LOCUS       NM_146142               3656 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus tudor domain containing 7 (Tdrd7), transcript variant
            2, mRNA.
ACCESSION   NM_146142
VERSION     NM_146142.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3656)
  AUTHORS   Chakravarty,S., Subramanian,G., Popli,S., Veleeparambil,M., Fan,S.,
            Chakravarti,R. and Chattopadhyay,S.
  TITLE     Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits
            its activation to suppress viral replication and pathogenesis
  JOURNAL   mBio 14 (5), e0061123 (2023)
   PUBMED   37712680
  REMARK    GeneRIF: Interferon-stimulated gene TDRD7 interacts with AMPK and
            inhibits its activation to suppress viral replication and
            pathogenesis.
REFERENCE   2  (bases 1 to 3656)
  AUTHORS   Anand,D., Al Saai,S., Shrestha,S.K., Barnum,C.E., Chuma,S. and
            Lachke,S.A.
  TITLE     Genome-Wide Analysis of Differentially Expressed miRNAs and Their
            Associated Regulatory Networks in Lenses Deficient for the
            Congenital Cataract-Linked Tudor Domain Containing Protein TDRD7
  JOURNAL   Front Cell Dev Biol 9, 615761 (2021)
   PUBMED   33665188
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3656)
  AUTHORS   Barnum,C.E., Al Saai,S., Patel,S.D., Cheng,C., Anand,D., Xu,X.,
            Dash,S., Siddam,A.D., Glazewski,L., Paglione,E., Polson,S.W.,
            Chuma,S., Mason,R.W., Wei,S., Batish,M., Fowler,V.M. and
            Lachke,S.A.
  TITLE     The Tudor-domain protein TDRD7, mutated in congenital cataract,
            controls the heat shock protein HSPB1 (HSP27) and lens fiber cell
            morphology
  JOURNAL   Hum Mol Genet 29 (12), 2076-2097 (2020)
   PUBMED   32420594
  REMARK    GeneRIF: The Tudor-domain protein TDRD7, mutated in congenital
            cataract, controls the heat shock protein HSPB1 (HSP27) and lens
            fiber cell morphology.
REFERENCE   4  (bases 1 to 3656)
  AUTHORS   Subramanian,G., Popli,S., Chakravarty,S., Taylor,R.T.,
            Chakravarti,R. and Chattopadhyay,S.
  TITLE     The interferon-inducible protein TDRD7 inhibits AMP-activated
            protein kinase and thereby restricts autophagy-independent virus
            replication
  JOURNAL   J Biol Chem 295 (20), 6811-6822 (2020)
   PUBMED   32273341
  REMARK    GeneRIF: The interferon-inducible protein TDRD7 inhibits
            AMP-activated protein kinase and thereby restricts
            autophagy-independent virus replication.
REFERENCE   5  (bases 1 to 3656)
  AUTHORS   Tanaka,T., Hosokawa,M., Vagin,V.V., Reuter,M., Hayashi,E.,
            Mochizuki,A.L., Kitamura,K., Yamanaka,H., Kondoh,G., Okawa,K.,
            Kuramochi-Miyagawa,S., Nakano,T., Sachidanandam,R., Hannon,G.J.,
            Pillai,R.S., Nakatsuji,N. and Chuma,S.
  TITLE     Tudor domain containing 7 (Tdrd7) is essential for dynamic
            ribonucleoprotein (RNP) remodeling of chromatoid bodies during
            spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10579-10584 (2011)
   PUBMED   21670278
  REMARK    GeneRIF: results identify TRPC3 as a pivotal signaling gateway in
            Ca(2+)-dependent control of cardiac gene expression
REFERENCE   6  (bases 1 to 3656)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3656)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3656)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 3656)
  AUTHORS   Yamochi,T., Nishimoto,I., Okuda,T. and Matsuoka,M.
  TITLE     ik3-1/Cables is associated with Trap and Pctaire2
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1045-1050 (2001)
   PUBMED   11527406
REFERENCE   10 (bases 1 to 3656)
  AUTHORS   Hrabe de Angelis,M.H., Flaswinkel,H., Fuchs,H., Rathkolb,B.,
            Soewarto,D., Marschall,S., Heffner,S., Pargent,W., Wuensch,K.,
            Jung,M., Reis,A., Richter,T., Alessandrini,F., Jakob,T., Fuchs,E.,
            Kolb,H., Kremmer,E., Schaeble,K., Rollinski,B., Roscher,A.,
            Peters,C., Meitinger,T., Strom,T., Steckler,T., Holsboer,F.,
            Klopstock,T., Gekeler,F., Schindewolf,C., Jung,T., Avraham,K.,
            Behrendt,H., Ring,J., Zimmer,A., Schughart,K., Pfeffer,K., Wolf,E.
            and Balling,R.
  TITLE     Genome-wide, large-scale production of mutant mice by ENU
            mutagenesis
  JOURNAL   Nat Genet 25 (4), 444-447 (2000)
   PUBMED   10932192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY783424.1, BC029689.1 and BY427120.1.
            
            On Mar 13, 2014 this sequence version replaced NM_146142.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 1. It encodes isoform
            2, which has a shorter N-terminus, compared to isoform 1. Variants
            2 and 3 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150077.1, BC029689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BY783424.1         66-191
            127-3652            BC029689.1         1-3526
            3653-3656           BY427120.1         372-375
FEATURES             Location/Qualifiers
     source          1..3656
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.48 cM"
     gene            1..3656
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /note="tudor domain containing 7"
                     /db_xref="GeneID:100121"
                     /db_xref="MGI:MGI:2140279"
     exon            1..140
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            141..353
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..3407
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /note="isoform 2 is encoded by transcript variant 2; tudor
                     domain-containing protein 7; trap; PCTAIRE2-binding
                     protein; tudor repeat associator with PCTAIRE 2"
                     /codon_start=1
                     /product="tudor domain-containing protein 7 isoform 2"
                     /protein_id="NP_666254.1"
                     /db_xref="CCDS:CCDS18142.1"
                     /db_xref="GeneID:100121"
                     /db_xref="MGI:MGI:2140279"
                     /translation="MLEADLVSKMLRAVLQSHKNGIVLPRLQGEYRSLTGDWIPFKQL
                     GYPTLEAYLRSVPAVVRIEASRSGEIVCYAVACTETARIAQLVARQRTSKRKIGRQIN
                     CQMRVKKAMPFFLEGKPKATLRQPGFASDYSISRKPNSALLRDRGSALGVKADVDMPP
                     YPDTPVQRHASMSANSRFSPKSSLPASFQTHISRACPTEVNDNLNQTVEKPNITPPAS
                     YTNKMDEVQNRIKEILDKHNNGIWISKLPHFYKEFYKEDLNQGVLQQFEHWPHICTVE
                     KPCGGGQDSLLYPARREQPLKSDQDPEKELPPPPPAPKQEVPSQGSPAVMPDVKEKVA
                     ELLGKYSSGLWASALPKAFEDMYKVKFPEDALKNLASLSDVCTINYISGNTQKAILYA
                     KLPLPTDKILKDEGQAQGDFDIKSMIEQEYLQIEKNMAESADEFLEDITVPPLVIPTE
                     ASPSVLVVELSNTNDVVIRYVGKDYSAAQELMEDEMKEFYSKNPRVTPIQTVHVGQLL
                     AVNAEEDAWLRAQIISTDENKIKVCYVDYGFCENIEKSKAYRLNPRFCSLSFQATKCK
                     LAGLEVLNDDPDLVKAVESLTCGKIFAVEILDKSDVPLVVLYDTSGEDDININATCLK
                     AICDRSLQVHLQVDAMYTNVKVTNICSDGTLYCQVPCKGLNKLNDLLHKTEDYFHCKH
                     MTSEYFISLPFCGKICLFHCKGKWLRVEITNVHSSRALDVQFLDSGNSTSVKVSELRE
                     IPPRFLQEMLAIPPQAIKCCLADLPQSIGMWTPDAVLWLRDSVLNCSDCSIKVTKMDE
                     TKGVAYVYLFTPNNFPDPHRSINRQITNADLWKHQKDVFLSAVSTAASSPGNRNGGTP
                     APGSPAESLRKSHPEVIKKSVLDHTSSFSLEELPPPVHLSRSGEHMDVYVPVACHPGH
                     FVIQPWQEIHKLEVLMEEMILYYSVSEERHIAVERDQVYAAKVENKWYRVLLKGILTN
                     GLVSVYELDYGKHELVNIRKVQPLVDVFRKLPFQAVTAQLAGVKCSQWSEEASMVFRN
                     HVEKKALVALVQTVVEHTNPWDRKVVLYLVDTSLPDTDTWIHDFMSQYLLELSKVN"
     exon            354..495
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            496..676
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            677..750
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            751..968
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1552
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1739
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1851
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2054
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2189
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2276
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2411
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2522
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..3025
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3186
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3656
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3629..3634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /note="hexamer: AATAAA"
     polyA_site      3652
                     /gene="Tdrd7"
                     /gene_synonym="5730495N10Rik; PCTAIRE2BP"
                     /note="major polyA site"
ORIGIN      
        1 gggcggggct ttaggtgatt cccaagccac ggctcaggcc gtgcggggaa accgaaagtg
       61 ggcggcggcc gccctggcgg agggagcgga gggagccggg cccagaggcg cgggcttggg
      121 ccgcgggtcc ccgggacgag gcaaagatgc tggaggcaga tctggtttca aagatgctaa
      181 gggctgtcct gcagtctcat aagaacggga tcgtattacc ccgtctccaa ggagagtacc
      241 gatctttgac tggagactgg atccccttca agcagctggg ctaccctact ttggaagcct
      301 acctgagaag cgtgccagca gttgtcagga tagaggctag tagatctgga gagatcgtct
      361 gctatgcagt agcctgcaca gaaactgcaa ggatcgctca gcttgtggct cgtcagagga
      421 cctctaaaag gaaaataggg cgacaaatta attgtcagat gagagtgaag aaagccatgc
      481 cgttctttct agaaggaaag ccaaaggcaa ctctcagaca accaggattt gcctcagatt
      541 attccatcag caggaaacct aattcagcgc tgttaagaga cagaggaagc gccttgggag
      601 ttaaggctga cgtggacatg ccgccgtacc cagacactcc agtgcagagg cacgcgagca
      661 tgtctgccaa tagcaggttc agtccaaagt catccttgcc agcgtctttc cagacacaca
      721 tctcaagggc ctgccctacg gaagtcaatg ataatttaaa tcagactgtt gagaaaccaa
      781 atatcacgcc tcctgcctct tacactaata agatggatga ggttcaaaac cgcataaagg
      841 aaatattaga caagcataac aatggcattt ggatatctaa gcttccacat ttttacaaag
      901 agttttataa agaagacctt aaccaaggag ttttacagca gtttgaacac tggcctcaca
      961 tttgcacggt ggaaaaacct tgtggtggtg gtcaagattc acttctttat cctgccagga
     1021 gagagcagcc cctgaaaagt gaccaggacc ctgagaagga gctcccacct ccacctcctg
     1081 ctcccaagca ggaggttcca tcccaaggga gcccagcagt gatgccagat gtcaaggaga
     1141 aagtggcaga actgctgggc aagtactcaa gtggcctttg ggcaagtgcg ctccccaaag
     1201 catttgagga catgtacaaa gtcaagttcc ctgaggatgc cttaaaaaat ctcgcctcgc
     1261 tctctgatgt gtgcaccata aactacattt ctggaaacac ccagaaggca attctctatg
     1321 cgaaactccc attgcccact gacaagatct taaaggatga agggcaggca caaggagatt
     1381 ttgacatcaa gtcgatgatt gaacaagagt atttgcagat agaaaaaaac atggctgaaa
     1441 gtgctgatga gtttctggag gacataactg tgccgcctct ggtaattcct accgaggcct
     1501 caccgtctgt gttggtggtt gagctgagca acacaaatga tgtggttatc aggtatgtag
     1561 gcaaagacta ctcagctgct caggaactga tggaggatga gatgaaggag ttttacagta
     1621 agaaccccag agtcacaccg atccagactg tgcacgtggg gcagctgctg gcagtcaatg
     1681 cagaggagga tgcctggttg cgagcacaga tcatttccac ggatgagaac aagataaagg
     1741 tgtgctatgt tgactatggc ttttgtgaaa acattgagaa gagtaaagcg tacagactga
     1801 acccacggtt ctgctcgctt tcctttcaag ccaccaagtg caagctggca gggttggagg
     1861 ttctgaatga tgaccctgac cttgtgaagg cggtggaatc actaacatgt gggaagatct
     1921 ttgctgtgga gatcctggac aagtcagatg tcccgctggt ggtgctgtac gacacgtcag
     1981 gagaggacga tatcaacatc aatgccacct gcctcaaggc aatatgtgac agatctctac
     2041 aagttcatct ccaggtggat gccatgtaca caaatgtcaa agtgaccaac atttgctctg
     2101 atggaacact ctactgccag gtgccctgca agggtctgaa taaactcaat gaccttctgc
     2161 ataagacaga ggactacttc cactgcaagc acatgacctc tgagtacttc atctcgctac
     2221 ccttctgtgg gaagatctgc ctcttccatt gcaaagggaa atggttacga gtggagatca
     2281 ctaatgttca tagcagccgt gcactcgacg ttcagttcct ggactctggc aattcgacat
     2341 ccgtgaaagt gtcagaactc agagaaatcc caccgcggtt cctgcaggaa atgcttgcca
     2401 taccccctca ggctataaag tgctgcttgg ctgatcttcc acagtccatt ggcatgtgga
     2461 caccagatgc tgttctgtgg ttaagagatt ctgttttgaa ttgctcggac tgtagtatta
     2521 aggttacaaa aatggatgag accaaggggg ttgcctatgt gtacttattc actcccaata
     2581 acttcccgga tccccatcgc agtattaacc ggcagatcac aaacgcagac ctgtggaaac
     2641 atcagaagga tgtgtttctg agcgcggtgt ctactgcggc cagttcccct ggcaacagga
     2701 atggtggcac acctgctccg ggcagccctg cagagagtct cagaaagagc cacccagagg
     2761 ttatcaagaa gtctgtcctg gaccatacca gctctttctc cttggaggaa ctgccccctc
     2821 ctgtccacct gtcaaggtca ggggaacaca tggatgtgta tgtgcctgtg gcctgtcacc
     2881 caggccattt tgtcatccag ccctggcagg agatccataa gctagaagtg ctgatggaag
     2941 agatgatcct gtactacagc gtgtccgagg agcgccacat agcggtggag cgagaccaag
     3001 tgtacgcagc caaagtggag aataagtggt acagggtact tttaaaagga atcctgacca
     3061 atgggctggt gtctgtgtac gagctggact acggcaagca tgagctcgtc aacataagga
     3121 aagtgcagcc cctagtggac gtgttccgaa agctgccctt ccaggcggtc accgctcaac
     3181 tggcaggcgt gaagtgcagc cagtggtcgg aggaggcttc gatggtgttt cgaaatcacg
     3241 tggagaagaa agccctggtg gcgttggtgc agacagttgt tgagcacact aatccttggg
     3301 accggaaagt ggtgctctat ctcgtagaca cgtcgctgcc cgacactgac acctggattc
     3361 atgactttat gtcacagtat ctgctagagc tttcgaaagt taattaatca ctgcttgaga
     3421 tgttgaccgc taatgagatt gttctcaaag caataataca aaatgtgtag gagggtctta
     3481 aaacatctta tttttactac atggctctga ctgttgtgga ggattgaaaa gaatatgctt
     3541 tgtttgatga aagatattta acaagttttg tttaatgcag ttgacttttc aaagaaaaat
     3601 tgcacttgaa ttattaatat aatattagaa taaaatgttt agcaatataa aacctg
//
