LOCUS       NM_001002238            4914 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus tudor domain containing 1 (Tdrd1), transcript variant
            1, mRNA.
ACCESSION   NM_001002238
VERSION     NM_001002238.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4914)
  AUTHORS   Gao,J., Jing,J., Shang,G., Chen,C., Duan,M., Yu,W., Wang,K.,
            Luo,J., Song,M., Chen,K., Chen,C., Zhang,T. and Ding,D.
  TITLE     TDRD1 phase separation drives intermitochondrial cement assembly to
            promote piRNA biogenesis and fertility
  JOURNAL   Dev Cell 59 (20), 2704-2718 (2024)
   PUBMED   39029469
REFERENCE   2  (bases 1 to 4914)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4914)
  AUTHORS   Graham-Paquin,A.L., Saini,D., Sirois,J., Hossain,I., Katz,M.S.,
            Zhuang,Q.K., Kwon,S.Y., Yamanaka,Y., Bourque,G., Bouchard,M. and
            Pastor,W.A.
  TITLE     ZMYM2 is essential for methylation of germline genes and active
            transposons in embryonic development
  JOURNAL   Nucleic Acids Res 51 (14), 7314-7329 (2023)
   PUBMED   37395395
REFERENCE   4  (bases 1 to 4914)
  AUTHORS   Tan,K., Kim,M.E., Song,H.W., Skarbrevik,D., Babajanian,E.,
            Bedrosian,T.A., Gage,F.H. and Wilkinson,M.F.
  TITLE     The Rhox gene cluster suppresses germline LINE1 transposition
  JOURNAL   Proc Natl Acad Sci U S A 118 (23) (2021)
   PUBMED   34083437
REFERENCE   5  (bases 1 to 4914)
  AUTHORS   Shiromoto,Y., Kuramochi-Miyagawa,S., Nagamori,I., Chuma,S.,
            Arakawa,T., Nishimura,T., Hasuwa,H., Tachibana,T., Ikawa,M. and
            Nakano,T.
  TITLE     GPAT2 is required for piRNA biogenesis, transposon silencing, and
            maintenance of spermatogonia in micedagger
  JOURNAL   Biol Reprod 101 (1), 248-256 (2019)
   PUBMED   30951587
REFERENCE   6  (bases 1 to 4914)
  AUTHORS   Chuma,S., Hosokawa,M., Kitamura,K., Kasai,S., Fujioka,M.,
            Hiyoshi,M., Takamune,K., Noce,T. and Nakatsuji,N.
  TITLE     Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell
            differentiation and nuage/germinal granule formation in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15894-15899 (2006)
   PUBMED   17038506
  REMARK    GeneRIF: targeted mutation in Tudor domain containing 1/mouse tudor
            repeat 1 (Tdrd1/Mtr-1), a tudor-related gene in mice, leads to male
            sterility because of postnatal spermatogenic defects
REFERENCE   7  (bases 1 to 4914)
  AUTHORS   Costa,Y., Speed,R.M., Gautier,P., Semple,C.A., Maratou,K.,
            Turner,J.M. and Cooke,H.J.
  TITLE     Mouse MAELSTROM: the link between meiotic silencing of unsynapsed
            chromatin and microRNA pathway?
  JOURNAL   Hum Mol Genet 15 (15), 2324-2334 (2006)
   PUBMED   16787967
REFERENCE   8  (bases 1 to 4914)
  AUTHORS   Pan,J., Goodheart,M., Chuma,S., Nakatsuji,N., Page,D.C. and
            Wang,P.J.
  TITLE     RNF17, a component of the mammalian germ cell nuage, is essential
            for spermiogenesis
  JOURNAL   Development 132 (18), 4029-4039 (2005)
   PUBMED   16093322
REFERENCE   9  (bases 1 to 4914)
  AUTHORS   Chuma,S., Hiyoshi,M., Yamamoto,A., Hosokawa,M., Takamune,K. and
            Nakatsuji,N.
  TITLE     Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid
            bodies/nuages in male germ cells and forms a complex with snRNPs
  JOURNAL   Mech Dev 120 (9), 979-990 (2003)
   PUBMED   14550528
  REMARK    GeneRIF: isolated Mouse tudor repeat-1 (Mtr-1) which encodes a MYND
            domain and four copies of the tudor domain. Mtr-1 is expressed in
            germ-line cells and is most abundant in fetal prospermatogonia and
            postnatal primary spermatocytes.
REFERENCE   10 (bases 1 to 4914)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158549.8 and AC125150.3.
            
            On Nov 18, 2009 this sequence version replaced NM_001002238.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. All four variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB183526.1, AB067571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC158549.8         163591-163646
            57-389              AC158549.8         168423-168755
            390-448             AC158549.8         171788-171846
            449-593             AC158549.8         175024-175168
            594-699             AC158549.8         176457-176562
            700-763             AC158549.8         178692-178755
            764-868             AC158549.8         179597-179701
            869-1051            AC158549.8         179920-180102
            1052-1195           AC158549.8         180527-180670
            1196-1367           AC158549.8         181145-181316
            1368-1454           AC158549.8         182259-182345
            1455-1622           AC158549.8         185987-186154
            1623-1730           AC158549.8         186265-186372
            1731-1901           AC158549.8         187281-187451
            1902-2141           AC158549.8         188708-188947
            2142-2279           AC158549.8         189275-189412
            2280-2390           AC158549.8         192668-192778
            2391-2561           AC158549.8         193352-193522
            2562-2831           AC125150.3         10029-10298
            2832-2951           AC125150.3         11890-12009
            2952-3068           AC125150.3         13298-13414
            3069-3236           AC125150.3         15896-16063
            3237-3464           AC125150.3         17399-17626
            3465-3511           AC125150.3         18049-18095
            3512-3604           AC125150.3         18174-18266
            3605-4914           AC125150.3         20327-21636
FEATURES             Location/Qualifiers
     source          1..4914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 52.0 cM"
     gene            1..4914
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /note="tudor domain containing 1"
                     /db_xref="GeneID:83561"
                     /db_xref="MGI:MGI:1933218"
     exon            1..56
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..389
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3604
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /codon_start=1
                     /product="tudor domain-containing protein 1"
                     /protein_id="NP_001002238.1"
                     /db_xref="CCDS:CCDS29922.1"
                     /db_xref="GeneID:83561"
                     /db_xref="MGI:MGI:1933218"
                     /translation="MMPRNNLEASTCKMAEPFNFEKKESKPPPQDPLRSPVAQHNHPT
                     FRLKSPENGNTKNNFLLCEQNKQYLASQEDSSVVSSNPAVVNGEVGGSKGDRKPPPTG
                     NPVSPLSLGNSSPPNQVKTKPSSNVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRS
                     TTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLNKLEDNKSPFET
                     KAIEVKSEVDCPPGVTKEITAGAERVMFSDLRSLQLKKTMEIKGTVTEFKHPSNFYIQ
                     LYSSEVLENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDV
                     LQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVA
                     AVKALLFEQFCSVKVMDILEEEVLTCAVDLVLQSSGKQLDHVLVEMGYGVKPGEQSST
                     EQSVDHSALEDVGRVTVESKIVTDRNALIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQ
                     LQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEES
                     VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAVCVMKE
                     MVQNRMVTVRVVGMLGTRALVELIDKSVAPHVSASKALIDSGFAIKEKDVADKGSSMH
                     TASVPLAIEGPAEALEWTWVEFTVDETVDVVVCMMYSPGEFYCHFLKDDALEKLDDLN
                     QSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVE
                     EVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEATARFQACVVGLKLQARVV
                     EITANGVGVELTDLSTPYPKIISDVLIREQLVLRCGSPQDSLMSRPANQHKQIDSHRV
                     QASPSAEQWKTMELPVNKTIAANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHC
                     NAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRV
                     QPIPASHLELPFQIIRCSLEGPMELNGSCSQLVMELLRNAMLNQSVVLSVKAISKNVH
                     AVSVEKCSENGMINIAENLVMCGLAENLTSKRKSASTKEIPHSRDCCCTELQKQIEKH
                     EQILLFLLNNPTNQSKFTEMKKLLRS"
     exon            390..448
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..593
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..699
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..763
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..868
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1051
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1195
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1367
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1454
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1622
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1730
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1901
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2141
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2279
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2390
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2561
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2831
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2951
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3068
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3236
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3464
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3511
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3604
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..4914
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4890..4895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /note="hexamer: AATAAA"
     polyA_site      4914
                     /gene="Tdrd1"
                     /gene_synonym="MTR-1"
                     /note="major polyA site"
ORIGIN      
        1 aaactgcgca ggcgcgggcc ccgcaccacg cggcggcttt gagcgtccga ggcgagacat
       61 cagtgaatgt taaattacac ctaatatgat gccacggaat aatttggaag cctctacttg
      121 taaaatggca gagccattta attttgagaa gaaggaaagc aagcccccgc cccaggaccc
      181 tctcagaagt cctgtagcac agcataacca ccccaccttc aggctgaaaa gcccagagaa
      241 cgggaataca aagaacaact ttttgctttg tgaacaaaac aaacagtatt tagctagtca
      301 ggaggacagt tcggtggtct cttcaaaccc tgctgttgtc aatggagaag tcggtgggtc
      361 caaaggagac aggaagccgc caccaacagg aaacccagtg tcaccattaa gtcttggaaa
      421 cagttcacct cctaaccaag taaaaactaa gcccagcagt aatgtgactc ctgaaaaatc
      481 aaaaaaatct cacaagttgt ttgagaatgc cttgtccgta aataatccag cactcttcaa
      541 ctcgttagga ccgccccttc ggtcaacaac ctgccaccgc tgtggcctgt ttgggtcgct
      601 gaggtgctcc cagtgcaagc agacgtacta ctgctccacg gcctgccaga ggagagactg
      661 gtcttcccac agcaccatct gtaggcctgt acagcaaagt ttgaacaagc ttgaagataa
      721 taaatcacca tttgaaacaa aggccattga agtgaagagt gaggttgact gtcccccggg
      781 agttactaaa gaaataacag cgggtgctga gagagtaatg ttctctgatt tgagaagtct
      841 ccaactcaag aaaaccatgg agataaaggg tacagttact gaattcaagc acccgagtaa
      901 cttttatatc cagttgtatt cttcagaggt tctagaaaac atgaaccaac tctctacaag
      961 cttgaaagag acatatgcaa atgtggtgcc tgaagatggt tatcttcctg ttaaggggga
     1021 agtttgtgtt gccaaataca cagttgatca gacctggaac agagccatag tacaagccgt
     1081 ggatgtgctg cagaggaagg cccacgtcct gtacattgac tatgggaacg aggagatgat
     1141 cccgatagac agcgttcacc cgctgagcag aggccttgac ttgtttcctc cttctgccat
     1201 aaagtgctgt gtgtcaggcg tcattcccac tgcgggcgag tggagtgaag gctgtgttgc
     1261 agctgtcaag gcccttctgt ttgagcagtt ctgctctgtc aaggtcatgg acatcttaga
     1321 ggaggaggta ctcacctgtg ccgttgacct tgttctacag agctcaggaa agcagctgga
     1381 ccatgtgctg gtggaaatgg ggtatggagt gaaacccggt gagcagagct ccacggagca
     1441 gagtgtggac cacagtgcat tggaggacgt tggaagagtg acagttgaga gcaagattgt
     1501 gacagacaga aatgccctga tccccaaagt gctgactttg aatgtgggtg atgagttctg
     1561 tggcgtggtt gcccacatcc agacaccaga ggacttcttt tgtcagcagc tgcagagcgg
     1621 ccacaagctt gcggagcttc aggaatccct cagtgaatac tgtggccatg tgattccacg
     1681 ctctgacttt tatccaacca ttggggacgt gtgctgtgct cagttctcag aggatgatca
     1741 gtggtaccgc gcctcggttc tggcctacgc ttctgaagaa tctgtcctgg ttggatatgt
     1801 cgattatggg aactttgaga ttctcagtct gaaaagactt tgtcccataa ttccaaagtt
     1861 gttggatttg ccgatgcaag ctctaaattg tgtgctggca ggcgtgaagc catcattagg
     1921 aatttggact ccagaagctg tgtgtgtcat gaaagagatg gtacagaaca ggatggtcac
     1981 agtgagagtg gtgggcatgc tggggaccag ggccctggtg gagctcatcg acaagtcggt
     2041 ggctcctcac gtcagcgctt ctaaagctct catagactcg ggctttgcca tcaaagaaaa
     2101 ggacgtggca gataaaggca gcagtatgca cacagccagt gttcccttgg ccattgaagg
     2161 tccagcagag gcgttggagt ggacgtgggt ggagttcact gttgacgaga ccgtggatgt
     2221 ggtggtctgc atgatgtaca gtcccgggga gttctactgc cactttctta aagatgatgc
     2281 cttagagaag ctcgatgact tgaatcagtc cttagcagac tactgtgcac aaaagccgcc
     2341 caatggcttt aaggcagaga tagggcggcc ttgctgtgcc tttttttcag gtgacggcaa
     2401 ctggtaccgg gctctagtca aggagatctt accaagtggg aatgttaaag tccactttgt
     2461 ggattacgga aatgttgaag aagttaccac agaccaactc caggcgatat taccacagtt
     2521 cttactactt ccatttcagg ggatgcagtg ctggctagta gatatacagc ccccaaacaa
     2581 gcattggaca aaagaggcca cagcaagatt tcaagcatgt gttgtggggc tcaaactcca
     2641 agccagagtt gtggaaatca ccgcgaacgg cgtgggcgtg gagctcaccg atctttccac
     2701 tccttacccc aaaatcatta gtgatgtgct catcagagag cagttggtct taaggtgtgg
     2761 ttcaccacag gactcactga tgagcagacc tgctaatcaa cataagcaga tcgacagcca
     2821 cagggtgcaa gccagccctt cagcagagca gtggaagaca atggaattgc cagttaacaa
     2881 gactatagca gcaaatgtac tagagatcat aagcccagcc ttgttctacg ccatccccag
     2941 tgaaatgtca gaaaatcaag agaagctgtg tgtgttagca gctgaattgt tagaacactg
     3001 taatgctcag aagggccagc cagcctacag accacggacc ggcgacgcgt gctgtgctaa
     3061 gtacacaaat gatgacttct ggtaccgggc cattgttctg gaaacgtcgg aatctgatgt
     3121 gaaagttctc tacgcagatt atggaaacat cgaaaccctg cctctttcca gagtgcagcc
     3181 catcccagcc agccacctgg agctgccctt ccagatcatt agatgctcac tagaggggcc
     3241 gatggagctg aatggaagct gttcgcagtt agtgatggag ctgctgagaa atgccatgct
     3301 gaaccagagt gtggttctct ctgtgaaagc catttcaaag aatgtccacg cagtgtcagt
     3361 tgaaaaatgt tctgagaacg gaatgatcaa tatagctgag aatctggtga tgtgtggcct
     3421 ggcagaaaac ctcacttcta aaaggaaaag tgcttccact aaagagatac cacacagcag
     3481 agactgctgt tgcacagagt tacagaaaca gattgagaaa cacgaacaga ttctcctctt
     3541 cctcttaaac aatccaacca accaaagtaa attcacagag atgaaaaagc tgctgagaag
     3601 ctaaaaacat catctcttgg aaataaacac tgggaagaaa gagacagcaa acgccagacc
     3661 tgagaaagaa ttgtgtgtgt gttttgttca ctagaattgc tgcttcctcc tctttcctta
     3721 gtgactttta gcctctccgc tgtgcttgct tactttgttc tgtcgggttt gctgccctct
     3781 ccccgattct ttccacgaaa tacatgaatc ttacagaaga gattcatgta tgagctaggc
     3841 gcggtggtgc acacctgtaa tcccagccat gagcagcatg aggcaagacc tcaggctcaa
     3901 agccagcaag ggcctagtta gatgctttct catcacaaac aaaaccaaaa ggacatcaag
     3961 attcaaaatg tatgagacga ctaggaaaga ctatgaggta ccttctgcta agagtgtgtg
     4021 tgtgtgtgtg tgtgtgtgtg tgtgtatgtg tgtgtgtgtg tgtatgtatt tgctctactg
     4081 agtatagaag ctcgagcctc tcatgtacga ggcaagctct cctcttcctc tgagctacag
     4141 tcccagctct agcatctctt tgtcttgaca gtgctgaaga ggaggaggct aggtgttgca
     4201 tggataggtg tggtcggtag ctgggtctta gcactgttgg tacgttccag gcctttcttt
     4261 gccagtggga cgctccctgt catctgctgc ctcgtcccga tgcgctctct ttggttcctt
     4321 gcttctgggt ggcatgtttt cctgggtaac ttgtggctca ctccaaggat gtgcactgct
     4381 tctctcagct gtgcttggat ggcttggctt ttcatcttgg atcatagtgt gtccacaagc
     4441 tccagccttg acactaggag gactccagag ggcctcctgg gatttttttt cccactagtc
     4501 tgtagccatt cagacttatg ctctagaaat aattcactgt cttctcaaac acaaattcag
     4561 tcatcaattt aaaaatggag agcacatttg tcatacctca tgatcagaga ttgtcctaac
     4621 cgtagccatg tgcagcagag tgtgccttcc tgacagccca gtagtctctc atacttgtcc
     4681 cacagtttca gtgccatgtg gccctgtggt aacctaatac gacatcatca actcaacgtt
     4741 gataagtaaa acattgacgt gggtgggttt gttttgtttt cctgttactg gcagtgtgag
     4801 tcagctcctc tgttgagtcg accttctcat gtaaaaagtt gcttggatgt tgatgtgtct
     4861 cagacagtta agtttgtcct gattcaggca ataaagccac ttgttttcac cttg
//
