LOCUS       NM_172605               2717 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tudor domain containing 3 (Tdrd3), transcript variant
            1, mRNA.
ACCESSION   NM_172605 XM_915898
VERSION     NM_172605.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2717)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2717)
  AUTHORS   Zhu,X., Joo,Y., Bossi,S., McDevitt,R.A., Xie,A., Wang,Y., Xue,Y.,
            Su,S., Lee,S.K., Sah,N., Zhang,S., Ye,R., Pinto,A., Zhang,Y.,
            Araki,K., Araki,M., Morales,M., Mattson,M.P., van Praag,H. and
            Wang,W.
  TITLE     Tdrd3-null mice show post-transcriptional and behavioral
            impairments associated with neurogenesis and synaptic plasticity
  JOURNAL   Prog Neurobiol 233, 102568 (2024)
   PUBMED   38216113
  REMARK    GeneRIF: Tdrd3-null mice show post-transcriptional and behavioral
            impairments associated with neurogenesis and synaptic plasticity.
REFERENCE   3  (bases 1 to 2717)
  AUTHORS   Yang,Y., McBride,K.M., Hensley,S., Lu,Y., Chedin,F. and
            Bedford,M.T.
  TITLE     Arginine methylation facilitates the recruitment of TOP3B to
            chromatin to prevent R loop accumulation
  JOURNAL   Mol Cell 53 (3), 484-497 (2014)
   PUBMED   24507716
REFERENCE   4  (bases 1 to 2717)
  AUTHORS   Xu,D., Shen,W., Guo,R., Xue,Y., Peng,W., Sima,J., Yang,J.,
            Sharov,A., Srikantan,S., Yang,J., Fox,D. 3rd, Qian,Y.,
            Martindale,J.L., Piao,Y., Machamer,J., Joshi,S.R., Mohanty,S.,
            Shaw,A.C., Lloyd,T.E., Brown,G.W., Ko,M.S., Gorospe,M., Zou,S. and
            Wang,W.
  TITLE     Top3beta is an RNA topoisomerase that works with fragile X syndrome
            protein to promote synapse formation
  JOURNAL   Nat Neurosci 16 (9), 1238-1247 (2013)
   PUBMED   23912945
REFERENCE   5  (bases 1 to 2717)
  AUTHORS   Newbury,A.J. and Rosen,G.D.
  TITLE     Genetic, morphometric, and behavioral factors linked to the
            midsagittal area of the corpus callosum
  JOURNAL   Front Genet 3, 91 (2012)
   PUBMED   22666227
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2717)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 2717)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2717)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW047213.1, AK033390.1, AK032892.1, BE983697.1 and BB668608.1.
            
            On Mar 27, 2009 this sequence version replaced NM_172605.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005670.1, SRR1660817.139109.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AW047213.1         1-351
            352-1273            AK033390.1         297-1218
            1274-2340           AK032892.1         1219-2285
            2341-2707           BE983697.1         22-388              c
            2708-2717           BB668608.1         402-411
FEATURES             Location/Qualifiers
     source          1..2717
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 44.17 cM"
     gene            1..2717
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /note="tudor domain containing 3"
                     /db_xref="GeneID:219249"
                     /db_xref="MGI:MGI:2444023"
     exon            1..266
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2457
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /note="isoform 1 is encoded by transcript variant 1; tudor
                     domain-containing protein 3"
                     /codon_start=1
                     /product="tudor domain-containing protein 3 isoform 1"
                     /protein_id="NP_766193.3"
                     /db_xref="CCDS:CCDS27305.2"
                     /db_xref="GeneID:219249"
                     /db_xref="MGI:MGI:2444023"
                     /translation="MAEVSGAALSQAGWYLSDEGVEACTSSPGKGSINDIILIALNTD
                     LRTIGKKFLPSDINGGKVEKLEGPCVLQIQKVRNVAAPKDNEESQAAPRMLRVQMTDG
                     HTSCTAVEFSYISKISLNTPPGTKVKLSGTVDIKNGFLLLSDSNTTVLGGEVEHLIDK
                     WALQRSLLKHNRSNIGAEGGPPPFLPFGQKCASNVQVDSRELDRRKTLQVSLPAKPAN
                     DNDEFEKQRTAAIAEVAKSKETKTFGGGGGGARSNLNIGAAGHRNREVLQKEKASKSE
                     SKNEGVYRELVDEKALKHITEMGFSKEASRQALMDNANNLEAALNVLLNSSKQKPAVG
                     PPARGRGKGRGRGRSEDEEDLGTARPSAPSTLFDFLESKMGTLNVEEPKSQPQHLHQG
                     QHRGWNAEQNGMKDGTQSRHLPRNDTRQPRNERPPRFQKDTPTSKSTVENSVLSRNRG
                     SERPSSSSGSDVWAEERIKCDRPYSRYDRTKDASHPLGLQHNDGAFKKRENSMQNRPG
                     RGPLYAEAKENPLPPEFVDYNNQRRGRRENQTGHPDHCYERKPRTMNSEAVSGLKIEK
                     HFSVNTDYPRPVQSNSLGVPNGETAPPLKGRRVGPIKSAGPVTAVPYDDKIFYNSGPK
                     RRSGPIKPEKVIESSIPVEYAKVWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVK
                     FTDYGNYEEVLLSNIKPVQTEAWEEEGTYDHTIEFRRGGDGQPRRSTRPTQQFYQPPR
                     ARN"
     exon            267..351
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            352..417
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            418..578
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            579..720
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            721..792
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            793..942
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1083
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1240
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1366
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..2214
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2340
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2465
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2717
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /note="hexamer: AATAAA"
     polyA_site      2713
                     /gene="Tdrd3"
                     /gene_synonym="4732418C03Rik; 6720468N18"
                     /note="major polyA site"
ORIGIN      
        1 cggccgctca caaaacgcgg cgagcggaac ccgcacgcgg aagcgcccgt ctcactgagc
       61 atgcccagtg gcacagtcga acagaggagt ttttttttct ttttcttttc tttcttcttt
      121 ttttccccct ctttcttctt tttctttttt ctgggtctcc agtaggaggc ccgtccccca
      181 ccctcagttc agacccccgc cgtccccgag cctgaacagc taaccatggc cgaggtgtcc
      241 ggcgccgcgt tgtcccaggc gggttggtac ctttcagatg aaggcgttga agcctgcaca
      301 agctctcctg ggaaaggcag cataaatgac atcatcctga ttgctctcaa tacagatttg
      361 agaacaattg gcaagaagtt ccttcccagt gacatcaacg gtggaaaggt agagaagctt
      421 gaaggtccat gtgtcttaca aattcagaag gtccgcaatg ttgctgcgcc aaaggataac
      481 gaggaatcgc aagctgcgcc aaggatgctc cgcgtgcaga tgacggatgg gcatacaagt
      541 tgtacggcag tagaattcag ttatatttca aaaataagcc tgaacacacc acctggcaca
      601 aaagtgaagc tctctggcac tgtggacata aagaacggat tcctgctctt aagtgactct
      661 aacaccacag ttcttggtgg tgaagtggaa cacctaattg acaagtgggc tttacagaga
      721 agcttattaa agcataacag aagcaatatt ggagctgaag gtggcccacc tccttttcta
      781 ccttttgggc agaagtgtgc atctaacgtc caagtggata gcagagagct tgatcgaaga
      841 aagacattac aagtttccct gcctgccaag cctgcaaatg ataatgatga atttgaaaag
      901 caaagaactg ctgccattgc agaggttgca aagagcaaag agaccaagac atttggagga
      961 ggtggaggtg gtgccagaag taatctcaat attggtgctg ctggtcaccg aaatagggag
     1021 gttttacaga aggaaaaggc ttccaagtca gagagcaaga acgaaggtgt ctatagagaa
     1081 ttggttgatg agaaagccct gaaacacata acagaaatgg gcttcagtaa ggaggcctca
     1141 aggcaagcgc tgatggataa tgccaacaac ttagaagcag cactgaatgt ccttctgaac
     1201 agcagtaaac agaagcctgc tgtgggccct cctgctagag gaagagggaa aggcaggggt
     1261 cgaggacgat cagaagatga ggaagacctg ggaaccgcaa gaccgtcagc accaagcacg
     1321 ttatttgatt tcttggagtc taaaatggga actctgaatg tggaagaacc taagtcacag
     1381 ccacagcacc ttcatcaagg acagcacaga ggatggaatg ccgagcaaaa tgggatgaag
     1441 gacggcactc agtcaagaca tcttcctcga aacgatacca ggcagccaag aaatgagagg
     1501 ccacctcgct ttcaaaaaga caccccaact tccaagtcaa ctgtagaaaa cagcgtatta
     1561 tctagaaata gaggctccga aaggccgagt agttcctcag gttctgatgt atgggcagaa
     1621 gagaggatca agtgtgacag gccatattct aggtatgaca gaactaaaga cgcttcacat
     1681 cctctaggcc ttcagcacaa cgatggtgct tttaaaaaga gagagaactc tatgcaaaac
     1741 agaccaggaa gaggcccttt gtatgcagag gccaaagaaa acccacttcc tccagaattc
     1801 gtagattaca ataatcaaag acgtgggaga agagaaaacc aaacaggtca tcctgatcac
     1861 tgttatgaga ggaaaccacg gacaatgaat agtgaagctg ttagtggtct aaaaattgag
     1921 aaacatttta gtgtaaacac tgattacccg aggcctgtgc agagcaatag tcttggtgtt
     1981 ccaaatggag agacagctcc gcctctgaaa ggaaggcgcg taggaccgat taagtcagca
     2041 ggacctgtca cagctgtgcc ctacgatgat aaaatatttt ataatagtgg gcccaaaaga
     2101 aggtctgggc caattaagcc tgaaaaggtg atagaatcat ctattcctgt ggagtatgca
     2161 aaagtgtgga aacctggcga tgaatgtttt gcactttatt gggaagacaa caagttttac
     2221 cgagcagaag ttgaagcctt gcattcttcg ggtatgacag cggtcgttaa gttcacggac
     2281 tacggcaact atgaagaggt gctactgagc aatatcaagc ctgttcagac agaggcatgg
     2341 gaagaagaag gcacctatga tcacaccatt gagttccgca gaggaggtga tggacagcca
     2401 cgaaggtcta ctcggccaac gcagcagttt taccaacctc ctcgagctcg gaactaatgt
     2461 gaaagggctt ttgtgaagga agagccactg actgaaacat cctggaagcc cactgataga
     2521 ttttccactt cttcagagag agactcaata tgctggatat gatttttgga gaaagaaaaa
     2581 aaaggcagat attagggaaa cgattcaatt tacacaaggc aatgggggga aatactgagt
     2641 tcgatagagc aaaatatctt tacaagtgga aaacttcttc tgccatcaat aaaagcattg
     2701 cattgttata taagttg
//
