LOCUS       NM_019911               1646 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus tryptophan 2,3-dioxygenase (Tdo2), mRNA.
ACCESSION   NM_019911
VERSION     NM_019911.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1646)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1646)
  AUTHORS   Van,N.T., Zhang,K., Wigmore,R.M., Kennedy,A.I., DaSilva,C.R.,
            Huang,J., Ambelil,M., Villagomez,J.H., O'Connor,G.J., Longman,R.S.,
            Cao,M., Snook,A.E., Platten,M., Kasenty,G., Sigal,L.J.,
            Prendergast,G.C. and Kim,S.V.
  TITLE     Dietary L-Tryptophan consumption determines the number of colonic
            regulatory T cells and susceptibility to colitis via GPR15
  JOURNAL   Nat Commun 14 (1), 7363 (2023)
   PUBMED   37963876
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1646)
  AUTHORS   Sin,R., Sotogaku,N., Ohnishi,Y.N., Shuto,T., Kuroiwa,M.,
            Kawahara,Y., Sugiyama,K., Murakami,Y., Kanai,M., Funakoshi,H.,
            Chakraborti,A., Bibb,J.A. and Nishi,A.
  TITLE     Inhibition of STAT-mediated cytokine responses to
            chemically-induced colitis prevents inflammation-associated
            neurobehavioral impairments
  JOURNAL   Brain Behav Immun 114, 173-186 (2023)
   PUBMED   37625556
REFERENCE   4  (bases 1 to 1646)
  AUTHORS   Li,S., Li,S., Zhao,Y., Zhang,B., Wang,X., Yang,X., Wang,Y., Jia,C.,
            Chang,Y. and Wei,W.
  TITLE     A comprehensive analysis of TDO2 expression in immune cells and
            characterization of immune cell phenotype in TDO2 knockout mice
  JOURNAL   Transgenic Res 30 (6), 781-797 (2021)
   PUBMED   34529208
  REMARK    GeneRIF: A comprehensive analysis of TDO2 expression in immune
            cells and characterization of immune cell phenotype in TDO2
            knockout mice.
REFERENCE   5  (bases 1 to 1646)
  AUTHORS   Hoffmann,D., Dvorakova,T., Schramme,F., Stroobant,V. and Van den
            Eynde,B.J.
  TITLE     Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual
            Stromal Cells Is Not Essential for Feto-Maternal Tolerance
  JOURNAL   Front Immunol 11, 601759 (2020)
   PUBMED   33363543
  REMARK    GeneRIF: Tryptophan 2,3-Dioxygenase Expression Identified in Murine
            Decidual Stromal Cells Is Not Essential for Feto-Maternal
            Tolerance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1646)
  AUTHORS   Kamiya,A., Inoue,Y., Kodama,T. and Gonzalez,F.J.
  TITLE     Hepatocyte nuclear factors 1alpha and 4alpha control expression of
            proline oxidase in adult liver
  JOURNAL   FEBS Lett 578 (1-2), 63-68 (2004)
   PUBMED   15581617
REFERENCE   7  (bases 1 to 1646)
  AUTHORS   Kaledin,V.I., Klimova,N.V., Vasil'ev,G.V., Ivanova,E.A.,
            Vasil'eva,E.D. and Il'nitskaya,S.I.
  TITLE     Predisposition to alcoholism, tryptophan oxygenase activity, and
            structure of intron 6 in the corresponding gene of C57BL/6J,
            CC57BR/Mv, and BALB/cJ mice
  JOURNAL   Bull Exp Biol Med 136 (4), 385-387 (2003)
   PUBMED   14714090
  REMARK    GeneRIF: No relationship was found between alcohol consumption,
            Tdo2 activity, and single nucleotide substitution in intron 6 of
            the Tdo2 gene assoiated with predisposition to alcoholism in
            humans.
REFERENCE   8  (bases 1 to 1646)
  AUTHORS   Matsui,T., Kinoshita,T., Hirano,T., Yokota,T. and Miyajima,A.
  TITLE     STAT3 down-regulates the expression of cyclin D during liver
            development
  JOURNAL   J Biol Chem 277 (39), 36167-36173 (2002)
   PUBMED   12147685
REFERENCE   9  (bases 1 to 1646)
  AUTHORS   Kamiya,A., Kinoshita,T., Ito,Y., Matsui,T., Morikawa,Y., Senba,E.,
            Nakashima,K., Taga,T., Yoshida,K., Kishimoto,T. and Miyajima,A.
  TITLE     Fetal liver development requires a paracrine action of oncostatin M
            through the gp130 signal transducer
  JOURNAL   EMBO J 18 (8), 2127-2136 (1999)
   PUBMED   10205167
REFERENCE   10 (bases 1 to 1646)
  AUTHORS   Haber,R., Bessette,D., Hulihan-Giblin,B., Durcan,M.J. and
            Goldman,D.
  TITLE     Identification of tryptophan 2,3-dioxygenase RNA in rodent brain
  JOURNAL   J Neurochem 60 (3), 1159-1162 (1993)
   PUBMED   7679723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC018390.1.
            
            On Jun 19, 2003 this sequence version replaced NM_019911.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018390.1, AK132271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 35.97 cM"
     gene            1..1646
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /note="tryptophan 2,3-dioxygenase"
                     /db_xref="GeneID:56720"
                     /db_xref="MGI:MGI:1928486"
     exon            1..70
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1256
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /EC_number="1.13.11.11"
                     /note="tdo variant1; tdo variant2; TRPO; tryptophanase;
                     tryptophan oxygenase; tryptophan pyrrolase; tryptamin
                     2,3-dioxygenase"
                     /codon_start=1
                     /product="tryptophan 2,3-dioxygenase"
                     /protein_id="NP_064295.2"
                     /db_xref="CCDS:CCDS17427.1"
                     /db_xref="GeneID:56720"
                     /db_xref="MGI:MGI:1928486"
                     /translation="MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGN
                     YLQLEKILNAQELQSEVKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHV
                     RDERNMLKVIARMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRL
                     LENKIGVLQSLRVPYNRKHYRDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPN
                     GFNFWGKFEKNILKGLEEEFLRIQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYL
                     LSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHR
                     MLGTKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTA
                     EYSDSSYFSSDESD"
     exon            71..176
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            177..267
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            268..338
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            339..466
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            467..653
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            654..761
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            762..873
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            874..931
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1011
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1102
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1635
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /note="hexamer: AATAAA"
     polyA_site      1635
                     /gene="Tdo2"
                     /gene_synonym="chky; TDO; TO"
                     /note="major polyA site"
ORIGIN      
        1 agcaaacctg tgtggtcctg agacacttca gtactatgag tgggtgcccg tttgcaggaa
       61 acagtgtagg atacactttg aaaaacgtat ctatggagga caatgaagaa gacagagctc
      121 aaactggtgt aaacagagcc agcaaaggag gacttatcta tggcaattac ttgcagttgg
      181 aaaagatttt gaatgcgcaa gaacttcaga gtgaagtaaa agggaacaaa atccatgacg
      241 agcacctatt catcataact catcaagctt atgaactttg gtttaaacaa atcctctggg
      301 aactagattc tgttcgtgaa atcttccaaa atggccatgt cagggatgag aggaacatgc
      361 tcaaggtgat agctcggatg catcgtgtgg tggtcatctt caagctcctg gtacagcagt
      421 tctcggttct ggaaacaatg actgctttgg acttcaatga cttcagagaa tacctgtctc
      481 cagcatcagg cttccagagt ctacagttcc ggctgctgga aaataagatt ggtgttcttc
      541 agagcttgag agtcccttac aacaggaaac actatcgtga taactttgga ggagactaca
      601 atgagctgtt gctgaaatca gagcaggagc agacgctgtt gcagctggtg gaggcatggc
      661 tggaaagaac acctggttta gagccaaatg gatttaattt ctggggaaag tttgaaaaaa
      721 atatcttgaa aggcctggaa gaagaatttc taaggattca ggctaaaacc gactctgaag
      781 aaaaagagga acagatggca gagttccgga agcagaagga ggtgctgctc tgcttgtttg
      841 atgagaagcg tcatgactac cttctgagta aaggtgaacg acgactgtca taccgtgcac
      901 tccagggagc actgatgata tatttttaca gggaggagcc tcgattccag gtccctttcc
      961 agctgctgac ctcacttatg gacattgaca cgctcatgac caaatggaga tataatcatg
     1021 tgtgcatggt gcacagaatg ctgggcacca aggctggcac tgggggatcc tcaggctatc
     1081 attacctgcg ttcaactgtg agcgacaggt acaaggtttt tgtggattta tttaacctct
     1141 caacatatct ggttcccaga cactgggtac caaagatgaa tccgatcatt cacaaattcc
     1201 tttacacagc cgagtacagt gacagctctt acttcagcag cgatgaatcg gattgagttc
     1261 ttctgaacat cagtgaaaac tacaggattc tcagtcggct ttttataaat ttttatgaat
     1321 acatgattgg tgtaatctat ttatatgtgt agttcagtgt tatgatgttt tggtccaatc
     1381 ctggaaaaaa gtttatgatc ttgcatatca tgatggtgag cgattaggag gattaagcat
     1441 tatgataact gatatagtaa aatgttagca tcatcgtaca tatgataaat tcttgctaca
     1501 actcaattta ccctgacatt tacctctgta gaaccatttc atataattat taccttattg
     1561 cttcatactt tataaagctt gttgagcagt tactttgtat tatagataca ataaatacta
     1621 cccttctgta caaaaaaaaa aaaaaa
//
