LOCUS       NM_009346               9842 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus TEA domain family member 1 (Tead1), transcript variant
            2, mRNA.
ACCESSION   NM_009346
VERSION     NM_009346.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9842)
  AUTHORS   Pelenyi,A., Atterton,C., Jones,J., Currey,L., Al-Khalily,M.,
            Wright,L., Kurniawan,N.D., Thor,S. and Piper,M.
  TITLE     Expression of the Hippo pathway effector, TEAD1, within the
            developing murine forebrain
  JOURNAL   Gene Expr Patterns 54, 119384 (2024)
   PUBMED   39557142
REFERENCE   2  (bases 1 to 9842)
  AUTHORS   Ren,Y., Zhou,L., Li,X., Zhu,X., Zhang,Z., Sun,X., Xue,X. and Dai,C.
  TITLE     Taz/Tead1 Promotes Alternative Macrophage Activation and Kidney
            Fibrosis via Transcriptional Upregulation of Smad3
  JOURNAL   J Immunol Res 2024, 9512251 (2024)
   PUBMED   39108258
  REMARK    GeneRIF: Taz/Tead1 Promotes Alternative Macrophage Activation and
            Kidney Fibrosis via Transcriptional Upregulation of Smad3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9842)
  AUTHORS   Sommerauer,C., Gallardo-Dodd,C.J., Savva,C., Hases,L.,
            Birgersson,M., Indukuri,R., Shen,J.X., Carravilla,P., Geng,K.,
            Norskov Sondergaard,J., Ferrer-Aumatell,C., Mercier,G., Sezgin,E.,
            Korach-Andre,M., Petersson,C., Hagstrom,H., Lauschke,V.M.,
            Archer,A., Williams,C. and Kutter,C.
  TITLE     Estrogen receptor activation remodels TEAD1 gene expression to
            alleviate hepatic steatosis
  JOURNAL   Mol Syst Biol 20 (4), 374-402 (2024)
   PUBMED   38459198
  REMARK    GeneRIF: Estrogen receptor activation remodels TEAD1 gene
            expression to alleviate hepatic steatosis.
REFERENCE   4  (bases 1 to 9842)
  AUTHORS   Grove,M., Kim,H., Pang,S., Amaya,J.P., Hu,G., Zhou,J., Lemay,M. and
            Son,Y.J.
  TITLE     TEAD1 is crucial for developmental myelination, Remak bundles, and
            functional regeneration of peripheral nerves
  JOURNAL   Elife 13, e87394 (2024)
   PUBMED   38456457
  REMARK    GeneRIF: TEAD1 is crucial for developmental myelination, Remak
            bundles, and functional regeneration of peripheral nerves.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9842)
  AUTHORS   Jacquemin,P., Hwang,J.J., Martial,J.A., Dolle,P. and Davidson,I.
  TITLE     A novel family of developmentally regulated mammalian transcription
            factors containing the TEA/ATTS DNA binding domain
  JOURNAL   J Biol Chem 271 (36), 21775-21785 (1996)
   PUBMED   8702974
REFERENCE   6  (bases 1 to 9842)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
REFERENCE   7  (bases 1 to 9842)
  AUTHORS   Shimizu,N., Smith,G. and Izumo,S.
  TITLE     Both a ubiquitous factor mTEF-1 and a distinct muscle-specific
            factor bind to the M-CAT motif of the myosin heavy chain beta gene
  JOURNAL   Nucleic Acids Res 21 (17), 4103-4110 (1993)
   PUBMED   8396764
REFERENCE   8  (bases 1 to 9842)
  AUTHORS   Blatt,C. and DePamphilis,M.L.
  TITLE     Striking homology between mouse and human transcription enhancer
            factor-1 (TEF-1)
  JOURNAL   Nucleic Acids Res 21 (3), 747-748 (1993)
   PUBMED   8441689
REFERENCE   9  (bases 1 to 9842)
  AUTHORS   Burglin,T.R.
  TITLE     The TEA domain: a novel, highly conserved DNA-binding motif
  JOURNAL   Cell 66 (1), 11-12 (1991)
   PUBMED   2070413
REFERENCE   10 (bases 1 to 9842)
  AUTHORS   Xiao,J.H., Davidson,I., Matthes,H., Garnier,J.M. and Chambon,P.
  TITLE     Cloning, expression, and transcriptional properties of the human
            enhancer factor TEF-1
  JOURNAL   Cell 65 (4), 551-568 (1991)
   PUBMED   1851669
  REMARK    GeneRIF: Studies in human provide evidence for the exclusive use of
            a non-AUG (AUU) start codon for translation initiation in vivo.
            This AUU codon is highly conserved among vertebrates.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140307.1, AK148375.1 and AC104930.9.
            
            On May 28, 2019 this sequence version replaced NM_009346.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1 and uses a
            non-AUG (AUU) start codon for translation initiation. The resulting
            isoform (2) lacks an internal protein segment compared to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               AK140307.1         38-729
            693-2517            AK148375.1         695-2519
            2518-9842           AC104930.9         94262-101586
FEATURES             Location/Qualifiers
     source          1..9842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.8 cM"
     gene            1..9842
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /note="TEA domain family member 1"
                     /db_xref="GeneID:21676"
                     /db_xref="MGI:MGI:101876"
     exon            1..371
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..627
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1718
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     non-AUG (AUU) translation initiation codon;
                     transcriptional enhancer factor TEF-1; NTEF-1; TCF-13;
                     transcription factor 13"
                     /codon_start=1
                     /transl_except=(pos:426..428,aa:Met)
                     /product="transcriptional enhancer factor TEF-1 isoform 2"
                     /protein_id="NP_033372.2"
                     /db_xref="CCDS:CCDS52366.1"
                     /db_xref="GeneID:21676"
                     /db_xref="MGI:MGI:101876"
                     /translation="MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQ
                     EALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKS
                     RDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGF
                     WPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPTSAPAPSVPAWQGRSIGTT
                     KLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGG
                     LKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFG
                     KQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTIL
                     LVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD"
     exon            628..692
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..755
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..767
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..902
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..949
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1011
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1136
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1310
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1451
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1604
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..9842
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9822..9827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /note="hexamer: AATAAA"
     polyA_site      9842
                     /gene="Tead1"
                     /gene_synonym="2610024B07Rik; B230114H05Rik; Gtrgeo5;
                     mTEF-1; Tcf13; TEAD-1; TEF-1"
                     /note="major polyA site"
ORIGIN      
        1 attccgcaca ttcttcgcat cgctcgcgcc gcgccgcgcc gcccgagccg agccgagcct
       61 ccgcggcccc gccgcccgcc gcgggcgccc cccagcactt cgcacactcg cttccagctc
      121 gcggggagtc cgcgcgccgg ggcccgggcc cggggcggcc gcggcggggc gcaggccatg
      181 cgctgacccc ccagcgcgca gcgtcgccgg agcgcgggca gctgccccgg cgcgccctgc
      241 ccgtcccggg agccggcgag gccgggttgg ggctgcccgg cgcgggagta ccgcagggag
      301 taccggctgg agtaacgcgg gggcggcggc ccagcgcccc gaagtttgcc gcgcccgctc
      361 gggctgccgt ggtttgtttt cttgaaaagg ctccaggctt cggcttggaa aacccaaccg
      421 ccaaaattga gcccagcagc tggagcggca gcgagagccc tgccgaaaac atggaaagga
      481 tgagcgactc ggcagataag ccgattgaca acgacgcgga gggcgtctgg agtcctgata
      541 ttgagcagag tttccaggag gccctggcta tctatccgcc gtgtgggagg agaaaaatca
      601 tcttatcaga cgaaggcaaa atgtatggta gaaatgaatt gatagccaga tacatcaaac
      661 tcaggacggg aaagacaagg accaggaagc aggtgtctag tcacattcag gttcttgcca
      721 gaaggaaatc tcgtgatttt cattccaagc tgaaggtaac aagcatggat cagactgcca
      781 aggacaaggc cctgcagcac atggctgcca tgtcatcagc ccagatcgtc tcggctactg
      841 ccatccacaa caagctgggg ctgcctggga ttccacgccc caccttcccg gggggtccgg
      901 ggttctggcc tgggatgata cagacaggac agccaggatc ctcacaagac gtcaagccct
      961 ttgtgcagca ggcctacccc atccagccag cagtcacagc ccccattcca gggtttgagc
     1021 ctacgtcagc cccagccccc tcagttcctg cctggcaggg ccgatccatt ggcacaacca
     1081 agcttcgcct ggtggaattc tccgctttcc ttgaacagca gagagaccca gactcgtaca
     1141 acaaacacct cttcgtgcac atcgggcatg ccaaccattc ttacagtgac ccgttgctcg
     1201 aatctgtgga cattcgtcag atatatgaca aatttcctga aaagaaaggt ggcttgaagg
     1261 agctgtttgg aaagggccct caaaacgcct tcttcctcgt caaattctgg gcggacttaa
     1321 actgcaatat ccaagacgac gccggggcct tttatggtgt gagcagtcag tatgagagtt
     1381 ctgagaacat gacagttacc tgttccacca aagtgtgctc ctttgggaaa caagtagtag
     1441 aaaaagtaga gacggagtat gcgaggttcg agaatggtcg attcgtgtac cgaataaacc
     1501 gctcgccaat gtgtgaatat atgatcaact tcatccacaa gctcaaacac ctaccagaga
     1561 aatatatgat gaacagtgtt ttggaaaact tcaccatatt attggtggta acaaacaggg
     1621 atacacaaga aactctgctc tgcatggcct gtgtatttga agtctcgaat agcgaacacg
     1681 gagcacagca ccatatctac aggcttgtga aggactgaac ctggttattt atatagagag
     1741 atatctgtat atacacacac atatgtgcac acacacactc tccattatcg aacgactgac
     1801 tgtaaacctc accgcacagg gtgctaccct ggccccccag gtcccaccct gacctttcta
     1861 atcctgttcg agtgaactta tttttttttt ccatgtgttc atgctatcat tgtagctgtg
     1921 aagttgtgat gcagtttttt gtgtattcct cagatctgca acccacaatt ccttggggaa
     1981 ggtgaatctt accagcctaa gctaagcctc tctgcagccc tgtttcctgt tgtggtagaa
     2041 aatactgaga cagaggattg gccacggggc attgactgcc tttatacaaa tgtatttagt
     2101 tctttttgtg tttttccaac ataaaattct tgttttaaga tacaagtaaa attaatcttt
     2161 aaatgtaaat gtaaattagt acaggaaaac taagattctt tagacttatc tttgtaacta
     2221 attaggatgg aagttatgga agaatgtaat tcactaaatt attttttaaa tgaaatcttt
     2281 ctttcttttt aaaaccaaat gttaaactat agccttaaga catgcttggt tgaactatcc
     2341 taatgagaca aatttatacc ttcccccagc ccccaaggtt aaaactaata ccctaattca
     2401 ttaaactctt gaaacaggtg tcacaaagga ggaagacatc acccctcacc cttaacatat
     2461 atagtatatt taaaaatgta aaattgtatt gtactaatgt gataattcat tatttaatga
     2521 aaaagaaaag atggctcttt ttgcaataag taggtaatac tgagacaagt ctaagcttac
     2581 aacgttatag tcttgtgtgt gcagttacat tttatatggt caaccaaatt ttttacagag
     2641 acgagttcac gtttgaacca ctgaaattta atagcaaatt taaaaattgg catgaatact
     2701 gcactgttga gttgcaaagg atgcagagtc ctgtggctgg aagaaacttg tcatcaaccg
     2761 agcaagcaga aggctcatca ggcttggtgt ctctgctccc cagaatgtca ctgtcacaag
     2821 cttcctggcc agcctgtgga tagattgttg ctggtaaccc agcgtgcata ggaagcatct
     2881 gtggctctag ctctgtgttc ttgcgcatgt ggacattcag ctctctgagc tcctgtttct
     2941 tgtcaatttg ctagttgctc attgcctctc tgcattatag acatggatgt attttctcta
     3001 agggcatctt tccataagcc tcagtggcac tttacacata tattcattct ctctctctct
     3061 ctctctctct ctctctctct ctctctctct ctctctctct ctgtctctct ctctctcccc
     3121 ctcatctttt caagcagatt ccctcattct cttaccaaga gaatattcca aagcattgcc
     3181 ctgcagagtt ggtctgatgt ggccagcctc gggttacttc cctaagtgct ttttcactgg
     3241 ggaagcaaga aaggttaacc ctccacttcc cagggaagat aagaggaaag taacagtttc
     3301 attacacaca ctcacatgtg tgagcacata caaatgtgca cacacacaca cacaactgtt
     3361 aggaatatgt aaacataata gaaatggtac aaacttttta ctttaaaaaa gcaaaaagca
     3421 tggcttgttt tttgcactaa ggcaaaattc tttatctaaa atctttatca aaattctaca
     3481 tctgctatat ccaggagaca cacgcacctc tttgccccag catcagctct gactgcttat
     3541 atcatattca gcatctttgg tcctcagtgg gtggatgccg ctggcatgta gttaaaagaa
     3601 gcacattgga ttgactctgt cttctcctag cagcatccct catccctggg aagaccagag
     3661 aagaatgtgc aagatgtttc catttgcaat gtgcctccct tatgtaaagc caatggggca
     3721 ctggttctcc tcaggagaac agcctaggtt ccctgtttct aagccagccc tcaaaggaat
     3781 ggctaccctg agtttctcac ctttatctgt ctgcagacca ggtatttaaa gatgtctcct
     3841 ggatgtgaca ttacttatta atcttttaga caaccctgtt agggagggtt ctttaccttt
     3901 gatctcctat ggccttattc aggaggaaac ccctgtgtct tgagaccagg aagatatgaa
     3961 tgaatgggta caaatgatct cctgtggcta tctgtcatct cagaatggga tgggggaggg
     4021 gtctgtcact caggagtaga gcttctcctc tgtaccacta aggctctggg gatttacctc
     4081 ccaagtacca gctagaggat agtggttggc agtgggctgg caaagatgtc acagagtcag
     4141 ggtggtgtgt cggctgcccc actgtcctct tcttcctaat gcctttctgg gcagtaggag
     4201 ctgggggggg cggtggatga cctgacttac tttttgctct taaaccagct ataaaactct
     4261 ttaatgtata ctaacccccg cccacactct tcccccacct tcttattttt acaccacacc
     4321 catatctcca cccctcccaa cttctcattc ttttttgcct ttaaaaagaa aataacctta
     4381 gtctcagtta cagttatatt gctatgatgt taacaatgcc caaaagcaag ttggggaata
     4441 aagtggactt atatttccac atcctagccc atcactgaag gcagtcaggg caggaacctg
     4501 agactacaag ttgatacaga gaccatgaag gagtgctact tactggcttt ctcctcatgg
     4561 cttgctcagc ctgctttctt atagaatcca ggactatcag cctatggatg gcgccgtgca
     4621 caatgggctt tccctgcccc ctccccatca ctgattaaga aaatgcccta cagccatttc
     4681 ttatggagat gttttctcaa ttgaggttcc cttttctgag atgactatag cttgtgttaa
     4741 gttgacataa aactagccag cacacccacc gtggccaatt tgtgctgccc atatactcat
     4801 aggtgtgggg acatccattg gaacatggtc aagcctgcca ggaaccacac ttttaaactg
     4861 agttctcttc ccctagaccc atccactctc aggagcccct cagccttgca gtgtcaacca
     4921 gccagctctc acggttgccg gagtttatga atacagtggc cctgtcatgt ccagatgacg
     4981 ctgttttgtt ccatacaccc caccccacat cctgttctta cggtctctgc tctgtcttca
     5041 gcgctggtag ctataagatc tgtaaatctt gtagagtttc cctgtcttaa tcagtgaccc
     5101 agttatccca gagttgcttt tatttcccaa gtgaaagcct gggtttgggg cgggaggtca
     5161 tgttctaacc tctcatccca gtctctaatc cctggctcct tcttccctct tctcagcttc
     5221 ctaaagctta ggacaccatt gctgaaccct gccctcaccg ttccctcccc agagctgtct
     5281 cacagtgact gggacagatc tatcctggac atcttgctta gccactacat agtgtaaagg
     5341 ccatctttcc aatgaaagag acataaaaat ccacccaaaa cttcttcaga acatgtcctg
     5401 ggatgcccag agtccagcta cctggaggcc agcaacattc tggaccagtt aattggccgt
     5461 accctgtgct tcgtcagagg attgaggatt cctagccact tccacaattc tcacagctcg
     5521 ttgccctgag ttgtgtaagg ttcagcctta attgaaaatg gctgcccttt ctcttactgg
     5581 tcacattagc atattgatag ccagtttttc tccgatccat gaaatctcgt ctatgacccc
     5641 cccacaccac accccaaccc cccgccccca atccctcagt ttttcaaggt caagaagaag
     5701 gaagtggcag gattcttcag cagcatcctt tcctctgtta gaggcctctc ctgcacagcc
     5761 accatctctt tcctgcagct ctttctctct tgcctgggaa agctggggac cgctggccag
     5821 cagcctccct gtagccatct gactcctctt taaagagcat ttctgatttg acttacagcc
     5881 tactctttcc cagggtttaa aaagatagtc ccctccccca cctggttctt tctcacaagc
     5941 ccccccctcc cccccgcctc ctcctcatcc ttttccagat agggtctgtc tcctcgacac
     6001 tgtttctgct gtccgcctca tgctccatgc tgtctgtcct atctcttcca tctttaggga
     6061 cgaagcagat ctggatctgt tccagaaggt gcctcatact caaacgaaaa gagagcacag
     6121 tctatcccgc ttcatcttga agggatgaga ggtgtctggt ccaggctccc agctatttag
     6181 tcacaggaca agggtgaggg cttctcttcc atctttggcc tcgcctgggt cgaagccatc
     6241 tttccttggt gctctgtgct taagtgaccc ctgagaatgc atggacagag tcagttcgga
     6301 tcccctagag ctgtctgggg aaccacaagt agatgatggc gaggctgaag caagcgcctt
     6361 ttgtttcctc agaggacagt tctccagccg caggctctga gtcaaatttc tatttaccat
     6421 acatcccagc agcaatgtcc tgtccacaca ccagccaaaa gaaaaccctt ggtgttaaaa
     6481 ttcttcagag gacttttaga tccaggtctt ctttcggctt cgataccaca gtggcgttag
     6541 ccatcatttt tatacaacca catgttattg aagtcacctg atggtcagtt ttacaaacca
     6601 ggtacctgta atttgtataa ttttgtatat gctctggcgt cccatggaag ggtagaatac
     6661 ctgtgtgttg gtgtcctcac ctgtgacatt aggatgcttg agttcctggc ctcttctatg
     6721 ttgatgtttc tgtggctaag ccctgcacgt gtcatttctg aaaagcctta aatcttagag
     6781 aagtcacatc gcagggtgtc agtgtgacag gctgcctggg aaccgtgagc ccttttgtaa
     6841 gctggaagca tttctcttac tactgttact tttcatagtt ttcagttcac agctgccaaa
     6901 gcctcccaga aaagccgtgc cttagtacta ccttgtagcc gccagccttt tctcagcctg
     6961 ttctgggtgc ccacttgcta attggccccg tatcagaagc aggacaagcc aaaatccttc
     7021 tcatttgtgt ttcaaaagcc cgtttttaaa tccagctcta taggaagctg atgacttggt
     7081 ttcaaacaac ctgaatcaga acccaagtcg attctttgac catgctctca cgaacgtatc
     7141 cataccaaaa ctaaaggctg cacctccgca gcttgctatg aagagcgaat tgtacttttc
     7201 attgatgcct ttttcaatcc atgaccaaat acttagctat ttgtgaatct tctgcactcc
     7261 agcttgaaag tgcctttggc tcgagattcc agcttagaaa gtgccaccat aataacgaca
     7321 atttgtagag agaccaaaaa tatttcgaga tcaccataat gcctttggtt aaccgggatg
     7381 aataaccaac cgcaggcttg tattcatgag agcaccgagc aacgtgtggt ccctgcctgc
     7441 tgtgagtctg cctgccaatg gggaacccca ccaccactgt cctgtacagc agtgtggcag
     7501 cggggagccc tgcgaactct tgtgtctgtg tatgccgcct ctcccggcat gtccaccaac
     7561 tcatcacccg gctctgcatc cctgggaagg aacttatgcg caagcaccga atcccggcca
     7621 gtgggcagac accatggctc tgccttcccc cactgtgtcc atgtccagac tgtggagact
     7681 catccactgg aacgacagtg tgcacttgcc tgcctacacg tttggttgtt ggaagcctcg
     7741 cattgagatg acagtgcaga acaaaaatta aaaatgggtt cattagggtc attgcagttg
     7801 aagtgtctct gggctgtttt gctggctctg gatgtccgaa tgtgctgtga gggacttgcg
     7861 aagagcacac catttgcaac tcggcatttt caaggacatt ctagccctca gccaactctt
     7921 taaagtgtgt gtcagcttag agtaaaacct tttttttttt aatctggaaa ccccatactg
     7981 taaggagaaa gaacaaagga ggcaaaaaga agccaagaaa aaaaaatagg tgttttgttt
     8041 tgttttgttt ttcttccttt gctgatgtaa gtgtaaaagt aatgacagac aactctgaaa
     8101 gttagcctca aaacactacc acacactctt ctctccgccc ctccctggtg tctaaggaat
     8161 agccgctccg ggctctgaaa ttgcccacgt gatttgtatc caccccaagt tgtgggtatg
     8221 tataaaagtc cagtttttgg ttttttgttt tgttttttca aagaaaaaat aactatcaaa
     8281 tggaaaggat aatttctcag tgcaggttag agttagtggt ttgctcttgt gtattccccc
     8341 ccaacccctg gcagggacac accacaactt gaagaactta gtcaaatgtg tgttctctcg
     8401 tgcctctctc tagtcattgc tgtctcgttt gcagtagttt tctctcctga gctctttgct
     8461 tatatctttt aaaatgaagg tttttgtatt ttaaatttac tgtgttgcaa agggtaggcc
     8521 tcactgaagt cacgcaccat taactaagat gagatatctg tatttattgt tccttcctaa
     8581 gccgtaactt gttttctctg tgaatctgca ttgggtcccg tggcccacac tacatcattt
     8641 tagataaaag cagcctttgt gtgtgtgtct tgcacccaat tcgttcacga ccatggggtc
     8701 aggtcccact agacctgtca tacccagcct tgctcagcct ggcccttgtc ggttcttact
     8761 acggacattt tgtctcttct ctctctgaaa gaggtgggca gaatccacac atccatcatg
     8821 ttagaaaacc tgtctatgag ttttgtgttt ttatttttca aattaattgt tttctgtgat
     8881 tagtttcaat gtgtaaaata gattattaac tgcacttctt taaaaaaaag aacaaaagga
     8941 tgtacatctc ctgttacctc cttgaaagac caacttctct aggccttttt cagtgggctt
     9001 atgacttcag acaagggaaa aaaaacagta aaaacaaaaa tagtacgtgc ctgaaaaatg
     9061 acaaaaaaaa atctttttgt aacatttaaa aaacctgaaa agcctttact tctttgatat
     9121 gctcaaattt tatgtaaatt ggtttttgcc acgtgtgttc cttcggattc taagcgactt
     9181 catggcttct ctgttgtctc gtgtaaagtg tataggatgg gcttgtggcg taagcatttc
     9241 atctggtcag tggctctttt gatactgtac tgctgctggg actgggctgg aacctgagcc
     9301 tctagagggt gactgggttc ctcttggggg agattgtgga gaagagggtg aggtggctca
     9361 tgttttctta aactgtttgc agaaactttc aaaaggcatt tggctaaacc tcccggcagt
     9421 acagtattct cgtactcatt aacgtttgtg tctaggtact ggtacctttc tgtttaaaaa
     9481 aatgttctaa gtgttggctt taaagtgaat ttatctttag tatgatagtt atatgaaaat
     9541 tatagggttt gtgtgcagag aattttttta taaagtgctt tgtaaaaaaa aaaacaaaaa
     9601 aacaaatgta ttctagcttt cgcggtacat atgtgtgata actttaatac ccatgacagt
     9661 taagtgcaat tatttcatca ctctaaaaat gctatttttg tgtcagttcc tgcaggtgtt
     9721 ttcatgtctt tgcaaagtga cacattttga tgccttcttg ataaagtggt agacattttg
     9781 tagctttcta gaaactttgt atccatacgg tatcaatgaa aaataaagaa aatgaaagtg
     9841 tg
//
