LOCUS       NM_001134741            3462 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tudor domain containing 5 (Tdrd5), transcript variant
            1, mRNA.
ACCESSION   NM_001134741 XM_129603
VERSION     NM_001134741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3462)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3462)
  AUTHORS   Gustafson,E.A., Seymour,K.A., Sigrist,K., Rooij,D.G.D.E. and
            Freiman,R.N.
  TITLE     ZFP628 Is a TAF4b-Interacting Transcription Factor Required for
            Mouse Spermiogenesis
  JOURNAL   Mol Cell Biol 40 (7), e00228-19 (2020)
   PUBMED   31932482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3462)
  AUTHORS   Sun,Y.H., Zhu,J., Xie,L.H., Li,Z., Meduri,R., Zhu,X., Song,C.,
            Chen,C., Ricci,E.P., Weng,Z. and Li,X.Z.
  TITLE     Ribosomes guide pachytene piRNA formation on long intergenic piRNA
            precursors
  JOURNAL   Nat Cell Biol 22 (2), 200-212 (2020)
   PUBMED   32015435
  REMARK    Erratum:[Nat Cell Biol. 2020 Mar;22(3):353. doi:
            10.1038/s41556-020-0482-3.. PMID: 32066908]
REFERENCE   4  (bases 1 to 3462)
  AUTHORS   Sun,Y.H., Jiang,F. and Li,X.Z.
  TITLE     Disruption of Tdrd5 decouples the stepwise processing of long
            precursor transcripts during pachytene PIWI-interacting RNA
            biogenesis
  JOURNAL   Biol Reprod 99 (4), 684-685 (2018)
   PUBMED   29733347
  REMARK    GeneRIF: By conditional inactivation of Tdrd5 in postnatal male
            germ cells (Tdrd5cKO), we show that spermatogenesis is arrested at
            the round spermatid stage, and the testes of Tdrd5cKO mice are
            about half the weight of wildtype controls.
REFERENCE   5  (bases 1 to 3462)
  AUTHORS   Ding,D., Liu,J., Midic,U., Wu,Y., Dong,K., Melnick,A., Latham,K.E.
            and Chen,C.
  TITLE     TDRD5 binds piRNA precursors and selectively enhances pachytene
            piRNA processing in mice
  JOURNAL   Nat Commun 9 (1), 127 (2018)
   PUBMED   29317670
  REMARK    GeneRIF: Conditional inactivation of TDRD5 in mouse postnatal germ
            cells reveals that TDRD5 selectively regulates the production of
            pachytene piRNAs from abundant piRNA-producing precursors, with
            little effect on low-abundant piRNAs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3462)
  AUTHORS   Yabuta,Y., Ohta,H., Abe,T., Kurimoto,K., Chuma,S. and Saitou,M.
  TITLE     TDRD5 is required for retrotransposon silencing, chromatoid body
            assembly, and spermiogenesis in mice
  JOURNAL   J Cell Biol 192 (5), 781-795 (2011)
   PUBMED   21383078
  REMARK    GeneRIF: TDRD5 is a novel component of the intermitochondrial
            cements (IMCs) and the chromatoid bodies (CBs), which are
            cytoplasmic ribonucleoprotein granules involved in RNA processing
            for spermatogenesis.
REFERENCE   7  (bases 1 to 3462)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3462)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   9  (bases 1 to 3462)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 3462)
  AUTHORS   Smith,J.M., Bowles,J., Wilson,M., Teasdale,R.D. and Koopman,P.
  TITLE     Expression of the tudor-related gene Tdrd5 during development of
            the male germline in mice
  JOURNAL   Gene Expr Patterns 4 (6), 701-705 (2004)
   PUBMED   15465492
  REMARK    GeneRIF: Tdrd5 expression is restricted to the male germline
            throughout development to adulthood
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV655037.1, AK132674.1, BC099972.1 and DV659775.1.
            
            On Sep 5, 2008 this sequence version replaced XM_129603.6.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DV655037.1         1-21
            22-2010             AK132674.1         8-1996
            2011-3342           BC099972.1         1717-3048
            3343-3462           DV659775.1         413-532
FEATURES             Location/Qualifiers
     source          1..3462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.71 cM"
     gene            1..3462
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /note="tudor domain containing 5"
                     /db_xref="GeneID:214575"
                     /db_xref="MGI:MGI:2684949"
     exon            1..38
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            39..274
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..3165
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /note="isoform 1 is encoded by transcript variant 1; tudor
                     domain containing protein 5"
                     /codon_start=1
                     /product="tudor domain-containing protein 5 isoform 1"
                     /protein_id="NP_001128213.1"
                     /db_xref="CCDS:CCDS56647.1"
                     /db_xref="GeneID:214575"
                     /db_xref="MGI:MGI:2684949"
                     /translation="MSEQERIQDCLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLP
                     LRILGYRSTMELVLDMPDVVSVCPGGDGTVILKAIPDESTKGIASLVAKQRRSHKVRN
                     SMPKGRPSICSGRVPYRGRVPPILPAVVKSELKDLLALSPVLLSDFEKAFARRFGRSF
                     QYMQYGFLSMFEVLNAASDVISVEQTRAGSLLTLKKSVSEDKQRGWPAGKVFTQPFRM
                     KQQGSYSTGFPVMKAHFSQPISNMEPPKQVLSMAKTPTFNSVEASRLNHTEKLNQLES
                     TFKSVIAQIGPGGTVDPELKRKIQFVVSKFPQGLFISKLLGEFELTFKEQLSPKQLGF
                     LNVTELVGALSDILRVEFSEERQDLLVFDADLKPLPSGGPLSSVRNSCLVQPDKKTEA
                     NPWTSSLSRNSLSTVAVKKTTWDCPLKNQKEPEQKIYKKPNLVVKPLQLQVETNKPQL
                     SLSVANHDIPPDAVRAKKLCRLPPLDTSTLVGVFVEYIISPSQFYIRIYSRDSSELLE
                     DMMIEMRRCYSNQLVSDRYIMPEYFIQPGHLCCVKISEDKWWYRVIIHRILGKKEVEV
                     FYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPAEEHWTARAILHFQKLCG
                     LKPLVGVVDEYIDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENAPSKGFRDFNP
                     PALYTNASSAGDMVLTDLGHPAQQHYLNEDQEILQQAQQDINDGKCISYLKSAPKELL
                     KDSKLSSLKTHKSCEEDPRWSILQPKDLKEENEDEVPTGMPCLESVTIGDDVWDENWL
                     PLQAKMGKAGSPASQLFTSNLVGKKQYQTGGEMAQKDWCFSTSKDIWDDSWQPLGLAN
                     DVKGGIHTPEGPIAQEKNTSTTRIQQQPDLQYPLDSSTLPKLEEFYISLIKSQQSAER
                     SQSEPASIQTHAGRAASKALSSTPAVGDSPENHSGSVESSPGSLKKEDVSNSRAEATA
                     KDKSQGAIDQLSFILSPQHQISQKLYIPRSTATAVLGAAARLATSRSLLHWYPSVKGG
                     KLEAERDGVK"
     exon            275..667
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            668..861
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            862..945
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1002
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1156
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1365
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1586
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1799
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1866
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2067
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2202
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2361
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2544
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2688
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2893
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3443
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3324..3329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /note="hexamer: AATGAA"
     polyA_site      3342
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /note="major polyA site"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /note="hexamer: AATGAA"
     polyA_site      3443
                     /gene="Tdrd5"
                     /gene_synonym="Gm103"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtgcga gggagcgagg cgggcgagcc gcagccagca cgatgtctga acaagagcgt
       61 atacaggact gtctgaggaa agagataagg tcccttctta tttccactaa ggatggtttg
      121 actccacaac agttggaaaa ggagtacctt ttgatggttg gcaaccatct cccgctccga
      181 atccttggat atcggtccac tatggaactg gtgttggata tgcccgatgt ggttagtgtc
      241 tgccccggtg gggatggtac cgtaatactg aaagccattc cagacgaatc caccaaagga
      301 atagcaagtt tggttgcaaa gcagagaagg agccataagg tccgaaactc catgccaaag
      361 ggaagaccca gcatatgctc tggccgggtg ccttaccgag gaagggtgcc cccaattctt
      421 ccagctgtag tgaagagtga gttgaaagac cttttggcat tgtctcccgt tctcctttct
      481 gactttgaaa aggcatttgc caggcgtttt ggacgatcat ttcagtatat gcagtatgga
      541 ttcctctcta tgtttgaagt gctgaatgca gcttcggatg tcatttctgt agagcagacc
      601 agagcaggtt ctctgttgac actaaaaaag agtgtatcag aggacaagca gagaggatgg
      661 ccagcaggta aagtttttac tcagccattt agaatgaaac aacaggggtc atattctaca
      721 ggattcccag taatgaaggc acacttttca caacccattt caaatatgga gccccccaaa
      781 caagtactga gcatggcgaa gacacccacg tttaattctg tggaggcttc aaggctgaac
      841 cacactgaaa aattaaatca gttggagagc acattcaaat ccgtgattgc acagattgga
      901 cctggaggga ctgttgatcc tgagctaaag cgcaagatac aatttgtcgt gtctaagttt
      961 ccacaaggtt tgtttatttc taaactgctt ggagaatttg agctaacttt taaagagcaa
     1021 ctttcaccaa aacaattagg gttcttaaac gtgacagaac ttgttggcgc tcttagtgac
     1081 attctccgag ttgagttcag tgaagaaagg caagacttgc tcgtgtttga tgctgacctg
     1141 aagcctctgc cgtctggtgg accgctttca tcagtcagaa attcgtgttt agttcaacca
     1201 gacaagaaaa cagaagctaa cccttggact tccagtctct ccagaaattc actatccact
     1261 gtagcagtta agaagaccac gtgggattgc cctttgaaga accagaagga gccagaacag
     1321 aagatataca agaagcctaa tctggtggtc aagcctctgc agctgcaggt agaaacaaac
     1381 aaaccgcagc tcagcctgtc agtggcaaac cacgatatcc caccagacgc tgtgcgtgcc
     1441 aagaaattgt gcagacttcc tccattagat accagcaccc ttgtgggggt cttcgtggag
     1501 tatataatct cccctagtca gttctacatc cggatctaca gcagagattc ctcagaacta
     1561 cttgaagaca tgatgattga aatgcgacgc tgctactcca accagctggt ctctgaccgg
     1621 tacattatgc cagaatattt tatacaacca ggacatctct gttgtgtaaa gatctctgag
     1681 gacaagtggt ggtaccgggt tattatccat cggatccttg ggaaaaagga agtggaagtg
     1741 ttctacccag atttcggaaa tatcggaact gtgcagaagt cctcgctgag gttcctcaaa
     1801 tgctgctaca caaagcttcc agctcaggct atcccttgct ctttggcgtg ggtgaggccc
     1861 gcagaggaac actggacagc cagagctatt ttgcacttcc agaagctgtg tggtttgaag
     1921 ccattggtgg gggtggtgga tgagtatata gacggaatcc ttaatatttt tctttgtgat
     1981 acgtcctcaa atgaagatgt gtattttcat catgtcttga ggacagaagg ccatgctatt
     2041 gtatgccgag aaaatgcccc atccaagggc ttcagggatt tcaacccacc agctctgtac
     2101 actaacgcca gctcagcggg cgacatggtc ctgacagacc tggggcatcc tgctcagcag
     2161 cactatttaa atgaagacca ggagatactg cagcaagccc agcaagatat taatgatgga
     2221 aagtgtataa gttaccttaa atctgcgccc aaggaattat taaaggattc taaattgagc
     2281 tcattgaaaa cacataagag ctgtgaagag gacccacggt ggtccatcct gcagcccaag
     2341 gatctgaagg aagaaaatga ggatgaggtc cctactggaa tgccatgcct ggagtcagtg
     2401 accataggtg acgatgtttg ggatgagaac tggctccctc tacaggccaa aatggggaag
     2461 gcagggagtc ctgcctccca gctgtttact tcaaaccttg ttgggaagaa acaatatcag
     2521 acaggtggag aaatggcaca aaaggactgg tgtttttcta catctaaaga tatatgggat
     2581 gattcctggc agcccttagg ccttgcgaat gatgtgaaag gaggaattca cacaccagaa
     2641 gggcccattg ctcaagaaaa aaataccagc acaacccgaa ttcaacagca gccagattta
     2701 cagtatcctt tggattcttc cacactgccc aaactggaag agttctacat ctctctgatc
     2761 aagtctcagc agtccgcaga gaggagccag tctgaacctg ccagcattca gactcatgcc
     2821 ggacgggcag cctcaaaagc actcagttca acccctgcag tgggtgactc tccagaaaac
     2881 cactctggct ctgtggaaag ctctccaggg agcctaaaga aagaagatgt ttctaatagc
     2941 cgtgctgaag ccacggccaa ggacaagagt cagggagcca tagaccagct ctctttcatt
     3001 ttgtcccccc agcaccagat ttctcagaag ctctacatcc ctcgaagtac agccacagct
     3061 gtcttgggag ctgcggcacg gttagccacg tccaggagcc tcctgcactg gtaccccagt
     3121 gtgaaaggag ggaagcttga ggcagagaga gatggagtga agtaacggtt ggggaggggt
     3181 cccttggcct ttctgggtga ccaggtgcta gctttgtttt gctaactgac tactttgatg
     3241 tgtaagtatt gataatttat gttagttctt atttttgttc atgattttac atcattctga
     3301 atggtttggt tcacctttgt tttaatgaag tactttaaag cagtttgtgt atatgttttt
     3361 ttttgttttt ttgtttgttt ttgtttttgt tttttgtttg tcttgtacat atcatgactg
     3421 ataaatgaag attgaaaaat taaaaaaaaa aaaaaaaaaa aa
//
