LOCUS       NM_001161366            7062 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tudor domain containing 6 (Tdrd6), transcript variant
            1, mRNA.
ACCESSION   NM_001161366
VERSION     NM_001161366.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7062)
  AUTHORS   Guo,R., Wu,H., Zhu,X., Wang,G., Hu,K., Li,K., Geng,H., Xu,C.,
            Zu,C., Gao,Y., Tang,D., Cao,Y. and He,X.
  TITLE     Bi-allelic variants in chromatoid body protein TDRD6 cause
            spermiogenesis defects and severe oligoasthenoteratozoospermia in
            humans
  JOURNAL   J Med Genet 61 (6), 553-565 (2024)
   PUBMED   38341271
  REMARK    GeneRIF: Bi-allelic variants in chromatoid body protein TDRD6 cause
            spermiogenesis defects and severe oligoasthenoteratozoospermia in
            humans.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7062)
  AUTHORS   Wei,H., Gao,J., Lin,D.H., Geng,R., Liao,J., Huang,T.Y., Shang,G.,
            Jing,J., Fan,Z.W., Pan,D., Yin,Z.Q., Li,T., Liu,X., Zhao,S.,
            Chen,C., Li,J., Wang,X., Ding,D. and Liu,M.F.
  TITLE     piRNA loading triggers MIWI translocation from the
            intermitochondrial cement to chromatoid body during mouse
            spermatogenesis
  JOURNAL   Nat Commun 15 (1), 2343 (2024)
   PUBMED   38491008
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7062)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7062)
  AUTHORS   MacDonald,C.C. and Grozdanov,P.N.
  TITLE     Nonsense in the testis: multiple roles for nonsense-mediated decay
            revealed in male reproduction
  JOURNAL   Biol Reprod 96 (5), 939-947 (2017)
   PUBMED   28444146
  REMARK    Review article
REFERENCE   5  (bases 1 to 7062)
  AUTHORS   Akpinar,M., Lesche,M., Fanourgakis,G., Fu,J., Anastassiadis,K.,
            Dahl,A. and Jessberger,R.
  TITLE     TDRD6 mediates early steps of spliceosome maturation in primary
            spermatocytes
  JOURNAL   PLoS Genet 13 (3), e1006660 (2017)
   PUBMED   28263986
  REMARK    GeneRIF: TDRD6 has a role in spliceosome maturation and mRNA
            splicing in prophase I spermatocytes
            Erratum:[PLoS Genet. 2017 Sep 1;13(9):e1006989. doi:
            10.1371/journal.pgen.1006989.. PMID: 28863135]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7062)
  AUTHORS   Vagin,V.V., Wohlschlegel,J., Qu,J., Jonsson,Z., Huang,X., Chuma,S.,
            Girard,A., Sachidanandam,R., Hannon,G.J. and Aravin,A.A.
  TITLE     Proteomic analysis of murine Piwi proteins reveals a role for
            arginine methylation in specifying interaction with Tudor family
            members
  JOURNAL   Genes Dev 23 (15), 1749-1762 (2009)
   PUBMED   19584108
REFERENCE   7  (bases 1 to 7062)
  AUTHORS   Vasileva,A., Tiedau,D., Firooznia,A., Muller-Reichert,T. and
            Jessberger,R.
  TITLE     Tdrd6 is required for spermiogenesis, chromatoid body architecture,
            and regulation of miRNA expression
  JOURNAL   Curr Biol 19 (8), 630-639 (2009)
   PUBMED   19345099
  REMARK    GeneRIF: Results suggest that Tdrd6 is essential for
            spermiogenesis, for chromatoid body structure, and for proper
            mature and precursor miRNA expression.
REFERENCE   8  (bases 1 to 7062)
  AUTHORS   Choi,E., Lee,J., Oh,J., Park,I., Han,C., Yi,C., Kim,D.H., Cho,B.N.,
            Eddy,E.M. and Cho,C.
  TITLE     Integrative characterization of germ cell-specific genes from mouse
            spermatocyte UniGene library
  JOURNAL   BMC Genomics 8, 256 (2007)
   PUBMED   17662146
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7062)
  AUTHORS   Hosokawa,M., Shoji,M., Kitamura,K., Tanaka,T., Noce,T., Chuma,S.
            and Nakatsuji,N.
  TITLE     Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain
            composition, intracellular localization, and function in male germ
            cells in mice
  JOURNAL   Dev Biol 301 (1), 38-52 (2007)
   PUBMED   17141210
  REMARK    GeneRIF: Tudor-related proteins, which contain multiple repeats of
            the Tudor domain, constitute an evolutionarily conserved class of
            nuage components in the germ-line, and their localization or
            accumulation to nuage is likely conferred by a Tudor domain
            structure
REFERENCE   10 (bases 1 to 7062)
  AUTHORS   Pan,J., Goodheart,M., Chuma,S., Nakatsuji,N., Page,D.C. and
            Wang,P.J.
  TITLE     RNF17, a component of the mammalian germ cell nuage, is essential
            for spermiogenesis
  JOURNAL   Development 132 (18), 4029-4039 (2005)
   PUBMED   16093322
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154647.2, CT010585.12, BC145247.1 and BU605232.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145247.1, SRR5189685.210088.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-931               AC154647.2         103556-104486       c
            932-6193            CT010585.12        236382-241643       c
            6194-6596           BC145247.1         6160-6562
            6597-7062           BU605232.1         22-487
FEATURES             Location/Qualifiers
     source          1..7062
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.75 cM"
     gene            1..7062
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /note="tudor domain containing 6"
                     /db_xref="GeneID:210510"
                     /db_xref="MGI:MGI:2679727"
     exon            1..6193
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..6552
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /note="isoform 1 is encoded by transcript variant 1; tudor
                     domain-containing protein 6; tudor repeat 2 protein"
                     /codon_start=1
                     /product="tudor domain-containing protein 6 isoform 1"
                     /protein_id="NP_001154838.1"
                     /db_xref="CCDS:CCDS50115.1"
                     /db_xref="GeneID:210510"
                     /db_xref="MGI:MGI:2679727"
                     /translation="MSSTPGLPTPGASLALRVSFVDVHPEVIPVQLWGLVGQRREEYV
                     RLSREIQEAAATRGPWALGGASASPGELCLVQVGLMWHRCRVVSRQAQDSRVFLLDEG
                     RTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGTGGGEPQQWSPRAVDFLSN
                     LQGKEVHGRVLDVLLLHRLVLLEVPVVSQQMEELGLARQVPDSLFCSLLKRYLTAAGQ
                     GSSGAPVLPRAAPKQEHPGLDYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIH
                     RLSESMAQVYRAPVGTDDEDSGSATWEEREESPDKPGSPCASCGLDGQWYRALLLETF
                     RPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDCGRGWSRSQV
                     GDLKALILGQAVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGVQSCCLADWFLQSQG
                     IEEEEEEDEDEVEAAFQSQSPAEEMEAEVSLPSLRSIRLKMNTFYDAQVEFVKSPSEF
                     WIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRL
                     DSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEATS
                     FFKKTVLHKELVVHVLDKQDHQYVIEILDESRMGEENISKVIAQAGFAKFQEFETKEN
                     IRLSAHSPGHVSGHFMAEPSKITSAKKAEGDQRAKKDNKTLSVSEALADTVSLSNLST
                     AQDTEKVTSDPSLLMLNFLKTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNA
                     QGFRTLMCDIEDYCKSSEPSPYEGDTRVCLAKRTASGRWSRALISGAHSLEHVRVVFV
                     DYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMGENPFVWDEKAVQAFSGFI
                     DSARQNNLELKCTVFALASRHEEEWFNVVDLLTPFQSACRFLVEKRLARPVKHQKPLE
                     PSVQLHSYYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKA
                     LLNLKASTLAPGTLCLARYTDGNWYRGIIIEKEPSKVFFVDFGNTYIAVDHLLPIPRD
                     AHDVLLLPMQALKCSLSDIPHHIPEEVTAWFQETVLDKSLKALVVAKDPDGRLIIELY
                     DDSVQINASINEKLGLLGYKNRTRRKEKENEIILYETKALEDKKESVKPSLADYLSKP
                     GESKAHSVEIMGESCKPKMGPACKELRYLQGSAKANLVPPYQDSVGNKNDGGFPLTRE
                     KKEDIFASSPMSGTKLDSALPERRMGEPSGRDLPPKFCEFPQKTIAPGFKTSVYVSHI
                     NDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRA
                     LVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVPVCKE
                     MVSYFSQRTDEAQIRCEFVKFQGTWEVILADEHGVIAEDMISRFPCNGNSQAGLTTQT
                     MKGDCLKIANKPNADTSVLLNWYNPKAKLIKAYATVIDGPEYFWCQFADSEKLQYLET
                     EVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGN
                     AEDCVDAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYFYDIVTEDVLDI
                     TILEIKRDVCNIPLAIVELRSKGENINEKMKKYAKTGVPKNDLSSEKRGPERKGSLAS
                     PDLGLKKPSHKIAQDKTFYGEARASELSERLEKDLNIETKTSKFYERSTRSIFNAFEN
                     SCKGKMGSERLEGSMDYHFVDRAKFDNNYLITGFNPILAHASEPKELLELSSLEVPLS
                     ADNDDECKEFLELESIELQHSPVGEEEKEELGLGSPMAPLSPGCQAGATLESFMMQLP
                     LDCEAEKQLELKLPTPQLSLEDSISPLSAAVSQDIQESRYSEDERKAGYMGSSDDDHS
                     RSPLLQHGKGGNSPAHGGRNLSEEEFPQFESRDSAALLAPLFSEEEAREGRKCGSMVP
                     AAQLQSTYTLKGFSVGSKCVVWSSLRNTWSKCEILELAEEGTRVLNLSNGVEETVSPE
                     NVWNGIPKVDKRPSEAVFQTVGKDLPFMPSDDATTKGFSSVSEEEACGGDADSLSTAK
                     LNI"
     exon            6194..6321
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6322..6411
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6412..6475
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /inference="alignment:Splign:2.1.0"
     exon            6476..7062
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7040..7045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /note="hexamer: AATAAA"
     polyA_site      7062
                     /gene="Tdrd6"
                     /gene_synonym="Tdr2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgagt ccccgaggcc ctgcgccggg cgcctggacg aaggatcgcc tctccgggcg
       61 tccttcccct tgcctcggtg ccccggacct ggcccggtgg gaccgtctcc ggacgctcgg
      121 agcagctctc ggttggccgc agccatgagt tcgactccgg ggctgcccac tcccggggcc
      181 tcgctggccc tgcgggtgtc cttcgtggac gtgcatcccg aggtgatccc agtgcagctg
      241 tggggactgg tgggtcagcg gcgggaggag tacgtgcggc tgagccggga gatccaggag
      301 gcagcagcca cgcgcggtcc ctgggcgctg ggtggggcgt cggcatcgcc gggagagctg
      361 tgcctggtgc aggtggggct catgtggcac cgctgccgcg tggtcagccg ccaggcgcaa
      421 gacagccgcg tcttcctgct ggatgagggc cgcaccatca cggcgggcgc gggctcgctg
      481 gcgccagggc gtagcgagtt cttccacctg ccctccgagg tgctgggctg tgtgctagca
      541 gggctggtgc ccgcgggcgg tggtggcact ggcggtggcg aaccccagca atggtccccc
      601 agggctgtgg atttccttag caacctgcag ggcaaggagg tgcacggacg ggtcctggat
      661 gtgttgctcc tccatcgcct ggtgctgctg gaggtgccag ttgtgtctca gcagatggag
      721 gagctgggtc tggcccggca agtgccggac agcctcttct gttcgctgct caaacgctac
      781 ctgactgcgg cagggcaggg cagctccgga gctccagttc tcccgcgagc cgcgcccaaa
      841 caagagcatc ctgggttgga ttacttttat ccccaactgc agctgggagt gacggagccg
      901 gtggtagtaa cccaagtatg ccatccccac cgaattcact gtcaactgcg gagcctctcg
      961 caggagatcc accgtctctc tgagagcatg gcccaggtat accgggcgcc tgtggggaca
     1021 gatgatgagg actctggcag tgccacctgg gaggagaggg aggagagccc tgacaaaccg
     1081 ggatctccat gtgcttcctg tggcttggac ggacagtggt accgggctct cttgcttgag
     1141 accttcaggc ctcagcgctg tgctcaggtg cttcacgtcg attacggaag gaaagaacta
     1201 gtaagctgca gcagcctccg ctatctgctg ccggagtatt ttcgaatgcc tgtggtgacc
     1261 tacccttgtg cgttgtacgg actctgggac tgcgggagag gctggtcccg gtcccaagta
     1321 ggtgatctga aagctctgat cctgggccag gcagtgaatg cgaagattga attttactgt
     1381 tcctttgagc atatgtatta tgtcaccctg tatggggaag atgggattaa tctcaacagt
     1441 gcattcggag tacaatcctg ttgcctggct gactggtttc ttcagagcca ggggatagag
     1501 gaggaagagg aggaagatga ggacgaagtg gaggcagcgt ttcagtctca gtcccccgct
     1561 gaggaaatgg aggcggaagt ttccctcccc tccttgagat ccatcaggct gaagatgaac
     1621 accttctatg acgcccaggt ggagttcgtg aagagccctt cggagttctg gattcgcctt
     1681 agaaagcaca agaacacctt cagcaagctg acgaagagaa tgtgcagttt ctattcttct
     1741 gccagtaagc tggatggggt tattttgaga ccagaaccgg atgacctttg ctgtgtaaaa
     1801 tggaaagaaa atggctatta ccgagccacg gtcacccgat tagacagcaa gagtgtggat
     1861 gtgttcctgg tggaccgggg caactctgag aatgtggact ggtgtgatgt gagaatgttg
     1921 ttgcctcagt ttagacagct accgatactg gctctgaagt gcaccctggc tgacatctgg
     1981 cctctgggga aaacttggag ccaggaagcc acctcatttt ttaaaaagac ggtactccac
     2041 aaagaattgg tggtccatgt tcttgataag caggatcacc aatatgtcat agagatcctg
     2101 gatgaatcca gaatggggga ggaaaacatt agtaaggtca tcgctcaagc tggctttgcc
     2161 aagttccagg agtttgaaac caaagaaaac atcagactca gtgcccattc ccctgggcat
     2221 gtttctggtc attttatggc ggagcctagc aaaataactt ctgccaagaa ggccgaagga
     2281 gaccagagag ccaaaaaaga taataaaacc ctctctgttt cagaagcttt ggcggacacg
     2341 gtcagccttt caaacctttc tactgcacag gacacagaga aggtaacgtc ggacccatct
     2401 ctcctcatgc tgaacttctt gaaaaccaaa ccagactgct gtggtaaagg ggaactggag
     2461 gtgggcagca ccgttgaagt caaggtgtct cacatcgaaa accctggctc cttctggtgt
     2521 cagctgatga ggaacgcgca aggcttcaga accttgatgt gtgacatcga ggactattgc
     2581 aaaagcagcg agccatctcc ctacgagggg gacactcgtg tttgtctggc aaagcgaaca
     2641 gcaagcggga gatggtccag agctctgatt agcggggcac actcgttaga gcatgttaga
     2701 gtggtgttcg tggattatgg agacagggac gtggtatcta cgaaggacat actctccgtc
     2761 agtgatgtgt tcttccaggt tagagctcag gccttccggt gcagtcttta taatttaatt
     2821 caaccgatgg gtgaaaatcc ctttgtctgg gatgaaaagg cagtacaggc tttcagcggg
     2881 ttcatcgata gcgctcggca gaataactta gaattaaaat gcacagtgtt tgctttggca
     2941 tcaaggcatg aggaagagtg gttcaatgtt gtggacttgc tgacgccctt tcagagcgcc
     3001 tgccgttttt tggtagaaaa gagacttgcg aggcctgtca aacatcagaa gcccctggaa
     3061 ccttccgttc agctacactc ttactactat tccacccatg acctaaaaat cggaagtgaa
     3121 gaactggtgt acgtaaccca tgccgacgac ccctggacat tttattgcca gctcgcgaga
     3181 aatacaaacg ttttagaaca actgtcgtac aacatcatgc agctaagtaa agccttactg
     3241 aatctaaaag catccacctt ggcccctgga accttgtgcc ttgccagata taccgacgga
     3301 aactggtata gaggaataat aatagagaaa gagccaagta aggtcttttt tgttgatttt
     3361 gggaacacgt acatagcagt cgatcatctg ctccccatcc cccgagatgc ccatgatgtc
     3421 ttacttctgc ccatgcaagc cttgaaatgc tccttatcgg acatccctca tcacatcccg
     3481 gaagaagtca cggcatggtt tcaggaaact gttttagata agtcactgaa ggctttagtt
     3541 gtagccaaag acccagatgg gagactgatt atagagctgt atgacgacag tgtccaaatc
     3601 aatgccagta tcaacgagaa gctcgggctc cttggttaca aaaacagaac caggagaaaa
     3661 gagaaagaga atgaaataat actctacgag accaaagctc ttgaagataa aaaggagagc
     3721 gtgaagccat cacttgcaga ctatctgagt aaaccgggag agagtaaagc acacagtgta
     3781 gagattatgg gtgaatcttg caaacccaag atgggtccag catgtaagga gctcagatat
     3841 ttacagggct cagcaaaggc caacctagtc ccaccgtatc aggactcagt gggcaacaaa
     3901 aatgatggag ggtttccatt aacaagggag aagaaagaag acatatttgc cagctcaccc
     3961 atgagtggca ccaaactaga ctctgctctt cctgagagaa gaatgggaga acctagcggc
     4021 agagatctgc ctcccaagtt ttgtgaattc ccacaaaaga caatagctcc tggctttaag
     4081 acctctgtgt atgtttctca tattaacgac ctttcagatt tttacatcca gctgatagaa
     4141 gatgaagctg agatcaacaa cctctcagag agactaaatg atgtcagaac acggccccag
     4201 taccacacag gtccgcagtg gcagagcgga gatgtgatat gtgccgtttt cccagaggat
     4261 aacttatggt accgagcgct tgtcatggaa cagcagccca atggccttct ctctgtccag
     4321 tttatcgatt atggcaacat gtctgtggtt cacactaaca gaaccggtcg gcttggccct
     4381 gttgacgcgg tgttacctgc actgtgcctc cattgctccc tatgggggct ttcggtacct
     4441 gtgtgtaagg aaatggtaag ctacttttcc cagaggacag acgaggctca gataagatgt
     4501 gaatttgtta aattccaagg cacctgggaa gtgatcctcg cagatgagca cggagtcata
     4561 gctgaagata tgattagcag gtttccatgc aatggaaact ctcaagcagg gcttaccacc
     4621 cagaccatga aaggggactg tttgaagata gctaacaaac ccaacgctga tacctcagtg
     4681 cttcttaact ggtataaccc caaagcaaaa ctgataaaag cctacgctac cgtgatagac
     4741 gggcctgagt acttttggtg tcagtttgcc gattccgaga agctgcagta tctggaaacg
     4801 gaggttcaaa gtgctggcaa gcagctctct gacagaagaa gctgcaccca atgtccacaa
     4861 attggagatc cgtgcatcgt gaggtacaga gaagacgggc attactacag agccctcatc
     4921 actaacatct gtgatggtga gcttgcgtcg gtcaggcttg tggactttgg gaatgcggag
     4981 gactgtgtgg acgccaagga gctttggagc atcccttctg agcttctgct ggtccccatg
     5041 caagcatttc catgctgcct cgctggattc tcagtctctg gcggtgtgtg ccctcaagaa
     5101 gggaatgatt atttttatga catagtcaca gaggacgtgt tggacataac gatcttggag
     5161 attaaaagag acgtttgcaa catcccctta gccatcgtgg agctaaggag caaaggcgag
     5221 aacattaacg agaagatgaa gaagtatgct aagacgggcg tgcccaagaa tgacctgtcc
     5281 tctgagaagc gtggcccaga gagaaaggga agcctcgcca gtcctgacct tggcctcaag
     5341 aagccaagtc ataaaatagc acaagataag acattctacg gggaagcccg ggcaagcgag
     5401 ctctcggaga gacttgaaaa ggatttaaac attgaaacca agacaagtaa attctatgaa
     5461 cgcagcaccc gtagcatctt caacgctttc gagaactcat gcaaaggtaa aatgggttct
     5521 gagaggctag aaggtagcat ggattaccac ttcgtggaca gagccaagtt tgataataac
     5581 taccttatca cgggatttaa cccgatattg gcccatgcta gtgagccaaa ggagttactg
     5641 gaactgagtt cactagaggt accactctct gctgacaatg acgatgaatg caaagaattc
     5701 ttagaactgg aatccattga gttacagcac tcccctgttg gggaggaaga gaaagaggag
     5761 ctaggcctgg ggtctccaat ggcaccgctg tctccaggct gccaggcagg agccaccctg
     5821 gagtcattca tgatgcaact tcccctggac tgtgaggctg agaagcagct ggaactgaag
     5881 ctgcccacac cccagctgtc tttggaggac agcataagcc ctttatctgc agctgtcagc
     5941 caggacatcc aggaatccag gtattcggag gatgagagaa aggccggcta catgggctct
     6001 tctgatgatg accacagcag gtctcccctc ctccaacacg ggaagggtgg caattcaccg
     6061 gcacacggtg gaaggaacct gtctgaagag gagtttccgc agtttgaaag tagagacagc
     6121 gccgccttat tggcaccctt gttctctgag gaagaagcca gagaaggaag gaagtgcggg
     6181 agcatggtac cagcagctca gctacagagc acctacactc tgaaaggctt ctctgtcgga
     6241 tcgaaatgcg tcgtgtggtc gagcctaaga aacacatggt ctaagtgtga gattctcgaa
     6301 ctagccgaag aaggaacaag ggttttgaac ctttcaaatg gtgtggagga gacagtaagc
     6361 cccgagaatg tctggaatgg gattcccaag gtagataaga gaccttctga ggctgtattc
     6421 caaacagtgg gaaaggacct tcccttcatg ccatcggatg acgccaccac caaaggtttt
     6481 tcttctgttt cagaggagga ggcgtgtgga ggtgatgcag attctctgag cacggccaag
     6541 ctgaacatat agacccagcc aatcagaagc cgtctttaac aagcccggtg ctacccagaa
     6601 caaacgtgct ggaggaaatg ttaaagcatt tgacccctgg aagttgtcct ttgggagaca
     6661 aatccatgtg tggtggaagc gataggtctc aggttgacaa gacagcctgt taattgctat
     6721 ttagcggcat ctggctttgg tccccagtcc aaagccttct cgtgtttctt ctcagccagg
     6781 ataatttatt ttgctaaaca atttgctaac atattgctat agtcctaaaa gtgctagctt
     6841 ttcaatagat tgtttatatt taaatggaaa cttctaggtt ccggatgagc atgataggat
     6901 gctgccgatg ccacggcttt gttagcaaga ttgccagcaa ccttgtttgt cttttgacgc
     6961 tttgccttgc gtgtctactg aaataggtgg ctactgctct gtttgaacct ggagtgcaac
     7021 aaatgcaacc caacatttga ataaagttta tccttaaagc tg
//
