LOCUS       NM_001361625            2465 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus testis development related protein (Tdrp), transcript
            variant 1, mRNA.
ACCESSION   NM_001361625 XM_006508900
VERSION     NM_001361625.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2465)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2465)
  AUTHORS   Piras,G., Rattazzi,L., Paschalidis,N., Oggero,S., Berti,G., Ono,M.,
            Bellia,F., D'Addario,C., Dell'Osso,B., Pariante,C.M., Perretti,M.
            and D'Acquisto,F.
  TITLE     Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1
            transgenic autoimmune-prone T cells
  JOURNAL   Brain Behav Immun 87, 689-702 (2020)
   PUBMED   32126289
REFERENCE   3  (bases 1 to 2465)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2465)
  AUTHORS   Mao,S., Wu,F., Cao,X., He,M., Liu,N., Wu,H., Yang,Z., Ding,Q. and
            Wang,X.
  TITLE     TDRP deficiency contributes to low sperm motility and is a
            potential risk factor for male infertility
  JOURNAL   Am J Transl Res 8 (1), 177-187 (2016)
   PUBMED   27069551
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2465)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2465)
  AUTHORS   Wang,X., Jiang,H., Zhou,W., Zhang,Z., Yang,Z., Lu,Y., Lu,B.,
            Wang,X., Ding,Q. and Hu,R.
  TITLE     Molecular cloning of a novel nuclear factor, TDRP1, in
            spermatogenic cells of testis and its relationship with
            spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 394 (1), 29-35 (2010)
   PUBMED   20170638
REFERENCE   7  (bases 1 to 2465)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139186.4.
            
            On Feb 15, 2022 this sequence version replaced NM_001361625.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.39673.1,
                                           SRR7345562.4425354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC139186.4         203019-203044       c
            27-239              AC139186.4         202510-202722       c
            240-337             AC139186.4         183713-183810       c
            338-2465            AC139186.4         180001-182128       c
FEATURES             Location/Qualifiers
     source          1..2465
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 6.44 cM"
     gene            1..2465
                     /gene="Tdrp"
                     /gene_synonym="2610019F03Rik"
                     /note="testis development related protein"
                     /db_xref="GeneID:72148"
                     /db_xref="MGI:MGI:1919398"
     exon            1..26
                     /gene="Tdrp"
                     /gene_synonym="2610019F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            27..239
                     /gene="Tdrp"
                     /gene_synonym="2610019F03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..686
                     /gene="Tdrp"
                     /gene_synonym="2610019F03Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     immuno-moodulin"
                     /codon_start=1
                     /product="testis development-related protein isoform a"
                     /protein_id="NP_001348554.1"
                     /db_xref="GeneID:72148"
                     /db_xref="MGI:MGI:1919398"
                     /translation="MWKLSRSRVLLDEPPEEEDVLRGAPPASAAAPASVRARVGAQGA
                     SLRGWKEATSLFNKDDEEHLLETSRSPKSKGTNQRLREELKAEKKSGFWDALVLKQNA
                     QPKKPDQIEGWEPPKLTAEDVVADHTEDDRSGCPPWSAWEDDTKGSTKYTSLANSASS
                     SRWSLRSAGKLVSIRRQSKGHLTETCEEGE"
     exon            240..337
                     /gene="Tdrp"
                     /gene_synonym="2610019F03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            338..2465
                     /gene="Tdrp"
                     /gene_synonym="2610019F03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2443..2448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdrp"
                     /gene_synonym="2610019F03Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2465
                     /gene="Tdrp"
                     /gene_synonym="2610019F03Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggatggacc acgcccatcg ggctggtcct ccgcactgtc ccagcgccgc ggcgggccgg
       61 gtgtcctcct tcagtcccgg agccaagctg cgcggagcgg tcgagcaccg gagatgtgga
      121 agctgagccg aagtcgagtg cttctggacg agccccccga ggaagaggat gtgctgcgag
      181 gggcaccgcc agcatcagca gccgccccgg cgtcggtgag ggcacgcgta ggggcgcagg
      241 gagcaagtct cagaggttgg aaagaagcaa cttctctgtt taataaagat gatgaagaac
      301 atctcctcga gacttccaga tctcctaagt ccaaaggaac taaccaacga ctaagagaag
      361 agctgaaggc agagaagaaa tcaggatttt gggacgcctt ggttttgaaa cagaatgccc
      421 agcctaaaaa accagatcag atcgaaggtt gggagcctcc caaacttact gctgaagacg
      481 tggtcgccga ccataccgag gatgatagaa gtggctgccc accctggtct gcctgggagg
      541 acgataccaa gggctctacc aagtacacca gcctcgccaa ctcagccagc agctcccgct
      601 ggagcctccg gtcagcggga aagctggtca gcatcaggcg acagagcaaa ggccacctga
      661 cagagacctg tgaagaggga gaatgaaccg aaggcgcatc acattgcttt atggttggca
      721 agcccgccag ccgcctacta gtgcaccatt aattcttgag ccctctcata cccggggaag
      781 gaacccactg agttgctagt gtttcgtgct cagtgaccca cacacaccat ggcttccggg
      841 tgacatctgg ttgccttgct gcggaaacat ccacccactg ggtgcatata tgctgaatgg
      901 atgtgtgcgc tgtagacact gtcctgtgag ccagtctcct ctaagttcat gccagcctca
      961 gtcacttgag attttaggac gtccccatct tgtctctgca tgcaacatga gtgttgtggc
     1021 tatctgaaca tggcctctgt ggcacctctc cccttgtcag aacgcaagaa gcatcttccg
     1081 aaggttacag taattcagtg taacaataga ttcatttttc ctcattcagt tacaaacgaa
     1141 gcaaaatcta gatgctggaa gcaactgaag gtggtttgag gtagggtgtc aggacatctt
     1201 gaggggcgca tctgctgagg aggagtggcc tgcagtgtgg gcctgggtag caagtagttc
     1261 ttttatggaa ttctattttt acttttgaac gtttaaatac agatctttat tttcttcaaa
     1321 taaatgttga ttttaaactt aaagatggaa gaaacactag gaataagttt tagtcaccca
     1381 gtaatcttga ctttgcttgg aaaacattaa cttgcttact gtagcgttaa actgtggata
     1441 aaacactgaa gtgcctcgtt tctattctca gatgcttagt ttttcaaaat gaaaaacttt
     1501 tatgattgat gtgaagtcta taagaagtgt ctctaccccc tagttctgcc tgtctcacac
     1561 tgctgactgt cctcggttgc ggtctcagta gggaatgttc acgtggtgcg catgtttgtc
     1621 ttgttttcca gttacagtgc ttggacaggg gagccgtggt tctctttgtt ttggttaata
     1681 atgaaaagcc tccagtcaca ctgtcctcga gtctccacag tgtaagcagt gtgcttcgtg
     1741 tacctgcgtg tcccacgcaa tgttctgtgg cacagctgag tggcccgggt ttactagatc
     1801 tacctgtcat tcacagctac ctgtctgtct accacccagc ttgccagcca cccgtaccca
     1861 tccacctgtc cacacatcag tctgtccacc cataaaccaa gctattaatc ttctaacaat
     1921 agaacaataa gtttacttag tgagctttga gaggagggtt caaataaaaa attgttaaca
     1981 cctggaagtt gtgaaattat ggagattttg attcataatg caaagcatgt aatttttact
     2041 ataacatgtg agtgtgaaaa tctctatcct caggtaaccg gttgagtgca tgagctctga
     2101 cttcgaaacg aggtaactgt aggatcggaa ggaagagcag gctcatgctg tcgcccacag
     2161 caggacccca ctggtgtgtc tggctaacca cctgtggccc aggaatacaa acccagcctt
     2221 gagaatgtag ggaaggagct cttgaacaca acacagcctc tgtctgtgtc tactgggcct
     2281 gtgctgagtg ctaagtgcct gtagctcact gcacccgtgt gcctgagatg cagtgttgca
     2341 cgttgacaca gggactttta ccctgtctcc tctcaggagg tgaagatgca ctgtaaacca
     2401 gaaagattaa ttacaaatga tttttttctt ctgttgtatc aaattaaaat atcttgtgtt
     2461 cgaga
//
