURES             Location/Qualifiers
     source          1..3076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 62.92 cM"
     gene            1..3076
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /note="TEA domain family member 4"
                     /db_xref="GeneID:21679"
                     /db_xref="MGI:MGI:106907"
     exon            1..519
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            520..774
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             570..1853
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /exception="alternative start codon"
                     /note="isoform a is encoded by transcript variant 1;
                     non-AUG (AUU) translation initiation codon;
                     transcriptional enhancer factor TEF-3; FGF-regulated 19;
                     ETF-related factor-2; RTEF-1; TEF-1-related factor 1;
                     TEF-1-related factor FR-19"
                     /codon_start=1
                     /transl_except=(pos:570..572,aa:Met)
                     /product="transcriptional enhancer factor TEF-3 isoform a"
                     /protein_id="NP_035697.3"
                     /db_xref="CCDS:CCDS39646.1"
                     /db_xref="GeneID:21679"
                     /db_xref="MGI:MGI:106907"
                     /translation="MTSNEWSSPDSPEGSSISGGSQALDKPIDNDAEGVWSPEIERSF
                     QEALAIYPPCGRRKIILTEEGKMYGRNELIARHIKLRTGKTRTRKQVSSHIQVLARRK
                     AREIQAKLKDQAAKNKALQSMAAMSSAQIVSATAFHSKMALARGPGYPAISGFWQGAL
                     PGQPGTSHDVKPFSQNTYPVQPPLPLPGFESPAGPTPSPSAPLAPPWQGRSIASSKLW
                     MLEFSAFLERQQDPDTYNKHLFVHISQSSPSYSDPYLETVDIRQIYDKFPEKKGGLKE
                     LFERGPSNAFFLVKFWADLNTNIDDEGSAFYGVSSQYESPENMIITCSTKVCSFGKQV
                     VEKVETEYARYENGHYLYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVV
                     TNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE"
     exon            775..839
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            840..902
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1031
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1075
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1131
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1271
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1445
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1586
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1739
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..3076
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /note="hexamer: AATAAA"
     polyA_site      2036
                     /gene="Tead4"
                     /gene_synonym="ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1;
                     TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a"
                     /note="major polyA site"
ORIGIN      
        1 gcgaggcgcg ccccaccccg gcggagggga cggttttcgg ctggaggtgg tggagagaca
       61 gttaggactc aacgcaaccc gggggtgtgg ggagctggat gagagcggga aatcggtaga
      121 tcagagtcaa ggggtgtggg tgcgagcggc gagaggcgcc gaggggtccg cggggttccc
      181 gggtgtctcc gccgtgtcct gtcccgtggc cgcccgcggt tcccgggctc cgcccagccg
      241 tggagcccag cctctctctg gcccggtctc ctcccaaagg tgcgggtggc agcgccactc
      301 cctccgctcc ctccccagcc gcgcgcgtct cattccagcg cccattccgt gcattcctgc
      361 cgggctcctc tgcaaactcc agtcccgggg gtggggaccg gcctcagcta cgcgctcggg
      421 gccccgcagc ggtcgccgcg gctggaagac ttggcgcccc gcgtggacct gccgcagccg
      481 gccgagctct cccaccccgc ctcccgaacc ctgggaccgg tccaacgggc gctcctccaa
      541 gccgagcctt ggagggcaag gccggcacca ttacctccaa cgagtggagc tctcccgact
      601 cccccgaggg gagcagcatc tctgggggca gccaggcact ggacaagccc atcgacaatg
      661 atgcagaggg tgtatggagc cccgaaattg agcgaagctt ccaggaggcc ctggccatct
      721 acccaccctg cggccgccgc aaaattatcc tgacggagga aggcaagatg tatggtcgga
      781 atgagctgat cgcacgccat atcaagctca ggacagggaa gacgcgcaca aggaagcagg
      841 tctccagcca catccaggtg cttgcccgtc gaaaagcccg ggagatccag gccaaactca
      901 aggaccaggc agctaagaac aaggccctgc agagcatggc tgccatgtcg tccgcacaga
      961 tcgtctcggc cacagccttc cacagtaaaa tggctcttgc ccggggccct ggctacccag
     1021 caatctcagg gttttggcaa ggagctttgc caggccaacc tggaacatcc cacgatgtga
     1081 aacctttctc tcaaaacacc taccctgtcc agcctccgct gcctctgcca ggctttgagt
     1141 ctcctgcagg gcccaccccc tcaccctccg caccgctcgc tcctccgtgg caaggccgca
     1201 gcatagctag ctccaagctc tggatgttgg agttctcggc tttcctggag cgccagcaag
     1261 atcccgacac atacaacaaa cacctgtttg tgcacatcag ccagtcaagc ccaagctaca
     1321 gtgaccccta cctcgaaact gtggacatcc gccaaatcta tgacaagttc ccagagaaga
     1381 agggaggcct caaggagcta tttgaacggg ggccctctaa tgccttcttc cttgtgaagt
     1441 tctgggcaga cctcaatacc aacatcgatg acgagggcag cgccttctat ggggtctcca
     1501 gccagtacga gagcccggag aacatgatta tcacctgctc tacgaaggtc tgctcatttg
     1561 gcaagcaagt ggtggagaaa gttgagacgg agtatgcccg ctatgagaat ggccactatt
     1621 tgtaccgcat ccaccggtcc cctctctgtg agtacatgat caactttatc cacaagctga
     1681 aacacttacc cgagaagtac atgatgaaca gtgtgctgga gaacttcacc atcctgcagg
     1741 tggtcaccaa ccgagacaca caggagacct tgctgtgtat tgcatatgtc ttcgaagttt
     1801 cagccagcga gcatggggct cagcaccaca tctaccgact tgtgaaagaa tgagagactt
     1861 ggagagcaat ggtagggggg acaagtccag gacatgggga cctgggaggg gaccttcagg
     1921 gacagtcccc tggaagtgcc aagagagcca agcagagttg ccaggtctct tcttaccagg
     1981 agcaaactgc ctgatcttgc agtgctcaac ccccaataaa cccaaggtgt caagtatttt
     2041 cagaggagct agtttggcct gtgtgagccc agaagggcag gggagaaggg ggcatcagga
     2101 agcaagctgg aagcaatggc ccaaagtact ccaggacagc caaggaacca gaaccccggt
     2161 ggactcagcc aggcatatca ccaagacacc aaagctcaag acccttctca gctgctggaa
     2221 cctcacactc ctgctgctgg tcaccctagt ggcctgagga cagattgcac gtaggtcaca
     2281 cacccagaga tgctgtgggt gactttatgt acactgtctg tctgtcctgc catcggtgcc
     2341 tgagaatggc tactgcagaa ggctccatcc ctgcaaacag ggctgggttt aggtgtggct
     2401 gcaacatagt tgttggaggg agactgggta agagctactc gggtggcttt gttctttctg
     2461 cagtggccct gcagggggca gggtctccaa actgaagcaa ggcttggagg tagggcgtcc
     2521 tgcctcaggg ccagcatttc cagctgcctg gcctccacag gctcctcggc ttctctatta
     2581 gtctcttttc ttctctgctc agcactgacg agggagggtg tctgtaaagt acccgggtct
     2641 tgcggtgcca gttaaataat ctaatcctca gccccattgc ttctctcact ctggagggcc
     2701 tggatctgtc tctctgctgc cctctcaagg ctttctggtg tctgctttcc ccagttggag
     2761 ccagttctaa tagtctggag cctcaggaag aaagatacaa cctgggcatg tttgtgtgta
     2821 tccaggactc agggatgcat ctgtgaggat gcagaaatgg gcagggcagc attgtggtga
     2881 tgctacagag gtgagggaca agggctctgg agtcagtcta gcctgacttt ggtgtgcaac
     2941 ctttaaaaaa aaaatgttgt ggtgcctcag tttccccatc tgtaaaatgg gtataacatt
     3001 cacctacctc gtgtatggac agtgcctcac acagtgctga gcacatccac atgttcaata
     3061 aatatgcatt ggtact
//
