LOCUS       NM_011565               1925 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus TEA domain family member 2 (Tead2), transcript variant
            2, mRNA.
ACCESSION   NM_011565 XM_356055
VERSION     NM_011565.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Pelenyi,A., Atterton,C., Jones,J., Currey,L., Al-Khalily,M.,
            Wright,L., Kurniawan,N.D., Thor,S. and Piper,M.
  TITLE     Expression of the Hippo pathway effector, TEAD1, within the
            developing murine forebrain
  JOURNAL   Gene Expr Patterns 54, 119384 (2024)
   PUBMED   39557142
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Guo,R., Dong,X., Chen,F., Ji,T., He,Q., Zhang,J., Sheng,Y., Liu,Y.,
            Yang,S., Liang,W., Song,Y., Fang,K., Zhang,L., Hu,G. and Yao,H.
  TITLE     TEAD2 initiates ground-state pluripotency by mediating chromatin
            looping
  JOURNAL   EMBO J 43 (10), 1965-1989 (2024)
   PUBMED   38605224
  REMARK    GeneRIF: TEAD2 initiates ground-state pluripotency by mediating
            chromatin looping.
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Cheng,Y., Xiao,Y., Ruan,Y., Wang,J., Tian,Y., Xiong,J., Wang,J.,
            Wang,F., Zhang,C., Xu,Y., Liu,L., Yu,M., Wang,J., Zhao,B.,
            Zhang,Y., Yang,R., Yang,Y., Yao,Z., Jian,R., Xiao,L. and Zhang,J.
  TITLE     Comparative expression analysis of TEADs and their splice variants
            in mouse embryonic stem cells
  JOURNAL   Gene Expr Patterns 47, 119302 (2023)
   PUBMED   36516960
  REMARK    GeneRIF: Comparative expression analysis of TEADs and their splice
            variants in mouse embryonic stem cells.
            Erratum:[Gene Expr Patterns. 2023 Sep;49:119332. doi:
            10.1016/j.gep.2023.119332.. PMID: 37523912]
REFERENCE   5  (bases 1 to 1925)
  AUTHORS   Park,S., Mossmann,D., Chen,Q., Wang,X., Dazert,E., Colombi,M.,
            Schmidt,A., Ryback,B., Ng,C.K.Y., Terracciano,L.M., Heim,M.H. and
            Hall,M.N.
  TITLE     Transcription factors TEAD2 and E2A globally repress acetyl-CoA
            synthesis to promote tumorigenesis
  JOURNAL   Mol Cell 82 (22), 4246-4261 (2022)
   PUBMED   36400009
  REMARK    GeneRIF: Transcription factors TEAD2 and E2A globally repress
            acetyl-CoA synthesis to promote tumorigenesis.
REFERENCE   6  (bases 1 to 1925)
  AUTHORS   Jacquemin,P., Hwang,J.J., Martial,J.A., Dolle,P. and Davidson,I.
  TITLE     A novel family of developmentally regulated mammalian transcription
            factors containing the TEA/ATTS DNA binding domain
  JOURNAL   J Biol Chem 271 (36), 21775-21785 (1996)
   PUBMED   8702974
REFERENCE   7  (bases 1 to 1925)
  AUTHORS   Suzuki,K., Yasunami,M., Matsuda,Y., Maeda,T., Kobayashi,H.,
            Terasaki,H. and Ohkubo,H.
  TITLE     Structural organization and chromosomal assignment of the mouse
            embryonic TEA domain-containing factor (ETF) gene
  JOURNAL   Genomics 36 (2), 263-270 (1996)
   PUBMED   8812452
REFERENCE   8  (bases 1 to 1925)
  AUTHORS   Yasunami,M., Suzuki,K., Houtani,T., Sugimoto,T. and Ohkubo,H.
  TITLE     Molecular characterization of cDNA encoding a novel protein related
            to transcriptional enhancer factor-1 from neural precursor cells
  JOURNAL   J Biol Chem 270 (31), 18649-18654 (1995)
   PUBMED   7629195
REFERENCE   9  (bases 1 to 1925)
  AUTHORS   Yin,X.M., Oltvai,Z.N., Veis-Novack,D.J., Linette,G.P. and
            Korsmeyer,S.J.
  TITLE     Bcl-2 gene family and the regulation of programmed cell death
  JOURNAL   Cold Spring Harb Symp Quant Biol 59, 387-393 (1994)
   PUBMED   7587091
  REMARK    Review article
REFERENCE   10 (bases 1 to 1925)
  AUTHORS   Burglin,T.R.
  TITLE     The TEA domain: a novel, highly conserved DNA-binding motif
  JOURNAL   Cell 66 (1), 11-12 (1991)
   PUBMED   2070413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150897.2.
            
            On Mar 28, 2020 this sequence version replaced NM_011565.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146595.1, AK144857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC150897.2         130618-130658       c
            42-279              AC150897.2         129000-129237       c
            280-344             AC150897.2         128305-128369       c
            345-407             AC150897.2         127244-127306       c
            408-515             AC150897.2         125905-126012       c
            516-574             AC150897.2         125749-125807       c
            575-639             AC150897.2         122705-122769       c
            640-782             AC150897.2         120655-120797       c
            783-956             AC150897.2         117638-117811       c
            957-1118            AC150897.2         114980-115141       c
            1119-1271           AC150897.2         114115-114267       c
            1272-1925           AC150897.2         112982-113635       c
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.19 cM"
     gene            1..1925
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /note="TEA domain family member 2"
                     /db_xref="GeneID:21677"
                     /db_xref="MGI:MGI:104904"
     exon            1..41
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            42..279
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1385
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /function="a putative transcription factor which binds to
                     the GT-IIC motif and is structurally related to
                     transcriptional enhancer factor-1 (TEF-1)"
                     /note="isoform a is encoded by transcript variant 2;
                     transcriptional enhancer factor TEF-4; embryonic TEA
                     domain-containing factor"
                     /codon_start=1
                     /product="transcriptional enhancer factor TEF-4 isoform a"
                     /protein_id="NP_035695.1"
                     /db_xref="CCDS:CCDS21236.1"
                     /db_xref="GeneID:21677"
                     /db_xref="MGI:MGI:104904"
                     /translation="MGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGV
                     WSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSS
                     HIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATEL
                     FQFWSGSSGPPWNVPDVKPFSQAPFSVSLTPPASDLPGYEPPPALSPLPPPAPSPPAW
                     QARALGTARLQLIEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYD
                     KFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGSSGGGGGFYGVSSQYESR
                     ELMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLP
                     ERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQYHIYRLVRD"
     exon            280..344
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            345..407
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            408..515
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            516..574
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            575..639
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            640..782
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            783..956
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1118
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1271
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1925
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /note="hexamer: AATATA"
     polyA_site      1925
                     /gene="Tead2"
                     /gene_synonym="Etdf; ETEF-1; ETF; TEAD-2; TEF-4; TEF4"
                     /note="major polyA site"
ORIGIN      
        1 ctcgccccgc ccgcccgcgg ctcccctgcc caggccggga ggcccagatg ggggatcccc
       61 ggactggggc ccccctggat gatggcgggg gctggacagg tagcgaggaa ggcagcgaag
      121 agggcaccgg aggcagcgag ggcgttggag gtgatggcag ccctgatgca gaaggtgtgt
      181 ggagccccga cattgagcag agttttcagg aggccctggc catctaccct ccctgtggcc
      241 gtcgcaagat catcctgtca gatgagggca agatgtatgg ccggaacgaa ctcattgccc
      301 gttacatcaa gctgaggaca gggaagacga gaacgcgaaa gcaggtctcc agccatattc
      361 aggttttggc tcgaaggaaa tcgagagaaa ttcagtccaa gctgaaggac caagtctcca
      421 aggacaaggc cttccagacg atggccacca tgtcttcggc acagctcatc tccgcccctt
      481 ccctccaggc caagctgggc ccttctggcc ctcaggccac tgagcttttc cagttctggt
      541 cagggagctc tgggccacca tggaatgttc cagacgtgaa gcccttctca caggcaccgt
      601 tctccgtgtc actgacgccc ccagcctctg acctaccagg gtacgagccg cccccagccc
      661 tctcacccct gcccccaccc gctccgtctc ccccagcctg gcaggctcgg gccctgggca
      721 ctgcccgcct gcagctgata gagttctcag cgtttgtgga accgccagac gcagttgact
      781 cgttccagag gcatctgttt gtccacatca gtcagcagtg tcccagccct ggagcaccac
      841 ccctagagag tgtggacgtg cggcagatct acgacaaatt ccctgagaag aagggcggcc
      901 tccgcgagct gtatgaccga gggccaccac atgccttctt cctcgtcaag ttctgggcgg
      961 acctgaactg gggccccagt gccgaggagg cagggagcag cggaggtggc ggtggcttct
     1021 atggagtgag cagccagtat gagagccggg agctcatgac actcacctgc tcctccaagg
     1081 tctgctcctt tggcaagcaa gtggtagaga aggtggagac ggaacgggcc cagctggagg
     1141 acgggcgctt tgtgtaccgt ctgctgcgct ctcccatgtg tgagtacctg gttaatttcc
     1201 tgcacaagct ccgtcagctg cctgaacgct acatgatgaa cagtgtcctg gagaacttca
     1261 ccatcctcca ggttgtgaca aacagggaca ctcaggaact gctgctgtgt actgcctacg
     1321 tctttgaagt ctccaccagt gaacgaggag cccagtacca catctaccgc ctggtcaggg
     1381 actgatggag cccccgccgc tggtgttttt cacaacaccc ccttcctggg aagggccctt
     1441 ttgctctctc tgtaagagag atttggagag gggcccatga tttttaaaaa ggcctaatct
     1501 cagaagcatg agccacgggg gctggctcct cttagaaagg aaccggaagc ctggttattg
     1561 agctgagtga gctgggtttg agtttagatc cccaacacga ggacctcaga gacaacattt
     1621 gacaggacac accactcctg agcatcaggg attggggaca ggagtgagct cacaggtaca
     1681 gcacgggcct ccgttctaca gggcccctcc ttgctcttct ggaaagggag ctgggctatg
     1741 tggggtgtct tactgactgc cttgtaacct tcctgcttcc cacgtgtctc atatctgcct
     1801 ctccccccac accctttctc tgggaactgt gacgtcacaa cccgaagata atgttttccc
     1861 agcttggggt agggtgaagt gggacctgaa aaaaaatttt aatataagga gatatttata
     1921 cacag
//
