LOCUS       NM_001368387            6169 bp    mRNA    linear   ROD 28-NOV-2023
DEFINITION  Mus musculus tudor domain containing 12 (Tdrd12), transcript
            variant 2, mRNA.
ACCESSION   NM_001368387 XM_011250698
VERSION     NM_001368387.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6169)
  AUTHORS   Schimenti JC and Handel MA.
  TITLE     Unpackaging the genetics of mammalian fertility: strategies to
            identify the 'reproductive genome'
  JOURNAL   Biol Reprod 99 (6), 1119-1128 (2018)
   PUBMED   29878059
  REMARK    Review article
REFERENCE   2  (bases 1 to 6169)
  AUTHORS   Pandey RR, Homolka D, Olotu O, Sachidanandam R, Kotaja N and Pillai
            RS.
  TITLE     Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via
            Its Interaction with TDRD12
  JOURNAL   Cell Rep 24 (13), 3423-3432 (2018)
   PUBMED   30257204
REFERENCE   3  (bases 1 to 6169)
  AUTHORS   Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK,
            Sachidanandam R, Fauvarque MO, McCarthy AA and Pillai RS.
  TITLE     PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from
            Cytosolic Targets of the Mouse piRNA Pathway
  JOURNAL   Mol Cell 61 (1), 138-152 (2016)
   PUBMED   26669262
REFERENCE   4  (bases 1 to 6169)
  AUTHORS   Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S,
            Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S and Pillai
            RS.
  TITLE     Tudor domain containing 12 (TDRD12) is essential for secondary PIWI
            interacting RNA biogenesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 110 (41), 16492-16497 (2013)
   PUBMED   24067652
  REMARK    GeneRIF: Tudor domain containing 12 (TDRD12) is essential for
            secondary PIWI interacting RNA biogenesis in mice.
REFERENCE   5  (bases 1 to 6169)
  AUTHORS   Asano Y, Akiyama K, Tsuji T, Takahashi S, Noguchi J and Kunieda T.
  TITLE     Characterization and linkage mapping of an ENU-induced mutant mouse
            with defective spermatogenesis
  JOURNAL   Exp Anim 58 (5), 525-532 (2009)
   PUBMED   19897936
REFERENCE   6  (bases 1 to 6169)
  AUTHORS   McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6169)
  AUTHORS   Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K,
            Maruyama M, Maeda M and Yamanaka S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151535.2.
            
            On Feb 9, 2019 this sequence version replaced XM_011250698.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC151535.2         3578-3779
            203-361             AC151535.2         12022-12180
            362-498             AC151535.2         17219-17355
            499-618             AC151535.2         19254-19373
            619-674             AC151535.2         29306-29361
            675-760             AC151535.2         29993-30078
            761-950             AC151535.2         32328-32517
            951-1045            AC151535.2         36223-36317
            1046-1122           AC151535.2         37063-37139
            1123-1203           AC151535.2         39823-39903
            1204-1264           AC151535.2         46962-47022
            1265-1372           AC151535.2         47356-47463
            1373-1558           AC151535.2         51178-51363
            1559-1715           AC151535.2         51938-52094
            1716-1843           AC151535.2         52529-52656
            1844-2035           AC151535.2         53570-53761
            2036-2164           AC151535.2         54011-54139
            2165-2282           AC151535.2         54756-54873
            2283-2422           AC151535.2         55554-55693
            2423-2643           AC151535.2         55868-56088
            2644-2743           AC151535.2         58154-58253
            2744-2931           AC151535.2         60089-60276
            2932-3142           AC151535.2         60942-61152
            3143-3235           AC151535.2         63147-63239
            3236-3408           AC151535.2         65188-65360
            3409-3518           AC151535.2         69992-70101
            3519-3582           AC151535.2         70973-71036
            3583-3696           AC151535.2         71127-71240
            3697-3850           AC151535.2         71323-71476
            3851-3917           AC151535.2         71561-71627
            3918-6169           AC151535.2         72101-74352
FEATURES             Location/Qualifiers
     source          1..6169
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.37 cM"
     gene            1..6169
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /note="tudor domain containing 12"
                     /db_xref="GeneID:71981"
                     /db_xref="MGI:MGI:1919231"
     exon            1..202
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..4012
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /EC_number="3.6.4.13"
                     /note="isoform 2 is encoded by transcript variant 2; tudor
                     domain-containing protein 12; ES cell associated
                     transcript 8; ES cell-associated transcript 8 protein;
                     putative ATP-dependent RNA helicase TDRD12"
                     /codon_start=1
                     /product="putative ATP-dependent RNA helicase TDRD12
                     isoform 2"
                     /protein_id="NP_001355316.1"
                     /db_xref="GeneID:71981"
                     /db_xref="MGI:MGI:1919231"
                     /translation="MFEVLVLKIEDPGCFWVIIKGCSHFLEQEVDYQKLNTAMNDFYN
                     SMCQDVEMKPLMLEEGQVCVVYCQELKCWCRALIKSIISSADHYLAECFLVDFAKYIP
                     VKSKNIRVAVESFMQLPYRAKKFRLYGTKPVTLHIDFCEDNAEIVPATKWDSAAIQYF
                     QNLLRATTQVEAKLCAVEEDTFEVYLYATIKNEKVCVNDDLVAKNFAYYVSPMGNKNL
                     NPLEKPRQSLNSVTCSSKLSPSLTLWPMLLQGKDYHRMENKALNYKDSLTDSPKMMLE
                     KQQQSLPLKHTEKCTESSVYWPTKRGITIYADPDVPSVSGSSQRPNEKPLRLTEKKDC
                     DEKNGCVKLLQFLNPDPLRADGTSDLHQLQKVKLGTLQPGVVLRNRIEPCLTLEKSPL
                     SADLKKALQRNKFPGPSHTASYSWPPIARGCDMVVISHCGNDPLLYLPPLLTILQMGG
                     CYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSMSSRPLHPVLLTIGLHKDEAKNMK
                     LPRGCDVIVTTPHSLLRLLTYRSLLFLRLCHLVLDEVHMLFFEANEQMFAILDNFKKN
                     VEVEERESAPHQIVAVGVHWNKHIDHLVREFMKDPCVVITALEEAALYGSVQQVVHLC
                     LECEKTSTLLQVLDFVPSQAQKTLIFTCSVAETETVCKVVESNSIFCLKMHKEMAFNL
                     KSILEQWKKKLSPGSHIVLTLTDDCIPLLAITDATCVVHFSFPSSPKVLGGRLYCMSD
                     HFQSLTEQGSPAEQGDKKTKSVLLLTERNASHAVGILRYLERADAKIPSELYEFTAGV
                     LEAKEDKKARRPLCPYLKAFGFCKDKRICPDRHHINPEMDIPRKLSNKTLPVFGHIRV
                     IPFYISNATNYFGRIIDKHVDLYETLNAEMNEYFKESSNKTSAEKVENLGLYGLEEKT
                     LFQRVQVLEVSQKEDTWGLGSILVKLIDEGRTKLITRDQLLLLPEKFHTLPPQAVEFI
                     VCRVKPADSEIEWNPKVTRYIHHKIVGKMHDAKVVLALGNTLWIDPMVHVTKLSNLKT
                     SIIDYNVRAEILSMGMGIDNSEHLEQLKKLYKEAKLPAFEDLPCQTSIPTTVEDTVCL
                     QGTQQGDGGTERGAGSQEDSDNQKPGVLSEDIGSETISSAPQPHGRSFHPQIKWFQKD
                     DVVILKIKIRNVKDYKCKFFTDRVIFSAWVGDKFYLADLELQGDIRKDDCKCIIKDDE
                     PLITLAKEKQECWCGLLKQRNPNVAFDFDHWEECEEDSPFSKVVNSKNLSCKVAALAE
                     SSGSSSDTTDGSESE"
     exon            203..361
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            362..498
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            499..618
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            619..674
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            675..760
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            761..950
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1045
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1122
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1203
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1264
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1372
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1558
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1715
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1843
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2035
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2164
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2282
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2422
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2643
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2743
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2931
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3142
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3235
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3408
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3518
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3582
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..3696
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3850
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..3917
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..6169
                     /gene="Tdrd12"
                     /gene_synonym="2410004F06Rik; 2410070K17Rik; ECAT8;
                     EG434165; G1-476-14; repro23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagcgtgg tgagcgccgg ccgttaggag tgcgtgcatg ctaggggctt acgaaggctg
       61 gtggtgcaga ggctcccagg ccaggtcttt ttgtcggtgg tgagggacgc tcactctcac
      121 tccgcgtgct gtctccccgt ctgtgtgctg tgatctcctc tgtgagagaa gggccaggat
      181 gttcgaggtc ctggtgctga agattgaaga tccaggttgc ttctgggtaa ttataaaagg
      241 atgtagtcat tttttagaac aagaagttga ctaccaaaaa ctaaacactg ccatgaatga
      301 cttctataac agcatgtgtc aggacgtaga aatgaaacca ttaatgctgg aagaagggca
      361 ggtgtgtgtg gtgtactgcc aggagctgaa gtgctggtgc agggctctga ttaagtccat
      421 catctcttct gcagaccatt acctggcaga gtgtttcctg gtcgattttg ccaagtatat
      481 tccagtaaaa tctaaaaaca tccgagttgc agtagagtct tttatgcagc ttccttacag
      541 agcaaaaaaa ttcagacttt acggtacaaa gcctgtgaca ttgcacattg acttctgtga
      601 agacaatgct gagattgtac ctgccacaaa atgggacagt gcagccatcc agtactttca
      661 gaaccttcta agagcaacta cccaagtgga agcaaaacta tgtgcggtgg aagaagatac
      721 ttttgaggtt tacctttatg caacaataaa aaatgaaaaa gtttgtgtta atgatgacct
      781 agttgcaaag aattttgctt attatgtgtc accaatgggg aataaaaacc tcaatccttt
      841 ggagaaaccc aggcagagtc tcaattcggt gacctgctcc agtaagctca gcccatcact
      901 tactctgtgg ccaatgcttc tacaaggaaa agactatcac agaatggaaa ataaagctct
      961 aaactataag gattccttga cagactcgcc taaaatgatg cttgagaagc agcagcagag
     1021 cctcccttta aagcacacgg agaagtgtac tgaatcttct gtgtactggc caaccaaaag
     1081 aggcataacc atatatgctg atccagatgt tccatcagta agtgggtcta gccagaggcc
     1141 gaatgagaag ccactgcggt tgactgaaaa gaaagactgt gacgagaaga acggctgtgt
     1201 aaaattactg cagtttctaa atcctgatcc tttgagagct gatgggacct cagacctgca
     1261 ccagttgcag aaggtgaagc tgggcacact gcagcctggg gtggtgctcc ggaacaggat
     1321 cgagccctgc ctaaccctgg agaaatcacc tctgtcggca gacctgaaga aggctcttca
     1381 aagaaacaag ttcccgggac ccagccacac tgcatcttac tcctggcctc ctattgcacg
     1441 tggctgtgat atggttgtca tttctcactg tgggaatgac cccttgttgt acttgccacc
     1501 gctgcttacg attttgcaga tggggggctg ctacaagtca ttaccaagta gaaatggacc
     1561 tcttgcagtc atcgtgtgtc ctgggtggaa aaaggctcag tttatttttg agttattggg
     1621 agactatagc atgtcctcca ggcctcttca tcctgtgtta ttaacaattg gacttcacaa
     1681 agatgaagcc aaaaatatga agcttccaag ggggtgtgat gtgattgtca caacgccaca
     1741 cagccttttg agacttctta cgtaccgaag cttgttattc cttagactct gccacctggt
     1801 tctggatgaa gtgcacatgc tgttctttga agctaatgag caaatgtttg ccatattaga
     1861 taactttaaa aaaaacgttg aagtggagga gcgggagtct gcaccacacc agattgtagc
     1921 cgtgggtgtt cactggaaca aacacataga ccatctagtc agagagttca tgaaggaccc
     1981 ctgcgtcgtg atcaccgccc tggaggaggc tgccctctat ggcagtgtcc agcaggtagt
     2041 gcatctgtgc ctggagtgtg agaagacctc tactttactc caagttcttg actttgttcc
     2101 aagtcaggcc cagaagacct tgatctttac ctgttctgta gcagagacag agactgtgtg
     2161 taaggtagta gaaagcaatt caatattttg cttgaaaatg cataaagaaa tggcttttaa
     2221 tttaaaaagt attttggagc agtggaagaa gaagttaagt cctggctccc acattgtgtt
     2281 aaccttaaca gacgactgca taccactcct ggccatcacc gatgccacgt gcgtcgtcca
     2341 cttcagcttt ccttcctcac caaaagtatt gggtggacgc ctgtattgca tgtctgatca
     2401 ttttcagagt ttaactgaac agggttcacc tgcagagcag ggagataaga aaactaaatc
     2461 tgtcttgctg ctgacggaga ggaatgcaag ccatgctgtt ggtatcctga gatacttgga
     2521 gcgagcagat gccaaaattc catcagagct gtatgagttt acagcagggg tcctggaagc
     2581 caaagaagat aagaaggcca gaagacctct ttgtccatat cttaaagctt ttggcttttg
     2641 caaagacaaa aggatctgtc ctgaccggca ccacattaat ccagaaatgg acatcccaag
     2701 gaaattatcc aataaaacac taccagtgtt tggacacatt agggtaatac ctttttacat
     2761 ttcaaatgca accaattact ttggtcgtat aattgataaa catgtggatc tttatgaaac
     2821 tcttaatgca gaaatgaatg aatattttaa ggagtccagt aataaaacat ctgctgaaaa
     2881 ggtggagaat ttggggttgt atggattaga agaaaaaaca cttttccaga gggttcaggt
     2941 gttggaggtg agccagaagg aagacacctg gggtttgggg agtatcctgg tgaaactcat
     3001 agatgaaggc aggaccaagc tcatcacaag agaccagctg ctgctgctcc ctgagaaatt
     3061 ccacactctg ccccctcagg ctgtggagtt cattgtttgt agggttaagc cagctgacag
     3121 tgaaattgaa tggaacccaa aggttactag atacattcat cataaaattg ttggaaaaat
     3181 gcatgatgct aaagtagtac tggctttggg aaataccctt tggattgatc caatggtaca
     3241 tgttacaaaa ctttcaaatc taaaaacttc tatcattgat tataatgttc gagctgaaat
     3301 tttatccatg ggaatgggta ttgataattc agaacaccta gaacaactga agaaactata
     3361 caaagaagct aaactgccag cctttgagga ccttccgtgc cagacctcga tacctacaac
     3421 agtagaagac accgtgtgtt tgcagggcac tcagcaagga gatggaggta cagaaagagg
     3481 agctggttcc caggaggact cagataacca aaagcctgga gttttatctg aagacattgg
     3541 cagcgagacc attagcagcg ctccacagcc acatggaaga agctttcacc cacaaataaa
     3601 gtggttccaa aaagatgatg tggtcatctt aaagataaaa ataaggaatg tcaaagacta
     3661 taagtgtaaa ttctttacag atagagtcat cttcagtgcc tgggtaggag acaagtttta
     3721 cttggctgat ctggaactgc aaggtgacat aaggaaagat gactgcaaat gcataattaa
     3781 ggatgatgaa cctctaataa cacttgcaaa agagaaacag gagtgctggt gtggcctcct
     3841 caagcagagg aatcctaatg tggcttttga ctttgaccac tgggaggagt gtgaggagga
     3901 cagccctttc tccaaggttg taaattctaa aaacctgtcc tgcaaagtgg cagcgttggc
     3961 tgagagcagc ggttcctctt cagacactac tgatgggagt gagagtgaat gagaccgtga
     4021 gtgaaccaac gccatggtga gaagacagaa ctggacacat aagtcatggc taactccttc
     4081 acctggagag tgacttgtca ctgtcattgt gtggcactgc catagatgac aatgagagat
     4141 tcttaattga cttaaagtgg gtagacatgc caggtgatag gttatgatga gattgtcaaa
     4201 gcaaagtcca ggaagggtct gcaatcaggg acacagaaag ttagagacat ttttttggtt
     4261 tggttttttt gttttgtttt tctttttttt tttttttttt tcgagacaag gtttctttgt
     4321 gtagccctgc tgtcctggaa ctcattctgt agaccatgct ggcctcgaac tcagaaatcc
     4381 acctgcctct gcctcccaga tgctaggatt aaaggcgcac gccaccattg ccccgaaagt
     4441 tagagacatt ttaaattcca acattcaaga gattgaggca ggaggattgc aagtttgagg
     4501 gcagtctggc ctttataggg aggttctgtt tccaaaaatg tctcttcaag caaaggtcca
     4561 acgtaagcca cactcgtgca gtgtgtgctc tcagtgactc tccgctcatc ctgactactc
     4621 catgtagaaa cggagggtga cggagggcga gcagccctgc ctgacattag gtagtagatt
     4681 gttcgtataa ggagttagtt tactcatttg ccatgtagac ctgagtgtga cactgctcaa
     4741 aacttgtctc acacacagaa actgaagttt ccatcttaca cttttaaaaa cccagccctt
     4801 cttgccagcc cctttcacca tgggacctaa atgcatctac tgctgccaca caaatacccc
     4861 ctaaattttt cctggctttg atagcttcta agagatgcaa attgacttct tttcccaaag
     4921 gcaagataga ctcactggga ccaaatgact tacaggccgc tgggcagaac tttctttcag
     4981 aaatgctaac atagtgcttg ttgttaacct tcagagcacc cagatgaggt gagtcctgag
     5041 aacactaaag gcaactttga atgcagctgt aacaccctgg cttggggaag gggtgtgtgc
     5101 agttatcatt taaatgccac tgaaataatt gggagggtga gcctctggga acttcacaac
     5161 cctgtgtctt agcatttctg catcagcttc cctagaagtg agaaggggcc tggatgagtc
     5221 agcgctgctg agtgactacc ccaagcactt gctcctcttc atatcagaaa gtatggatat
     5281 cccaggatgt gcccatgcct ataattccag cttttgagag gtggagacag gaggatctag
     5341 aagtgtcagg ccagcgtggg ctacataaga accagtgtca aaaaaactga agaaaaaaat
     5401 aaaaagaaac acagatgtca agacttctgt tactccagga gtgagccact gcagagttca
     5461 ggctctctgt gccaggagca gggctgggcc cacactggtt cttggttttc ttatctgtaa
     5521 aataagatct gagcacatga agcccaagat agtccagggt gttgtggggt ggacacctgg
     5581 ctttcacagt gactgtgaga aggattaaac ctgtgccagt ggtcagagac tgcccagctt
     5641 gggcagctac caggaggaca tcctttttgc tgttatgact ctcaggttga ttggctggta
     5701 tcagagtggc cataatacaa agtggctctt gagacagcag aaagcatggt gtcttgctgg
     5761 aacaattcag ctgggaggct gggcgtggcc agtgtccatt tgtacaaatg caggtccccc
     5821 cagctggtga agggctgtgg tggcactgaa cactgagtgc aagtggcagg ctgtcccaga
     5881 agacccaagg aaatgggaca cagctctgtt tacaccattt ttttcaggtg gtcagatttt
     5941 ccaatactta aacctctgag caatatcttg tagcacatgg gagactggct atgcaaacat
     6001 cagctattgt tttcctatat tatattaaac tgtgctgatt gaggtagatt tctgaaatgt
     6061 gacatggaaa tgcttgagga gtttgtgctc tagaattgct cccatataat acgaacgtct
     6121 tgtctttgca gtggatcatc aataaagcac cagtgtaatg ttggccaca
//
