LOCUS       NM_029056               4809 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus tudor domain containing 9 (Tdrd9), mRNA.
ACCESSION   NM_029056 XM_001475772 XM_988185
VERSION     NM_029056.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4809)
  AUTHORS   Zhang,H., Jiang,J.C., Wu,Y.W., Yu,Y.S., Wang,H.N., Ding,N.Z. and
            Fan,H.Y.
  TITLE     The RNA ligase RNA terminal phosphate cyclase B regulates mRNA
            alternative splicing and is required for mouse oocyte development
            and maintenance
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36178098
REFERENCE   2  (bases 1 to 4809)
  AUTHORS   Yoshimura,T., Watanabe,T., Kuramochi-Miyagawa,S., Takemoto,N.,
            Shiromoto,Y., Kudo,A., Kanai-Azuma,M., Tashiro,F., Miyazaki,S.,
            Katanaya,A., Chuma,S. and Miyazaki,J.I.
  TITLE     Mouse GTSF1 is an essential factor for secondary piRNA biogenesis
  JOURNAL   EMBO Rep 19 (4) (2018)
   PUBMED   29437694
REFERENCE   3  (bases 1 to 4809)
  AUTHORS   Wenda,J.M., Homolka,D., Yang,Z., Spinelli,P., Sachidanandam,R.,
            Pandey,R.R. and Pillai,R.S.
  TITLE     Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI
            Slicing-Triggered Mammalian piRNA Biogenesis and Function
  JOURNAL   Dev Cell 41 (6), 623-637 (2017)
   PUBMED   28633017
  REMARK    GeneRIF: ATPase activity of TDRD9 is dispensable for piRNA
            biogenesis but is essential for transposon silencing and male
            fertility
REFERENCE   4  (bases 1 to 4809)
  AUTHORS   Inoue,H., Ogonuki,N., Hirose,M., Hatanaka,Y., Matoba,S., Chuma,S.,
            Kobayashi,K., Wakana,S., Noguchi,J., Inoue,K., Tanemura,K. and
            Ogura,A.
  TITLE     Mouse D1Pas1, a DEAD-box RNA helicase, is required for the
            completion of first meiotic prophase in male germ cells
  JOURNAL   Biochem Biophys Res Commun 478 (2), 592-598 (2016)
   PUBMED   27473657
REFERENCE   5  (bases 1 to 4809)
  AUTHORS   Kato,Y., Katsuki,T., Kokubo,H., Masuda,A. and Saga,Y.
  TITLE     Dazl is a target RNA suppressed by mammalian NANOS2 in sexually
            differentiating male germ cells
  JOURNAL   Nat Commun 7, 11272 (2016)
   PUBMED   27072294
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4809)
  AUTHORS   Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Takamatsu,K.,
            Chuma,S., Kojima-Kita,K., Shiromoto,Y., Asada,N., Toyoda,A.,
            Fujiyama,A., Totoki,Y., Shibata,T., Kimura,T., Nakatsuji,N.,
            Noce,T., Sasaki,H. and Nakano,T.
  TITLE     MVH in piRNA processing and gene silencing of retrotransposons
  JOURNAL   Genes Dev 24 (9), 887-892 (2010)
   PUBMED   20439430
REFERENCE   7  (bases 1 to 4809)
  AUTHORS   Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
            Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
            Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
            Nakatsuji,N. and Chuma,S.
  TITLE     The TDRD9-MIWI2 complex is essential for piRNA-mediated
            retrotransposon silencing in the mouse male germline
  JOURNAL   Dev Cell 17 (6), 775-787 (2009)
   PUBMED   20059948
  REMARK    GeneRIF: Results identify TDRD9 as a functional partner of MIWI2
            and indicate that the tudor-piwi association is a conserved
            feature, while two separate axes, TDRD9-MIWI2 and TDRD1-MILI,
            cooperate in the piwi-small RNA pathway in the mouse male germline.
REFERENCE   8  (bases 1 to 4809)
  AUTHORS   Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
            Hannon,G.J. and Bortvin,A.
  TITLE     Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
  JOURNAL   PLoS Genet 5 (12), e1000764 (2009)
   PUBMED   20011505
REFERENCE   9  (bases 1 to 4809)
  AUTHORS   Vagin,V.V., Wohlschlegel,J., Qu,J., Jonsson,Z., Huang,X., Chuma,S.,
            Girard,A., Sachidanandam,R., Hannon,G.J. and Aravin,A.A.
  TITLE     Proteomic analysis of murine Piwi proteins reveals a role for
            arginine methylation in specifying interaction with Tudor family
            members
  JOURNAL   Genes Dev 23 (15), 1749-1762 (2009)
   PUBMED   19584108
REFERENCE   10 (bases 1 to 4809)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB362563.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_988185.2, XM_001475772.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB362563.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.14 cM"
     gene            1..4809
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /note="tudor domain containing 9"
                     /db_xref="GeneID:74691"
                     /db_xref="MGI:MGI:1921941"
     exon            1..304
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..4235
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /EC_number="3.6.4.13"
                     /note="putative ATP-dependent RNA helicase TDRD9; tudor
                     domain-containing protein 9"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase TDRD9"
                     /protein_id="NP_083332.1"
                     /db_xref="CCDS:CCDS49184.1"
                     /db_xref="GeneID:74691"
                     /db_xref="MGI:MGI:1921941"
                     /translation="MLRKLTVDQINDWFTIGKTVTNVELLGLPPAFPAEAPREEVQRS
                     EEVPNEDPTAQAQVPVKATAPARPASTSGRSLSQRSSEMEYINKYRQLEEQELDIYGQ
                     DQPPSGPGLRSPLAKLSNVACIPETTYKYPDLPINRCKEEVISLIESNSVVIIHGATG
                     SGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVG
                     LEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLL
                     RTNSRFVKVVLMSATINCKQFADYFAVPVQNKMNPAYVFEVEGKPHAIEEYYLNDLGH
                     IYHSGLPYRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTWSGAQFVSERSSVLVF
                     LPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAE
                     SSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYR
                     LIPRDFWDSAIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERT
                     ILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDEC
                     LIIAAALSLKNFFTMPFRQHLDGYRNKVHFSGSSRSDCLALVEAFRAWQACRQRGELR
                     RPKDELDWGRLNYIQIKRIREVAELYEELKNRISQFNMFVGPHHPVLDQEYPYKQRFI
                     LQVVLAGAFYPNYFTFGQPDEEMAVRELAGKDPKTTVVLKHIPPYGFLYYKQLQSLFR
                     QCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVNLAVKMSQLKVSLELSVHAAEEIEG
                     KVQGGSVSKLRNTRVNVDFQKQTVDPMQVSFNTLDRPRTVADLLLTIDVTEVVEVGHF
                     WGYRIDERNAELLKQLTAEINRLELVPLPIHPHPDLVCLAPFTDYNKESYFRAQILYV
                     SGNSAEVFFVDYGNRSHVDLDLLREIPCQFLELPFQALEFKICKMRPSAKSLICGEHW
                     SGGAHGRFAALVGGCPLLVKVFSIVHSVLHVDVYRYSGAQDAVNVRDVLIREGYAELA
                     EESYESKQSYEVLKGFFAKSVDTMPDGSVSSPLKDDEKHLLRILLESFASNRLGAPNC
                     KAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVVISDSPADLHQRMLVAASLSV
                     NETGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDREGKCYTGVLCGLGWNSATE
                     APILPEHDIELAFDVRLNVEDIVEINILRAAINKLVCDGPNGSKYLGPERIAQLQENA
                     RQKLLGLFCRLKPREKITPQWHEKPYEWNQVDPRLIMEQAEPEGSPGKSTSLYQLHTP
                     VVLSP"
     exon            305..411
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            412..509
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            510..731
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            732..854
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            855..935
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1100
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1201
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1266
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1321
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1406
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1464
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1569
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1667
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1799
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1965
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2029
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2093
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2138
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2192
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2309
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2417
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2518
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2692
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2804
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..3017
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3107
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3368
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3524
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3595
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3705
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3706..3802
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3941
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3942..4060
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4133
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4134..4809
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4377..4382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4395
                     /gene="Tdrd9"
                     /gene_synonym="4930441E05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gttggcctgc tgagcagggc agcgctcata aggctttgcc accattggag tcgggcagtt
       61 gaggcagcgc ttaggcaccg aggatgttgc gcaagctcac ggtcgaccag ataaatgact
      121 ggttcaccat cggcaagacg gtgaccaatg tggagcttct gggcttgcca cccgccttcc
      181 ctgcggaggc gccccgggag gaggtacagc gctcggagga ggtccccaat gaggatccta
      241 cggcccaggc ccaggttcca gttaaggcca cagcaccggc cagaccagct tcaacctccg
      301 ggaggtcact cagtcagagg agctcagaaa tggagtatat taacaaatac agacaacttg
      361 aagaacaaga acttgatatt tatggccagg atcagccacc cagtggacca ggtctgaggt
      421 caccattggc taagttaagt aatgtggcat gcatcccaga gacaacttat aaatatcctg
      481 atttgcctat aaatcggtgt aaagaagagg tcatttcctt gatagaaagc aattctgtgg
      541 tgatcataca cggtgccaca ggaagcggca agagcacaca gctcccacag tacgtgctag
      601 accactacac ccagcgctct gccttctgca acatcgtagt cacccagccg cggaagatag
      661 gggccagcag cattgccagg tggatcagta aggagcgttc ctggacgctg ggtggcttgg
      721 taggctatca ggtagggctg gagaaaatcg caacagaaga cactaggtta atttacatga
      781 ccactggagt cctgcttcag aaaattgtaa gtgccaagag cctgatggag ttcacgcaca
      841 tcttcattga cgaggtgcat gaacggaccg aggagatgga tttcctgctc ttggtcgtcc
      901 gtaaactctt gaggacaaat tcacggtttg tgaaggtggt cctcatgtct gccaccatca
      961 actgcaagca gtttgcagac tactttgctg ttcccgttca gaacaagatg aacccggcat
     1021 atgtttttga agtggaaggc aagccccacg ctattgaaga gtattacctt aatgacttgg
     1081 ggcacattta tcatagtggg cttccctacc gtctggagga gccagtgata acaaaggatg
     1141 tctatgaagt tgctgtctct ctcattcaga tgttcgatga cctggacatg aaagagagcg
     1201 ggaacaagac ctggtccggg gcgcagtttg tgtcggagcg gagcagcgtg ctggtgttcc
     1261 tgccaggtct gggtgagatc aattacatgc atgagctcct cacaaacatg attcacaaaa
     1321 ggttacaggt ctatccactc cattccagtg tgactttaga agaacagaat aacgtatttt
     1381 taagtccagt ccctgggtac agaaagatta ttctgtcaac caacatcgca gagagttctg
     1441 tcacagttcc tgatgtcaaa tatgttatag atttctgtct gaccagaact ctggtttgtg
     1501 atgaagatac aaattatcag agtctgcgac taagctgggc ttccaagacc agctgtgacc
     1561 agagaaaagg ccgtgctgga cgagtgtcta aaggatactg ctacagactg atccccaggg
     1621 acttctggga cagtgctatc cctgaccacg ttgttcctga gatgctgcgc tgtccgctgg
     1681 gaagcacaat attgaaggtg aagttgcttg acatgggtga accgagagct ctgctggcca
     1741 ccgccctgtc tccgcccagc ctgagtgaca ttgagcgcac cattcttctg ttaaaggagg
     1801 ttggtgcact ggcggtcagt gggcagaggg aggacgagaa cccccacgat ggcgagttga
     1861 ccttcctggg acgagtgctg gcacagctcc ctgtcagcca gcagctgggt aaactcgttg
     1921 tgctgggaca tgtgtttggg tgcctggatg agtgtctcat catagcggca gctctttctc
     1981 tgaagaattt tttcacgatg ccttttcggc agcatctgga tggatatagg aacaaagtgc
     2041 acttctcagg tagcagcagg agtgactgcc tggcacttgt ggaggcgttc agggcctggc
     2101 aggcttgcag acagcgagga gagctgcggc gtcccaagga tgagcttgac tggggacggc
     2161 taaattacat tcaaataaag agaatcagag aggtggctga attatatgaa gaattgaaga
     2221 atagaatctc acagttcaac atgtttgtgg gtcctcacca tcccgtcttg gatcaagaat
     2281 atccttataa gcagcgcttc atcctgcagg ttgtgctggc aggcgctttt tatccaaact
     2341 acttcacttt tgggcagcca gatgaggaga tggcagtgag ggaactggct ggcaaagacc
     2401 ccaagacaac agtcgtgctg aaacacatcc ctccctatgg atttctttac tacaagcaac
     2461 tgcagtctct ctttagacag tgtggtcaag tcaagtccat tgtatttgat ggtgcaaaag
     2521 catttgtgga gttttcacgg aatccaacag aaagatttaa gaccctccct gctgtgaact
     2581 tggcagtcaa gatgtcccag ttgaaagtgt ccctagagct cagtgtccat gctgcagagg
     2641 agatcgaggg gaaggtgcaa ggcggctcgg tgtcaaagct caggaacaca agggtgaacg
     2701 tggacttcca gaagcagacg gtggatccca tgcaggtgtc gttcaacacc ttggacagac
     2761 cccgcaccgt tgcagacctc ctcctgacaa tcgatgtcac tgaggtggta gaagtggggc
     2821 acttctgggg gtacaggatc gacgaaagga atgcagagct gctgaaacaa ctgactgctg
     2881 agataaaccg cctagagctg gtccctctgc ctatccaccc acatccagac ttggtctgtc
     2941 tggcaccttt tactgattac aacaaggaaa gctactttag agctcaaatt ctttatgttt
     3001 ctggaaattc cgctgaggta ttctttgtag actatgggaa taggtctcat gtagacctag
     3061 atctcttgag ggagatcccc tgtcagtttt tggagcttcc atttcaggct ttggaattca
     3121 agatttgcaa aatgcgacca tcagcaaagt ctctcatctg tggcgagcac tggagtgggg
     3181 gtgcccatgg gcgctttgct gccttggtcg gcggctgtcc tctcctggtg aaggtgttct
     3241 ccattgtaca cagtgttctg catgtggacg tgtaccgcta ctcgggtgcc caggatgctg
     3301 tcaacgtcag agatgttctc atcagggagg gctatgctga gctcgcagag gagtcctatg
     3361 agtcaaaaca aagctatgaa gtcctcaagg gtttctttgc taagtcagtg gacaccatgc
     3421 cggacggctc tgtctcctct cctctgaagg acgatgagaa gcatctccta cggattctgt
     3481 tggagagctt tgcctccaac cggctaggcg ctccgaactg caaggctgtt ctccatgggc
     3541 cctttaaccc ttatgagctg aagtgtcata gtctgaccag aatatccaag ttcagatgtg
     3601 tgtggattga gaaggagagc atcaattctg tcgtcatcag tgacagccct gccgacctgc
     3661 accagaggat gctggttgca gcttcactct cagttaacga gaccggctcc accatgctcc
     3721 tgagagagac ctccctgatg ccgcacatcc caggcctccc agcgctcctc agcatgctgt
     3781 tcgcaccagt gatggagctg agagttgacc gtgagggaaa atgttacact ggggtccttt
     3841 gtggtttggg atggaattca gctacagagg cccctatcct gccagagcat gacatcgagc
     3901 tggcctttga tgtgcgctta aacgtggagg acatcgttga gattaatatt ctcagggctg
     3961 ctatcaacaa gctagtgtgt gatgggccaa atggatccaa gtatcttggg cctgaaagaa
     4021 tcgctcagtt gcaggagaat gcacgccaga aacttctagg cttgttctgt cggttgaaac
     4081 ctcgagagaa gattactcct cagtggcacg agaaacccta cgagtggaac caggtggatc
     4141 caaggctgat catggagcaa gctgagccag agggcagccc aggaaagagc acgtcactgt
     4201 accagctgca cacgcctgtg gtgctcagcc cctaacgggc tcgtccccag cagaggtcac
     4261 agcgttccag cggttgcttc accatcttgt tgcctttgct cagtgtgggg agtggcattt
     4321 ctgtttgggt gggaaaaatc agaaagtcta ggcttttcaa gaaatggggt cacagtatta
     4381 aatacttggc aaaaagttgt tctgaaagaa gattttgttt tgggaaaagc ttctttaaat
     4441 gtatgagggt aaatctaaat agtcgaggag acaagatcca gagcgtgttt gtatgctatc
     4501 ctgtcacagt ggtagctgtg gtgcgagaga gagccagact gctggcttac cacaggacac
     4561 aggcggaccc tgatccccaa cgtgtatgtc tgcaagcata tgtgtgtgtg tgcttaaaaa
     4621 ccctgtggca ttttctgaag atcttttcct cattgaaaag atgtggtttt ggtaaacctt
     4681 cagttttgtg tatttaggac ttgtggttag atttaagcct cttggtctgt gttttggaaa
     4741 tcaggagatg tgacctggca cccggcatat ctggggaaac aataaaggca ttgggcttgg
     4801 tttctgttc
//
