LOCUS       NM_019551               1977 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tyrosyl-DNA phosphodiesterase 2 (Tdp2), mRNA.
ACCESSION   NM_019551
VERSION     NM_019551.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Alvarez-Quilon,A., Terron-Bautista,J., Delgado-Sainz,I.,
            Serrano-Benitez,A., Romero-Granados,R., Martinez-Garcia,P.M.,
            Jimeno-Gonzalez,S., Bernal-Lozano,C., Quintero,C.,
            Garcia-Quintanilla,L. and Cortes-Ledesma,F.
  TITLE     Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer
            predisposition linked to ATM deficiency
  JOURNAL   Nat Commun 11 (1), 910 (2020)
   PUBMED   32060399
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Canela,A., Maman,Y., Huang,S.N., Wutz,G., Tang,W.,
            Zagnoli-Vieira,G., Callen,E., Wong,N., Day,A., Peters,J.M.,
            Caldecott,K.W., Pommier,Y. and Nussenzweig,A.
  TITLE     Topoisomerase II-Induced Chromosome Breakage and Translocation Is
            Determined by Chromosome Architecture and Transcriptional Activity
  JOURNAL   Mol Cell 75 (2), 252-266 (2019)
   PUBMED   31202577
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Maciejewski,S., Ullmer,W. and Semler,B.L.
  TITLE     VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization
            and proteolytic cleavage
  JOURNAL   Virology 516, 139-146 (2018)
   PUBMED   29353210
  REMARK    GeneRIF: EMCV yields are significantly reduced during infection of
            mouse embryonic fibroblasts genetically ablated for TDP2.
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Hoa,N.N., Shimizu,T., Zhou,Z.W., Wang,Z.Q., Deshpande,R.A.,
            Paull,T.T., Akter,S., Tsuda,M., Furuta,R., Tsutsui,K., Takeda,S.
            and Sasanuma,H.
  TITLE     Mre11 Is Essential for the Removal of Lethal Topoisomerase 2
            Covalent Cleavage Complexes
  JOURNAL   Mol Cell 64 (3), 580-592 (2016)
   PUBMED   27814490
  REMARK    Erratum:[Mol Cell. 2016 Dec 1;64(5):1010. doi:
            10.1016/j.molcel.2016.11.028.. PMID: 27912094]
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Schellenberg,M.J., Perera,L., Strom,C.N., Waters,C.A., Monian,B.,
            Appel,C.D., Vilas,C.K., Williams,J.G., Ramsden,D.A. and
            Williams,R.S.
  TITLE     Reversal of DNA damage induced Topoisomerase 2 DNA-protein
            crosslinks by Tdp2
  JOURNAL   Nucleic Acids Res 44 (8), 3829-3844 (2016)
   PUBMED   27060144
  REMARK    GeneRIF: The results collectively provide a structural mechanism
            for Tdp2 engagement of heterogeneous DNA damage that causes Top2
            poisoning.
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Vermeire,L., Ibrahimi,A., Voet,T., Umans,L., Coddens,K.,
            Francis,A., Van de Putte,T., van Grunsven,L.A., Zwijsen,A.,
            Huylebroeck,D. and Nelles,L.
  TITLE     Essential validation of gene trap mouse ES cell lines: a test case
            with the gene Ttrap
  JOURNAL   Int J Dev Biol 53 (7), 1045-1051 (2009)
   PUBMED   19598121
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Rodrigues-Lima,F., Josephs,M., Katan,M. and Cassinat,B.
  TITLE     Sequence analysis identifies TTRAP, a protein that associates with
            CD40 and TNF receptor-associated factors, as a member of a
            superfamily of divalent cation-dependent phosphodiesterases
  JOURNAL   Biochem Biophys Res Commun 285 (5), 1274-1279 (2001)
   PUBMED   11478795
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Pype,S., Declercq,W., Ibrahimi,A., Michiels,C., Van
            Rietschoten,J.G., Dewulf,N., de Boer,M., Vandenabeele,P.,
            Huylebroeck,D. and Remacle,J.E.
  TITLE     TTRAP, a novel protein that associates with CD40, tumor necrosis
            factor (TNF) receptor-75 and TNF receptor-associated factors
            (TRAFs), and that inhibits nuclear factor-kappa B activation
  JOURNAL   J Biol Chem 275 (24), 18586-18593 (2000)
   PUBMED   10764746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY719852.1, BC132511.1 and AL589699.4.
            
            On Dec 16, 2009 this sequence version replaced NM_019551.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135925.1, AJ251328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY719852.1         2-38
            38-1629             BC132511.1         1-1592
            1630-1977           AL589699.4         136447-136794
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.7 cM"
     gene            1..1977
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /note="tyrosyl-DNA phosphodiesterase 2"
                     /db_xref="GeneID:56196"
                     /db_xref="MGI:MGI:1860486"
     exon            1..271
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1186
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /note="5'-tyrosyl-DNA phosphodiesterase; tyr-DNA
                     phosphodiesterase 2; 5'-Tyr-DNA phosphodiesterase; TRAF
                     and TNF receptor-associated protein"
                     /codon_start=1
                     /product="tyrosyl-DNA phosphodiesterase 2"
                     /protein_id="NP_062424.1"
                     /db_xref="CCDS:CCDS26381.1"
                     /db_xref="GeneID:56196"
                     /db_xref="MGI:MGI:1860486"
                     /translation="MASGSSSDAAEPAGPAGRAASAPEAAQAEEDRVKRRRLQCLGFA
                     LVGGCDPTMVPSVLRENDWQTQKALSAYFELPENDQGWPRQPPTSFKSEAYVDLTNED
                     ANDTTILEASPSGTPLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFL
                     QEVIPPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNL
                     LCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLR
                     DQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYKHRFDRIFFRAEE
                     GHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL"
     exon            272..357
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            358..528
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            529..620
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            621..739
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            740..910
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1977
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1286..1291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /note="hexamer: AATAAA"
     polyA_site      1313
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /note="hexamer: AATAAA"
     polyA_site      1971
                     /gene="Tdp2"
                     /gene_synonym="D13Ertd656e; Ttrap"
                     /note="major polyA site"
ORIGIN      
        1 aggttccggc gttcgcgatc agtcgcgcgg gaagcagcgt gaagagcggg tgttttgagg
       61 ggaccctgcg gcgatggcgt ctggcagcag ttccgatgcg gcggagcccg cagggccggc
      121 agggcgggcg gcgtcggcgc ccgaagcagc acaggcggag gaggaccggg tgaagaggcg
      181 gcggcttcag tgcctgggct ttgcgttggt ggggggatgc gaccccacga tggtccccag
      241 cgtcctgcgg gagaacgact ggcagacgca gaaagccctg agcgcctact tcgagctgcc
      301 agagaacgac caagggtggc cgcgccagcc tcccacgtcc ttcaagtccg aggcctatgt
      361 tgatctaacc aacgaggatg caaatgatac aaccatttta gaagccagtc catctggaac
      421 tcctctagaa gatagcagca ctatttcttt cattacctgg aatattgatg gattagatgg
      481 atgcaatctg cccgagaggg ctcgaggggt gtgttcctgc ctagctttgt atagtccaga
      541 tgtggtattt ctacaggaag ttatcccccc atactgtgcc tacctaaaga agagagcagc
      601 cagttacaca attattacag gtaatgaaga aggatatttc acagctatac tattgaagaa
      661 aggaagagtg aaatttaaaa gtcaggagat tattcctttt ccaaatacca aaatgatgag
      721 aaacctgcta tgcgtaaatg tgagtttggg tggaaatgaa ttttgcctta tgacatccca
      781 tttggagagc accagagaac attctgcgga acgaataaga caattaaaaa ctgttcttgg
      841 aaaaatgcaa gaggctccag attcaaccac ggttatattt gcaggagata caaatttaag
      901 agatcaagaa gttatcaaat gtggtggttt acctgacaac gtttttgatg cctgggaatt
      961 tttaggcaaa cctaaacatt gccagtatac atgggatacg aaagcaaata acaacctcag
     1021 gatccctgct gcttataagc atcgttttga tcgaatattt ttcagagcag aagaggggca
     1081 ccttattcct caaagtttag accttgttgg gttggaaaaa ctggactgtg gtagatttcc
     1141 gagtgatcac tgggggctct tgtgcacctt gaatgtagta ttgtgaaaag cttcccactt
     1201 gcagctttac acgtttgtta gcactagttc tgaatttgtg taggtctcaa cctttcagga
     1261 catctgggtc taatacagaa gaattaataa actggatgat tactacagca aaagcagcta
     1321 acgttttact ttgtatcttg tgtcctcaga attaagaact ggtgtttgta ataaatcaaa
     1381 gcatgcttat gtcagaatgt gtgggctttg gtttaaagga cataacctct ccgcttgtga
     1441 caaagtcatt gttgccatca ggatttcaag taatgggcgt atctcagggc taactattgt
     1501 ttgaattagg caccaatata ttttaaatca ttttattaag agaaaaagta agccattgaa
     1561 ctcttgagac tgcattgtct tatattctgt aagttcagaa atgtaagtga aaaagccgtg
     1621 accaaccgta gtaaagtaga tgacagctgt tgtatatcag acttaatttt gtcagctgat
     1681 agtatatagt gactgatgag tcagtcacag ttccactgac tcccagttac tgttctgatt
     1741 agtggtagtt atttgctggg aactgacaaa gttcatcttg gcaatgatta aacccagctt
     1801 agcaacgtga gaattatttt tttttttcta agaagaaaat tcagaagaaa agtaactgag
     1861 ttttgttact ggtaaaatgg aaatacttca cagagtgaat aaagaatact tttttttttg
     1921 taaatgttct gtaaagaaaa aatgtacagt aaataaagtg ttttatttgt agactga
//
