LOCUS       NM_011566               2616 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus TEA domain family member 3 (Tead3), transcript variant
            2, mRNA.
ACCESSION   NM_011566
VERSION     NM_011566.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2616)
  AUTHORS   Pelenyi,A., Atterton,C., Jones,J., Currey,L., Al-Khalily,M.,
            Wright,L., Kurniawan,N.D., Thor,S. and Piper,M.
  TITLE     Expression of the Hippo pathway effector, TEAD1, within the
            developing murine forebrain
  JOURNAL   Gene Expr Patterns 54, 119384 (2024)
   PUBMED   39557142
REFERENCE   2  (bases 1 to 2616)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2616)
  AUTHORS   Cheng,Y., Xiao,Y., Ruan,Y., Wang,J., Tian,Y., Xiong,J., Wang,J.,
            Wang,F., Zhang,C., Xu,Y., Liu,L., Yu,M., Wang,J., Zhao,B.,
            Zhang,Y., Yang,R., Yang,Y., Yao,Z., Jian,R., Xiao,L. and Zhang,J.
  TITLE     Comparative expression analysis of TEADs and their splice variants
            in mouse embryonic stem cells
  JOURNAL   Gene Expr Patterns 47, 119302 (2023)
   PUBMED   36516960
  REMARK    GeneRIF: Comparative expression analysis of TEADs and their splice
            variants in mouse embryonic stem cells.
            Erratum:[Gene Expr Patterns. 2023 Sep;49:119332. doi:
            10.1016/j.gep.2023.119332.. PMID: 37523912]
REFERENCE   4  (bases 1 to 2616)
  AUTHORS   Niki,Y., Kobayashi,Y. and Moriyama,K.
  TITLE     Expression pattern of transcriptional enhanced associate domain
            family member 1 (Tead1) in developing mouse molar tooth
  JOURNAL   Gene Expr Patterns 40, 119182 (2021)
   PUBMED   33984529
REFERENCE   5  (bases 1 to 2616)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2616)
  AUTHORS   Jiang,S.W., Wu,K. and Eberhardt,N.L.
  TITLE     Human placental TEF-5 transactivates the human chorionic
            somatomammotropin gene enhancer
  JOURNAL   Mol Endocrinol 13 (6), 879-889 (1999)
   PUBMED   10379887
  REMARK    GeneRIF: Experimental evidence for non-AUG translation initiation
            of human TEF-5. This non-AUG start site, AUA, is conserved in
            mouse.
REFERENCE   7  (bases 1 to 2616)
  AUTHORS   Jacquemin,P., Hwang,J.J., Martial,J.A., Dolle,P. and Davidson,I.
  TITLE     A novel family of developmentally regulated mammalian transcription
            factors containing the TEA/ATTS DNA binding domain
  JOURNAL   J Biol Chem 271 (36), 21775-21785 (1996)
   PUBMED   8702974
REFERENCE   8  (bases 1 to 2616)
  AUTHORS   Blanar,M.A., Crossley,P.H., Peters,K.G., Steingrimsson,E.,
            Copeland,N.G., Jenkins,N.A., Martin,G.R. and Rutter,W.J.
  TITLE     Meso1, a basic-helix-loop-helix protein involved in mammalian
            presomitic mesoderm development
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 5870-5874 (1995)
   PUBMED   7597044
REFERENCE   9  (bases 1 to 2616)
  AUTHORS   Burgess,R., Cserjesi,P., Ligon,K.L. and Olson,E.N.
  TITLE     Paraxis: a basic helix-loop-helix protein expressed in paraxial
            mesoderm and developing somites
  JOURNAL   Dev Biol 168 (2), 296-306 (1995)
   PUBMED   7729571
REFERENCE   10 (bases 1 to 2616)
  AUTHORS   Burglin,T.R.
  TITLE     The TEA domain: a novel, highly conserved DNA-binding motif
  JOURNAL   Cell 66 (1), 11-12 (1991)
   PUBMED   2070413
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF617964.1, Y10027.1 and
            CT025652.7.
            
            On Feb 18, 2011 this sequence version replaced NM_011566.3.
            
            Summary: This gene product is a member of the transcriptional
            enhancer factor (TEF) family of transcription factors, which
            contain the TEA/ATTS DNA-binding domain. It is predominantly
            expressed in the placenta and thought to play a role in placental
            gene regulation and development. Alternative splicing, and
            alternate use of an upstream AUG translation initiation codon, and
            an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has a different 5' terminal
            exon and initiates translation from an in-frame, downstream,
            non-AUG (AUA) start site, compared to variant 1. Variants 2 and 3
            encode the same isoform (2), which is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021364.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 10379887, 9671946
            RefSeq Select criteria   :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               CF617964.1         1-238
            239-1861            Y10027.1           1-1623
            1862-2616           CT025652.7         30617-31371
FEATURES             Location/Qualifiers
     source          1..2616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.66 cM"
     gene            1..2616
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /note="TEA domain family member 3"
                     /db_xref="GeneID:21678"
                     /db_xref="MGI:MGI:109241"
     exon            1..197
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            198..449
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1567
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /exception="alternative start codon"
                     /note="isoform 2 is encoded by transcript variant 2;
                     non-AUG (AUA) translation initiation codon;
                     transcriptional enhancer factor TEF-5; ETF-related factor
                     1"
                     /codon_start=1
                     /transl_except=(pos:248..250,aa:Met)
                     /product="transcriptional enhancer factor TEF-5 isoform 2"
                     /protein_id="NP_035696.3"
                     /db_xref="CCDS:CCDS28577.3"
                     /db_xref="GeneID:21678"
                     /db_xref="MGI:MGI:109241"
                     /translation="MASNSWTANSSPGEAREDGSEGLDKGLDNDAEGVWSPDIEQSFQ
                     EALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKV
                     REYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSSSSR
                     FWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPALNSYESLAPLPPAAASATASAPA
                     WQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIY
                     DKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTIS
                     VSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMN
                     SVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD"
     exon            450..514
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            515..577
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            578..589
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            590..727
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            728..777
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            778..839
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            840..985
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1159
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1300
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1453
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2616
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /note="hexamer: ATTAAA"
     polyA_site      2573
                     /gene="Tead3"
                     /gene_synonym="DTEF-1; ETFR-1; Tcf13r2; TEAD-3; TEF-5"
                     /note="major polyA site"
ORIGIN      
        1 ccccgcccgg ctccctcaac acaaactttc cgtcccgctc gctccctcct ccgcgcccag
       61 cacctcccgc tccggccggg ctcattccgt acattccggc catccccctg cccacgaccc
      121 cccttcccgg cccccctcac tactccctcg ggcccggcgg agcggcccgg cggagcgccc
      181 cccggagctc ggagcaggct caggccatcc agggggctca ggcccagagc ccaaagcaac
      241 cagcacaata gcgtccaaca gctggaccgc caacagcagc cccggggagg cccgggaaga
      301 tgggtccgaa ggcctggaca agggtctgga caacgatgcg gagggagtgt ggagcccgga
      361 catcgagcag agctttcagg aggccctggc catctacccg ccttgcggac ggcgcaagat
      421 catcctgtca gatgagggca agatgtacgg tcgaaatgag ctgattgccc gctacatcaa
      481 gctgaggact ggaaaaacca ggacaagaaa acaggtgtcc agccacatac aggttctagc
      541 tcggaagaag gttcgggaat accaggttgg cattaaggct atgaacctgg accaagtctc
      601 caaggacaaa gctctccaga gcatggcatc catgtcgtct gcccaaatcg tctctgccag
      661 cgttctacag aacaagttca gcccgccctc ccctctaccc caggctgtct tctcctcctc
      721 ctcaaggttc tggagcagcc cccctctgct aggacaacag cctggacctt ctcaggacat
      781 caagcccttt gcccagcctg cctaccccat ccagcctccc ttgccaccag cgctcaacag
      841 ttatgagtcc ctcgccccgc tgcccccagc cgctgcctca gccaccgcct ctgcgcctgc
      901 atggcaggac cgcaccatcg cctcctcccg gctacgcctc ctggagtatt ctgccttcat
      961 ggaggtgcaa cgggaccctg acacgtacag caaacacctg tttgtacaca tcggccagac
     1021 aaaccctgcc ttctcagacc cacccctgga ggcagtggat gtacgacaga tctacgacaa
     1081 gttccccgag aagaaggggg ggctgaagga actctacgag aaggggcccc cgaacgcttt
     1141 cttccttgtc aagttctggg ctgacctcaa cagcacaatc caggaaggcc ctggggcctt
     1201 ctacggggtc agctcgcagt acagctcagc cgacagcatg accatcagcg tctccaccaa
     1261 ggtctgctcc ttcggcaagc aggtggtaga gaaggtggag accgagtacg cccgcctgga
     1321 gaacggccgc ttcgtgtacc gcatccaccg ctcacccatg tgcgagtaca tgatcaattt
     1381 catccacaaa ctgaagcatc tgcccgagaa gtacatgatg aacagtgtgc tggagaactt
     1441 caccatcctg caggtggtca caagtcggga ctcgcaggag accctgctgg tcattgcttt
     1501 tgtctttgaa gtctccacca gcgagcatgg ggcgcagcac cacgtctaca agcttgtcaa
     1561 agactagcca gccctcgacc tccacaggat gcaaggcgga catcctccac acacctgcct
     1621 gcctggtctt cccgtgtggg ttgggggacc tagcccagcc cccctgggtt tcaggctggg
     1681 acccaggctg cctccctggc tccagcacac atgctccctg ccactgttct gcgctttact
     1741 ggagagaaga gggctccacg gtggggtggc ttgcttgggc actgagccac agatgaccag
     1801 gctccacctg gcctcaagtg acaccagaat tgtaccatgg aggacacctt ggggcttagt
     1861 gtgtggttgc tggcccctag gggaatgaat gtgctgggca ggtgagggtt gcattgagac
     1921 tggggaaagg cagcttgcaa ggaggccctg gtacaaggtg tcaggttggg gaggttgaga
     1981 agggcccaca cttctttgta ccttctgggt accagtctgt tcccaggtcc cttacccagc
     2041 aagtttgggt ctcccatatc agacaatgtg ccaagatgga ggcccacaga agtggacgga
     2101 gggagctggg gctggttcag ctacctccct agcagagctg cctatggggc ggggaagggg
     2161 ctctgctggg ctgaagccta gacagggctc tatttcctgt tccccccagc ataccagcca
     2221 ctagcgcccc cccccccccc cgccctcttc tgtgtcctga agacaggtgg cagggaacag
     2281 gaggctgcct ctgccttctc cacatccagg tcccaaggtc acctgggtat ttatgagttt
     2341 caaatgaagt actgtgcccc caatccagcc cgagcttccg gaaggttttc gccattgctc
     2401 aggccacctc caaaccccac gtaggtttta taacatgtat tatatatata tatttttgtg
     2461 tatttttaaa atccagctgt gatgggctac atcataaatg gctcaaggca ggggccactc
     2521 aaggcctggc tcctgcttta aagaaaaaaa ttaaaaagct gtttctgggt caagacagtt
     2581 gtgccatatg caaccttgta ccctacctag tcaaaa
//
